Ligand-modified gene carriers increased uptake in target cells but reduced DNA release and transfection efficiency

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 6, Issue 2, 2010, Pages 334-343

  Cu, Yen ^a   LeMoëllic, Cathy ^b   Caplan, Michael J ^b   Saltzman, W Mark ^a  

^a Yale University   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Controlled release; Gene delivery; Luciferase; Megalin; Polymer particle

Indexed keywords

BOVINE SERUM ALBUMINS; CELL UPTAKE; COATED PARTICLES; CONTROLLED RELEASE; DNA DELIVERY; DNA RELEASE; GENE CARRIER; GENE DELIVERY; HIGH DENSITY; OVERALL EFFECTIVENESS; PARTICLE CARRIERS; PARTICLE SURFACE; POLY LACTIC-CO-GLYCOLIC ACID; POLYMER DRUGS; POLYMER PARTICLES; RENAL EPITHELIAL CELLS; TARGET CELLS; TRANSFECTION EFFICIENCY;

BIODEGRADABLE POLYMERS; BODY FLUIDS; CELLS; DNA; DRUG THERAPY; GENE TRANSFER; NUCLEIC ACIDS; PLASTIC COATINGS;

GENE EXPRESSION;

BOVINE SERUM ALBUMIN; DNA; MEGALIN; POLYGLACTIN;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CELL TRANSPORT; CHEMICAL MODIFICATION; CONTROLLED STUDY; DEGRADATION; DRUG PENETRATION; ELECTRON MICROSCOPY; GEL ELECTROPHORESIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; KIDNEY CELL; MATERIAL COATING; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PH; PROTEIN EXPRESSION; SURFACE PROPERTY; TARGET CELL; ZETA POTENTIAL;

ANIMALS; CELLS, CULTURED; DNA; DRUG CARRIERS; KIDNEY; LIGANDS; OPOSSUMS; TRANSFECTION;

BOVINAE;

EID: 77949917538     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2009.09.001     Document Type: Article

References (38)

