Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significanly correlated with cytochrome P450 suppression

World Journal of Gastroenterology

Volumn 15, Issue 15, 2009, Pages 1829-1835

  Chen, Xia ^a   Sun, Chang Kai ^a   Han, Guo Zhu ^a   Peng, Jin Yong ^a   Li, Ying ^a   Liu, Yan Xia ^a   Lv, Yuan Yuan ^a   Liu, Ke Xin ^a   Zhou, Qin ^a   Sun, Hui Jun ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Cytochrome P450; Paracetamol induced hepatotoxicity; Tea polyphenols

Indexed keywords

ACETYLCYSTEINE; CHLORAMPHENICOL; CYTOCHROME B; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; PARACETAMOL; POLYPHENOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG MEGADOSE; GENE EXPRESSION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LIVER PROTECTION; LIVER TOXICITY; LOW DRUG DOSE; MALE; MORTALITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEA; TISSUE LEVEL; ULTRAVIOLET SPECTROPHOTOMETRY; WESTERN BLOTTING;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; ISOENZYMES; LIVER; MALE; MICE; MICROSOMES, LIVER; PHENOLS; TEA;

EID: 67651249826     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.1829     Document Type: Article

References (29)

1. Trevisanato SI, Kim YI. Tea and health. Nutr Rev 2000; 58: 1-10
2. Yang CS, Wang ZY. Tea and cancer. J Natl Cancer Inst 1993; 85: 1038-1049
3. Higdon JV, Frei B. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sci Nutr 2003; 43: 89-143
4. Naasani I, Oh-Hashi F, Oh-Hara T, Feng WY, Johnston J, Chan K, Tsuruo T. Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo. Cancer Res 2003; 63: 824-830
5. Liu TT, Liang NS, Li Y, Yang F, Lu Y, Meng ZQ, Zhang LS. Effects of long-term tea polyphenols consumption on hepatic microsomal drug-metabolizing enzymes and liver function in Wistar rats. World J Gastroenterol 2003; 9: 2742-2744
6. Pan H, Wu J, Zheng S. [Inhibition of colorectal carcinoma induced by 1, 2-dimethylhydrazine in mice with tea polyphenols] Zhonghua Yufang Yixue Zazhi 1995; 29: 356-359
7. Mukhtar H, Wang ZY, Katiyar SK, Agarwal R. Tea components: antimutagenic and anticarcinogenic effects. Prev Med 1992; 21: 351-360
8. Guengerich FP. Cytochrome P450 enzymes. Am Sci 1993; 81: 440-447
9. Cho MK, Kim YG, Lee MG, Kim SG. Suppression of rat hepatic cytochrome P450s by protein-calorie malnutrition: complete or partial restoration by cysteine or methionine supplementation. Arch Biochem Biophys 1999; 372: 150-158
10. McCloskey P, Edwards RJ, Tootle R, Selden C, Roberts E, Hodgson HJ. Resistance of three immortalized human hepatocyte cell lines to acetaminophen and N-acetyl-p-benzoquinoneimine toxicity. J Hepatol 1999; 31: 841-851
11. Lewerenz V, Hanelt S, Nastevska C, El-Bahay C, Röhrdanz E, Kahl R. Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity. Toxicology 2003; 191: 179-187
12. Mitchell JR, Jollow DJ, Potter WZ, Gillette JR, Brodie BB. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther 1973; 187: 211-217
13. Savides MC, Oehme FW. Acetaminophen and its toxicity. J Appl Toxicol 1983; 3: 96-111
14. Ozdemirler G, Aykaç G, Uysal M, Oz H. Liver lipid peroxidation and glutathione-related defence enzyme systems in mice treated with paracetamol. J Appl Toxicol 1994; 14: 297-299
15. Bessems JG, Vermeulen NP. Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Crit Rev Toxicol 2001; 31: 55-138
16. Nedelcheva V, Gut I. P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer. Xenobiotica 1994; 24: 1151-1175
17. Cheung C, Yu AM, Ward JM, Krausz KW, Akiyama TE, Feigenbaum L, Gonzalez FJ. The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity. Drug Metab Dispos 2005; 33: 449-457
18. Raucy JL, Lasker JM, Lieber CS, Black M. Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2. Arch Biochem Biophys 1989; 271: 270-283
19. Jaeschke H, Knight TR, Bajt ML. The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol Lett 2003; 144: 279-288
20. Souidi M, Parquet M, Férézou J, Lutton C. Modulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase activities by steroids and physiological conditions in hamster. Life Sci 1999; 64: 1585-1593
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275
22. Liu GT. Empirical method of enzymology. In: Xu SY, Bian RL, Chen X. Pharmacological empirical methodology. Beijing: Renmin Hygiene Publishing Company, 2001: 513
23. Hu YZ, Yao TW. In vitro metabolism and inductive or inhibitive effect of DL111 on rat cytochrome P4501A enzyme. Chem Biol Interact 2004; 147: 109-117
24. Oz HS, McClain CJ, Nagasawa HT, Ray MB, de Villiers WJ, Chen TS. Diverse antioxidants protect against acetaminophen hepatotoxicity. J Biochem Mol Toxicol 2004; 18: 361-368
25. Dahlin DC, Miwa GT, Lu AY, Nelson SD. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc Natl Acad Sci USA 1984; 81: 1327-1331
26. Lee SS, Buters JT, Pineau T, Fernandez-Salguero P, Gonzalez FJ. Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 1996; 271: 12063-12067
27. Genter MB, Liang HC, Gu J, Ding X, Negishi M, McKinnon RA, Nebert DW. Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. Biochem Pharmacol 1998; 55: 1819-1826
28. Sohn OS, Surace A, Fiala ES, Richie JP Jr, Colosimo S, Zang E, Weisburger JH. Effects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 rat. Xenobiotica 1994; 24: 119-127
29. Chen L, Bondoc FY, Lee MJ, Hussin AH, Thomas PE, Yang CS. Caffeine induces cytochrome P4501A2: induction of CYP1A2 by tea in rats. Drug Metab Dispos 1996; 24: 529-533