Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity

Journal of Translational Medicine

Volumn 8, Issue , 2010, Pages

  Brown, Kelly L ^a,b,d   Falsafi, Reza ^a   Kum, Winnie ^a   Hamill, Pamela ^a   Gardy, Jennifer L ^a   Davidson, Donald J ^b,c   Turvey, Stuart ^b   Finlay, Brett B ^a   Speert, David P ^b   Hancock, Robert E W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4; CHEMOKINE; CYTOKINE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; IRAK4 PROTEIN, HUMAN;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STIMULATION; CHILD; CLINICAL INDICATOR; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE PREDISPOSITION; DNA MICROARRAY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE REPRESSION; GRAM NEGATIVE INFECTION; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN VERSUS ANIMAL COMPARISON; IMMUNITY; IN VITRO STUDY; INFECTION RESISTANCE; INNATE IMMUNITY; MALE; MONOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; SURVIVAL RATE; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; WILD TYPE; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECT; GENETICS; IMMUNOLOGY; METHODOLOGY; MOUSE; PATHOGENICITY; POLYMERASE CHAIN REACTION;

ANIMALS; CHEMOKINES; CHILD; CYTOKINES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MONOCYTES; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 77649309624     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-8-6     Document Type: Article

References (48)

1. Akira S, Uematsu S, Takeuchi O. Pathogen Recognition and Innate Immunity. Cell 2005, 124:783-801.
2. Martino F, Tschoop J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol 2005, 26:449-454.
3. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004, 4:499-511. 10.1038/nri1391, 15229469.
4. Dunne A, O'Neill LA. Adaptor usage and Toll-like receptor signalling specificity. FEBS Lett 2005, 579:3330-3335. 10.1016/j.febslet.2005.04.024, 15876435.
5. Kim T, Kim YJ. Overview of innate immunity in Drosophila. J Biochem Mol Biol 2005, 38:121-127.
6. Akira S. Toll-like receptors: lessons from knockout mice. Biochem Soc Trans 2000, 28:551-556.
7. Takeuchi O, Hoshino K, Akira S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol 2000, 165:5392-5396.
8. Skerrett SJ, Liggitt HD, Hajjar AM, Wilson CB. Cutting edge: myeloid differentiation factor 88 is essential for pulmonary host defence against Pseudomonas aeruginosa but not Staphylococcus aureus. J Immunol 2004, 172:3377-3381.
9. Fremond CM, Yeremeev V, Nicolle DM, Jacobs M, Quesniaux VF, Ryffel B. Fatal Mycobacterium tuberculosi s infection despite adaptive immune response in the absence of MyD88. J Clin Invest 2004, 114:1790-1799. 535064, 15599404.
10. Feng CG, Scanga CA, Collazo-Custodio CM, Cheever AW, Hieny S, Caspar P, Sher A. Mice lacking myeloid differentiation factor 88 display profound defects in host resistance and immune responses to Mycobacterium avium infection not exhibited by Toll-like receptor 2 (TLR2)- and TLR4-deficient animals. J Immunol 2003, 171:4758-4764.
11. Seki E, Tsutsui H, Tsuji NM, Hayashi N, Adachi K, Nakano H, Futatsugi-Yumikura S, Takeuchi O, Hoshino K, Akira S, Fujimoto J, Nakanishi K. Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol 2002, 169:3863-3868.
12. Ku CL, Yang K, Bustamante Puel A, von Bernuth A, Santos OF, Lawrence T, Chang HH, Al-Mousa H, Picard C. Inherited disorders of human Toll-like receptor signalling: immunological implications. Immunol Rev 2005, 203:10-20. 10.1111/j.0105-2896.2005.00235.x, 15661018.
13. Currie AJ, Davidson DJ, Reid GS, Bharya S, MacDonald KL, Devon RS, Speert DP. Primary immunodeficiency to pneumococcal infection due to a defect in Toll-like receptor signalling. J Pediatr 2004, 144:512-518. 10.1016/j.jpeds.2003.10.034, 15069402.
14. Davidson DJ, Currie AJ, Bowdish DME, Brown KL, Rosenberger CM, Ma RC, Bylund J, Campsall PA, Puel A, Picard C, Casanova JL, Turvey SE, Devon RE, Hancock REW, Speert DP. IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL1R responses in human myeloid and non-myeloid cells. J Immunol 2006, 177:8202-8211.
