Prospects for the manufacture of red cells for transfusion

British Journal of Haematology

Volumn 149, Issue 1, 2010, Pages 22-34

  Mountford, Jo ^a,b   Olivier, Emmanuel ^a   Turner, Marc ^b,c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cellular therapy; Red cell transfusion; Stem cells

Indexed keywords

CD34 ANTIGEN; CD36 ANTIGEN; CD45 ANTIGEN; CD71 ANTIGEN; ERYTHROPOIETIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; RHESUS D ANTIGEN; STEM CELL FACTOR;

ANTIGEN EXPRESSION; BLOOD GROUP O; BURST FORMING UNIT E; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CELL MATURATION; CELL PROLIFERATION; CELL RENEWAL; COLONY FORMING UNIT E; EMBRYONIC STEM CELL; ERYTHROBLAST; ERYTHROCYTE; ERYTHROCYTE COUNT; ERYTHROCYTE TRANSFUSION; ERYTHROID CELL; ERYTHROPOIESIS; GENETIC TRANSFECTION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LARGE SCALE PRODUCTION; MICROENVIRONMENT; MOLECULAR MECHANICS; NONHUMAN; ONTOGENY; PLURIPOTENT STEM CELL; PRACTICE GUIDELINE; PRIORITY JOURNAL; PRODUCT DEVELOPMENT; REVIEW; SCALE UP; STEM CELL MOBILIZATION;

CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; ERYTHROCYTE TRANSFUSION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; PLURIPOTENT STEM CELLS;

EID: 77949362084     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08079.x     Document Type: Review

References (127)

1. Amit, M., Margulets, V., Segev, H., Shariki, K., Laevsky, I., Coleman, R. & Itskovitz-Eldor, J. (2003) Human feeder layers for human embryonic stem cells. Biology of Reproduction, 68, 2150-2156.
2. Amit, M., Shariki, C., Margulets, V. & Itskovitz-Eldor, J. (2004) Feeder-layer and serum-free culture of human embryonic stem cells. Biology of Reproduction, 70, 837-845.
3. Baek, E.J., Kim, H.S., Kim, S., Jin, H., Choi, T.Y. & Kim, H.O. (2008) In vitro clinical grade generation of red blood cells from human umbilical cord blood CD34+ cells. Transfusion, 48, 2235-2245.
4. Baek, E.J., Kim, H-S., Kim, J-H., Kim, N-J. & Kim, H.O. (2009) Stroma-free mass production of clinical grade red blood cells (RBCs) by using poloxamer 188 as an RBC survival enhancer. Transfusion, 49, 2285-2295.
5. Basran, S., Frumento, R.J., Cohen, A., Lee, S., Du, Y., Nishanian, E., Kaplan, H.S., Stafford-Smith, M. & Bennett-Guerrero, E. (2006) The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgery. Anesthesia and Analgesia, 103, 15-20.
6. Berezina, T.L., Zaets, S.B., Morgan, C., Spillert, C.R., Kamiyama, M., Spolarics, Z., Deitch, E.A. & Machledo, G.W. (2002) Influences of storage on red blood cell rheological properties. The Journal of Surgical Research, 102, 6-12.
7. Bessis, M., Mize, C. & Prenant, M. (1978) Erythropoiesis: comparison of in vivo and in vitro amplification. Blood Cells, 4, 155-174.
8. Bowles, K.M., Vallier, L., Smith, J.R., Alexander, M.R.J. & Pederson, R.A. (2006) HOXB4 overexpression promotes hematopoietic stem cell development by human embryonic stem cells. Stem Cells, 24, 1359-1369.
9. Calvi, L.M., Adams, G.B., Weibrecht, K.W., Weber, J.M., Olson, D.P., Knight, M.C., Martin, R.P., Schipani, E., Divieti, P., Bringhurst, F.R., Milner, L.A., Kronenberg, H.M. & Scadden, D.T. (2003) Osteoblastic cells regulate the haematopoietic stem cell niche. Nature, 425, 841-846.