1. Panyam J., and Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 55 (2003) 329-347
2. Bejjani R.A., BenEzra D., Cohen H., Rieger J., Andrieu C., Jeanny J.C., et al. Nanoparticles for gene delivery to retinal pigment epithelial cells. Mol Vis 11 (2005) 124-132
3. Cohen H., Levy R.J., Gao J., Fishbein I., Kousaev V., Sosnowski S., et al. Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles. Gene Ther 7 (2000) 1896-1905
4. Stern M., Ulrich K., Geddes D.M., and Alton E.W. Poly (D, L-lactide-co-glycolide)/DNA microspheres to facilitate prolonged transgene expression in airway epithelium in vitro, ex vivo and in vivo. Gene Ther 10 (2003) 1282-1288
5. Kang S.W., Lim H.W., Seo S.W., Jeon O., Lee M., and Kim B.S. Nanosphere-mediated delivery of vascular endothelial growth factor gene for therapeutic angiogenesis in mouse ischemic limbs. Biomaterials 29 (2008) 1109-1117
6. Jang J.H., and Shea L.D. Intramuscular delivery of DNA releasing microspheres: microsphere properties and transgene expression. J Controlled Release 112 (2006) 120-128
7. Senthilkumar M., Mishra P., and Jain N.K. Long circulating PEGylated poly(D,L-lactide-co-glycolide) nanoparticulate delivery of docetaxel to solid tumors. J Drug Target 16 (2008) 424-435
8. Gao Z.G., Lee D.H., Kim D.I., and Bae Y.H. Doxorubicin loaded pH-sensitive micelle targeting acidic extracellular pH of human ovarian A2780 tumor in mice. J Drug Target 13 (2005) 391-397
9. Kawashima Y., Yamamoto H., Takeuchi H., and Kuno Y. Mucoadhesive DL-lactide/glycolide copolymer nanospheres coated with chitosan to improve oral delivery of elcatonin. Pharm Dev Technol 5 (2000) 77-85
10. Krishnamachari Y., Madan P., and Lin S. Development of pH- and time-dependent oral microparticles to optimize budesonide delivery to ileum and colon. Int J Pharm 338 (2007) 238-247
11. Fahmy T.M., Samstein R.M., Harness C.C., and Mark Saltzman W. Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting. Biomaterials 26 (2005) 5727-5736
12. Keegan M.E., Royce S.M., Fahmy T., and Saltzman W.M. In vitro evaluation of biodegradable microspheres with surface-bound ligands. J Controlled Release 110 (2006) 574-580
13. McCarron P.A., Marouf W.M., Donnelly R.F., and Scott C. Enhanced surface attachment of protein-type targeting ligands to poly(lactide-co-glycolide) nanoparticles using variable expression of polymeric acid functionality. J Biomed Mater Res A (2008)
14. Nobs L., Buchegger F., Gurny R., and Allemann E. Poly(lactic acid) nanoparticles labeled with biologically active neutravidin for active targeting. Eur J Pharm Biopharm 58 (2004) 483-490
15. Jia W.J., Liu J.G., De Zhang Y., Wang J.W., Wang J., Sun C.Y., et al. Preparation, characterization, and optimization of pancreas-targeted 5-Fu loaded magnetic bovine serum albumin microspheres. J Drug Target 15 (2007) 140-145
16. Kreuter J., Hekmatara T., Dreis S., Vogel T., Gelperina S., and Langer K. Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain. J Controlled Release 118 (2007) 54-58
17. Langer K., Anhorn M.G., Steinhauser I., Dreis S., Celebi D., Schrickel N., et al. Human serum albumin (HSA) nanoparticles: reproducibility of preparation process and kinetics of enzymatic degradation. Int J Pharm 347 (2008) 109-117
18. Thakkar H., Sharma R.K., Mishra A.K., Chuttani K., and Murthy R.R. Albumin microspheres as carriers for the antiarthritic drug celecoxib. AAPS PharmSciTech 6 (2005) E65-73
19. Christensen E.I., and Birn H. Megalin and cubilin: multifunctional endocytic receptors. Nat Rev Mol Cell Biol 3 (2002) 256-266
20. Czekay R.P., Orlando R.A., Woodward L., Lundstrom M., and Farquhar M.G. Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes. Mol Biol Cell 8 (1997) 517-532
21. Cu Y., and Saltzman W.M. Controlled surface modification with poly(ethylene)glycol enhances diffusion of PLGA nanoparticles in human cervical mucus. Mol Pharm 6 (2009) 173-181
22. Zhai X.Y., Nielsen R., Birn H., Drumm K., Mildenberger S., Freudinger R., et al. Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney. Kidney Int 58 (2000) 1523-1533
23. Brunskill N.J., Nahorski S., and Walls J. Characteristics of albumin binding to opossum kidney cells and identification of potential receptors. Pflugers Arch 433 (1997) 497-504
24. Cartiera M.S., Johnson K.M., Rajendran V., Caplan M.J., and Saltzman W.M. The uptake and intracellular fate of PLGA nanoparticles in epithelial cells. Biomaterials 30 (2009) 2790-2798
25. Ikehata M., Yumoto R., Nakamura K., Nagai J., and Takano M. Comparison of albumin uptake in rat alveolar type II and type I-like epithelial cells in primary culture. Pharm Res 25 (2008) 913-922
26. Wang C., Ge Q., Ting D., Nguyen D., Shen H.R., Chen J., et al. Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines. Nat Mater 3 (2004) 190-196
27. Little S.R., Lynn D.M., Puram S.V., and Langer R. Formulation and characterization of poly (beta amino ester) microparticles for genetic vaccine delivery. J Controlled Release 107 (2005) 449-462
28. Kocbek P., Baumgartner S., and Kristl J. Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs. Int J Pharm 312 (2006) 179-186
29. Kou G., Gao J., Wang H., Chen H., Li B., Zhang D., et al. Preparation and characterization of paclitaxel-loaded PLGA nanoparticles coated with cationic SM5-1 single-chain antibody. J Biochem Mol Biol 40 (2007) 731-739
30. Sun B., Ranganathan B., and Feng S.S. Multifunctional poly(D,L-lactide-co-glycolide)/montmorillonite (PLGA/MMT) nanoparticles decorated by trastuzumab for targeted chemotherapy of breast cancer. Biomaterials 29 (2008) 475-486
31. Mo Y., and Lim L.Y. Paclitaxel-loaded PLGA nanoparticles: potentiation of anticancer activity by surface conjugation with wheat germ agglutinin. J Controlled Release 108 (2005) 244-262
32. Yin Y., Chen D., Qiao M., Wei X., and Hu H. Lectin-conjugated PLGA nanoparticles loaded with thymopentin: ex vivo bioadhesion and in vivo biodistribution. J Controlled Release 123 (2007) 27-38
33. Walter F., Scholl I., Untersmayr E., Ellinger A., Boltz-Nitulescu G., Scheiner O., et al. Functionalisation of allergen-loaded microspheres with wheat germ agglutinin for targeting enterocytes. Biochem Biophys Res Commun 315 (2004) 281-287
34. Weissenboeck A., Bogner E., Wirth M., and Gabor F. Binding and uptake of wheat germ agglutinin-grafted PLGA-nanospheres by caco-2 monolayers. Pharm Res 21 (2004) 1917-1923
35. Kim S.H., Jeong J.H., Chun K.W., and Park T.G. Target-specific cellular uptake of PLGA nanoparticles coated with poly(L-lysine)-poly(ethylene glycol)-folate conjugate. Langmuir 21 (2005) 8852-8857
36. Zhang N., Chittasupho C., Duangrat C., Siahaan T.J., and Berkland C. PLGA nanoparticle-peptide conjugate effectively targets intercellular cell-adhesion molecule-1. Bioconjug Chem 19 (2008) 145-152
37. Jeon O., Lim H.W., Lee M., Song S.J., and Kim B.S. Poly(L-lactide-co-glycolide) nanospheres conjugated with a nuclear localization signal for delivery of plasmid DNA. J Drug Target 15 (2007) 190-198
38. Gu F., Zhang L., Teply B.A., Mann N., Wang A., Radovic-Moreno A.F., et al. Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers. Proc Natl Acad Sci U S A 105 (2008) 2586-2591