메뉴 건너뛰기




Volumn 106, Issue 11, 2009, Pages 4513-4518

Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation

Author keywords

Cystathionine synthase (CBS); Cystathionine lyase (CSE); H2s penile erection; L cysteine

Indexed keywords

AMINOOXYACETIC ACID; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; CYSTEINE; HYDROGEN SULFIDE; PROPARGYLGLYCINE; SODIUM HYDROGEN SULFIDE; UNCLASSIFIED DRUG;

EID: 63449129269     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0807974105     Document Type: Article
Times cited : (181)

References (38)
  • 1
    • 21744443081 scopus 로고    scopus 로고
    • Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse
    • Li L, et al. (2005) Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB J 19:1196-1198.
    • (2005) FASEB J , vol.19 , pp. 1196-1198
    • Li, L.1
  • 2
    • 0142042338 scopus 로고    scopus 로고
    • The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase
    • Zhong G, Chen F, Cheng Y, Tang C, Du J (2003) The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase. J Hypertens 21:1879-1885.
    • (2003) J Hypertens , vol.21 , pp. 1879-1885
    • Zhong, G.1    Chen, F.2    Cheng, Y.3    Tang, C.4    Du, J.5
  • 3
    • 16344392164 scopus 로고    scopus 로고
    • Role of hydrogen sulfide in acute pancreatitis and associated lung injury
    • Bhatia M, et al. (2005) Role of hydrogen sulfide in acute pancreatitis and associated lung injury. FASEB J 19:623-625.
    • (2005) FASEB J , vol.19 , pp. 623-625
    • Bhatia, M.1
  • 4
    • 0035503695 scopus 로고    scopus 로고
    • 2S as a novel endogenous gaseous Katp channel opener
    • 2S as a novel endogenous gaseous Katp channel opener. EMBO J 20:6008-6016.
    • (2001) EMBO J , vol.20 , pp. 6008-6016
    • Zhao, W.1    Zhang, J.2    Lu, Y.3    Wang, R.4
  • 5
    • 0036845556 scopus 로고    scopus 로고
    • 2S be the third endogenous gaseous transmitter?
    • 2S be the third endogenous gaseous transmitter? FASEB J 16:1792-1798.
    • (2002) FASEB J , vol.16 , pp. 1792-1798
    • Wang, R.1
  • 6
    • 33745920516 scopus 로고    scopus 로고
    • The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver
    • Fiorucci S, Distrutti E, Cirino G, Wallace J-L (2006) The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver. Gastroenterology 131:259-271.
    • (2006) Gastroenterology , vol.131 , pp. 259-271
    • Fiorucci, S.1    Distrutti, E.2    Cirino, G.3    Wallace, J.-L.4
  • 7
    • 0034176207 scopus 로고    scopus 로고
    • Human cystathionine γ-lyase: Developmental and in vitro expression of two isoforms
    • Levonen A-L, Lapatto R, Saksela M, Raivio K-O (2000) Human cystathionine γ-lyase: Developmental and in vitro expression of two isoforms. Biochem J 347:291-295.
    • (2000) Biochem J , vol.347 , pp. 291-295
    • Levonen, A.-L.1    Lapatto, R.2    Saksela, M.3    Raivio, K.-O.4
  • 8
    • 0029551277 scopus 로고
    • Changes in cystathionine γ-lyase in various regions of rat brain during development
    • Awata S, Nakayama K, Suzuki I, Sugahara K, Kodama H (1995) Changes in cystathionine γ-lyase in various regions of rat brain during development. Biochem Mol Biol Int 35:1331-1338.
    • (1995) Biochem Mol Biol Int , vol.35 , pp. 1331-1338
    • Awata, S.1    Nakayama, K.2    Suzuki, I.3    Sugahara, K.4    Kodama, H.5
  • 9
    • 0031589557 scopus 로고    scopus 로고
    • The possible role of hydrogen sulfide as an endogenoussmooth muscle relaxantin synergywith nitricoxide
    • Hosoki R, Matsuki N, Kimura H (1997) The possible role of hydrogen sulfide as an endogenoussmooth muscle relaxantin synergywith nitricoxide. Biochem Biophys Res Commun 237:527-531.
    • (1997) Biochem Biophys Res Commun , vol.237 , pp. 527-531
    • Hosoki, R.1    Matsuki, N.2    Kimura, H.3
  • 10
    • 29544448705 scopus 로고    scopus 로고
    • Erectile dysfunction: Pathophysiologic mechanisms pointing to underlying cardiovascular disease
    • Ganz P (2005) Erectile dysfunction: Pathophysiologic mechanisms pointing to underlying cardiovascular disease. Am J Cardiol 96:8M-12M.
    • (2005) Am J Cardiol , vol.96
    • Ganz, P.1
  • 11
    • 35948978799 scopus 로고    scopus 로고
    • The temporal relationship between erectile dysfunction and cardiovascular disease
    • Hodges L-D, Kirby M, Solanki J, O'Donnell J, Brodie D-A (2007) The temporal relationship between erectile dysfunction and cardiovascular disease. Int J Clin Pract 61:2019-2025.
    • (2007) Int J Clin Pract , vol.61 , pp. 2019-2025
    • Hodges, L.-D.1    Kirby, M.2    Solanki, J.3    O'Donnell, J.4    Brodie, D.-A.5