10. Cerdan, C., Rouleau, A. & Bhatia, M. (2004) VEGF-A165 augments erythryopoietic development from human embryonic stem cells. Blood, 103, 2504-2512.
11. Chadwick, K., Wang, L., Li, L., Menendez, P., Murdoch, P., Rouleau, A. & Bhatia, M. (2003) Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood, 102, 906-915.
12. Chang, K.H., Nelson, A.M., Cao, H., Wang, L., Nakamoto, B., Ware, C.B. & Papayannopoulou, T. (2006) Definitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globin. Blood, 108, 1515-1523.
13. Cipolleschi, M.G., D'Ippolito, G., Bernabei, P.A., Caporale, R., Nannini, R., Mariana, M., Fabbiani, M., Rossi-Ferrini, P., Olivotto, M. & Sbarba, P.D. (1997) Severe hypoxia enhances the formation of erythroid bursts from human cord blood cells and the maintenance of BFU-E in vitro. Experimental Hematology, 25, 1187-1194.
14. Daley, G.Q. (2003) From embryos to embryoid bodies: generating blood from embryonic stem cells. Annals of the New York Academy of Sciences, 996, 122-131.
15. De Angeli, S., Di Liddo, R., Buoro, S., Toniolo, L., Conconi, M.T., Beloni, A.S., Parnigotto, P.P. & Nussdorfer, G.G. (2004) New immortalised human stromal cell lines enhancing in vitro expansion of cord blood haematopoietic stem cells. International Journal of Molecular Medicine, 13, 363-371.
16. Dexter, T.M., Allen, T.D. & Lajtha, L.G. (1977) Conditions controlling the proliferation of haemopoietic stem cells in vitro. Journal of Cell Physiology, 91, 335.
17. Douay, L. (2001) Experimental culture conditions are critical for ex vivo expansion of hematopoietic cells. Journal of Hematotherapy and Stem Cell Research, 21, 341-346.
18. Douay, L. & Andreu, G. (2007) Ex vivo production of human red blood cells from hematopoietic stem cells: What is the future in transfusion? Transfusion Medicine Reviews, 2, 91-100.
19. Douay, L. & Giarratana, M.C. (2009). Ex vivo generation of human red blood cells: a new advance in stem cell engineering. In: Stem Cells in Regenerative Medicine, Methods and Protocols, Vol 482, Chapter 8 (eds J. Audet & W.L. Stanford), pp. 127-140, Humana Press, New York.
20. Douay, L., Lapillone, H. & Turhan, A.G. (2009) Stem Cells - a source of adult red blood cells for transfusion purposes: present and future. Critical Care Clinics, 25, 383-398.
21. Fibach, E., Manor, D., Oppenheim, A. & Rachmilewitz, E.A. (1989) Proliferation and maturation of human erythroid progenitors in liquid culture. Blood, 73, 100-103.
22. Fibach, E., Manor, D., Treves, A. & Rachmilewitz, E.A. (1991) Growth of human normal erythroid progenitors in liquid culture: a comparison with colony growth in semisolid culture. International Journal of Cell Cloning, 9, 57-64.
23. Freyssinier, J.M., Lecoq-Lafon, C., Amsellen, S., Piard, F., Ducrocq, R., Mayeux, P., Lacombe, C. & Fichelson, S. (1999) Purification, amplification and characterization of a population of human erythroid progenitors. British Journal of Haematology, 106, 912-922.
24. Frisch, B.J., Porter, R.L., Gigliotti, B.J., Olm-Shipman, A.J., Weber, J.M., O'Keefe, R.J., Jordan, C.T. & Calvi, L.M. (2009). In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells. Blood, 114, 4054-4063.
25. + cells by co-culturing with macrophages. International Journal of Hematology, 87, 339-350.
