-
2
-
-
0020742527
-
Tumors of the liver: Pathologic features
-
Edmondson HA, Peters RL. Tumors of the liver: pathologic features. Semin Roentgenol 1983;18:75-83
-
(1983)
Semin Roentgenol
, vol.18
, pp. 75-83
-
-
Edmondson, H.A.1
Peters, R.L.2
-
3
-
-
33745570822
-
Southern Europe as an example of interaction between various environmental factors: A systematic review of the epidemiologic evidence
-
Donato F, Gelatti U, Limina RM, Fattovich G. Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence. Oncogene 2006;25:3756-70
-
(2006)
Oncogene
, vol.25
, pp. 3756-3770
-
-
Donato, F.1
Gelatti, U.2
Limina, R.M.3
Fattovich, G.4
-
4
-
-
33745521748
-
Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity
-
Seeff LB, Hoofnagle JH. Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity. Oncogene 2006;25:3771-7
-
(2006)
Oncogene
, vol.25
, pp. 3771-3777
-
-
Seeff, L.B.1
Hoofnagle, J.H.2
-
5
-
-
0021965806
-
Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients
-
Okuda K, Ohtsuki T, Obata H, et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer 1985;56:918-28
-
(1985)
Cancer
, vol.56
, pp. 918-928
-
-
Okuda, K.1
Ohtsuki, T.2
Obata, H.3
-
6
-
-
0002704757
-
Primary hepatocellular cancer: Western experience
-
L. Blumgart, editor, Churchill Livingstone, London;
-
Huguet C, Stipa F, Gavelli A. Primary hepatocellular cancer: western experience. In: L. Blumgart, editor, Surgery of the liver and billary tract. Churchill Livingstone, London; 2000. p. 1365-69
-
(2000)
Surgery of the liver and billary tract
, pp. 1365-1369
-
-
Huguet, C.1
Stipa, F.2
Gavelli, A.3
-
7
-
-
0026735844
-
Hepatocellular carcinoma
-
Colombo M. Hepatocellular carcinoma. J Hepatol 1992;15:225-36
-
(1992)
J Hepatol
, vol.15
, pp. 225-236
-
-
Colombo, M.1
-
8
-
-
0031048958
-
Treatment of hepatocellular carcinoma: A systematic review of randomized controlled trials
-
Simonetti RG, Liberati A, Angiolini C, Pagliaro L. Treatment of hepatocellular carcinoma: a systematic review of randomized controlled trials. Ann Oncol 1997;8:117-36
-
(1997)
Ann Oncol
, vol.8
, pp. 117-136
-
-
Simonetti, R.G.1
Liberati, A.2
Angiolini, C.3
Pagliaro, L.4
-
9
-
-
0034941503
-
Improving survival results after resection of hepatocellular carcinoma: A prospective study of 377 patients over 10 years
-
Poon RT, Fan ST, Lo CM, et al. Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years. Ann Surg 2001;234:63-70
-
(2001)
Ann Surg
, vol.234
, pp. 63-70
-
-
Poon, R.T.1
Fan, S.T.2
Lo, C.M.3
-
10
-
-
40549090890
-
Treatment of large and advanced hepatocellular carcinoma
-
Abdalla EK, Denys A, Hasegawa K, et al. Treatment of large and advanced hepatocellular carcinoma. Ann Surg Oncol 2007;15:979-85
-
(2007)
Ann Surg Oncol
, vol.15
, pp. 979-985
-
-
Abdalla, E.K.1
Denys, A.2
Hasegawa, K.3
-
12
-
-
58849136702
-
Molecular targeted therapy for hepatocellular carcinoma
-
Thomas M. Molecular targeted therapy for hepatocellular carcinoma. J Gastroenterol 2009;44(Suppl 19):136-41
-
(2009)
J Gastroenterol
, vol.44
, Issue.SUPPL. 19
, pp. 136-141
-
-
Thomas, M.1
-
13
-
-
61449426233
-
Early development of sunitinib in hepatocellular carcinoma
-
Zhu AX, Raymond E. Early development of sunitinib in hepatocellular carcinoma. Expert Rev Anticancer Ther 2009;9:143-50
-
(2009)
Expert Rev Anticancer Ther
, vol.9
, pp. 143-150
-
-
Zhu, A.X.1
Raymond, E.2
-
14
-
-
27144557565
-
A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma
-
Yeo W, Mok TS, Zee B, et al. A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma. J Natl Cancer Inst 2005;97:1532-8
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 1532-1538
-
-
Yeo, W.1
Mok, T.S.2
Zee, B.3
-
15
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-109