  • 12
    • 33645408052 scopus 로고    scopus 로고
    • Possible role forthe novel gasotransmitter hydrogen sulfide in erectile dysfunction: A pilot study
    • Srilatha B, Adaikan P-G, Moore P-K (2006) Possible role forthe novel gasotransmitter hydrogen sulfide in erectile dysfunction: A pilot study. Eur J Pharmacol 535:280-282.
    • (2006) Eur J Pharmacol , vol.535 , pp. 280-282
    • Srilatha, B.1    Adaikan, P.-G.2    Moore, P.-K.3
  • 13
    • 34548312390 scopus 로고    scopus 로고
    • Hydrogen sulfide: A novel endogenous gasotransmitter facilitates erectile function
    • Srilatha B, Adaikan P-G, Li L, Moore P-K (2007) Hydrogen sulfide: A novel endogenous gasotransmitter facilitates erectile function. J Sex Med 4:1304-1311.
    • (2007) J Sex Med , vol.4 , pp. 1304-1311
    • Srilatha, B.1    Adaikan, P.-G.2    Li, L.3    Moore, P.-K.4
  • 14
    • 0034440240 scopus 로고    scopus 로고
    • A standardized procedure for using human corpus cavernosum strips to evaluate drug activity
    • Mirone V, et al. (2000) A standardized procedure for using human corpus cavernosum strips to evaluate drug activity. J Pharmacol Toxicol Methods 44:477-482.
    • (2000) J Pharmacol Toxicol Methods , vol.44 , pp. 477-482
    • Mirone, V.1
  • 15
    • 33745274131 scopus 로고    scopus 로고
    • Endogenous hydrogen sulfide and the cardiovascular system: What's the smell all about?
    • Pearson R-J, Wilson T, Wang R (2006) Endogenous hydrogen sulfide and the cardiovascular system: What's the smell all about? Clin Invest Med29:146-150.
    • (2006) Clin Invest Med , vol.29 , pp. 146-150
    • Pearson, R.-J.1    Wilson, T.2    Wang, R.3
  • 16
    • 33644648518 scopus 로고    scopus 로고
    • 2S) protects against regional myocardial ischemia-reperfusion injury: Evidence for a role of Katp channels
    • 2S) protects against regional myocardial ischemia-reperfusion injury: Evidence for a role of Katp channels. Basic Res Cardiol 101:53-60.
    • (2006) Basic Res Cardiol , vol.101 , pp. 53-60
    • Johansen, D.1    Ytrehus, K.2    Baxter, G.-F.3
  • 17
    • 27644492323 scopus 로고    scopus 로고
    • Down-regulation of endogenous hydrogen sulfide pathway in pulmonary hypertension and pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats
    • Xiaohui L, et al. (2005) Down-regulation of endogenous hydrogen sulfide pathway in pulmonary hypertension and pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats. Circ J 69:1418-1424.
    • (2005) Circ J , vol.69 , pp. 1418-1424
    • Xiaohui, L.1
  • 18
    • 2442499521 scopus 로고    scopus 로고
    • Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol
    • Geng B, et al. (2004) Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol. Biochem Biophys Res Commun 318:756-763.
    • (2004) Biochem Biophys Res Commun , vol.318 , pp. 756-763
    • Geng, B.1
  • 19
    • 54949084607 scopus 로고    scopus 로고
    • 2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine γ-lyase
    • 2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine γ-lyase. Science 322:587-590.
    • (2008) Science , vol.322 , pp. 587-590
    • Yang, G.1
  • 20
    • 33750967344 scopus 로고    scopus 로고
    • Ali M-Y, et al. (2006)Regulation of vascular nitric oxide in vitroand in vivo: A newrole for endogenous hydrogen sulfide? Br J Pharmacol 149:625-634.
    • Ali M-Y, et al. (2006)Regulation of vascular nitric oxide in vitroand in vivo: A newrole for endogenous hydrogen sulfide? Br J Pharmacol 149:625-634.
  • 21
    • 18044372877 scopus 로고    scopus 로고
    • Nitric oxide and penile erectile function
    • Toda N, Ayajiki K, Okamura T (2005) Nitric oxide and penile erectile function. Pharmacol Ther 106:233-266.
    • (2005) Pharmacol Ther , vol.106 , pp. 233-266
    • Toda, N.1    Ayajiki, K.2    Okamura, T.3
  • 23
    • 0025081992 scopus 로고
    • Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle
    • Ignarro LJ, et al. (1990) Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun 170:843-850.
    • (1990) Biochem Biophys Res Commun , vol.170 , pp. 843-850
    • Ignarro, L.J.1
  • 24
    • 0026353632 scopus 로고
    • Nitricoxide asa mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
    • Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ (1992)Nitricoxide asa mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl JMed 326:90-94.
    • (1992) N Engl JMed , vol.326 , pp. 90-94
    • Rajfer, J.1    Aronson, W.J.2    Bush, P.A.3    Dorey, F.J.4    Ignarro, L.J.5
  • 25
    • 0037965488 scopus 로고    scopus 로고
