Workshop to identify critical windows of exposure for children's health: Neurobehavioral work group summary

Environmental Health Perspectives

Volumn 108, Issue SUPPL. 3, 2000, Pages 535-544

  Adams, Jane ^a   Barone Jr , Stan ^b   LaMantia, Anthony ^c   Philen, Rossanne ^d   Rice, D C ^e   Spear, Linda ^f   Susser, Ezra ^g  

^a UNIVERSITY OF MASSACHUSETTS BOSTON   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^e U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^f BINGHAMTON UNIVERSITY   (United States)

^g Department of Medicine   (United States)

Author keywords

Abnormal neurological development; Behavioral teratology; Behavioral testing methodology; Delayed neurotoxicity; Developmental disorders; Developmental neurotoxicology; Environmental health; Neurobiological substrates of function; Neuronal plasticity

Indexed keywords

LEAD; METHYLMERCURY;

ADOLESCENCE; ARTICLE; BEHAVIOR; BRAIN DEVELOPMENT; CONCEPTION; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL ANIMAL; HUMAN; NERVOUS SYSTEM DEVELOPMENT; NEURAL TUBE; NEUROECTODERM; NEUROTOXICOLOGY; NONHUMAN; PRIORITY JOURNAL; RHOMBENCEPHALON; RISK ASSESSMENT;

EID: 0033910788     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.00108s3535     Document Type: Article

References (100)

