Investigation on the isoform selectivity of histone deacetylase inhibitors using chemical feature based pharmacophore and docking approaches

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1777-1791

  Zhu, Yong ^a   Li, Hui Fang ^a   Lu, Shuai ^a   Zheng, Yi Xuan ^a   Wu, Zeng ^a   Tang, Wei Fang ^a   Zhou, Xiang ^a   Lu, Tao ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

HDAC1 inhibitors; Molecular docking; Pharmacophore; Selectivity

Indexed keywords

HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITOR; TRICHOSTATIN A;

ARTICLE; DRUG SELECTIVITY; ENZYME INHIBITION; HYDROPHOBICITY; MOLECULAR DOCKING; PHARMACOPHORE;

BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITORS; ISOENZYMES; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 77949490416     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.010     Document Type: Article

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