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
16
-
-
33749238553
-
Discovery and development of sorafenib: A multikinase inhibitor for treating cancer
-
Wilhelm SM, Carter C, Lynch M, et al. Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev 2006;5:835-44
-
(2006)
Nat Rev
, vol.5
, pp. 835-844
-
-
Wilhelm, S.M.1
Carter, C.2
Lynch, M.3
-
17
-
-
67649715548
-
Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
-
In press
-
Huynh H, Ngo VC, Koong HN, et al. Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Cell Mol Med 2009:1-12. In press
-
(2009)
J Cell Mol Med
, pp. 1-12
-
-
Huynh, H.1
Ngo, V.C.2
Koong, H.N.3
-
18
-
-
33846212284
-
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
-
Liu L, Cao Y, Chen C, et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 2006;66:11851-8
-
(2006)
Cancer Res
, vol.66
, pp. 11851-11858
-
-
Liu, L.1
Cao, Y.2
Chen, C.3
-
19
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-90
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
20
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
-
Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009;10:25-34
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
-
21
-
-
47949090620
-
-
Roberts LR. Sorafenib in liver cancer-just the beginning. N Engl J Med 2008;359:420-2
-
Roberts LR. Sorafenib in liver cancer-just the beginning. N Engl J Med 2008;359:420-2
-
-
-
-
22
-
-
67149143399
-
Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Jacobetz MA, Davidson CJ, et al. Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009;324:1457-61
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
-
23
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23:1011-27
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
24
-
-
33645740560
-
Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: Importance of angiopoietin-2 and hypoxia-induced factor-1 alpha
-
Wada H, Nagano H, Yamamoto H, et al. Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin-2 and hypoxia-induced factor-1 alpha. Liver Int 2006;26:414-23
-
(2006)
Liver Int
, vol.26
, pp. 414-423
-
-
Wada, H.1
Nagano, H.2
Yamamoto, H.3
-
25
-
-
37749049919
-
Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats
-
Tugues S, Fernandez-Varo G, Munoz-Luque J, et al. Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology 2007;46:1919-26
-
(2007)
Hepatology
, vol.46
, pp. 1919-1926
-
-
Tugues, S.1
Fernandez-Varo, G.2
Munoz-Luque, J.3
-
26
-
-
0030723789
-
Increased expression of vascular endothelial growth factor in human hepatocellular carcinoma
-
Miura H, Miyazaki T, Kuroda M, et al. Increased expression of vascular endothelial growth factor in human hepatocellular carcinoma. J Hepatol 1997;27:854-61
-
(1997)
J Hepatol
, vol.27
, pp. 854-861
-
-
Miura, H.1
Miyazaki, T.2
Kuroda, M.3
-
27
-
-
4944234987
-
Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma
-
Poon RT, Ho JW, Tong CS, et al. Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma. Br J Surg 2004;91:1354-60
-
(2004)
Br J Surg
, vol.91
, pp. 1354-1360
-
-
Poon, R.T.1
Ho, J.W.2
Tong, C.S.3
-
28
-
-
32944480899
-
Opportunities for targeted therapies in hepatocellular carcinoma
-
Thomas MB, Abbruzzese JL. Opportunities for targeted therapies in hepatocellular carcinoma. J Clin Oncol 2005;23:8093-108
-
(2005)
J Clin Oncol
, vol.23
, pp. 8093-8108
-
-
Thomas, M.B.1
Abbruzzese, J.L.2
-
29
-
-
29344456631
-
Overexpression of platelet-derived growth factor receptor alpha in endothelial cells of hepatocellular carcinoma associated with high metastatic potential
-
Zhang T, Sun HC, Xu Y, et al. Overexpression of platelet-derived growth factor receptor alpha in endothelial cells of hepatocellular carcinoma associated with high metastatic potential. Clin Cancer Res 2005;11:8557-63
