Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase

Journal of Biological Chemistry

Volumn 282, Issue 45, 2007, Pages 32974-32982

  Hacisalihoglu, Ayse ^a   Panizzi, Peter ^b   Bock, Paul E ^b   Camire, Rodney M ^a   Krishnaswamy, Sriram ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c 310 Abramson ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; CATALYSIS; CONFORMATIONS; FLUORESCENCE;

CLEAVAGE SITE; PROTHROMBINASE; SUBSTRATE AFFINITY; ZYMOGEN;

ENZYME ACTIVITY;

ARGININE; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; ECARIN; ENZYME PRECURSOR; MEIZOTHROMBIN; PROTHROMBIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SUBSTRATE; FLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; STOICHIOMETRY;

BINDING SITES; FACTOR XA; MUTATION; PROTHROMBIN; SUBSTRATE SPECIFICITY; THROMBOPLASTIN;

EID: 36349026346     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M706529200     Document Type: Article

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