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Volumn 5, Issue 1, 2010, Pages

Itk derived signals regulate the expression of Th-POK and controls the development of CD4 + T cells

Author keywords

[No Author keywords available]

Indexed keywords

EOMESODERMIN; GRANZYME B; KINASE ITK; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PERFORIN; PHOSPHOTRANSFERASE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX3; TRANSCRIPTION FACTOR TH POK; UNCLASSIFIED DRUG; EMT PROTEIN TYROSINE KINASE; EMT PROTEIN-TYROSINE KINASE; PROTEIN TYROSINE KINASE; TH POK PROTEIN, MOUSE; TH-POK PROTEIN, MOUSE;

EID: 77749277170     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008891     Document Type: Article
Times cited : (7)

References (57)
  • 1
    • 14844286998 scopus 로고    scopus 로고
    • Receptor signals and nuclear events in CD4 and CD8 T cell lineage commitment
    • Laky K, Fowlkes BJ (2005) Receptor signals and nuclear events in CD4 and CD8 T cell lineage commitment. Curr Opin Immunol 17: 116-121.
    • (2005) Curr Opin Immunol , vol.17 , pp. 116-121
    • Laky, K.1    Fowlkes, B.J.2
  • 2
    • 0029988961 scopus 로고    scopus 로고
    • MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
    • Matechak EO, Killeen N, Hedrick SM, Fowlkes BJ (1996) MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 4: 337-347.
    • (1996) Immunity , vol.4 , pp. 337-347
    • Matechak, E.O.1    Killeen, N.2    Hedrick, S.M.3    Fowlkes, B.J.4
  • 3
    • 0030002882 scopus 로고    scopus 로고
    • The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
    • Itano A, Salmon P, Kioussis D, Tolaini M, Corbella P, et al. (1996) The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J Exp Med 183: 731-741.
    • (1996) J Exp Med , vol.183 , pp. 731-741
    • Itano, A.1    Salmon, P.2    Kioussis, D.3    Tolaini, M.4    Corbella, P.5
  • 5
    • 0032740314 scopus 로고    scopus 로고
    • Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and lck signaling
    • Sharp LL, Hedrick SM (1999) Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and lck signaling. J Immunol 163: 6598-6605.
    • (1999) J Immunol , vol.163 , pp. 6598-6605
    • Sharp, L.L.1    Hedrick, S.M.2
  • 6
    • 33645059700 scopus 로고    scopus 로고
    • TCR and Notch signaling in CD4 and CD8 T-cell development
    • Laky K, Fleischacker C, Fowlkes BJ (2006) TCR and Notch signaling in CD4 and CD8 T-cell development. Immunol Rev 209: 274-283.
    • (2006) Immunol Rev , vol.209 , pp. 274-283
    • Laky, K.1    Fleischacker, C.2    Fowlkes, B.J.3
  • 7
    • 0034732334 scopus 로고    scopus 로고
    • The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate
    • Yasutomo K, Doyle C, Miele L, Fuchs C, Germain RN (2000) The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate. Nature 404: 506-510.
    • (2000) Nature , vol.404 , pp. 506-510
    • Yasutomo, K.1    Doyle, C.2    Miele, L.3    Fuchs, C.4    Germain, R.N.5
  • 8
    • 1542377327 scopus 로고    scopus 로고
    • Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo
    • Liu X, Bosselut R (2004) Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo. Nat Immunol 5: 280-288.
    • (2004) Nat Immunol , vol.5 , pp. 280-288
    • Liu, X.1    Bosselut, R.2
  • 9
    • 0035986609 scopus 로고    scopus 로고
    • The Tec Family of tyrosine kinases in T cells, amplifiers of T cell receptor signals
    • August A, Fischer A, Hao S, Mueller C, Ragin M (2002) The Tec Family of tyrosine kinases in T cells, amplifiers of T cell receptor signals. Int J Biochem & Cell Biol 34: 1184-1189.