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8557-8563
-
-
Zhang, T.1
Sun, H.C.2
Xu, Y.3
-
31
-
-
14644446018
-
A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
-
Pietras K, Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 2005;23:939-52
-
(2005)
J Clin Oncol
, vol.23
, pp. 939-952
-
-
Pietras, K.1
Hanahan, D.2
-
32
-
-
59149094763
-
Preliminary results from a phase II, randomized, double-blind study of sorafenib plus doxorubicin versus placebo plus doxorubicin in patients with advanced hepatocellular carcinoma
-
23, 27 September, Barcelona, Spain
-
Abou-Alfa G, Johnson P, Knox J, et al. Preliminary results from a phase II, randomized, double-blind study of sorafenib plus doxorubicin versus placebo plus doxorubicin in patients with advanced hepatocellular carcinoma. Proceedings of the 14th European Cancer Conference; 23 - 27 September 2007; Barcelona, Spain
-
(2007)
Proceedings of the 14th European Cancer Conference
-
-
Abou-Alfa, G.1
Johnson, P.2
Knox, J.3
-
33
-
-
33749544080
-
An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases
-
Kim DW, Jo YS, Jung HS, et al. An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases. J Clin Endocrinol Metab 2006;91:4070-6
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 4070-4076
-
-
Kim, D.W.1
Jo, Y.S.2
Jung, H.S.3
-
34
-
-
33947504730
-
Sunitinib: From rational design to clinical efficacy
-
Chow LQ, Eckhardt SG. Sunitinib: from rational design to clinical efficacy. J Clin Oncol 2007;25:884-96
-
(2007)
J Clin Oncol
, vol.25
, pp. 884-896
-
-
Chow, L.Q.1
Eckhardt, S.G.2
-
35
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356:115-24
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
36
-
-
33749505836
-
Efficacy and safety of Sunitinib in patients with advanced GISTs after failure of imatinib: A randomized controlled trial
-
Demetri G, Van Oosterom A, Garrett C, et al. Efficacy and safety of Sunitinib in patients with advanced GISTs after failure of imatinib: a randomized controlled trial. Lancet 2006;368:1329-38
-
(2006)
Lancet
, vol.368
, pp. 1329-1338
-
-
Demetri, G.1
Van Oosterom, A.2
Garrett, C.3
-
37
-
-
70349158101
-
Sunitinib (SUTENT, SU11248) suppresses tumor growth and induces apoptosis in xenograft models of human hepatocellular carcinoma
-
Huynh H, Ngo VC, Choo SP, et al. Sunitinib (SUTENT, SU11248) suppresses tumor growth and induces apoptosis in xenograft models of human hepatocellular carcinoma. Curr Cancer Drug Targets 2009;9:738-47
-
(2009)
Curr Cancer Drug Targets
, vol.9
, pp. 738-747
-
-
Huynh, H.1
Ngo, V.C.2
Choo, S.P.3
-
38
-
-
77749329578
-
-
Zhu AX, Sahani DV, di Tomaso E, et al. A phase II study of sunitinib in patients with advanced hepatocellular carcinoma. ASCO 2007: Proceedings of the 2007 ASCO Annual Meeting; June 1 - 5 2007; Chicago, USA. J Clin Oncol 2007;25:18S
-
Zhu AX, Sahani DV, di Tomaso E, et al. A phase II study of sunitinib in patients with advanced hepatocellular carcinoma. ASCO 2007: Proceedings of the 2007 ASCO Annual Meeting; June 1 - 5 2007; Chicago, USA. J Clin Oncol 2007;25:18S
-
-
-
-
39
-
-
77749325914
-
Phase II trial investigating the efficacy and safety of sunitinib in patients with unresectable hepatocellular carcinoma (HCC)
-
Faivre SJ, Raymond E, Douillard J, et al. Phase II trial investigating the efficacy and safety of sunitinib in patients with unresectable hepatocellular carcinoma (HCC). Eur J Cancer Suppl 2007;5(4):270
-
(2007)
Eur J Cancer Suppl
, vol.5
, Issue.4
, pp. 270
-
-
Faivre, S.J.1
Raymond, E.2
Douillard, J.3
-
40
-
-
69549131042
-
Development of sunitinib in hepatocellular carcinoma: Rationale, early clinical experience, and correlative studies
-