26. Garrett, R.W. & Emerson, S.G. (2009) Bone and blood vessels: the hard and the soft of hematopoietic stem cell niches. Cell Stem Cell, 4, 503-506.
27. Gartner, S. & Kaplan, H.S. (1980) Long-term culture of human bone marrow cells. Proceedings of the National Academy of Sciences USA, 77, 4756.
28. Genbacev, O., Krtolica, A., Zdravkovic, T., Brunette, E., Powell, S., Nath, A., Caceres, E., McMaster, M., McDonagh, S., Li, Y., Mandalam, R., Lebkowski, J. & Fisher, S.J. (2005) Serum-free derivation of human embryonic stem cell lines on human placental fibroblast feeders. Fertility and Sterility, 83, 1517-1529.
29. Giarratana, M.C., Kobari, L., Lapillonne, H., Chalmers, D., Kigler, L., Cynober, T., Marden, M.C., Wajcman, H. & Douay, L. (2005) Ex vivo generation of fully mature human red blood cells from hematopoietic stem cells. Nature Biotechnology, 23, 69-74.
30. Gilson, C.R., Kraus, T.S., Hod, E.A., Hendrickson, J.E., Spitalnik, S.L., Hillyer, C.D., Shaz, B.H. & Zimring, J.C. (2009) A novel model of red blood cell storage and posttransfusion in vivo survival. Transfusion, 49, 1546-1553.
31. Gregory, C.J. & Eaves, A.C. (1978) Three stages of erythropoietic progenitor cell differentiation distinguished by a number of physical and biologic properties. Blood, 51, 527-537.
32. Hanspal, M. (1997) Importance of cell-cell interactions in regulation of erythropoiesis. Current Opinion in Hematology, 4, 142-147.
33. Hanspal, M. & Hanspal, J.S. (1994) The association of erythroblasts with macrophages promotes erythroid proliferation and maturation: a 30kD heparin-binding protein is involved in this contact. Blood, 84, 3494-3504.
34. Hanspal, M., Smockova, Y. & Uong, Q. (1998) Molecular identification and functional characterisation of a novel protein that mediates the attachment of erythroblasts to macrophages. Blood, 92, 2940.
35. Hovatta, O., Mikkola, M., Gertow, K., Stromberg, A.M., Inzunza, J., Hreinsson, J., Rozell, B., Blennow, E., Andang, M. & Ahrlund-Richter, L. (2003) A culture system using human foreskin fibroblasts as feeder cells allows production of human embryonic stem cells. Human Reproduction, 18, 1-6.
36. Itskovitz-Eldor, J., Schuldiner, M., Karsenti, D., Eden, A., Yanuka, O., Amit, M., Soreq, H. & Benvenisty, N. (2000) Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Molecular Medicine, 6, 88-95.
37. Kaufman, D.S., Hanson, E.T., Lewis, R.L., Auerbach, R. & Thomson, J.A. (2001) Hematopoietic colony-forming cells derived from human embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 98, 10716-10721.
38. Kawano, Y., Kobune, M., Yamaguchi, M., Nakamura, K., Ito, Y., Sasaki, K., Takahashi, S., Nakamura, T., Chiba, H., Sato, T., Matsunaga, T., Azuma, H., Ikebuchi, K., Ikeda, H., Kato, J., Niitsu, Y. & Hamada, H. (2003) Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a co-culture system with human telomerase catalytic subunit (hTERT)-transfected human stromal cells. Blood, 101, 532-540.
39. Keller, G. (2005) Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes and Development, 19, 1129-1155.
40. Keller, G., Kennedy, M., Papayannopoulou, T. & Wiles, M. (1993) Hematopoietic commitment during embryonic ste,m cell differentiation in culture. Molecular and Cellular Biology, 13, 473-486.
41. Kennedy, M., D' Souza, S.L., Lynch-Kattman, M., Schwantz, S. & Keller, G. (2007) Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation culture. Blood, 109, 2679-2687.
