Therapeutic efficacy of Cintredekin Besudotox (IL13-PE38QQR) in murine lung fibrosis is unaffected by immunity to Pseudomonas aeruginosa exotoxin A

PLoS ONE

Volumn 5, Issue 1, 2010, Pages

  Rosada, Rogério S ^a   Moreira, Ana P ^b   Frantz, Fabiani G ^a   Puri, Raj K ^c   Rahman, Aquilur ^d   Standiford, Theodore J ^b   Zárate Bladés, Carlos R ^a   Silva, Célio L ^a   Hogaboam, Cory M ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d NeoPharm Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CINTREDEKIN BESUDOTOX; EXOTOXIN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; NEUTRALIZING ANTIBODY; SODIUM CHLORIDE; BACTERIAL TOXIN; IL13-PE38QQR; IMMUNOTOXIN; INTERLEUKIN 13; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TOXA PROTEIN, PSEUDOMONAS AERUGINOSA; VIRULENCE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BACTERIAL INFECTION; C57BL 6 MOUSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HISTOPATHOLOGY; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNITY; LUNG FIBROSIS; LUNG PARENCHYMA; MOUSE; NONHUMAN; PSEUDOMONAS AERUGINOSA; SENSITIZATION; SERUM; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; IMMUNOLOGY;

MURINAE; MUS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS EXOTOXIN;

ADP RIBOSE TRANSFERASES; ANIMALS; BACTERIAL TOXINS; BLEOMYCIN; EXOTOXINS; IMMUNOTOXINS; INTERLEUKIN-13; MICE; MICE, INBRED C57BL; PULMONARY FIBROSIS; VIRULENCE FACTORS;

EID: 77649296790     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008721     Document Type: Article

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