Zhu AX, Duda DG, Sahani DV, Jain RK. Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies. Cancer J 2009;15:263-8
-
(2009)
Cancer J
, vol.15
, pp. 263-268
-
-
Zhu, A.X.1
Duda, D.G.2
Sahani, D.V.3
Jain, R.K.4
-
41
-
-
34548322506
-
Assessment of safety and drug-induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC)
-
Faivre SJ, Raymond E, Douillard JBE, et al. Assessment of safety and drug-induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC). J Clin Oncol 2007;25:18S
-
(2007)
J Clin Oncol
, vol.25
-
-
Faivre, S.J.1
Raymond, E.2
Douillard, J.B.E.3
-
42
-
-
58149175849
-
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
-
Huynh H, Ngo VC, Fargnoli J, et al. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res 2008;14:6146-53
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6146-6153
-
-
Huynh, H.1
Ngo, V.C.2
Fargnoli, J.3
-
44
-
-
77749345616
-
-
Batchelor T, Sorensen G, di Tomaso E, et al. A multidisciplinary phase II study of AZD2171 (cediranib), an oral pan-VEGF receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. ASCO 2008: Proceedings of the 2008 ASCO Annual Meeting; May 30 - June 3 2008; Chicago, USA. J Clin Oncol 2008;26. Abstract LB-247
-
Batchelor T, Sorensen G, di Tomaso E, et al. A multidisciplinary phase II study of AZD2171 (cediranib), an oral pan-VEGF receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. ASCO 2008: Proceedings of the 2008 ASCO Annual Meeting; May 30 - June 3 2008; Chicago, USA. J Clin Oncol 2008;26. Abstract LB-247
-
-
-
-
45
-
-
61349124193
-
A phase I and pharmacokinetic study of daily oral cediranib, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer. A study of the National Cancer Institute of Canada Clinical Trials Group
-
Goss G, Shepherd FA, Laurie S, et al. A phase I and pharmacokinetic study of daily oral cediranib, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer. A study of the National Cancer Institute of Canada Clinical Trials Group. Eur J Cancer 2009;45(5):782-8
-
(2009)
Eur J Cancer
, vol.45
, Issue.5
, pp. 782-788
-
-
Goss, G.1
Shepherd, F.A.2
Laurie, S.3
-
46
-
-
61349149253
-
Phase III trial of FOLFOX plus bevacizumab or cediranib (AZD2171) as first-line treatment of patients with metastatic colorectal cancer: HORIZON III
-
Robertson JD, Botwood NA, Rothenberg ML, Schmoll HJ. Phase III trial of FOLFOX plus bevacizumab or cediranib (AZD2171) as first-line treatment of patients with metastatic colorectal cancer: HORIZON III. Clin Colorectal Cancer 2009;8:59-60
-
(2009)
Clin Colorectal Cancer
, vol.8
, pp. 59-60
-
-
Robertson, J.D.1
Botwood, N.A.2
Rothenberg, M.L.3
Schmoll, H.J.4
-
47
-
-
77749329576
-
An open-label, phase I study of cediranib (RECENTIN™) in patients with acute myeloid leukemia
-
In press
-
Fiedler W, Mesters R, Heuser M, et al. An open-label, phase I study of cediranib (RECENTIN™) in patients with acute myeloid leukemia. Leukemia Res 2009. In press
-
(2009)
Leukemia Res
-
-
Fiedler, W.1
Mesters, R.2
Heuser, M.3
-
48
-
-
44649202112
-
Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
-
Huynh H, Chow PK, Palanisamy N, et al. Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Hepatol 2008;49:52-60
-
(2008)
J Hepatol
, vol.49
, pp. 52-60
-
-
Huynh, H.1
Chow, P.K.2
Palanisamy, N.3
-
49
-
-
19144366561
-
Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor
-
Mise M, Arii S, Higashituji H, et al. Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor. Hepatology 1996;23:455-64
-
(1996)
Hepatology
, vol.23
, pp. 455-464
-
-
Mise, M.1
Arii, S.2
Higashituji, H.3
-
50
-
-
0025998068
-
Extracellular matrix and cell shape: Potential control points for inhibition of angiogenesis
-
Ingber D. Extracellular matrix and cell shape: potential control points for inhibition of angiogenesis. J Cell Biochem 1991;47:236-41