    • 3-adrenergic receptor activation via cyclic GMP- but not NO-dependentmechanisms in human corpus cavernosum function
    • 3-adrenergic receptor activation via cyclic GMP- but not NO-dependentmechanisms in human corpus cavernosum function. Proc Natl Acad Sci USA 100:5531-5536.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5531-5536
    • Cirino, G.1
  • 26
    • 15944376265 scopus 로고    scopus 로고
    • Peripheral relaxant activity of apomor- phine and of a D1selective receptor agoniston human corpus cavernosum strips
    • d'Emmanuele di Villa Bianca R, et al. (2005) Peripheral relaxant activity of apomor- phine and of a D1selective receptor agoniston human corpus cavernosum strips. Int J Impot Res 17:127-133.
    • (2005) Int J Impot Res , vol.17 , pp. 127-133
    • d'Emmanuele di1    Villa Bianca, R.2
  • 27
    • 31144447534 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces endo- thelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum
    • d'Emmanuele di Villa Bianca R, et al. (2006) Sphingosine 1-phosphate induces endo- thelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. J Pharmacol Exp Ther 316:703-708.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 703-708
    • d'Emmanuele di1    Villa Bianca, R.2
  • 28
    • 33846184714 scopus 로고    scopus 로고
    • Wallace J-L, Caliendo G, SantagadaV,CirinoG, Fiorucci S(2007)Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology 132:261-271.
    • Wallace J-L, Caliendo G, SantagadaV,CirinoG, Fiorucci S(2007)Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology 132:261-271.
  • 29
    • 33847128813 scopus 로고    scopus 로고
    • Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: Contribution to dual modulation of vascular tension
    • Kubo S, Doe I, Kurokawa Y, Nishikawa H, Kawabata A (2007) Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: Contribution to dual modulation of vascular tension. Toxicology 232:138-146.
    • (2007) Toxicology , vol.232 , pp. 138-146
    • Kubo, S.1    Doe, I.2    Kurokawa, Y.3    Nishikawa, H.4    Kawabata, A.5
  • 30
    • 0035134310 scopus 로고    scopus 로고
    • Antagonism of Rho kinase stimulates rat penile erection via a nitric oxide-independent pathway
    • Chitaley K, et al. (2001) Antagonism of Rho kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med 7:119-122.
    • (2001) Nat Med , vol.7 , pp. 119-122
    • Chitaley, K.1
  • 33
    • 33751088803 scopus 로고    scopus 로고
    • 3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice
    • Ovechkin AV, et al. (2006) 3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice. Am J Physiol 291:L905-L911.
    • (2006) Am J Physiol , vol.291
    • Ovechkin, A.V.1
  • 34
    • 0028937163 scopus 로고
    • Mice deficient in cystathionine β-synthase: Animal models for mild and severe homocyst(e)inemia
    • Watanabe M, et al. (1995) Mice deficient in cystathionine β-synthase: Animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci USA 92:1585-1589.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1585-1589
    • Watanabe, M.1
  • 35
    • 0036144873 scopus 로고    scopus 로고
    • Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine β-synthase-deficient mice
    • Weiss N, et al. (2002) Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine β-synthase-deficient mice. Arterioscler Thromb Vasc Biol 22:34-41.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 34-41
    • Weiss, N.1
  • 36
    • 30744450012 scopus 로고    scopus 로고
    • Elevated levels of homocysteine compromise blood-brain barrier integrity in mice
    • Kamath AF, et al. (2006) Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Blood107:591-593.
    • (2006) Blood , vol.107 , pp. 591-593
    • Kamath, A.F.1
  • 37
    • 15944425802 scopus 로고    scopus 로고
    • Chronicadministration ofphosphodiesterase5 inhibitor improves erectile and endothelial function in a rat model of diabetes
    • Ahn G-J,et al. (2005)Chronicadministration ofphosphodiesterase5 inhibitor improves erectile and endothelial function in a rat model of diabetes. Int J Impot Res17:134-141.
    • (2005) Int J Impot Res , vol.17 , pp. 134-141
    • Ahn, G.-J.1
  • 38
    • 0020483746 scopus 로고
    • Characterization of the enzymic capacity for cysteine desulfhydration in liver and kidney of the rat
    • Stipanuk M-H, Beck P-W(1982) Characterization of the enzymic capacity for cysteine desulfhydration in liver and kidney of the rat. Biochem J206:267-277.
    • (1982) Biochem J , vol.206 , pp. 267-277
    • Stipanuk, M.-H.1    Beck, P.-W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.