15. Picard C, Puel A, Bonnet M, Ku CL, Bustamante J, Yang K, Soudais C, Dupuis S, Feinberg J, Fieschi C, Elbim C, Hitchcock R, Lammas D, Davies G, Al-Ghonaium A, Al-Rayes H, Al-Jumaah A, Al-Hajjar S, Al-Mohsen IZ, Frayha HH, Rucker R, Hawn TR, Aderem A, Tufenkji H, Haraguchi S, Day NK, Good RA, Gougerot-Pocidalo MA, Ozinsky A, Casanova JL. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 2003, 299:2076-2079. 10.1126/science.1081902, 12637671.
16. Medvedev AE, Lentschat A, Kuhns DB, Blanco JC, Salkowski C, Zhang S, Arditi M, Gallin JI, Vogel SN. Distinct mutations in IRAK-4 Confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections. J Exp Med 2003, 198:521-531. 10.1084/jem.20030701, 2194174, 12925671.
17. Chapel H, Puel A, von Bernuth H, Picard C, Casanova JL. Shigella sonnei meningitis due to interleukin-1 receptor-associated kinase-4 deficiency: first association with a primary immune deficiency. Clin Infect Dis 2005, 40:1227-1231. 10.1086/428733, 15825022.
18. Enders A, Pannicke U, Berner R, Henneke P, Radlinger K, Schwarz K, Ehl S. Two siblings with lethal pneumococcal meningitis in a family with a mutation in Interleukin-1 receptor-associated kinase 4. J Pediatr 2004, 145:698-700. 10.1016/j.jpeds.2004.06.065, 15520784.
19. Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, Mirtsos C, Takada H, Wakeham A, Itie A, Li S, Penninger JM, Wesche H, Ohashi PS, Mak TW, Yeh WC. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 2002, 416:750-756. 10.1038/nature736, 11923871.
20. Vosse E, van Dissel JT, Ottenhoff TH. Genetic deficiencies of innate immune signalling in human infectious disease. Lancet Infect Dis 2009, 9:688-698. 10.1016/S1473-3099(09)70255-5, 19850227.
21. Ku CL, von Bernuth H, Picard C, Zhang SY, Chang HH, Yang K, Chrabieh M, Issekutz AC, Cunningham CK, Gallin J, Holland SM, Roifman C, Ehl S, Smart J, Tang M, Barrat FJ, Levy O, McDonald D, Day-Good NK, Miller R, Takada H, Hara T, Al-Hajjar S, Al-Ghonaium A, Speert D, Sanlaville D, Li X, Geissmann F, Vivier E, Maródi L, Garty BZ, Chapel H, Rodriguez-Gallego C, Bossuyt X, Abel L, Puel A, Casanova JL. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med 2007, 204:2407-2422. 10.1084/jem.20070628, 2118442, 17893200.
22. Suzuki N, Suzuki S, Eriksson U, Hara H, Mirtosis C, Chen NJ, Wada T, Bouchard D, Hwang I, Takeda K, Fujita T, Der S, Penninger JM, Akira S, Saito T, Yeh WC. IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC. J Immunol 2003, 171:6065-6071.
23. Kawagoe T, Sato S, Jung A, Yamamoto M, Matsui K, Kato H, Uematsu S, Takeuchi O, Akira S. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signalling. J Exp Med 2007, 204:1013-1024. 10.1084/jem.20061523, 2118579, 17485511.
24. Kim TW, Staschke K, Bulek K, Yao J, Peters K, Oh KH, Vandenburg Y, Xiao H, Qian W, Hamilton T, Min B, Sen G, Gilmour R, Li X. A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J Exp Med 2007, 204:1025-1036. 10.1084/jem.20061825, 2118590, 17470642.
25. Mookherjee N, Brown KL, Bowdish DME, Doria S, Falsafi R, Hokamp K, Roche RM, Mu R, Doho GH, Pistolic J, Powers JP, Bryan J, Brinkman FS, Hancock RE. Modulation of the Toll-like receptor-mediated inflammatory response by the endogenous human host defence peptide LL-37. J Immunol 2006, 176:2455-2464.
26. Hirschfeld AF, Bettinger JA, Victor RE, Davidson DJ, Currie AJ, Ansermino JM, Scheifele DW, Orange JS, Turvey SE. Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection. Clin Immunol 2007, 122:271-8. 10.1016/j.clim.2006.10.012, 17157070.
27. Brown KL, Maiti A, Johnson P. Role of sulfation in CD44-mediated hyaluronan binding induced by inflammatory mediators in human CD14+ peripheral blood monocytes. J Immunol 2001, 167:5367-5374.
