Subtle defects in pre-TCR signaling in the absence of the Tec kinase Itk

Journal of Immunology

Volumn 179, Issue 11, 2007, Pages 7561-7567

  Lucas, Julie A ^a   Felices, Martin ^a   Evans, John W ^a   Berg, Leslie J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPASE C GAMMA1; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; AGAMMAGLOBULINAEMIA TYROSINE KINASE; CD4 ANTIGEN; CD8 ANTIGEN; EMT PROTEIN TYROSINE KINASE; EMT PROTEIN-TYROSINE KINASE; LYMPHOCYTE ANTIGEN RECEPTOR; TEC PROTEIN TYROSINE KINASE; TEC PROTEIN-TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRE T LYMPHOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYMOCYTE; THYMUS; WILD TYPE; ANIMAL; C57BL MOUSE; CYTOLOGY; GENETICS; IMMUNOLOGY; MOUSE MUTANT; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THYMUS GLAND;

EID: 38849176860     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.11.7561     Document Type: Article

References (32)

1. Michie, A. M., and J. C. Zuniga-Pflucker. 2002. Regulation of thymocyte differentiation: pre-TCR signals and β-selection. Semin. Immunol. 14: 311-323.
2. lck. Nature 357: 161-164.
3. lck controls allelic exclusion of T cell receptor β-chain genes. Nature 365: 552-554.
4. lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes. Eur. J. Immunol. 25: 1312-1318.
5. Groves, T., P. Smiley, M. P. Cooke, K. Forbush, R. M. Perlmutter, and C. J. Guidos. 1996. Fyn can partially substitute for Lck in T lymphocyte development. Immunity 5: 417-428.
6. van Oers, N. S. C., B. Lowin-Kropf, D. Finlay, K. Connolly, and A. Weiss. 1996. αβ T cell development is abolished in mice lacking both lck and fyn protein tyrosine kinases. Immunity 5: 429-436.
7. Cheng, A. M., I. Negishi, S. J. Anderson, A. C. Chan, J. Bolen, D. Y. Loh, and T. Pawson. 1997. The Syk and Zap-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc. Natl. Acad. Sci. USA 94: 9797-9801.
8. Clements, J. L., B. Yang, S. E. Ross-Barta, S. L. Eliason, R. F. Hrstka, R. A. Williamson, and G. A. Koretzky. 1998. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 281: 416-419.
9. Pivniouk, V., E. Tsitsikov, P. Swinton, G. Rathbun, F. W. Alt, and R. S. Geha. 1998. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 94: 229-238.
10. Zhang, W., C. L. Sommers, D. N. Burshtyn, C. C. Stebbins, J. B. DeJarnette, R. P. Trible, A. Grinberg, H. C. Tsay, H. M. Jacobs, C. M. Kessler, et al. 1999. Essential role of LAT in T cell development. Immunity 10: 323-332.
11. Yoder, J., C. Pham, Y. M. Iizuka, O. Kanagawa, S. K. Liu, J. McGlade, and A. M. Cheng. 2001. Requirement for the SLP-76 adaptor GADS in T cell development. Science 291: 1987-1991.
12. + thymocytes. Proc. Natl. Acad. Sci. USA 93: 4683-4687.
13. Gartner, F., F. W. Alt, R. Monroe, M. Chu, B. P. Sleckman, L. Davidson, and W. Swat. 1999. Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion. Immunity 10: 537-546.
14. Sommers, C. L., C. S. Park, J. Lee, C. Feng, C. L. Fuller, A. Grinberg, J. A. Hildebrand, E. Lacana, R. K. Menon, E. W. Shores, et al. 2002. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 296: 2040-2043.
15. Aguado, E., S. Richelme, S. Nunez-Cruz, A. Miazek, A. M. Mura, M. Richelme, X. J. Guo, D. Sainty, H. T. He, B. Malissen, and M. Malissen. 2002. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296: 2036-2040.
16. Liu, K. Q., S. C. Bunnell, C. B. Gurniak, and L. J. Berg. 1998. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J. Exp. Med. 187: 1721-1727.
17. Schaeffer, E. M., J. Debnath, G. Yap, D. McVicar, X. C. Liao, D. R. Littman, A. Sher, H. E. Varmus, M. J. Lenardo, and P. L. Schwartzberg. 1999. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 284: 638-641.
18. Schaeffer, E. M., C. Broussard, J. Debnath, S. Anderson, D. W. McVicar, and P. L. Schwartzberg. 2000. Tec family kinases modulate thresholds for thymocyte development and selection. J. Exp. Med. 192: 987-1000.
19. Heyeck, S. D., and L. J. Berg. 1993. Developmental regulation of a murine T cell-specific tyrosine kinase gene, Tsk. Proc. Natl. Acad. Sci. USA 90: 669 - 673.
20. Hu, Q., D. Davidson, P. L. Schwartzberg, F. Macchiarini, M. J. Lenardo, J. A. Bluestone, and L. A. Matis. 1995. Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. J. Biol. Chem. 270: 1928-1934.
21. Liao, X. C., and D. R. Littman. 1995. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity 3: 757-769.
22. Miller, A. T., and L. J. Berg. 2002. Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase. J. Immunol. 168: 2163-2172.
23. Lucas, J. A., L. O. Atherly, and L. J. Berg. 2002. The absence of Itk inhibits positive selection without changing lineage commitment. J. Immunol. 168: 6142-6151.
24. Azzam, H. S., A. Grinberg, K. Lui, H. Shen, E. W. Shores, and P. E. Love. 1998. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 188: 2301-2311.
25. Tarakhovsky, A., S. B. Kanner, J. Hombach, J. A. Ledbetter, W. Muller, N. Killeen, and K. Rajewsky. 1995. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269: 535-537.
26. -/- mice in the absence of TCR β chain expression. Int. Immunol. 6: 995-1001.
27. lck. Nature 357: 161-164.
28. Turner, M., P. J. Mee, A. E. Walters, M. E. Quinn, A. L. Mellor, R. Zamoyska, and V. L. Tybulewicz. 1997. A requirement for the ρ-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity 7: 451-460.
29. + thymocytes. Nature 374: 474-477.
30. Miller, A. T., H. M. Wilcox, Z. Lai, and L. J. Berg. 2004. Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Immunity 21: 67-80.
31. Vasseur, F., A. Le Campion, and C. Penit. 2001. Scheduled kinetics of cell proliferation and phenotypic changes during immature thymocyte generation. Eur. J. Immunol. 31: 3038-3047.
32. Ellmeier, W., S. Jung, M. J. Sunshine, F. Hatam, Y. Xu, D. Baltimore, H. Mano, and D. R. Littman. 2000. Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk. J. Exp. Med. 192: 1611-1624.