    • (2002) Int J Biochem & Cell Biol , vol.34 , pp. 1184-1189
    • August, A.1    Fischer, A.2    Hao, S.3    Mueller, C.4    Ragin, M.5
  • 10
    • 17144384996 scopus 로고    scopus 로고
    • Tec family kinases in T lymphocyte development and function
    • PMID:15771581
    • Berg L, Finkelstein L, Lucas J, Schwartzberg P (2005) Tec family kinases in T lymphocyte development and function. Annu Rev Immunol 23: 549-600. PMID:15771581.
    • (2005) Annu Rev Immunol , vol.23 , pp. 549-600
    • Berg, L.1    Finkelstein, L.2    Lucas, J.3    Schwartzberg, P.4
  • 11
    • 61849110214 scopus 로고    scopus 로고
    • Tec kinases regulate T-lymphocyte development and function: New insights into the roles of Itk and Rlk/Txk
    • Readinger J, Mueller K, Venegas A, Horai R, Schwartzberg P (2009) Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk. Immunol Rev 228.
    • (2009) Immunol Rev , pp. 228
    • Readinger, J.1    Mueller, K.2    Venegas, A.3    Horai, R.4    Schwartzberg, P.5
  • 12
    • 61849142482 scopus 로고    scopus 로고
    • The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development
    • Prince A, Yin C, Enos M, Felices M, Berg L (2009) The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development. Immunol Rev 228: 115-131.
    • (2009) Immunol Rev , vol.228 , pp. 115-131
    • Prince, A.1    Yin, C.2    Enos, M.3    Felices, M.4    Berg, L.5
  • 13
    • 0033597440 scopus 로고    scopus 로고
    • Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity
    • Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, et al. (1999) Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 284: 638-641.
    • (1999) Science , vol.284 , pp. 638-641
    • Schaeffer, E.M.1    Debnath, J.2    Yap, G.3    McVicar, D.4    Liao, X.C.5
  • 14
    • 13344270890 scopus 로고    scopus 로고
    • Liao XC, Littman DR (1995) Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity 3: 757-769.
    • Liao XC, Littman DR (1995) Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity 3: 757-769.
  • 15
    • 0034596946 scopus 로고    scopus 로고
    • Tec Family Kinases Modulate Thresholds for Thymocyte Development and Selection
    • Schaeffer E, Broussard C, Debnath J, Anderson S, McVicar D, et al. (2000) Tec Family Kinases Modulate Thresholds for Thymocyte Development and Selection. J Exp Med 192: 987-1000.
    • (2000) J Exp Med , vol.192 , pp. 987-1000
    • Schaeffer, E.1    Broussard, C.2    Debnath, J.3    Anderson, S.4    McVicar, D.5
  • 16
    • 0037097635 scopus 로고    scopus 로고
    • The absence of Itk inhibits positive selection without changing lineage commitment
    • Lucas J, Atherly L, Berg L (2002) The absence of Itk inhibits positive selection without changing lineage commitment. J Immunol 168: 6142-6151.
    • (2002) J Immunol , vol.168 , pp. 6142-6151
    • Lucas, J.1    Atherly, L.2    Berg, L.3
  • 17
    • 38849176860 scopus 로고    scopus 로고
    • Subtle defects in pre-TCR signaling in the absence of the Tec kinase Itk
    • Lucas JA, Felices M, Evans JW, Berg LJ (2007) Subtle defects in pre-TCR signaling in the absence of the Tec kinase Itk. J Immunol 179: 7561-7567.
    • (2007) J Immunol , vol.179 , pp. 7561-7567
    • Lucas, J.A.1    Felices, M.2    Evans, J.W.3    Berg, L.J.4
  • 18
    • 0037097635 scopus 로고    scopus 로고
    • The absence of Itk inhibits positive selection without changing lineage commitment
    • Lucas JA, Atherly LO, Berg LJ (2002) The absence of Itk inhibits positive selection without changing lineage commitment. J Immunol 168: 6142-6151.