42. Klump, H., Schiedlmeier, B. & Baum, C. (2005) Control of self-renewal and differentiation of hematopoietic stem cells: HOXB4 on the threshold. Annals of the New York Academy of Sciences, 1044, 6-15.
43. Koch, C.G., Li, L., Sessler, D.I., Figueroa, P., Hoeltge, G.A., Mihaljevic, T. & Blackstone, E.H. (2008) Duration of red cell storage and complications after cardiac surgery. New England Journal of Medicine, 358, 1229-1239.
44. Koivisto, H., Hyvarinen, M., Stromberg, A-M., Inzunza, J., Matilainen, E., Mikkola, M., Hovatta, O. & Teerijoki, H. (2004) Cultures of human embryonic stem cells - serum replacement medium of serum-containing media and the effect of basic fibroblast growth factor. Reproductive Biomedicine Online, 9, 330-337.
45. Koller, M.R. & Palsson, B.O. (1993) Tissue engineering: reconstitution of human haematopoiesis ex vivo. Biotechnology and Bioengineering, 42, 909.
46. Koller, M.R., Emerson, S.G. & Palsson, B.O. (1993) Large scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures. Blood, 82, 378-384.
47. Koller, M.R., Bradley, M.S. & Palsson, B.O. (1995) Growth factor consumption and production in perfusion cultures of human bone marrow correlates with specific cell production. Experimental Hematology, 23, 1275-1283.
48. Koller, M.R., Manchel, I., Palsson, M.A., Maher, R.J. & Palsson, B.O. (1996) Different measures of human hematopoietic cell culture performance are optimised under vastly different conditions. Biotechnology and Bioengineering, 50, 505-513.
49. Koller, M.R., Manchel, I., Maher, R.J., Goltry, K.L., Armstrong, R.D. & Smith, A.K. (1998) Clinical-scale human umbilical cord blood cell expansion in a novel automated perfusion culture system. Bone Marrow Transplantation, 21, 653-663.
50. Kyba, M. & Daley, G.Q. (2003) Hematopoiesis from embryonic stem cells: lessons to and from ontogeny. Experimental Hematology, 31, 994-1006.
51. Kyba, M., Perlingeiro, R.C. & Daley, G.Q. (2002) HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell, 109, 29-37.
52. Lacoste, A., Berenshteyn, F. & Brivanlou, A.H. (2009) An efficient and reversible transposable system for gene delivery and lineage-specific differentiation in human embryonic stem cells. Cell Stem Cell, 5, 332-342.
53. Lansdorp, P.M., Dragowska, W. & Mayani, H. (1993) Ontogeny-related changes in proliferative potential of human hematopoietic cells. Journal of Experimental Medicine, 178, 787-791.
54. Lapidot, T., Pflumio, F. & Dick, J.E. (1993) Modeling hematopoiesis in immunodeficient mice. Laboratory Animal Science, 43, 147-150.
55. Ledran, M.H., Krassowska, A., Armstrong, L., Dimmick, I., Renstrom, J., Lang, R., Yung, S., Santibanez-Coref, M., Dzierzak, E., Stojkovic, M., Oostendorp, R.A.J., Forrester, L. & Lako, M. (2008) Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell, 3, 85-98.
56. Lee, G.S., Kim, B.S., Sheih, J.H. & Moore, M. (2008) Forced expression of HoxB4 enhances hematopoietic differentiation by human embryonic stem cells. Molecules and Cells, 25, 487-493.
57. Lengerke, C., Grauer, M., Niebuhr, N.I., Riedt, T., Kanz, L., Park, I.H. & Daley, G.Q. (2009) Hematopoietic development from human induced pluripotent stem cells. Annals of the New York Academy of Sciences, 1176, 219-227.
58. Lichtman, L.A. (1981) The ultrastructure of the hemopoietic environment of the marrow; a review. Experimental Hematology, 9, 391-410.
