Distribution study of orally administered lipoic acid in rat brain tissues

Brain Research

Volumn 1251, Issue , 2009, Pages 80-86

  Chng, H T ^a   New, L S ^a   Neo, A H ^b   Goh, C W ^b   Browne, E R ^b   Chan, E C Y ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b Helios Building #03 01/02   (Singapore)

Author keywords

Alzheimer's disease; Blood brain barrier; Distribution; Endogenous; Lipoic acid; Pharmacokinetics

Indexed keywords

THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TISSUE; CONTROLLED STUDY; DRUG DISTRIBUTION; EQUILIBRIUM DIALYSIS; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SINGLE DRUG DOSE; SYSTEMIC CIRCULATION; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN CHEMISTRY; CHROMATOGRAPHY, LIQUID; MALE; MASS SPECTROMETRY; METABOLIC CLEARANCE RATE; RATS; THIOCTIC ACID;

ANIMALIA; RATTUS;

EID: 58149378140     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.11.025     Document Type: Article

References (33)

1. Arivazhagan P., Juliet P., and Panneerselvam C. Effect of DL-α-lipoic acid on the status of lipid peroxidation and antioxidants in aged rats. Pharmacol. Res. 41 (2000) 209-303
2. Arivazhagan P., Shila S., Kumaran S., and Panneerselvam C. Effect of DL-α-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats. Exp. Gerontol. 37 (2002) 803-811
3. Biewenga G.P., Haenen G.R.M.M., and Bast A. The pharmacology of the antioxidant lipoic acid. Gen. Pharmacol. 29 (1997) 315-331
4. Brown E.A., Griffiths R., Harvey C.A., and Owen D.A. Pharmacological studies with SK and F93944 (temelastine), a novel histamine H1-receptor antagonist with negligible ability to penetrate the central nervous system. Br. J. Pharmacol. 87 (1986) 569-578
5. Grögler K.B., Niebch G., Schneider E., Erb K., Hermann R., Blume H.H., Schug B.S., and Belz G.G. Dose-proportionality of oral thioctic acid-coincidence of assessments via pooled plasma and individual data. Eur. J. Pharm. Sci. 8 (1999) 57-65
6. Hager K., Marahrens A., Kenklies M., Riederer P., and Münch G. Alpha-lipoic acid as a new treatment option for Alzheimer type dementia. Arch. Gerontol. Geriatr. 32 (2001) 275-282
7. Hager K., Kenklies M., McAfoose J., Engel J., and Münch G. Alpha-lipoic acid as a new treatment option for Alzheimer's disease-a 48 months follow-up analysis. J. Neural. Transm. suppl. 72 (2007) 189-193
8. 14C]lipoic acid in the rat. Arch. Biochem. Biophys. 160 (1974) 514-522
9. Hermann R., Niebch G., Borbe H.O., Fieger-Buschges H., Ruus P., Nowak H., Riethmuller-Winzen H., Peukert M., and Blume H. Enantioselective pharmacokinetics and bioavailability of different racemic α-lipoic acid formulations in healthy volunteer. Eur. J. Pharm. Sci. 4 (1996) 167-174
10. Holmquist L., Stuchbury G., Berbaum K., Muscat S., Young S., Hager K., Engel J., and Munch G. Lipoic acid as a novel treatment for Alzheimer's disease and related dementias. Pharmacol. Ther. 113 (2007) 154-164
11. Kalvass J.C., and Maurer T.S. Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery. Biopharm. Drug Dispos. 23 (2002) 327-338
12. Liu J. The effects and mechanisms of mitochondrial nutrient α-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview. Neurochem. Res. 33 (2008) 194-203
13. Lovell M.A., Ehmann W.D., Butler S.M., and Markesberg W.R. Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease. Neurology 45 (1995) 1594-1601
14. Maczurek A., Hager K., Kenklies M., Sharman M., Martins R., Engel J., Carlson D.A., and Münch G. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Adv. Drug Deliver. Rev. 60 (2008) 1463-1470
15. Maurer T.S., DeBartolo D.B., Tess D.A., and Scott D.O. Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice. Drug Metab. Dispos. 33 (2005) 175-181
16. Mignini F., Streccioni V., Tomassoni D., Traini E., and Amenta F. Comparative crossover, randomized, open-label bioequivalence study on the bioequivalence of two formulations of thioctic acid in healthy volunteers. Clin. Exp. Hypertens. 29 (2007) 575-586
17. Packer L., Tritschler H.J., and Wessel K. Neuroprotection by the metabolic antioxidant α-lipoic acid. Free Radic. Biol. Med. 22 (1997) 359-378
18. Panigrahi M., Sadguna Y., Shivakumar B.R., Kolluri S.V.R., Roy S., Packer L., and Ravindranath V. α-lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 717 (1996) 184-188
19. Peinado J., Sies H., and Akerboom T.P.M. Hepatic lipoate uptake. Arch. Biochem. Biophys. 273 (1989) 389-395
20. Seaton T.A., Jenner P., and Marsden C.D. The isomers of thioctic acid alter 14C-deoxyglucose incorporation in rat basal ganglia. Biochem. Pharmacol. 51 (1996) 983-986
21. Shay K.P., Moreau R.F., Smith E.J., and Hagen T.M. Is α-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. Life 60 (2008) 362-367
22. Shila S., Kokilavani V., Subathra M., and Panneerselvam C. Brain regional responses in antioxidant system to α-lipoic acid in arsenic intoxicated rat. Toxicology 210 (2005) 25-36
23. Smith A.R., Shenvi S.V., Widlansky M., Suh J.H., and Hagen T.M. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr. Med. Chem. 11 (2004) 1135-1146
24. Spence J.T., and McCormick D.B. Lipoic acid metabolism in the rat. Arch Biochem. Biophys. 174 (1976) 13-19
25. Suh J.H., Wang H., Liu R.M., Liu J., and Hagen T.M. (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch Biochem. Biophys. 423 (2004) 126-135
26. Suh J.H., Moreau R., Heath S.H., and Hagen T.M. Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex. Redox Rep. 10 (2005) 52-60
27. Summerfield S.G., Stevens A.J., Cutler L., Osuna M.C., Hammond B., Tang S.P., Hersey A., Spalding D.J., and Jeffrey P. Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain. J. Pharmacol. Exp. Ther. 316 (2006) 1282-1290
28. Teichert J., Hermann R., Ruus P., and Preiss R. Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers. J. Clin. Pharmacol. 43 (2003) 1257-1267
29. Teichert J., Tuemmers T., Achenbach H., Preiss C., Hermann R., Ruus P., and Preiss R. Pharmacokinetics of alpha-lipoic acid in subjects with severe kidney damage and end-stage renal disease. J. Clin. Pharmacol. 45 (2005) 313-328
30. Trivedi R.K., Kallem R.R., Mamidi R.N.V.S., Mullangi R., and Srinivas N.R. Determination of lipoic acid in rat plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a pharmacokinetic study. Biomed. Chromatogr. 18 (2004) 681-686
31. Whitwell J.L., Przybelski S.A., Weigand S.D., Knopman D.S., Boeve B.F., Petersen R.C., and Jack Jr. C.R. 3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease. Brain 130 (2007) 1777-1786
32. Zhang W., and Frei B. α-lipoic acid inhibits TNF- α-induced NF-κ-B activation and adhesion molecule expression in human aortic endothelial cells. Faseb J. 15 (2001) 2423-2432
33. Zhang L., Xing G.Q., Barker J.L., Chang Y., Maric D., Ma W., Li B.S., and Rubinow D.R. α-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway. Neurosci. Lett. 312 (2001) 125-128