-
(1991)
J Cell Biochem
, vol.47
, pp. 236-241
-
-
Ingber, D.1
-
51
-
-
0034906312
-
The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma
-
El Assal ON, Yamanoi A, Ono T, et al. The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma. Clin Cancer Res 2001;7:1299-305
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1299-1305
-
-
El Assal, O.N.1
Yamanoi, A.2
Ono, T.3
-
52
-
-
0034802560
-
Correlation of serum basic fibroblast growth factor levels with clinicopathological features and postoperative recurrence in hepatocellular carcinoma
-
Poon RT, Ng IO, Lau C, et al. Correlation of serum basic fibroblast growth factor levels with clinicopathological features and postoperative recurrence in hepatocellular carcinoma. Am J Surg 2001;182:298-304
-
(2001)
Am J Surg
, vol.182
, pp. 298-304
-
-
Poon, R.T.1
Ng, I.O.2
Lau, C.3
-
53
-
-
18344363186
-
Synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in murine hepatocellular carcinoma
-
Yoshiji H, Kuriyama S, Yoshii J, et al. Synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in murine hepatocellular carcinoma. Hepatology 2002;35:834-42
-
(2002)
Hepatology
, vol.35
, pp. 834-842
-
-
Yoshiji, H.1
Kuriyama, S.2
Yoshii, J.3
-
54
-
-
0030823411
-
Basic fibroblast growth factor regulates proliferation and motility of human hepatoma cells by an autocrine mechanism
-
Kin M, Sata M, Ueno T, et al. Basic fibroblast growth factor regulates proliferation and motility of human hepatoma cells by an autocrine mechanism. J Hepatol 1997;27:677-87
-
(1997)
J Hepatol
, vol.27
, pp. 677-687
-
-
Kin, M.1
Sata, M.2
Ueno, T.3
-
55
-
-
33645670595
-
-
Bhide RS, Cai ZW, Zhang YZ, et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4] triazin-6-yloxy)propan-2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J Med Chem 2006;49:2143-6
-
Bhide RS, Cai ZW, Zhang YZ, et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4] triazin-6-yloxy)propan-2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J Med Chem 2006;49:2143-6
-
-
-
-
56
-
-
21044443128
-
In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models
-
Lee SH, Lopes DM, Vora J, et al. In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models. Clin Cancer Res 2005;11:3633-41
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3633-3641
-
-
Lee, S.H.1
Lopes, D.M.2
Vora, J.3
-
57
-
-
0032773895
-
Transforming growth factor-alpha and epidermal growth factor receptor in chronic liver disease and hepatocellular carcinoma
-
Harada K, Shiota G, Kawasaki H. Transforming growth factor-alpha and epidermal growth factor receptor in chronic liver disease and hepatocellular carcinoma. Liver 1999;19:318-25
-
(1999)
Liver
, vol.19
, pp. 318-325
-
-
Harada, K.1
Shiota, G.2
Kawasaki, H.3
-
58
-
-
27544497021
-
EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer
-
Huether A, Hopfner M, Baradari V, et al. EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer. Biochem Pharmacol 2005;70:1568-78
-
(2005)
Biochem Pharmacol
, vol.70
, pp. 1568-1578
-
-
Huether, A.1
Hopfner, M.2
Baradari, V.3
-
59
-
-
9644255742
-
Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma
-
Hopfner M, Sutter AP, Huether A, et al. Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma. J Hepatol 2004;41:1008-16
-
(2004)
J Hepatol
, vol.41
, pp. 1008-1016
-
-
Hopfner, M.1
Sutter, A.P.2
Huether, A.3
-
60
-
-
27244447373
-
Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer
-
Philip PA, Mahoney MR, Allmer C, et al. Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol 2005;23:6657-63
-
(2005)
J Clin Oncol
, vol.23
, pp. 6657-6663
-
-
Philip, P.A.1
Mahoney, M.R.2
Allmer, C.3
-
61
-
-
60849124241
-
Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma
-
Thomas MB, Morris JS, Chadha R, et al. Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J Clin Oncol 2009;27:843-50
-
(2009)
J Clin Oncol
, vol.27
, pp. 843-850
-
-
Thomas, M.B.1
Morris, J.S.2
Chadha, R.3
-
62
-
-
68149164263
-
A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer
-
Ramanathan RK, Belani CP, Singh DA, et al. A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer. Cancer Chemother Pharmacol 2009;64:777-83
-
(2009)
Cancer Chemother Pharmacol
, vol.64
, pp. 777-783
-
-
Ramanathan, R.K.1
Belani, C.P.2
Singh, D.A.3
-
63
-
-
77749342574
-
-
O'Dwyer PJ, Giantonio BJ, Levy DE, et al. Gefitinib in advanced unresectable hepatocellular carcinoma: Results from the Eastern Cooperative Oncology Group's Study E1203. ASCO 2006: Proceedings of the 2006 ASCO Annual Meeting; June 2 - 6 2006; Atlanta, USA. J Clin Oncol 2006;24:18S
-
O'Dwyer PJ, Giantonio BJ, Levy DE, et al. Gefitinib in advanced unresectable hepatocellular carcinoma: Results from the Eastern Cooperative Oncology Group's Study E1203. ASCO 2006: Proceedings of the 2006 ASCO Annual Meeting; June 2 - 6 2006; Atlanta, USA. J Clin Oncol 2006;24:18S
-
-
-
-
64
-
-
18344390418
-
ERBB receptors and cancer: The complexity of targeted inhibitors
-
Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005;5:341-54
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
65
-
-
33847069207
-
Genomics and signaling pathways in hepatocellular carcinoma
-
Villanueva A, Newell P, Chiang DY, et al. Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis 2007;27:55-76
-
(2007)
Semin Liver Dis
, vol.27
, pp. 55-76
-
-
Villanueva, A.1
Newell, P.2
Chiang, D.Y.3
-
66
-
-
0030715557
-
Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma
-
Mckillop IH, Schmidt CM, Cahill PA, et al. Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma. Hepatology 1997;26:1484-91
-
(1997)
Hepatology
, vol.26
, pp. 1484-1491
-
-
Mckillop, I.H.1
Schmidt, C.M.2
Cahill, P.A.3
-
67
-
-
0035799529
-
Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein
-
Giambartolomei S, Covone F, Levrero M, Balsano C. Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein. Oncogene 2001;20:2606-10
-
(2001)
Oncogene
, vol.20
, pp. 2606-2610
-
-
Giambartolomei, S.1
Covone, F.2
Levrero, M.3
Balsano, C.4
-
68
-
-
38349071703
-
Targeting MEK is effective chemoprevention of hepatocellular carcinoma in TGF-alpha-transgenic mice
-
Wentz SC, Wu H, Yip-Schneider MT, et al. Targeting MEK is effective chemoprevention of hepatocellular carcinoma in TGF-alpha-transgenic mice. J Gastrointest Surg 2008;12:30-7
-
(2008)
J Gastrointest Surg
, vol.12
, pp. 30-37
-
-
Wentz, S.C.1
Wu, H.2
Yip-Schneider, M.T.3
-
69
-
-
33846781365
-
Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma
-
Huynh H, Soo KC, Chow PK, Tran E. Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. Mol Cancer Ther 2007;6:138-46
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 138-146
-
-
Huynh, H.1
Soo, K.C.2
Chow, P.K.3
Tran, E.4
-
70
-
-
77749342575
-
AZD6244 enhances the antitumor activity of rapamycin in mouse models of human HCC
-
In press
-
Huynh H. AZD6244 enhances the antitumor activity of rapamycin in mouse models of human HCC. Cancer 2009. In press
-
(2009)
Cancer
-
-
Huynh, H.1
-
71
-
-
2442637885
-
Over-expression of c-raf-1 proto-oncogene in liver cirrhosis and hepatocellular carcinoma
-
Hwang YH, Choi JY, Kim S, et al. Over-expression of c-raf-1 proto-oncogene in liver cirrhosis and hepatocellular carcinoma. Hepatol Res 2004;29:113-21
-
(2004)
Hepatol Res
, vol.29
, pp. 113-121
-
-
Hwang, Y.H.1
Choi, J.Y.2
Kim, S.3
-
72
-
-
33749319933
-
Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells
-