    • (2002) J Immunol , vol.168 , pp. 6142-6151
    • Lucas, J.A.1    Atherly, L.O.2    Berg, L.J.3
  • 19
    • 0037307394 scopus 로고    scopus 로고
    • The role of Tec family kinases in T cell development and function
    • Lucas JA, Miller AT, Atherly LO, Berg LJ (2003) The role of Tec family kinases in T cell development and function. Immunol Rev 191: 119-138.
    • (2003) Immunol Rev , vol.191 , pp. 119-138
    • Lucas, J.A.1    Miller, A.T.2    Atherly, L.O.3    Berg, L.J.4
  • 20
    • 0034596946 scopus 로고    scopus 로고
    • Tec family kinases modulate thresholds for thymocyte development and selection
    • Schaeffer EM, Broussard C, Debnath J, Anderson S, McVicar DW, et al. (2000) Tec family kinases modulate thresholds for thymocyte development and selection. J Exp Med 192: 987-1000.
    • (2000) J Exp Med , vol.192 , pp. 987-1000
    • Schaeffer, E.M.1    Broussard, C.2    Debnath, J.3    Anderson, S.4    McVicar, D.W.5
  • 21
    • 34249693078 scopus 로고    scopus 로고
    • Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development
    • Berg LJ (2007) Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development. Nat Rev Immunol 7: 479-485.
    • (2007) Nat Rev Immunol , vol.7 , pp. 479-485
    • Berg, L.J.1
  • 22
    • 33745986018 scopus 로고    scopus 로고
    • Broussard C, Fleischacker C, Horai R, Chetana M, Venegas AM, et al. (2006) Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25: 93-104.
    • Broussard C, Fleischacker C, Horai R, Chetana M, Venegas AM, et al. (2006) Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25: 93-104.
  • 23
    • 33745969458 scopus 로고    scopus 로고
    • The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells
    • Atherly LO, Lucas JA, Felices M, Yin CC, Reiner SL, et al. (2006) The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity 25: 79-91.
    • (2006) Immunity , vol.25 , pp. 79-91
    • Atherly, L.O.1    Lucas, J.A.2    Felices, M.3    Yin, C.C.4    Reiner, S.L.5
  • 24
    • 33747043542 scopus 로고    scopus 로고
    • ITK and IL-15 support two distinct subsets of CD8+ T cells
    • Dubois S, Waldmann TA, Muller JR (2006) ITK and IL-15 support two distinct subsets of CD8+ T cells. Proc Natl Acad Sci U S A 103: 12075-12080.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12075-12080
    • Dubois, S.1    Waldmann, T.A.2    Muller, J.R.3
  • 26
    • 0031897801 scopus 로고    scopus 로고
    • Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and betachain genes under the control of heterologous regulatory elements
    • Barnden MJ, Allison J, Heath WR, Carbone FR (1998) Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and betachain genes under the control of heterologous regulatory elements. Immunol Cell Biol 76: 34-40.
    • (1998) Immunol Cell Biol , vol.76 , pp. 34-40
    • Barnden, M.J.1    Allison, J.2    Heath, W.R.3    Carbone, F.R.4
  • 27
    • 45549105834 scopus 로고    scopus 로고
    • Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development
    • Hu J, August A (2008) Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development. J Immunol 180: 6544-6552.
    • (2008) J Immunol , vol.180 , pp. 6544-6552
    • Hu, J.1    August, A.2
  • 28
    • 35348835445 scopus 로고    scopus 로고
    • Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk
    • Hu J, Sahu N, Walsh E, August A (2007) Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk. Eur J Immunol 37: 2892-2899.
    • (2007) Eur J Immunol , vol.37 , pp. 2892-2899
    • Hu, J.1    Sahu, N.2    Walsh, E.3    August, A.4
  • 29
    • 33745986018 scopus 로고    scopus 로고
    • Broussard C, Fleischecker C, Horai R, Chetana M, Venegas A, et al. (2006) Altered development of CD8+ T cell lineages in mice deficient for the tec kinases Itk and Rlk. Immunity 25: 93-104.
    • Broussard C, Fleischecker C, Horai R, Chetana M, Venegas A, et al. (2006) Altered development of CD8+ T cell lineages in mice deficient for the tec kinases Itk and Rlk. Immunity 25: 93-104.