28. Brown KL, Bylund J, MacDonald KL, Song-Zhao GX, Elliott M, Falsafi R, Hancock R, Speert DP. ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease. Clin Immunol 2008, 129:90-102. 10.1016/j.clim.2008.06.005, 18676204.
29. Scott MG, Dullaghan E, Mookherjee N, Glavas N, Waldbrook M, Thompson A, Wang A, Lee K, Doria S, Hamill P, Yu JJ, Li Y, Donini O, Guarna MM, Finlay BB, North JR, Hancock REW. An anti-infective peptide that selectively modulates the innate immune response. Nat Biotechnol 2007, 25:465-472. 10.1038/nbt1288, 17384586.
30. Hokamp K, Roche FM, Acab M, Rousseau ME, Kuo B, Goode D, Aeschliman D, Bryan J, Babiuk LA, Hancock REW, Brinkman FS. ArrayPipe: a flexible processing pipeline for microarray data. Nucl Acids Res 2004, 32:W457-459. 10.1093/nar/gkh446, 441584, 15215429.
31. Shannon P, Markiel A, Ozier Q, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 2003, 13:2498-2504. 10.1101/gr.1239303, 403769, 14597658.
32. Zhang B, Schmoyer D, Kirov K, Snoddy J. GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies. BMC Bioinformatics 2004, 5:16-23. 10.1186/1471-2105-5-16, 373441, 14975175.
33. Hoiseth SK, Stocker BA. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 1981, 291:238-239. 10.1038/291238a0, 7015147.
34. Faure K, Sawa T, Ajayi T, Fujimoto J, Moriyama K, Shime N, Wiener-Kronish JP. TLR signalling is essential for survival in acute lung injury induced by virulent Pseudomonas aeruginosa secreting type III secretory toxins. Respir Res 2004, 5:1-10. 10.1186/1465-9921-5-1, 389879, 15040820.
35. Mahieu T, Park JM, Revets H, Paschel B, Lengeling A, Staelens J, Wullaert A, Vanlaere I, Hochepied T, van Roy F, Karin M, Libert C. The wild-derived inbred mouse strain SPRET_Ei is resistant to LPS and defective in IFN-β production. PNAS 2006, 103:2292-2297. 10.1073/pnas.0510874103, 1413734, 16455798.
36. Modlin RL, Brightbill HD, Godowski PJ. The Toll of Innate Immunity on Microbial Pathogens. NEJM 1999, 340:1834-1835. 10.1056/NEJM199906103402312, 10362831.
37. Koziczak-Holbro M, Glück A, Tschopp C, Mathison JC, Gram H. IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes. Eur J Immunol 2008, 38:788-96. 10.1002/eji.200737886, 18266302.
38. Covert MW, Leung TH, Gaston JE, Baltimore D. Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 2005, 309:1854-1857. 10.1126/science.1112304, 16166516.
39. Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999, 11:115-122. 10.1016/S1074-7613(00)80086-2, 10435584.
40. Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature 2004, 430:218-222. 10.1038/nature02738, 15241416.
41. Carballo E, Lai WS, Blackshear PJ. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 1998, 281:1001-1005. 10.1126/science.281.5379.1001, 9703499.
42. Muchamuel T, Menon S, Pisacane P, Howard MC, Cockayne DA. IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production. J Immunol 1997, 158:2898-2903.
43. Pasare C, Medzhitov R. Control of B-cell responses by Toll-like receptors. Nature 2005, 438:364-368. 10.1038/nature04267, 16292312.
44. Denny P, Hopes E, Gingles N, Broman KW, McPheat W, Morten J, Alexander J, Andrew PW, Brown SD. A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice. Mamm Genome 2003, 14:448-453. 10.1007/s00335-002-2261-9, 12925893.
45. Esche C, Stellato C, Beck LA. Chemokines: key players in innate and adaptive immunity. J Invest Dermatol 2005, 125:615-628. 10.1111/j.0022-202X.2005.23841.x, 16185259.
46. Björkbacka H, Fitzgerald KA, Huet F, LI X, Gregory JA, Lee MA, Ordija CM, Dowley NE, Golenbock DT, Freeman MW. The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Physiological Genomics 2004, 19:319-330. 10.1152/physiolgenomics.00128.2004, 15367722.
47. Brown KL, Cosseau C, Gardy JL, Hancock REW. Complexities of targeting innate immunity to treat infection. Trends Immunol 2007, 28:260-66. 10.1016/j.it.2007.04.005, 17468048.
48. Li X. IRAK4 in TLR/IL-1R signalling: possible clinical applications. Eur J Immunol 2008, 38:614-618. 10.1002/eji.200838161, 18286571.