59. Lin, T., Ambasudhan, R., Yuan, X., Li, W., Hilcove, S., Abujarour, R., Lin, X., Hahm, H.S., Hao, E., Hayek, A. & Ding, S. (2009) A chemical platform for improved induction of human iPSCs. Nature Methods, 6, 805-808.
60. Loken, M.R., Shah, V.O., Dattilio, K.L. & Civin, C.I. (1987) Flow cytometric analysis of human bone marrow: I. Normal erythroid development. Blood, 69, 255-263.
61. Lord, B.I. (1990) The architecture of bone marrow cell populations. International Journal of Cell Cloning, 8, 317-331.
62. Lu, L. & Broxmeyer, H.E. (1985) Comparative influences of phytohaemagglutinin stimulated leucocyte conditioned medium, hemin, prostaglandin E and low oxygen tension on colony formation by erythroid progenitor cells in normal human bone marrow. Experimental Hematology, 13, 989.
63. Lu, S.J., Feng, Q., Park, J.S., Vida, L., Lee, B.S., Strausbauch, M., Wettstein, P.J., Honig, G.R. & Lanza, R. (2008) Biological properties and enucleation of red blood cells from human embryonic stem cells. Blood, 112, 4475-4484.
64. Ma, F., Ebihara, Y., Umeda, K., Sakai, H., Hanada, S., Zhang, H., Zaike, Y., Tsuchida, E., Nakahata, T., Nakauchi, H. & Tsuji, K. (2008) Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America, 105, 13087-13092.
65. Maggakis-Kelemen, C., Bork, M., Kayser, P., Biselli, M. & Artmann, G.M. (2003) Biological and mechanical quality of red blood cells cultured from human umbilical cord blood stem cells. Medical and Biological Engineering and Computing, 41, 350-356.
66. Malik, P., Fisher, T.C., Barsky, L.L.W., Zeng, L., Izadi, P., Hiti, A.L., Weinberg, K.I., Coates, T.D., Meiselman, H.J. & Kohn, D.B. (1998) An in vitro model of human red blood cell production from hematopoietic progenitor cells. Blood, 91, 2664-2671.
67. Marchetto, M.C., Yeo, G.W., Kainohana, O., Marsala, M., Gage, F.H. & Muotri, A.R. (2009) Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS ONE, 4, e7076.
68. Medvinski, A. & Dzierzak, E. (1996) Definitive hematopoiesis is autonomously initiated by the AGM region. Cell, 86, 897-906.
69. Miharada, K., Hiroyama, T., Sudo, K., Nagasawa, T. & Nakamura, Y. (2006) Efficient enucleation of erythroblasts differentiated in vitro from hematopoietic stem and progenitor cells. Nature Biotechnology, 24, 1255-1256.
70. Morris, L., Crocker, P.R., Fraser, I., Hill, M. & Gordon, S. (1991) Expression of a divalent cation dependent erythroblast adhesion receptor by stromal macrophages from murine bone marrow. Journal of Cell Science, 99, 141.
71. Nakahata, T. & Okumura, N. (1994) Cell surface, antigen expression in human erythroid progenitors: erythroid and megakaryocytic markers. Leukaemia and Lymphoma, 13, 401-409.
72. Neildez-Nguyen, T.M.A., Wajcman, H., Marden, M.C., Bensidhoum, M., Moncollin, V., Giarratana, M.C., Kobari, L., Thierry, D. & Douay, L. (2002) Human erythroid cells produced ex vivo at large scale differentiate into red blood cells in vivo. Nature Biotechnology, 5, 467-472.
73. Ng, E.S., Davis, R.P., Azzola, L., Stanley, E.G. & Elefanty, A.G. (2005) Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation. Blood, 106, 1601-1603.
74. North, T.E., Goessling, W., Walkley, C.R., Lengerke, C., Kopani, K.R., Lord, A.M., Weber, G.J., Bowman, T.V., Jang, I.H., Grosser, T., Fitzgerald, G.A., Daley, G.Q., Orkin, S.H. & Zon, L.I. (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature, 447, 1007-1011.