  • 30
    • 33745969458 scopus 로고    scopus 로고
    • The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells
    • Atherly L, Lucas J, Felices M, Yin C, Reiner S, et al. (2006) The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity 25: 79-91.
    • (2006) Immunity , vol.25 , pp. 79-91
    • Atherly, L.1    Lucas, J.2    Felices, M.3    Yin, C.4    Reiner, S.5
  • 31
    • 36048946331 scopus 로고    scopus 로고
    • Requirements for selection of conventional and innate T lymphocyte lineages
    • Horai R, Mueller K, Handon R, Cannons J, Anderson S, et al. (2007) Requirements for selection of conventional and innate T lymphocyte lineages. Immunity 27: 775-785.
    • (2007) Immunity , vol.27 , pp. 775-785
    • Horai, R.1    Mueller, K.2    Handon, R.3    Cannons, J.4    Anderson, S.5
  • 32
    • 33747043542 scopus 로고    scopus 로고
    • ITK and IL-15 support two distinct subsets of CD8+ T cells
    • Dubois S, Waldmann T, Müller J (2006) ITK and IL-15 support two distinct subsets of CD8+ T cells. Proc Natl Acad Sci U S A 103: 12075-12080.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12075-12080
    • Dubois, S.1    Waldmann, T.2    Müller, J.3
  • 33
    • 0034193990 scopus 로고    scopus 로고
    • DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope
    • Robertson J, Jensen P, Evavold B (2000) DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope. J Immunol 164: 4706-4712.
    • (2000) J Immunol , vol.164 , pp. 4706-4712
    • Robertson, J.1    Jensen, P.2    Evavold, B.3
  • 34
    • 0032445491 scopus 로고    scopus 로고
    • CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity
    • Azzam HS, Grinberg A, Lui K, Shen H, Shores EW, et al. (1998) CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J Exp Med 188: 2301-2311.
    • (1998) J Exp Med , vol.188 , pp. 2301-2311
    • Azzam, H.S.1    Grinberg, A.2    Lui, K.3    Shen, H.4    Shores, E.W.5
  • 35
    • 0028063488 scopus 로고
    • Bcl-2 expression during T-cell development: Early loss and late return occur at specific stages of commitment to differentiation and survival
    • Gratiot-Deans J, Merino R, Nunez G, Turka LA (1994) Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival. Proc Natl Acad Sci U S A 91: 10685-10689.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10685-10689
    • Gratiot-Deans, J.1    Merino, R.2    Nunez, G.3    Turka, L.A.4
  • 36
    • 18744398397 scopus 로고    scopus 로고
    • Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    • Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, et al. (2002) Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111: 621-633.
    • (2002) Cell , vol.111 , pp. 621-633
    • Taniuchi, I.1    Osato, M.2    Egawa, T.3    Sunshine, M.J.4    Bae, S.C.5
  • 37
    • 34547744867 scopus 로고    scopus 로고
    • The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
    • Egawa T, Tillman RE, Naoe Y, Taniuchi I, Littman DR (2007) The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med 204: 1945-1957.
    • (2007) J Exp Med , vol.204 , pp. 1945-1957
    • Egawa, T.1    Tillman, R.E.2    Naoe, Y.3    Taniuchi, I.4    Littman, D.R.5
  • 38
    • 0035501077 scopus 로고    scopus 로고
    • Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage
    • Hayashi K, Abe N, Watanabe T, Obinata M, Ito M, et al. (2001) Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage. J Immunol 167: 4957-4965.
    • (2001) J Immunol , vol.167 , pp. 4957-4965
    • Hayashi, K.1    Abe, N.2    Watanabe, T.3    Obinata, M.4    Ito, M.5
  • 39
    • 0036194770 scopus 로고    scopus 로고
    • TOX: An HMG box protein implicated in the regulation of thymocyte selection
    • Wilkinson B, Chen JY, Han P, Rufner KM, Goularte OD, et al. (2002) TOX: an HMG box protein implicated in the regulation of thymocyte selection. Nat Immunol 3: 272-280.
