Role of hydrogen sulfide in the female reproductive tract

Expert Review of Obstetrics and Gynecology

Volumn 5, Issue 2, 2010, Pages 203-213

  Carson, Ray J ^a   Konje, Justin C ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Fetal membranes; Hydrogen sulfide; Myometrium; Placenta; Reproduction; Uterus

Indexed keywords

ACETYLCYSTEINE; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; CYSTEINE; DICLOFENAC; HYDROGEN SULFIDE;

AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; AMINO ACID TRANSPORT; BLOOD LEVEL; DRUG ACTIVITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG TARGETING; ENZYME ACTIVITY; FEMALE GENITAL SYSTEM; HUMAN; HYDROGEN SULFIDE BLOOD LEVEL; MYOMETRIUM; NONHUMAN; OXIDATION; PREGNANCY; PROTEIN EXPRESSION; REVIEW; SMOOTH MUSCLE RELAXATION; UTERUS CONTRACTION; VASODILATATION;

EID: 77949371131     PISSN: 17474108     EISSN: None     Source Type: Journal    
DOI: 10.1586/eog.10.5     Document Type: Review

References (65)

1. Reiffenstein RJ, Hulbert WC, Roth SH. Toxicology of hydrogen sulfde. Annu. Rev. Pharmacol. Toxicol. 32, 109-134 (1992).
2. Abe K, Kimura H. The possible role of hydrogen sulfde as an endogenous neuromodulator. J. Neurosci. 16(3), 1066-1071 (1996).
3. Hosoki R, Matsuki N, Kimura H. The possible role of hydrogen sulfde as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem. Biophys. Res. Commun. 237(3), 527-531 (1997).
4. Carson RJ, Seyffarth G, Mian R, Maddock H. Interactions between gasotransmitters. In: Signal Transduction and the Gasotransmitter. Wang R (Ed.). Humana Press, NJ, USA, 33-55 (2004).
5. Acevedo CH, Ahmed A. Hemeoxygenase-1 inhibits human myometrial contractility via carbon monoxide and is upregulated by progesterone during pregnancy. J. Clin. Invest. 101(5), 949-955 (1998).
6. Yallampalli C, Garfeld RE, Byam-Smith M. Nitric oxide inhibits uterine contractility during pregnancy but not during delivery. Endocrinology 133(4), 1899-1902 (1993).
7. Ledingham MA, Thomson AJ, Greer IA, Norman JE. Nitric oxide in parturition. BJOG 107(5), 581-593 (2000).
8. 2S be the third endogenous gaseous transmitter? FASEB J. 16(13), 1792-1798 (2002).
9. Shibuya N, Tanaka M, Yoshida M et al. 3-mercaptopyruvate sulfurtransferase produces hydrogen sulfde and bound sulfane sulfur in the brain. Antioxid. Redox Signal. 11(4), 703-714 (2009).
10. Shibuya N, Mikami Y, Kimura Y, Nagahara N, Kimura H. Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfde. J. Biochem. 146(5), 623-626 (2009).
11. (ATP) channel opener. EMBO J. 20(21), 6008-6016 (2001).
12. 2S in rat tissues. Can. J. Physiol. Pharmacol. 81(9), 848-853 (2003).
13. Stipanuk MH, Beck PW. Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat. Biochem. J. 206(2), 267-277 (1982).
14. Bian JS, Yong QC, Pan TT et al. Role of hydrogen sulfde in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes. J. Pharmacol. Exp. Ther. 316(2), 670-678 (2006).
15. Zerangue N, Kavanaugh MP. Interaction of L-cysteine with a human excitatory amino acid transporter. J. Physiol. 493(Pt 2), 419-423 (1996).
16. Kimura H. Hydrogen sulfde: from brain to gut. Antioxid. Redox Signal. (2009) (Epub ahead of print).
17. 2S)-the third gas of interest for pharmacologists. Pharmacol. Rep. 59(1), 4-24 (2007).
18. Whiteman M, Li L, Rose P, Tan CH, Parkinson D, Moore P. The effect of hydrogen sulfde donors on lipopolysaccharide-induced formation of infammatory mediators in macrophages. Antioxid. Redox Signal. (2009) (Epub ahead of print).
19. Olson KR. Is hydrogen sulfde a circulating 'gasotransmitter' in vertebrate blood? Biochim. Biophys. Acta 1787(7), 856-863 (2009).
20. Ueland PM. Homocysteine species as components of plasma redox thiol status. Clin. Chem. 41(3), 340-342 (1995).
21. Yaman H, Akgul EO, Kurt YG et al. Plasma total homocysteine concentrations in a Turkish population sample. Acta Cardiol. 64(2), 247-251 (2009).
