Physiologically based pharmacokinetic modeling of deltamethrin: Development of a rat and human diffusion-limited model

Toxicological Sciences

Volumn 115, Issue 2, 2010, Pages 330-343

  Godin, Stephen J ^a,d   DeVito, Michael J ^b,e   Hughes, Michael F ^b   Ross, David G ^b   Scollon, Edward J ^b,c   Starr, James M ^c   Setzer, R Woodrow ^c   Conolly, Rory B ^c   Tornero Velez, Rogelio ^c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d Stiefel Laboratories Inc   (United States)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Bioavailability; Deltamethrin; Extrapolation; Physiologically based pharmacokinetic modeling; Pyrethroids

Indexed keywords

DELTAMETHRIN;

ABSORPTION; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BRAIN LEVEL; CONTROLLED STUDY; DIFFUSION; HUMAN; HUMAN TISSUE; HYDROLYSIS; LONG EVANS RAT; MALE; MATHEMATICAL MODEL; NONHUMAN; RAT; SENSITIVITY ANALYSIS; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROCYTES; HUMANS; INSECTICIDES; INTESTINAL ABSORPTION; MALE; MODELS, BIOLOGICAL; NITRILES; PYRETHRINS; RATS; RATS, LONG-EVANS; SPECIES SPECIFICITY;

RATTUS;

EID: 77953703862     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq051     Document Type: Article

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