    • (2002) Nat Immunol , vol.3 , pp. 272-280
    • Wilkinson, B.1    Chen, J.Y.2    Han, P.3    Rufner, K.M.4    Goularte, O.D.5
  • 40
    • 2442597781 scopus 로고    scopus 로고
    • TOX provides a link between calcineurin activation and CD8 lineage commitment
    • Aliahmad P, O'Flaherty E, Han P, Goularte OD, Wilkinson B, et al. (2004) TOX provides a link between calcineurin activation and CD8 lineage commitment. J Exp Med 199: 1089-1099.
    • (2004) J Exp Med , vol.199 , pp. 1089-1099
    • Aliahmad, P.1    O'Flaherty, E.2    Han, P.3    Goularte, O.D.4    Wilkinson, B.5
  • 41
    • 0035879288 scopus 로고    scopus 로고
    • Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice
    • Nawijn MC, Ferreira R, Dingjan GM, Kahre O, Drabek D, et al. (2001) Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice. J Immunol 167: 715-723.
    • (2001) J Immunol , vol.167 , pp. 715-723
    • Nawijn, M.C.1    Ferreira, R.2    Dingjan, G.M.3    Kahre, O.4    Drabek, D.5
  • 43
    • 60749096510 scopus 로고    scopus 로고
    • Decision by committee: New light on the CD4/CD8-lineage choice
    • Rothenberg E (2009) Decision by committee: new light on the CD4/CD8-lineage choice. Immunol Cell Biol 87: 109-112.
    • (2009) Immunol Cell Biol , vol.87 , pp. 109-112
    • Rothenberg, E.1
  • 44
    • 0032493380 scopus 로고    scopus 로고
    • HD mice: A novel mouse mutant with a specific defect in the generation of CD4(+) T cells
    • Dave VP, Allman D, Keefe R, Hardy RR, Kappes DJ (1998) HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells. Proc Natl Acad Sci U S A 95: 8187-8192.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8187-8192
    • Dave, V.P.1    Allman, D.2    Keefe, R.3    Hardy, R.R.4    Kappes, D.J.5
  • 45
    • 0033527615 scopus 로고    scopus 로고
    • Regulation of lineage commitment distinct from positive selection
    • Keefe R, Dave V, Allman D, Wiest D, Kappes DJ (1999) Regulation of lineage commitment distinct from positive selection. Science 286: 1149-1153.
    • (1999) Science , vol.286 , pp. 1149-1153
    • Keefe, R.1    Dave, V.2    Allman, D.3    Wiest, D.4    Kappes, D.J.5
  • 46
    • 14544288635 scopus 로고    scopus 로고
    • The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment
    • He X, He X, Dave VP, Zhang Y, Hua X, et al. (2005) The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 433: 826-833.
    • (2005) Nature , vol.433 , pp. 826-833
    • He, X.1    He, X.2    Dave, V.P.3    Zhang, Y.4    Hua, X.5
  • 47
    • 40249095991 scopus 로고    scopus 로고
    • CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcriptionfactor locus
    • He X, Park K, Wang H, He X, Zhang Y, et al. (2008) CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcriptionfactor locus. Immunity 28: 346-358.
    • (2008) Immunity , vol.28 , pp. 346-358
    • He, X.1    Park, K.2    Wang, H.3    He, X.4    Zhang, Y.5
  • 48
    • 16844375768 scopus 로고    scopus 로고
    • The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection
    • Sun G, Liu X, Mercado P, Jenkinson SR, Kypriotou M, et al. (2005) The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat Immunol 6: 373-381.
    • (2005) Nat Immunol , vol.6 , pp. 373-381
    • Sun, G.1    Liu, X.2    Mercado, P.3    Jenkinson, S.R.4    Kypriotou, M.5
  • 49
    • 38949185052 scopus 로고    scopus 로고
    • Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development
    • Setoguchi R, Tachibana M, Naoe Y, Muroi S, Akiyama K, et al. (2008) Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science 319: 822-825.