22. Tan IK, Gajra B. Plasma and urine amino acid profles in a healthy adult population of Singapore. Ann. Acad. Med. Singap. 35(7), 468-475 (2006).
23. Ishigami M, Hiraki K, Umemura K, Ogasawara Y, Ishii K, Kimura H. A source of hydrogen sulfde and a mechanism of its release in the brain. Antioxid. Redox Signal. 11(2), 205-214 (2009).
24. Stipanuk MH. Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu. Rev. Nutr. 24, 539-577 (2004).
25. Whiteman M, Moore PK. Hydrogen sulfde and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability? J. Cell. Mol. Med. 13(3), 488-507 (2009).
26. Li L, Salto-Tellez M, Tan CH, Whiteman M, Moore PK. GYY4137, a novel hydrogen sulfde-releasing molecule, protects against endotoxic shock in the rat. Free Radic. Biol. Med. 47(1), 103-113 (2009).
27. Pearson RJ, Wilson T, Wang R. Endogenous hydrogen sulfde and the cardiovascular system-what's the smell all about? Clin. Invest. Med. 29(3), 146-150 (2006).
28. Cheng Y, Ndisang JF, Tang G, Cao K, Wang R. Hydrogen sulfde-induced relaxation of resistance mesenteric artery beds of rats. Am. J. Physiol. Heart Circ. Physiol. 287(5), H2316-H2323 (2004).
29. Kiss L, Deitch EA, Szabo C. Hydrogen sulfde decreases adenosine triphosphate levels in aortic rings and leads to vasorelaxation via metabolic inhibition. Life Sci. 83(17-18), 589-594 (2008).
30. Lee SW, Cheng Y, Moore PK, Bian JS. Hydrogen sulphide regulates intracellular pH in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 358(4), 1142-1147 (2007).
31. 2)S-induced vasorelaxation and underlying cellular and molecular mechanisms. Am. J. Physiol. Heart Circ. Physiol. 283(2), H474-H480 (2002).
32. 2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine g-lyase. Science 322(5901), 587-590 (2008).
33. Li L, Bhatia M, Moore PK. Hydrogen sulphide-a novel mediator of infammation? Curr. Opin. Pharmacol. 6(2), 125-129 (2006).
34. Hu LF, Wong PT, Moore PK, Bian JS. Hydrogen sulfde attenuates lipopolysaccharide-induced infammation by inhibition of p38 mitogen-activated protein kinase in microglia. J. Neurochem. 100(4), 1121-1128 (2007).
35. Kimura Y, Goto YI, Kimura H. Hydrogen sulfde increases glutathione production and suppresses oxidative stress in mitochondria. Antioxid. Redox Signal. 12(1), 1-13 (2010).
36. Hayden LJ, Franklin KJ, Roth SH, Moore GJ. Inhibition of oxytocin-induced but not angiotensin-induced rat uterine contractions following exposure to sodium sulfde. Life Sci. 45(26), 2557-2560 (1989).
37. Hayden LJ, Goeden H, Roth SH. Growth and development in the rat during sub-chronic exposure to low levels of hydrogen sulfde. Toxicol. Ind. Health 6(3-4), 389-401 (1990).
38. Hayden LJ, Goeden H, Roth SH. Exposure to low levels of hydrogen sulfde elevates circulating glucose in maternal rats. J. Toxicol. Environ. Health 31(1), 45-52 (1990).
39. Sidhu R, Singh M, Samir G, Carson RJ. L-cysteine and sodium hydrosulphide inhibit spontaneous contractility in isolated pregnant rat uterine strips in vitro. Pharmacol. Toxicol. 88(4), 198-203 (2001).
40. Wray S, Kupittayanant S, Shmygol A, Smith RD, Burdyga T. The physiological basis of uterine contractility: a short review. Exp. Physiol. 86(2), 239-246 (2001).
41. 2+ signaling and force in pregnant human myometrium. Am. J. Obstet. Gynecol. 188(4), 1031-1038 (2003).
42. Patel P, Vatish M, Heptinstall J, Wang R, Carson RJ. The endogenous production of hydrogen sulphide in intrauterine tissues. Reprod. Biol. Endocrinol. 7, 10 (2009).
43. 2S biogenesis by human cystathionine g-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J. Biol. Chem. 284(17), 11601-11612 (2009).
44. Aubard Y, Darodes N, Cantaloube M. Hyperhomocysteinemia and pregnancy review of our present understanding and therapeutic implications. Eur. J. Obstet. Gynecol. Reprod. Biol. 93(2), 157-165 (2000).
