The IL-13 Receptor Structure Differs on Various Cell Types and May Share More Than One Component with IL-4 Receptor

Journal of Immunology

Volumn 158, Issue 2, 1997, Pages 756-764

  Obiri, Nicholas I ^a   Leland, Pamela ^a   Murata, Takashi ^a   Debinski, Waldemar ^b   Puri, Raj K ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; EXOTOXIN; IL13RA1 PROTEIN, HUMAN; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 13 RECEPTOR ALPHA1; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN RECEPTOR; LEUKOCYTE ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TOXA PROTEIN, PSEUDOMONAS AERUGINOSA; VIRULENCE FACTOR;

ANTIBODY SPECIFICITY; ARTICLE; BINDING COMPETITION; BIOLOGICAL MODEL; CELL ADHESION; CELL CULTURE; CROSS REACTION; HUMAN; IMMUNOLOGY; PROTEIN BINDING;

ADP RIBOSE TRANSFERASES; ANTIGENS, CD; BACTERIAL TOXINS; BINDING, COMPETITIVE; CELL ADHESION; CROSS REACTIONS; EXOTOXINS; HUMANS; INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT; MODELS, IMMUNOLOGICAL; ORGAN SPECIFICITY; PROTEIN BINDING; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-13; RECEPTORS, INTERLEUKIN-4; TUMOR CELLS, CULTURED; VIRULENCE FACTORS;

EID: 0031568012     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Brown, K. D., S. M. Zurawski, T. R. Mosmann, and G. Zurawski. 1989. A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes. J. Immunol. 142: 679.
2. Minty, A., P. Chalon, J-M. Derocq, X. Dumont, J-C. Guillemot, M. Kaghad, C. Labit, P. Leplatois, P. Liauzum, B. Miloux, C. Minty, P. Casekkas, G. Loison, J. Lupker, D. Shire, P. Ferrara, and D. Caput. 1993. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 362: 248.
3. Zurawski, G., and J. E. de Vries. 1994. Interleukin-13 an interleukin 4-like cytokine that acts on monocytes and B cells but not on T cells, Immunol. Today 15:19.
4. Idzerda, R. L., C. J. March, B. Mosley, S. D. Lyman, T. V. Bos, S. D. Gimpel, W. S. Din, K. H. Grabstein, M. B. Widmer, L. S. Park, D. Cosman, and M. P. Beckmann. 1990. Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J. Exp. Med. 171:861.
5. Russell, S. M., A. D. Keegan, N. Harada, Y. Nakamura, M. Noguchi, P. Leland, M. C. Freedman, A. Miyajima, R. K. Puri, W. E. Paul, and W. J. Leonard. 1993. Interleukin-2 receptor γ chain: a functional component of the interleukin-4 receptor. Science 262:1880.
6. Obiri, N. I., and R. K. Puri. 1994. Characterization of interleukin-4 receptors expressed on human renal cell carcinoma cells. Oncol. Res. 6:419.
7. Hilton, D., J-G. Zhang, D. Metcalf, W. Alexander, N. A. Nicola, and T. A. Wilson. 1996. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc. Natl. Acad. Sci. USA 93:497.
8. Obiri, N. I., W. Debinski, W. J. Leonard, and R. K. Puri. 1995. Receptor for interleukin 13: interaction with interleukin 4 by a mechanism that does not involve the common γ chain shared by receptors for interleukins 2, 4, 7, 9 and 15. J. Biol. Chem. 270:8797.
9. Zurawski, S. M., P. Chomarat, O. Djossou, C. Bidaud, A. N. J, McKenzie, P. Miossec, J. Banchereau, and G. Zurawski. 1995. The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor. J. Biol. Chem. 270:13869.
10. Vita, N., S. Lefort, P. Laurent, D. Caput, and P. Ferrara. 1995. Characterization and comparison of the interleukin-13 receptor with the interleukin 4 receptor on several cell types. J. Biol. Chem. 270:3512.
11. Zurawski, S. M., F. Vega, Jr., B. Huyghe, and G. Zurawski. 1993. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J. 12:2663.
12. Welham, M. J., L. Learmonth, H. Bone, and J. W. Schrader. 1995. Interleukin-13 signal transduction in lymphopoietic cells: similarities and differences in signal transduction with interleukin-4 and insulin. J. Biol. Chem. 270:12286.
13. Smerz-Bertling, C., and A. Duschl. 1995. Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor. J. Biol. Chem. 270:966.
14. Murata, T., P. D. Noguchi, and R. K. Puri. 1995. Interleukin-4 receptors on human colon carcinoma cells do not associate with common chain and signal through IRS-1, JAK-1 and IL4-STAT but not through JAK 3 pathways. J. Biol. Chem. 270:30829.
15. Murata, T., P. D. Noguchi, and R. K. Puri. 1996. IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling. J. Immunol. 156:2972.
16. Tony, H. P., B-J. Shen, P. Reusch, and W. Sebald. 1994. Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency. Eur. J. Biochem. 225:659.
17. Lin, J-X., T. S. Migone, M. Tsang, M. Friedmann, J. A. Weatherbee, Z. Li, A. Yamauchi, E. Bloom, J. Mietz, S. John, and W. J. Leonard. 1995. The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7,1L-13, and IL-15. Immunity 2:1.
18. Debinski, W., N. Obiri, I. Pastan, and R. K. Puri. 1995. A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4. J. Biol. Chem. 270:16775.
19. Obiri, N. I., G. Hillman, G. P. Haas, S. Sudha, and R. K. Puri. 1993. Expression of high affinity interleukin-4 receptors on human renal carcinoma cells and inhibition of tumor growth in vitro by interleukin-4. J. Clin. Invest. 91:88.
20. Puri, R. K., P. Leland, R. J. Kreitman, and I. Pastan, 1994. Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein. Int. J. Cancer 58:574.
21. Debinski, W., N. I. Obiri, S. K. Powers, I. Pastan, and R. K. Puri. 1995. Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin. Clin. Cancer Res. 1:1253.
22. Puri, R. K., P. Leland, N. I. Obiri, S. R. Husain, R. J. Kreitman, G. P. Haas, I. Pastan, and W. Debinski. 1996. Targeting of interleukin 13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A (PE38QQR). Blood 86:4333.
23. Obiri, N., S. R. Husain, W. Debinski, and R. K. Puri. 1996. Interleukin-13 inhibits growth of human renal cell carcinoma cells independently of the p140 IL-4 receptor chain. Clin. Cancer Res. 2:1743.