    • (2008) Science , vol.319 , pp. 822-825
    • Setoguchi, R.1    Tachibana, M.2    Naoe, Y.3    Muroi, S.4    Akiyama, K.5
  • 50
    • 0029658305 scopus 로고    scopus 로고
    • Requirement for p56lck tyrosine kinase activation in T cell receptor- mediated thymic selection
    • Hashimoto K, Sohn S, Levin S, Tada T, Perlmutter R, et al. (1996) Requirement for p56lck tyrosine kinase activation in T cell receptor- mediated thymic selection. J Exp Med 184: 931-943.
    • (1996) J Exp Med , vol.184 , pp. 931-943
    • Hashimoto, K.1    Sohn, S.2    Levin, S.3    Tada, T.4    Perlmutter, R.5
  • 51
    • 0029658305 scopus 로고    scopus 로고
    • Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection
    • Hashimoto K, Sohn SJ, Levin SD, Tada T, Perlmutter RM, et al. (1996) Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection. J Exp Med 184: 931-943.
    • (1996) J Exp Med , vol.184 , pp. 931-943
    • Hashimoto, K.1    Sohn, S.J.2    Levin, S.D.3    Tada, T.4    Perlmutter, R.M.5
  • 52
    • 52549133772 scopus 로고    scopus 로고
    • Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells
    • Epub Sep
    • Wang L, Wildt K, Zhu J, Zhang X, Feigenbaum L, et al. (2008) Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol 9: 1122-1130. Epub 2008 Sep.
    • (2008) Nat Immunol , vol.9 , pp. 1122-1130
    • Wang, L.1    Wildt, K.2    Zhu, J.3    Zhang, X.4    Feigenbaum, L.5
  • 53
    • 60549090859 scopus 로고    scopus 로고
    • Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs
    • Jan 2012
    • Cruz-Guilloty F, Pipkin M, Djuretic I, Levanon D, Lotem J, et al. (2009) Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med 206: 51-59. Epub 2009 Jan 2012.
    • (2009) J Exp Med 206: 51-59. Epub , pp. 2009
    • Cruz-Guilloty, F.1    Pipkin, M.2    Djuretic, I.3    Levanon, D.4    Lotem, J.5
  • 54
    • 70349247895 scopus 로고    scopus 로고
    • CD4-CD8 lineage differentiation: Thpok-ing into the nucleus
    • Wang L, Bosselut R (2009) CD4-CD8 lineage differentiation: Thpok-ing into the nucleus. J Immunol 183: 2903-2910.
    • (2009) J Immunol , vol.183 , pp. 2903-2910
    • Wang, L.1    Bosselut, R.2
  • 55
    • 38949185052 scopus 로고    scopus 로고
    • Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development
    • Setoguchi R, Tachibana M, Naoe Y, Muroi S, Akiyama K, et al. (2008) Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science 319: 822-825.
    • (2008) Science , vol.319 , pp. 822-825
    • Setoguchi, R.1    Tachibana, M.2    Naoe, Y.3    Muroi, S.4    Akiyama, K.5
  • 56
    • 52549124338 scopus 로고    scopus 로고
    • Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol
    • Sep 1117
    • Muroi S, Naoe Y, Miyamoto C, Akiyama K, Ikawa T, et al. (2008) Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol 9: 1113-1121. Epub 2008 Sep 1117.
    • (2008) Epub , pp. 2008
    • Muroi, S.1    Naoe, Y.2    Miyamoto, C.3    Akiyama, K.4    Ikawa, T.5
  • 57
    • 0033213484 scopus 로고    scopus 로고
    • Impaired NFATc Translocation and Failure of Th2 Development in Itk Deficient CD4 T Cells
    • Fowell D, Shinkai K, Liao X, Beebe A, Coffman R, et al. (1999) Impaired NFATc Translocation and Failure of Th2 Development in Itk Deficient CD4 T Cells. Immunity 11: 399-409.
    • (1999) Immunity , vol.11 , pp. 399-409
    • Fowell, D.1    Shinkai, K.2    Liao, X.3    Beebe, A.4    Coffman, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.