75. North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E. & Zon, L.I. (2009) Hematopoietic stem cell development is dependent on blood flow. Cell, 137, 736-748.
76. Oberlin, E., Tavian, M., Blazsek, I. & Peault, B. (2002) Blood-forming potential of vascular endothelium in the human embryo. Development, 129, 4147-4157.
77. Okita, K., Ichisaka, T. & Yamanaka, S. (2007) Generation of germlilne-competent induced pluripotent stem cells. Nature, 448, 313-317.
78. Okumura, N., Tsuji, K. & Nakahata, T. (1992) Changes in cell surface expression during proliferation and differentiation of human erythroid progenitors. Blood, 80, 642-650.
79. Olivier, E.N., Qiu, C., Velho, M., Hirsch, R.E. & Bouhassira, E.E. (2006) Large-scale production of embryonic red blood cells from human embryonic stem cells. Experimental Hematology, 34, 1635-1642.
80. Olsen, A.L., Stachura, D.L. & Weiss, M.J. (2006) Designer blood: creating hematopoietic lineages from embryonic stem cells. Blood, 107, 1265-1275.
81. Olsson, M.L. & Clausen, H. (2008) Modifying the red cell surface: towards an ABO-universal blood supply. British Journal of Haematology, 140: 3-12.
82. Palis, J. & Segel, G-B. (1998) Developmental biology of erythropoiesis. Blood Reviews, 12, 106-114.
83. Palsson, B.O., Paek, S-H., Schwartz, R.M., Palsson, M., Lee, G.M., Silver, S. & Emerson, S.G. (1993) Expansion of human bone marrow progenitor cells in a high cell density continuous perfusion culture system. Biotechnology, 11, 368-371.
84. Panzenbock, B., Bartunek, P., Mapara, M.Y. & Zenke, M. (1998) Growth and differentiation of human stem cell factor/erythropoietic dependent erythroid progenitor cells in vitro. Blood, 92, 3658-3668.
85. Park, I.H., Zhao, R., West, J.A., Yabuuchi, A., Huo, H., Ince, T.A., Lerou, P.H., Lensch, M.W. & Daley, G. (2008) Reprogramming of human somatic cells to pluripotency with defined factors. Nature, 451, 141-16.
86. Parmar, K., Mauch, P., Vergilio, J.A., Sackstein, R. & Down, J.D. (2007) Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proceedings of the National Academy of Sciences of the United States of America, 104, 5431-5436.
87. Porter, R.L. & Calvi, L.M. (2008) Communications between bone cells and haematopoietic stem cells. Archives of Biochemistry and Biophysics, 473, 193-200.
88. Qiu, L.B., Dickson, H., Hajibagheri, N. & Crocker, P.R. (1995) Extruded erythroblast nuclei are bound and phagocytosed by a novel macrophage receptor. Blood, 85, 1630-1639.
89. Qiu, C., Hanson, E., Olivier, E., Inada, M., Kaufman, D.S., Gupta, S. & Bouhassira, E.E. (2005) Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development. Experimental Hematology, 33, 1450-1458.
90. Qiu, C., Olivier, E.N., Velho, M. & Bouhassira, E.E. (2008) Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells. Blood, 111, 2400-2408.
91. Robert-Bobee, I. (2006). Projections de Population Pour la France Metropolitaine a L'Horizon 2050, INSEE Premiere, Paris.
92. Sadahira, Y., Yoshino, T. & Monobe, Y. (1995) Very late activation antigen 4 - vascular cell adhesion molecule-1 interaction is involved in the formation of erythroblastic islands. Journal of Experimental Medicine, 181, 411.
93. Sandstrom, C.E., Bender, J.G., Papoutsakis, E.T. & Miller, W.M. (1995) Effects of CD34 + selection and perfusion on ex vivo expansion of peripheral blood mononuclear cells. Blood, 86, 958-970.
