Novel amide derivatives as inhibitors of histone deacetylase: Design, synthesis and SAR

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1067-1085

  Andrianov, Victor ^a   Gailite, Vija ^a   Lola, Daina ^a   Loza, Einars ^a   Semenikhina, Valentina ^a   Kalvinsh, Ivars ^a   Finn, Paul ^b   Petersen, Kamille Dumong ^b   Ritchie, James W A ^b   Khan, Nagma ^b   Tumber, Anthony ^b   Collins, Laura S ^b   Vadlamudi, Sree M ^b   Björkling, Fredrik ^b   Sehested, Maxwell ^b,c  

^a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^b BioAlliance Pharma   (France)

^c Rigshospitalet   (Denmark)

Author keywords

HDAC inhibitor; Hydroxamic acid; SAR

Indexed keywords

3 (4 CHLORO 2 FLUOROPHENYL) N [6 (HYDROXYAMINO) 6 OXOHEXYL] 2 PROPENAMIDE; 4 (DIMETHYLAMINO) N [6 (HYDROXYAMINO) 6 OXOHEXYL]BENZENECARBOXAMIDE; 6 [[2 (10,11 DIHYDRO 5H DIBENZO[A,D]CYCLOHEPTEN 5 YLIDEN)ACETYL]AMINO] N HYDROXYHEXANAMIDE; 6 [[2 (9H FLUOREN 9 YLIDEN)ACETYL]AMINO] N HYDROXYHEXANAMIDE; AMIDE; HISTONE DEACETYLASE INHIBITOR; N 6 (HYDROXYAMINO) 6 OXOHEXYL] 5 PHENYL 4 PENTENAMIDE; N [4 (HYDROXYAMINO) 4 OXOBUTYL] 4 METHYL 5 PHENYL 2,4 PENTADIENAMIDE; N [5 (HYDROXYAMINO) 5 OXOPENTYL] 2 NAPHTHAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 2 NAPHTHAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 3 (2 NAPHTHYL) 2 PROPENAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 3 (2 PYRIDINYL) 2 PROPENAMIDE OXALATE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 3 (3 PYRIDINYL) 2 PROPENAMIDE OXALATE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 3 (4 PYRIDINYL) 2 PROPENAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 3 (7 QUINOLINYL) 2 PROPENAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 3 (8 QUINOLINYL) 2 PROPENAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 3 METHYL 5 PHENYL 2,4 PENTADIENAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 3 PHENYL 2 PROPENAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 3,3 DIPHENYLACRYLAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 4 PHENYL 3 BUTENAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 5 PHENYL 2,4 PENTADIENAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL] 6 QUINOLINECARBOXAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL](1,10 BIPHENYL) 4 CARBOXAMIDE; N [6 (HYDROXYAMINO) 6 OXOHEXYL]BENZENECARBOXAMIDE; N [7 (HYDROXYAMINO) 7 OXOHEPTYL] 2 NAPHTHAMIDE; N [8 (HYDROXYAMINO) 8 OXOOCTYL] 2 NAPHTHAMIDE; N HYDROXY 6 [(3 PHENYLPROPANOYL)AMINO]HEXANAMIDE; N HYDROXY 6 [(4 PHENYLBUTANOYL)AMINO]HEXANAMIDE; N HYDROXY 6 [(5 PHENYLPENTANOYL)AMINO]HEXANAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; LEUKEMIA P 388; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMIDES; DRUG DESIGN; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60549095162     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.06.020     Document Type: Article

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