45. Steegers-Theunissen RP, Van Iersel CA, Peer PG, Nelen WL, Steegers EA. Hyperhomocysteinemia, pregnancy complications, and the timing of investigation. Obstet. Gynecol. 104(2), 336-343 (2004).
46. Fayed MR, Youssef M, Odah MM. Hyperhomocysteinemia is a risk marker for development of maternal pre-eclampsia. Boll. Chim. Farm. 143(7), 281-287 (2004).
47. Seyffarth G, Nelson PN, Dunmore SJ, Rodrigo N, Murphy DJ, Carson RJ. Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture. Reprod. Biol. Endocrinol. 2, 29 (2004).
48. 2-dependent manner. Am. J. Physiol. Heart Circ. Physiol. 292(4), H1953-H1960 (2007).
49. Srilatha B, Hu L, Adaikan GP, Moore PK. Initial characterization of hydrogen sulfde effects in female sexual function. J. Sex. Med. 6(7), 1875-1884 (2009).
50. Maul H, Longo M, Saade GR, Garfeld RE. Nitric oxide and its role during pregnancy: from ovulation to delivery. Curr. Pharm. Des. 9(5), 359-380 (2003).
51. Kubo S, Doe I, Kurokawa Y, Nishikawa H, Kawabata A. Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfde: contribution to dual modulation of vascular tension. Toxicology 232(1-2), 138-146 (2007).
52. Sweazea K, Walker BR. Antioxidant and vasodilatory effects of heme oxygenase on mesenteric vasoreactivity following chronic hypoxia. Microcirculation 16(2), 131-141 (2009).
53. Olson KR, Dombkowski RA, Russell MJ et al. Hydrogen sulfde as an oxygen sensor/ transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation. J. Exp. Biol. 209(Pt 20), 4011-4023 (2006).
54. Olson KR. Hydrogen sulfde and oxygen sensing in the cardiovascular system. Antioxid. Redox Signal. DOI: 10.1089/ ars.2009.2921 (2009) (Epub ahead of print).
55. Baskar R, Sparatore A, Del Soldato P, Moore PK. Effect of S-diclofenac, a novel hydrogen sulfde releasing derivative inhibit rat vascular smooth muscle cell proliferation. Eur. J. Pharmacol. 594(1-3), 1-8 (2008).
56. Nemmani KV, Mali SV, Borhade N et al. NO-NSAIDs: gastric-sparing nitric oxide-releasable prodrugs of non-steroidal anti-infammatory drugs. Bioorg. Med. Chem. Lett. 19(18), 5297-5301 (2009).
57. Li L, Whiteman M, Guan YY et al. Characterization of a novel, water-soluble hydrogen sulfde-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfde. Circulation 117(18), 2351-2360 (2008).
58. Shukla N, Rossoni G, Hotston M et al. Effect of hydrogen sulphide-donating sildenafl (ACS6) on erectile function and oxidative stress in rabbit isolated corpus cavernosum and in hypertensive rats. BJU Int. 103(11), 1522-1529 (2009).
59. Guzman MA, Navarro MA, Carnicer R et al. Cystathionine b-synthase is essential for female reproductive function. Hum. Mol. Genet. 15(21), 3168-3176 (2006).
60. VanAerts LA, Poirot CM, Herberts CA et al. Development of methionine synthase, cystathionine-b-synthase and S-adenosyl-homocysteine hydrolase during gestation in rats. J. Reprod. Fertil. 103(2), 227-232 (1995)
61. d'Emmanuele di Villa Bianca R, Sorrentino R, Maffa P et al. Hydrogen sulfde as a mediator of human corpus cavernosum smooth-muscle relaxation. Proc. Natl Acad. Sci. USA 106(11), 4513-4518 (2009).
62. Olson KR, Whitfeld NL, Bearden SE et al. Hypoxic pulmonary vasodilation: a paradigm shift with a hydrogen sulfde mechanism. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298(1), R51-R60 (2010).
63. Srilatha B, Adaikan PG, Li L, Moore PK. Hydrogen sulphide: a novel endogenous gasotransmitter facilitates erectile function. J. Sex. Med. 4(5), 1304-1311 (2007).
64. Vaisanen-Tommiska MR. Nitric oxide in the human uterine cervix: endogenous ripening factor. Ann. Med. 40(1), 45-55 (2008).
65. Sidhapuriwala J, Li L, Sparatore A, Bhatia M, Moore PK. Effect of S-diclofenac, a novel hydrogen sulfde releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat. Eur. J. Pharmacol. 569(1-2), 149-154 (2007).