1. Wilson JG. Environment and Birth Defects. New York:Academic Press, 1973.
2. Schaefer GB, Bodensteiner JB. Evaluation of the child with idiopathic mental retardation. Pediatr Clin North Am 39:929-943 (1992).
3. Kimmel CA, Buelke-Sarr J. Developmental Toxicology. New York:Raven Press, 1981.
4. Slikker WJ, Chang LW. Handbook of Developmental Neurotoxicology San Diego:Academic Press, 1998.
5. Riley EP, Vorhees CV. Handbook of Behavioral Teratology. New York:Plenum Press, 1986.
6. Adams J. Structure-activity and dose-response relationships in the neural and behavioral teratogenesis of retinoids. Neurotoxicol Teratol 15:193-202 (1993).
7. Adams J, Holson RR. The neurobehavioral teratology of Vitamin A analogs. In: Handbook of Developmental Neurotoxicology (Slikker WJ, Chang LW, eds). San Diego:Academic Press, 998:631-642.
8. Freeman JHJ, Barone SJ, Stanton ME. Cognitive and neuroanatomical effects of triethyltin in developing rats: role of age of exposure. Brain Res 634:85-95 (1994).
9. Barone SJ. Developmental differences in neural damage following trimethyl-tin as demonstrated with GFAP immunohistochemistry. Ann NY Acad Sci 679:306-316 (1993).
10. Freeman JHJ, Barone SJ, Stanton ME. Triethyltin produces neural damage and cognitive deficits in developing rats that depend on age of exposure. Brain Res 634:85-95 (1994).
11. Meyer JS. Behavioral assessment in developmental neurotoxicology: approaches involving unconditioned behaviors and pharmacologic challenges in rodents. In: Handbook of Developmental Neurotoxicology (Slikker WJ, Chang LW, eds). San Diego: Academic Press, 1998;403-426.
12. Kimmel CA. Current approaches to risk assessment for developmental neurotoxicology. In: Handbook of Developmental Neurotoxicology (Slikker WJ, Chang LW, eds). San Diego: Academic Press, 1998;675-686.
13. Adams J. Methods in behavioral teratology. In: Handbook of Behavioral Teratology (Riley EP, Vorhees CV, eds). New York:Plenum Press, 1986;67.
14. U.S. EPA. Health Effects Test Guidelines. OPPTS 870.6300 Developmental Neurotoxicity Study Washington, DC:U.S. Environmental Protection Agency, 1996.
15. Vorhees CV. Origins of behavioral teratology. In: Handbook of Behavioral Teratology (Riley EP, Vorhees CV, eds). New York:Plenum Press, 1986;3-22.
16. Vorhees CV. Principles of behavioral teratology. In: Handbook of Behavioral Teratology (Riley EP, Vorhees CV, eds). New York:Plenum Press, 1986;23-48.
17. Buznikov GA, Shmukler Y, Lauder JM. Changes in the physiological roles of neurotransmitters during individual development. Neurosci Behav Physiol 29:11-21 (1999).
18. Rice DC, Barone SJ. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect 108:511-533 (2000).
19. Vorhees CV. Reliability, sensitivity and validity of behavioral indices of neurotoxicity. Neurotoxicol Teratol 9:445-464 (1987).
20. Kimmel CA, Buelke-Sam J. Collaborative Behavioral Teratology Study: background and overview. Neurobehav Toxicol Teratol 7:541-545 (1985).
21. Holson RR. When is a rat a boy? In: Organ System Maturation and Functional Postnatal Development: Aspects to Consider for Pediatric Safety Assessment (Tassinari M, ed). Bethesda, MD:Teratology Society, 1999;D1-D42.
22. Jensen KF, Catalano SM. Brain morphogenesis and developmental neurotoxicology. In: Handbook of Developmental Neurotoxicology (Slikker WJ, Chang LW, eds). San Diego:Academic Press, 1998;3-42.
23. Bennett GD, Finnell GD. Periods of susceptibility to induced malformations of the developing mammalian brain. In: Handbook of Developmental Neurotoxicology (Slikker WJ, Chang LW, eds). San Diego:Academic Press, 1998;189-208.
24. Rodier PM. Neuroteratology of autism. In: Handbook of Developmental Neurotoxicology (Slikker WJ, Chang LW, eds). San Diego:Academic Press, 1998;661-672.
25. Rodier PM, Ingram JL, Tisdale B, Nelson S, Romano J. Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei. J Comp Neurol 370:247-261 (1996).
26. Holson RR, Gazzara RA, Ferguson SA, Ali SF, Laborde JB, Adams J. Gestational retinoic acid exposure a sensitive period for effects on neonatal mortality and cerebellar development. Neurotoxicol Teratol 19:335-346 (1997).
27. Holson RR, Gazzara RA, Ferguson SA, Adams J. Behavioral effects of low-dose gestational day 11-13 retinoic acid exposure. Neurotoxicol Teratol 19:355-362 (1997).
28. Holson RR, Gazzara RA, Ferguson SA, Adams J. A behavioral and neuroanatomical investigation of the lethality caused by gestational day 11-13 retinoic acid exposure. Neurotoxicol Teratol 19:347-353 (1997)
29. Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, Braun JT, Curry CJ, Fernhoff PM, Grik AW Jr, Lott IT. Retinoic acid embryopathy N Engl J Med 313:837-841 (1985).
30. Dansky LV, Finnell RH. Parental epilepsy, anticonvulsant drugs, and reproductive outcome: epidemiologic and experimental findings spanning three decades. 2: Human studies. Reprod Toxicol 5:301-335 (1991).
31. Finnell RH, Dansky LV. Parental epilepsy, anticonvulsant drugs, and reproductive outcome epidemiologic and experimental findings spanning three decades I: Animal studies. Reprod Toxicol 5:281-299 (1991).
32. Hansen DK, Holson RR. Developmental neurotoxicology of antiepileptic drugs. In: Handbook of Developmental Neurotoxicology (Slicker WJ, Chang LW, eds). San Diego Academic Press, 1998;643-660.
33. Kempermann G, Gage FH. New nerve cells for the adult brain. Sci Am 280:48-53 (1999).
34. Barone SJ. Applications of the neurotrophic hypothesis to developmental neurotoxicology. In: Target Organ Toxicity -Neurotoxicology (Tilson HA, Harry GJ, eds). Washington, DC:Taylor & Francis, 1999;179-200.
35. Barone SJ, Das KD, Lassiter TL, White LD. Vulnerable processes of nervous system development: a review of markers and methods. Neurotoxicology 21(1-2):15-36 (1999).
36. Dietrich K. Environmental toxicants and child development. In: Neurodevelopmental Disorders Contributions to a New Framework from the Cognitive Neurosciences (Tager-Flusberg H, ed) Cambridge, MA MIT Press, 1999;469-490
37. Bellinger D, Dietrich KN. Low level lead exposure and cognitive function in children. Pediatr Ann 23(11):600-605 (1994).
38. Dietrich KN, Berger OG, Succop PA, Hammond PB, Bornshein RL. The developmental consequences of low to moderate prenatal and postnatal lead exposure: intellectual attainment in the Cincinnati Lead Study Cohort following school entry. Neurotoxicol Teratol 15(1):37-44 (1993).
39. Rice DC. Behavioral effects of lead: commonalities between experimental and epidemiologic data. Environ Health Perspect 104(suppl 2):337-351 (1996).
40. Rice DC. Developmental lead exposure: neurobehavioral consequences. In: Handbook of Developmental Neurotoxicology (Slikker WJ, Chang LW, eds). San Diego:Academic Press, 1998;539-557.
41. Dietrich KN, Succop PA, Bornschein RL, Krafft KM, Berger O, Hammond PB, Buncher CR. Lead exposure and neurobehavioral development in later infancy. Environ Health Perspect 89:13-19 (1990)
42. Averill D, Needleman H. Neonatal lead exposure retards cortical synaptogenesis in the rat. In Low Level Lead Exposure: The Clinical Implications of Current Research (Needleman H, ed). New York:Raven Press, 1980;210-219.
43. McCauley PT, Bull RJ, Tonti AP, Lutkenhoff SD, Meister MV, Doerger JU, Stober JA. The effect of prenatal and postnatal lead exposure on neonatal synaptogenesis in rat cerebral cortex. J Toxicol Environ Health 10:639-651 (1982).
44. Hoff SF. Synaptogenesis in the hippocampal dentate gyrus effects of in utero ethanol exposure. Brain Res Bull 21:47-54 (1988).
45. Kawamoto JC, Overmann SR, Woolley DE, Vijayan VK. Morphometric effects of preweaning lead exposure on the hippocampal formation of adult rats. Neurotoxicology 5:125-148 (1984).
46. Audesirk G, Audesirk T. Neurite development. In Handbook of Developmental Neurotoxicology (Slikker WJ, Chang LW, eds). San Diego:Academic Press, 1998;61-86
47. Gilbert ME, Mack CM, Lasley SM. The influence of developmental period of lead exposure on long-term potentiation in the adult rat dentate gyrus in vivo. Neurotoxicology 20:57-69 (1999).
48. Johnston MV, Goldstein GW. Selective vulnerability of the developing brain to lead. Curr Opin Neurol 11(6):689-693 (1998).
49. Cookman GR, King W, Regan CM. Chronic low level lead exposure impairs embryonic to adult conversion of the neural cell adhesion molecule. J Neurochem 49(2):399-403 (1987).
50. Harry GJ, Toews AD, Krigman MR, Morell P. The effect of lead toxicity and milk deprivation of myelination in the rat. Toxicol Appl Pharmacol 77:458-464 (1985).
51. Harry GJ, Toews AD. Myelination, dysmyelination, and demyelination. In: Handbook of Developmental Neurotoxicology (Slikker WJ, Chang LW, eds). San Diego:Academic Press, 1998;87-116.
52. Cookman GR, Hemmens SE, Keane GJ, King WB, Regan CM. Chronic low level lead exposure precociously induces rat glial development in vitro and in vivo. Neurosci Lett 86(1):33-37 (1988).
