Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring

Journal of Medicinal Chemistry

Volumn 53, Issue 5, 2010, Pages 1937-1950

  Oger, Frédérik ^a   Lecorgne, Aurélien ^b   Sala, Elisa ^c   Nardese, Vanessa ^c   Demay, Florence ^a   Chevance, Soizic ^b   Desravines, Danielle C ^d   Aleksandrova, Nataliia ^d   Guével, Rémy Le ^a,h   Lorenzi, Simone ^e   Beccari, Andrea R ^e   Barath, Peter ^f   Hart, Darren J ^e   Bondon, Arnaud ^g   Carettoni, Daniele ^c   Simonneaux, Gérard ^b   Salbert, Gilles ^a  

^a UMR CNRS6026 UniversitéRennes 1   (France)

^b INSTITUT DES SCIENCES CHIMIQUES DE RENNES   (France)

^c Axxam   (Italy)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^e Chemistry Section   (Italy)

^f CANCER RESEARCH INSTITUTE   (Slovakia)

^g UNIVERSITÉ DE RENNES 1   (France)

^h Faculté de Médecine   (France)

Author keywords

[No Author keywords available]

Indexed keywords

8 [(2 METHYLPHENYL)AMINO] 8 OXOOCTANOIC ACID; 8 [(3 METHYLPHENYL)AMINO] 8 OXOOCTANOIC ACID; 8 [(4 METHOXYPHENYL)AMINO] 8 OXOOCTANOIC ACID; 8 [(4 METHYLPHENYL)AMINO] 8 OXOOCTANOIC ACID; ACID ANHYDRIDE; ALKYL GROUP; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 5; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 7; HISTONE DEACETYLASE INHIBITOR; N (2 ETHYLPHENYL) N' HYDROXYOCTANEDIAMIDE; N (2,3 DIMETHYLPHENYL) N' HYDROXYOCTANEDIAMIDE; N (2,4 DIMETHYLPHENYL) N' HYDROXYOCTANEDIAMIDE; N (2,5 DIMETHYLPHENYL) N' HYDROXYOCTANEDIAMIDE; N (2,6 DIMETHYLPHENYL) N' HYDROXYOCTANEDIAMIDE; N (3 ETHYLPHENYL) N' HYDROXYOCTANEDIAMIDE; N (3,4 DIMETHYLPHENYL) N' HYDROXYOCTANEDIAMIDE; N (3,5 DIMETHYLPHENYL) N' HYDROXYOCTANEDIAMIDE; N (4 ETHYLPHENYL) N' HYDROXYOCTANEDIAMIDE; N HYDROXY N' (2 METHOXYPHENYL)OCTANEDIAMIDE; N HYDROXY N' (3 METHOXYPHENYL)OCTANEDIAMIDE; N HYDROXY N' (4 METHOXYPHENYL)OCTANEDIAMIDE; N HYDROXY N' (4 METHYLPHENYL)OCTANEDIAMIDE; PHENYL GROUP; PROLINE; SUBERIC ANHYDRIDE; UNCLASSIFIED DRUG; VORINOSTAT;

ACETYLATION; ARTICLE; BIOPHYSICS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

BLOTTING, WESTERN; CACO-2 CELLS; CELL GROWTH PROCESSES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEP G2 CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77949355643     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901561u     Document Type: Article

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