Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model

Toxicology and Applied Pharmacology

Volumn 244, Issue 2, 2010, Pages 208-217

  Tornero Velez, Rogelio ^a   Mirfazaelian, Ahmad ^b   Kim, Kyu Bong ^c   Anand, Sathanandam S ^d   Kim, Hyo J ^e   Haines, Wendy T ^f   Bruckner, James V ^e   Fisher, Jeffrey W ^e  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c Inje University   (South Korea)

^d DUPONT COMPANY   (United States)

^e UNIVERSITY OF GEORGIA   (United States)

^f UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Children's risk assessment; Deltamethrin; Maturation; PBPK modeling; Pyrethroids; Toxicokinetics

Indexed keywords

CARBOXYLESTERASE; CYTOCHROME P450 2E1; DELTAMETHRIN;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSIMETRY; INTESTINE ABSORPTION; MALE; MICHAELIS MENTEN KINETICS; NONHUMAN; PARTITION COEFFICIENT; PERMEABILITY; RAT; RISK ASSESSMENT; STOMACH ABSORPTION; TOXICOKINETICS;

AGE FACTORS; AGING; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; MALE; MODELS, BIOLOGICAL; NITRILES; ORGAN SPECIFICITY; PYRETHRINS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

RATTUS;

EID: 77950047421     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.12.034     Document Type: Article

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