53. Lasley SM, Green MC, Gilbert ME. Influence of exposure period on in vivo hippocampal glutamate and GABA release in rats chronically exposed to lead. Neurotoxicology 20:619-630 (1999).
54. Guilarte TR. The N-Methyl-o-aspartate receptor: physiology and neurotoxicology in the developing brain. In: Handbook of Developmental Neurotoxicology (Slikket WJ, Chang: LW, eds). San Diego:Academic Press, 1998;285-304.
55. Chang LW, Reuhl KR, Lee GW. Degenerative changes in the developing nervous system as a result of in utero exposure to methylmercury. Environ Res 14:414-423 (1977).
56. Burbacher TM, Rodier PM, Weiss B. Methylmercury developmental neurotoxicity: a comparison of effects in humans and animals. Neurotoxicol Teratol 12:191-202 (1990).
57. Chang LW, Guo TL. Fetal Minamata Disease. In: Handbook of Developmental Neurotoxicolgy (Slikker WJ, Chang LW, eds). San Diego:Academic Press, 998;507-516.
58. Barone S Jr, Haykal-Coates N, Parran DK, Tilson HA. Gestational exposure to methylmercury alters the developmental pattern of trk-like immunoreactivity in the rat brain and results in cortical dysmorphology. Dev Brain Res 109:13-31 (1998).
59. Haykal-Coates N, Shafer TJ, Mundy WR, Barone S Jr. Effects of gestational methylmercury exposure on immunoreactivity of specific isoforms of PKC and enzyme activity during post-natal development of the rat brain. Dev Brain Res 109:33-49 (1998).
60. Mundy WR, Parran DK, Barone S Jr. Gestational exposure to methylmercury alters the developmental pattern of neurotrophin-and neurotransmitter-induced phosphoinositide (PI) hydrolysis. Neurotoxicol Res (in press).
61. Jernigan TL, Trauner DA, Hesselink JR, Tallal PA. Maturation of human cerebrum observed in vivo during adolescence. Brain 114(Pt 5):2037-2049 (1991).
62. van Eden CG, Kros JM, Uylings HBM. The development of the rat prefrontal cortex: its size and development of connections with thalamus, spinal cord and other cortical areas. In: Vol. 85: The Prefrontal Cortex: Its Structure, Function, and Pathology (Uylings HBM, van Eden CG, DeBruin JPC, Corner MA, Feenstra MGP, eds). Amsterdam:Elsevier, 1999;169-183.
63. Zecevic N, Rakic P. Synaptogenesis in monkey somatosensory cortex. Cereb Cortex 1:510-523 (1991).
64. Lewis DA. Development of the prefrontal cortex during adolescence: insights into vulnerable neural circuits in schizophrenia. Neuropsychopharmacology 16:385-398 (1997).
65. Andersen SL, Dumont NL, Teicher MH. Developmental differences in dopamine synthesis inhibition by (+)-7-OH-DPAT. Naunyn-Schmeidelberg's Arch Pharmacol 356:173-181 (1997)
66. Te cher MH, Barber NI, Gelbard HA, Gallitano AL, Campbell A, Marsh E, Baldessarini RJ. Developmental differences in acute nigrostriatal and mesocorticolimbic system response to haloperidol. Neuropsychopharmacology 9:147-156 (1993).
67. Benes FM. Myelination of cortical-hippocampal relays during late adolescence. Schizophr Bull 15:585-593 (1989).
68. Dumas TC, Foster TC. Late developmental changes in the ability of adenosine A1 receptors to regulate synaptic transmission in the hippocampus. Dev Brain Res 105:137-139 (1998).
69. Choi S, Weisberg SN, Kellogg CK. Control of endogenous norepinephrine release in the hypothalamus of male rats changes over adolescent development. Dev Brain Res 98:134-141 (1997).
70. Salimov RM, McBride WJ, McKinzie DL, Lumeng L, Li TK. Effects of ethanol consumption by adolescent alcohol-preferring P rats on subsequent behavioral performance in the cross-maze and slip funnel tests. Alcohol 13:297-300 (1996).
71. Goliszek AG, Crawford GE, Lawrence HS, Bennett J, Williams F, Hurley SL. Effects of prepubertal stress on subsequent ACTH response to novel stress and CRH in male vs female rats. Stress Med 12:199-204 (1996).
72. Spear LP. The adolescent brain and age-related behavioral manifestations. Neurosci Behav Rev (in press).
73. Spear LP. Neurobehavioral changes in adolescence. Curr Dir Psychol Sci (in press).
74. Rice DC. Age-related increase in auditory impairment in monkeys exposed in utero plus postnatally to methylmercury. Toxicol Sci 44:191-196 (1998).
75. Rice DC, Hayward S. Comparison of visual function at adulthood and during aging in monkeys exposed to lead or methylmercury. Neurotoxicology 20(5):767-784 (1999).
76. Barone SJ, Stanton ME, Mundy WR. Neurotoxic effects of neonatal triethyltin (TET) exposure are exacerbated with aging. Neurobiol Aging 16:723-735 (1995).
77. Spear LP, Campbell J, Snyder K, Silveri M, Katovic N. Animal behavior models. Increased sensitivity to stressors and other environmental experiences after prenatal cocaine exposure. Ann NY Acad Sci 846:76-88 (1998).