94. Seifinejad, A., Taei, A., Totonchi, M., Vazirinasab, H., Hasani, S.N., Aghdami, N., Shahbazi, E., Salekdeh, G.H. & Baharvand, H. (2010) Generation of human induced pluripotent stem cells from a Bombay individual: moving towards 'universal-donor' red blood cells. Biochemical and Biophysical Research Communications, 391, 329-334.
95. Snodgrass, H.R., Schmitt, R.M. & Bruyuns, E. (1992) Embryonic stem cells and in vitro hematopoiesis. Journal of Cell Biochemistry, 9, 225-230.
96. Spradling, A., Drummond-Barbosa, D. & Kai, T. (2001) Stem cells find their niche. Nature, 414, 98-104.
97. Stadtfeld, M., Nagaya, M., Utikal, J., Weir, G. & Hochedlinger, K. (2008) Induced pluripotent stem cells generated without viral integration. Science, 322, 945-949.
98. Taichman, R.S. & Emerson, S.G. (1994) Human osteoblasts support hematopoiesis through the production of granulocyte colonystimulating factor. Journal of Experimental Medicine, 179, 1677-1682.
99. Taichman, R.S. & Emerson, S.G. (1998) The role of osteoblasts in the hematopoietic microenvironment. Stem Cells, 16, 7-15.
100. Takahashi, K. & Yamanaka, S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126, 663-676.
101. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. & Yamanaka, S. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131, 861-872.
102. Taoudi, S., Gonneau, C., Moore, K., Sheridan, J.M., Blackburn, C.C., Taylor, E. & Medvinsky, A. (2008) Extensive hematopoietic stem cell generation in the AGM region via maturation of VE-cadherin+ CD45 + pre-definitive HSCs. Cell Stem Cell, 3, 99-108.
103. Tavian, M., Coulombel, L., Luton, D., Clemente, H.S., Dieterlen-Lievre, F. & Peault, B. (1996) Aorta-associated CD34 + hematopoietic cells in the early human embryo. Blood, 87, 67-72.
104. Tavian, M., Hallais, M.F. & Peault, B. (1999) Emergence of intraembryonic hematopoietic precursors in the pre-liver human embryo. Development, 126, 793-803.
105. Tavian, M., Robin, C., Coulombel, L. & Peault, B. (2001) The human embryo, but not its yolk sac, generates lymphomyeloid stem cells: mapping multipotent hematopoietic cell fate in intraembryonic mesoderm. Immunity, 15, 487-495.
106. Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S. & Jones, J.M. (1998) Embryonic stem cell lines derived from human blastocysts. Science, 282, 1145-1147.
107. Tian, X., Morris, J.K., Linehad, J.L. & Kaufman, D.S. (2004) Cytokine requirements differ for stroma and embryoid body-mediated hematopoiesis from human embryonic stem cells. Experimental Hematology, 32, 1000-1009.
108. Unger, C., Kärner, E., Treschow, A., Stellan, B., Felldin, U., Concha, H., Wendel, M., Hovatta, O., Aints, A., Ahrlund-Richter, L. & Dilber, M.S. (2008) Lentiviral-mediated HoxB4 expression in human embryonic stem cells initiates early hematopoiesis in a dose-dependent manner but does not promote myeloid differentiation. Stem Cells, 26, 2455-2466.
109. Van Zant, G., Rummel, S.A., Koller, M.R., Larson, D.B., Drubachevsky, I., Palsson, M. & Emerson, S.G. (1994) Expansion in bioreactors of human progenitor populations from cord blood and mobilised peripheral blood. Blood Cells, 20, 482-491.
110. Vijayaragavan, K., Szabo, E., Bossé, M., Ramos-Mejia, V., Moon, R.T. & Bhatia, M. (2009) Noncanonical Wnt signaling orchestrates early developmental events toward hematopoietic cell fate from human embryonic stem cells. Cell Stem Cell, 4, 248-262.
