Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine

Journal of Pharmacology and Experimental Therapeutics

Volumn 333, Issue 1, 2010, Pages 341-350

  Ito, Sumito ^a   Kusuhara, Hiroyuki ^a   Kuroiwa, Yushun ^a   Wu, Chunyong ^a   Moriyama, Yoshinori ^b   Inoue, Katsuhisa ^c   Kondo, Tsunenori ^d   Yuasa, Hiroaki ^c   Nakayama, Hideki ^d   Horita, Shigeru ^d   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

^d TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CATION; LACTIC ACID; METFORMIN; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1; PROTEIN; PROTON; PYRIMETHAMINE; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ARTICLE; BILIARY EXCRETION; BRUSH BORDER VESICLE; CATION EXCHANGE; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; DRUG UPTAKE; EMBRYO; GLUCONEOGENESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY; KIDNEY TUBULE EPITHELIUM; LIVER; MALE; MEMBRANE VESICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; URINARY EXCRETION;

ANIMALS; BILE CANALICULI; BIOLOGICAL TRANSPORT; CELL LINE; HUMANS; KIDNEY; LACTIC ACID; LIVER; MALE; METFORMIN; MICE; MICROVILLI; ORGANIC CATION TRANSPORT PROTEINS; PYRIMETHAMINE; TETRAETHYLAMMONIUM;

EID: 77949675459     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.163642     Document Type: Article

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