78. Strupp BJ, Himmelstein S, Bunsey M, Levitsky DA, Kesler M. Cognitive profile of rats exposed to lactational hyperphenylalaninemia: correspondence with human mental retardation. Dev Psychobiol 23:195-214 (1990).
79. Strupp BJ, Bunsey M, Levitsky DA, Hamberger K. Deficient cumulative learning: an animal model of retarded cognitive development. Neurotoxicol Teratol 16:71-79 (1994).
80. Paule MG, Meck WH, McMillan DE, McClure GY, Bateson M, Popke EJ, Chelonis JJ, Hinton SC. The use of timing behaviors in animals and humans to detect drug and/or toxicant effects. Neurotoxicol Teratol 21:491-502 (1999).
81. Vorhees CV. Fetal anticonvulsant syndrome in rats: dose-and period-response relationships of prenatal diphenylhydantoin, trimethadione, and phenobarbitol exposure on the structural and functional development of the offspring. J Pharmacol Exp Ther 227:274-287 (1983).
82. Pennington BF. Attention deficit hyperactivity disorder. In: Diagnosing Learning Disorders (Pennington BF, ed). New York:Guilford Press, 1991;82-110.
83. Henderson MG, McConnaughey MM, McMillen BA. Long-term consequences of prenatal exposure to cocaine or related drugs: effects on rat brain monoaminergic receptors. Brain Res Bull 26:941-945 (1991).
84. Moody CA, Frambes NA, Spear LP. Psychopharmacological responsiveness to the dopamine agonist quinpirole in normal weanlings and in weanling offspring exposed gestationally to cocaine. Psychopharmacol Ser (Berl) 108:256-262 (1992).
85. Kelley BM, Groseclose CH, Middaugh LD. Prenatal cocaine exposure increases the reinforcing strength of oral ethanol in C57 mice Neurotoxicol Teratol 19:391-398 (1997).
86. Freeman JHJ, Barone SJ, Stanton ME. Disruption of cerebellar maturation by an antimitotic agent impairs the ontogeny of eyeblink conditioning in rats. J Neurosci 15:7301-7314 (1995).
87. Darr J. Ranking and Screening Risks in the OPPT Existing Chemicals Program. Available: http://www.epa.gov/opptintr/ cie/ranking.htm [cited 6 April 2000].
88. United Nations, Environmental Programme. Screening Information Data Set. Available: http://irptc.unep.ch/irptc/sids/ sidspub.html [cited 18 April 2000].
89. Susser E, Brown A, Gorman J. Prenatal Exposures in Schizophrenia. Washington, DC:American Psychiatric Press, (1999).
90. Susser EB, Brown A, Matte TD. Prenatal factors and adult mental and physical health. Can J Psychiatry 44:326-334 (1999).
91. Hoek HW, Brown AS, Susser E. The Dutch famine and schizcphrenia spectrum disorders. Soc Psychiatry Psychiatr Epidemiol 33:373-379 (1998).
92. Selten JP, Brown AS, Moons KG, Slaets JP, Susser ES, Kahn RS. Prenatal exposure to the 1957 influenza pandemic and non-affective psychosis in The Netherlands. Schizophr Res 38:85-91 (1999).
93. Keshavan MS, Hogarty GE. Brain maturational processes and delayed onset in schizophrenia. Dev Psychopathol 11:525-543 (1999).
94. LaMantia AS. Forebrain induction, retinoic acid, and vulnerability to schizophrenia: insights from molecular and genetic analysis in developing mice. Biol Psychiatry 46:19-30 (1999).
95. Richardson GA, Day NL. Epidemiologic studies of the effects of prenatal cocaine exposure on child development and behavior. In Handbook of Developmental Neurotoxicology (Slikker WJ, Chang LW, eds) San Diego:Academic Press, 1998;487-496.
96. Hardy JF, Drage JS, Jackson EC. The First Year of Life: The Collaborative Perinatal Project on the National Institute of Neurological and Communicative Disorders and Stroke. Baltimore:The Johns Hopkins University Press, 1979.
97. Fried PA, Makin JE. Neonatal behavioural correlates of prenatal exposure to marihuana, cigarettes and alcohol in a low risk population. Neurotoxicol Teratol 9:1-7 (1987).
98. Stanton ME, Spear LP. Workshop on the qualitative and quantitative comparability of human and animal developmental neurotoxicity, Work Group I report: comparability of measures of developmental neurotoxicity in humans and laboratory animals. Neurotoxicol Teratol 12:261-267 (1990).
99. Buelke-Sam J, Mactutus CF. Workshop on the qualitative and quantitative comparability of human and animal developmental neurotoxicity, Work Group II report: testing methods in developmental neurotoxicity for use in human risk assessment. Neurotoxicol Teratol 12:269-274 (1990).
100. Davis JM, Otto DA, Weil DE, Grant LD. The comparative developmental neurotoxicity of lead in humans and animals. Neurotoxicol Teratol 12:215-229 (1990).