Lee HC, Tian B, Sedivy JM, et al. Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology 2006;131:1208-17
-
(2006)
Gastroenterology
, vol.131
, pp. 1208-1217
-
-
Lee, H.C.1
Tian, B.2
Sedivy, J.M.3
-
73
-
-
71349084002
-
AZD6244 enhances the antitumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)
-
Huynh H, Ngo VC, Koong HN, et al. AZD6244 enhances the antitumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC). J Hepatol 2010;52:79-87
-
J Hepatol
, vol.2010
, Issue.52
, pp. 79-87
-
-
Huynh, H.1
Ngo, V.C.2
Koong, H.N.3
-
74
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
75
-
-
36549013178
-
Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection
-
Schmitz KJ, Wohlschlaeger J, Lang H, et al. Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol 2008;48:83-90
-
(2008)
J Hepatol
, vol.48
, pp. 83-90
-
-
Schmitz, K.J.1
Wohlschlaeger, J.2
Lang, H.3
-
76
-
-
33846463379
-
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
-
Boyault S, Rickman DS, de Reynies A, et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology 2007;45:42-52
-
(2007)
Hepatology
, vol.45
, pp. 42-52
-
-
Boyault, S.1
Rickman, D.S.2
de Reynies, A.3
-
77
-
-
11144236505
-
mTOR and P70 S6 kinase expression in primary liver neoplasms
-
Sahin F, Kannangai R, Adegbola O, et al. mTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res 2004;10:8421-5
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8421-8425
-
-
Sahin, F.1
Kannangai, R.2
Adegbola, O.3
-
78
-
-
85047694402
-
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
-
Horie Y, Suzuki A, Kataoka E, et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004;113:1774-83
-
(2004)
J Clin Invest
, vol.113
, pp. 1774-1783
-
-
Horie, Y.1
Suzuki, A.2
Kataoka, E.3
-
79
-
-
26444448463
-
The survival kinases Akt and Pim as potential pharmacological targets
-
Amaravadi R, Thompson CB. The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest 2005;115:2618-24
-
(2005)
J Clin Invest
, vol.115
, pp. 2618-2624
-
-
Amaravadi, R.1
Thompson, C.B.2
-
80
-
-
10344231428
-
FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation
-
Lee TK, Man K, Ho JW, et al. FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis 2004;25:2397-405
-
(2004)
Carcinogenesis
, vol.25
, pp. 2397-2405
-
-
Lee, T.K.1
Man, K.2
Ho, J.W.3
-
81
-
-
34047118033
-
Vascular remodelling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma
-
Semela D, Piguet AC, Kolev M, et al. Vascular remodelling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol 2007;46:840-8
-
(2007)
J Hepatol
, vol.46
, pp. 840-848
-
-
Semela, D.1
Piguet, A.C.2
Kolev, M.3
-
82
-
-
54349106781
-
RAD001 (everolimus) inhibits tumor growth in xenograft models of human hepatocellular carcinoma
-
In press
-
Huynh H, Chow P, Soo KC, et al. RAD001 (everolimus) inhibits tumor growth in xenograft models of human hepatocellular carcinoma. J Cell Mol Med 2008. In press
-
(2008)
J Cell Mol Med
-
-
Huynh, H.1
Chow, P.2
Soo, K.C.3
-
83
-
-
0034901515
-
Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition
-
Dudkin L, Dilling MB, Cheshire PJ, et al. Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition. Clin Cancer Res 2001;7:1758-64
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1758-1764
-
-
Dudkin, L.1
Dilling, M.B.2
Cheshire, P.J.3
-
84
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-84
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
85
-
-
55249103589
-
RAD001 vs placebo in patients with metastatic renal cell carcinoma (RCC) after progression on VEGFr-TKI therapy: Results from a randomized, double-blind, multicenter phase-III study
-
Abstract LBA-5026
-
Motzer RJ, Escudier B, Oudard S, et al. RAD001 vs placebo in patients with metastatic renal cell carcinoma (RCC) after progression on VEGFr-TKI therapy: Results from a randomized, double-blind, multicenter phase-III study. J Clin Oncol 2008;26. Abstract LBA-5026