111. Vodyanik, M.A., Bork, J.A., Thomson, J.A. & Slukvin, II., (2005) Human embryonic stem cell-derived CD34 + cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential. Blood, 105, 617-626.
112. Vodyanik, M.A., Thomson, J.A. & Slukvin, II., (2006) Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures. Blood, 108, 2095-2105.
113. Wada, H., Suda, T., Miura, Y., Kajii, E., Ikemoto, S. & Yawata, Y. (1990) Expression of major blood group antigens on human erythroid progeniors in two phase liquid culture. Blood, 75, 505-511.
114. Wang, L., Li, L., Shojaei, F., Levac, K., Cerdan, C., Menendez, P., Martin, T., Rouleau, A. & Bhatia, M. (2004) Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Immunity, 21, 31-41.
115. Wang, L., Menendez, P., Shojaei, F., Li, L., Mazurier, F., Dick, J.E., Cerdan, C., Levac, K. & Bhatia, M. (2005a) Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression. Journal of Experimental Medicine, 201, 1603-1614.
116. Wang, J., Zhao, H.P., Lin, G., Xie, C.Q., Nie, D.S., Wang, Q.R. & Lu, G.X. (2005b) In vitro hematopoietic differentiation of human embryonic stem cells induced by co-culture with human bone marrow stromal cells and low dose cytokines. Cell Biology International, 29, 654-661.
117. Wernig, M., Meissner, A., Foreman, R., Brambrink, T., Ku, M., Hochedlinger, K., Bernstein, B.E. & Jaemisch, R. (2007) In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature, 448, 318-324.
118. Wilson, A. & Trumpp, A. (2006) Bone marrow haematopoietic stem cell niches. Nature Reviews in Immunology, 6, 93-106.
119. Wolfe, L.C. (1985) The membrane and the lesions of storage in preserved red cells. Transfusion, 25, 185-203.
120. Woll, P.S., Morris, J.K., Painschab, M.S., Marcus, R.K., Kohn, A.D., Biechele, T.L., Moon, R.T. & Kaufman, D.S. (2008) Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells. Blood, 111, 122-131.
121. Yu, J., Vodyanik, M.A., Smuga-Otto, K., Antosiewicz-Bourrget, J., Frane, J.L., Tian, S., Nie, J., Vonsdottir, G.A., Ruotti, V., Stewart, R., Slukin, II. & Thomson, J.A. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science, 318, 1917-1920.
122. Zambidis, E.T., Peault, B., Park, T.S., Bunz, F. & Civin, C.I. (2005) Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development. Blood, 106, 860-870.
123. Zambidis, E.T., Park, T.S., Yu, W., Tam, A., Levine, M., Yuan, X., Pryzhkova, M. & Péault, B. (2008) Expression of angiotensin- converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells. Blood, 112, 3601-3614.
124. Zermati, Y., Fichelson, S., Valensi, F., Fressinier, J.M., Rouyer-Fessard, P., Cramer, E., Guichard, J., Varet, B. & Hermine, O. (2000) Transforming growth factor inhibits erythropoiesis by blocking proliferation and accelerating differentiation of erythroid progenitors. Experimental Hematology, 28, 885-894.
125. Zhang, J., Niu, C., Ye, L., Huahg, H., he, X., Tong, W.G., Ross, J., Haug, J., Johnson, T., Feng, J.Q., Harris, S., Wiedemann, L.M., Mishina, Y. & Li, L. (2003) Identification of the haematopoietic stem cell niche and control of the niche size. Nature, 425, 836-841.
126. Zhou, H., Wu, S., Joo, J.Y., Zhu, S., Han, D.W., Lin, T., Trauger, S., Bien, G., Yao, S., Zhu, Y., Siuzdak, G., Schöler, H.R., Duan, L. & Ding, S. (2009) Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell, 4, 381-384.
127. Zhu, J. & Emerson, S.G. (2004) A new bone to pick: osteoblasts and the haematopoietic stem-cell niche. Bioessays, 26, 595-599.