-
(2008)
J Clin Oncol
, pp. 26
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
86
-
-
40149098824
-
Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer
-
Rizell M, Andersson M, Cahlin C, et al. Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer. Int J Clin Oncol 2008;13:66-70
-
(2008)
Int J Clin Oncol
, vol.13
, pp. 66-70
-
-
Rizell, M.1
Andersson, M.2
Cahlin, C.3
-
87
-
-
0035142665
-
Activation of STAT proteins and growth control
-
Bromberg JF. Activation of STAT proteins and growth control. Bioessays 2001;23:161-9
-
(2001)
Bioessays
, vol.23
, pp. 161-169
-
-
Bromberg, J.F.1
-
88
-
-
33745216415
-
Ionizing radiation antagonizes tumor hypoxia induced by antiangiogenic treatment
-
Riesterer O, Honer M, Jochum W, et al. Ionizing radiation antagonizes tumor hypoxia induced by antiangiogenic treatment. Clin Cancer Res 2006;12:3518-24
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3518-3524
-
-
Riesterer, O.1
Honer, M.2
Jochum, W.3
-
89
-
-
3543150890
-
Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway
-
Yun C, Cho H, Kim SJ, et al. Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway. Mol Cancer Res 2004;2:159-69
-
(2004)
Mol Cancer Res
, vol.2
, pp. 159-169
-
-
Yun, C.1
Cho, H.2
Kim, S.J.3
-
90
-
-
0036717295
-
Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation
-
Yoshida T, Hanada T, Tokuhisa T, et al. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J Exp Med 2002;196:641-53
-
(2002)
J Exp Med
, vol.196
, pp. 641-653
-
-
Yoshida, T.1
Hanada, T.2
Tokuhisa, T.3
-
91
-
-
33645976174
-
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC
-
Calvisi DF, Ladu S, Gorden A, et al. Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology 2006;130:1117-28
-
(2006)
Gastroenterology
, vol.130
, pp. 1117-1128
-
-
Calvisi, D.F.1
Ladu, S.2
Gorden, A.3
-
92
-
-
0345722740
-
Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas
-
Park WS, Dong SM, Kim SY, et al. Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas. Cancer Res 1999;59:307-10
-
(1999)
Cancer Res
, vol.59
, pp. 307-310
-
-
Park, W.S.1
Dong, S.M.2
Kim, S.Y.3
-
93
-
-
44349155339
-
Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma
-
Osada S, Kanematsu M, Imai H, Goshima S. Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma. Hepatogastroenterology 2008;55:544-9
-
(2008)
Hepatogastroenterology
, vol.55
, pp. 544-549
-
-
Osada, S.1
Kanematsu, M.2
Imai, H.3
Goshima, S.4
-
94
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
-
Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000;92:205-16
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
-
95
-
-
33645051467
-
Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC
-
Maione P, Gridelli C, Troiani T, Ciardiello F. Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC. Oncologist 2006;11:274-84
-
(2006)
Oncologist
, vol.11
, pp. 274-284
-
-
Maione, P.1
Gridelli, C.2
Troiani, T.3
Ciardiello, F.4
-
96
-
-
16544389873
-
A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells
-
Ganslmayer M, Ocker M, Zopf S, et al. A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells. Oncol Rep 2004;11:943-50
-
(2004)
Oncol Rep
, vol.11
, pp. 943-950
-
-
Ganslmayer, M.1
Ocker, M.2
Zopf, S.3
-
97
-
-
21844477801
-
Overadditive anti-proliferative and pro-apoptotic effects of a combination therapy on colorectal carcinoma cells
-
Herold C, Ganslmayer M, Ocker M, et al. Overadditive anti-proliferative and pro-apoptotic effects of a combination therapy on colorectal carcinoma cells. Int J Oncol 2003;23:751-6
-
(2003)
Int J Oncol
, vol.23
, pp. 751-756
-
-
Herold, C.1
Ganslmayer, M.2
Ocker, M.3
|