-
1
-
-
0028929614
-
Increasing the susceptibility of the rat 208f fibroblast cell-line to radiation-induced apoptosis does not alter its clonogenic survival dose - Response
-
Aldridge DR, Arends MJ, Radford R (1995) Increasing the susceptibility of the rat 208f fibroblast cell-line to radiation-induced apoptosis does not alter its clonogenic survival dose - response. Br J Cancer 71:571-577
-
(1995)
Br J Cancer
, vol.71
, pp. 571-577
-
-
Aldridge, D.R.1
Arends, M.J.2
Radford, R.3
-
2
-
-
57049155399
-
Directing cancer cells to self-destruct with pro-apoptotic receptor agonists
-
Ashkenazi A (2008) Directing cancer cells to self-destruct with pro-apoptotic receptor agonists. Nat Rev Drug Discov 7:1001-1012
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 1001-1012
-
-
Ashkenazi, A.1
-
3
-
-
0032713075
-
Safety and antitumor activity of recombinant soluble Apo2 ligand
-
Ashkenazi A, Pai RC, Fong S, Leung S, Lawrence DA, Masters SA, Blackie C, Chang L, McMurtrey AE, Hebert A et al (1999) Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 104:155-162
-
(1999)
J Clin Invest
, vol.104
, pp. 155-162
-
-
Ashkenazi, A.1
Pai, R.C.2
Fong, S.3
Leung, S.4
Lawrence, D.A.5
Masters, S.A.6
Blackie, C.7
Chang, L.8
McMurtrey, A.E.9
Hebert, A.10
-
4
-
-
0036687419
-
Anti-apoptotic Bcl-2 proteins: Structure, function and relevance for radiation biology
-
Belka C, Budach W (2002) Anti-apoptotic Bcl-2 proteins: structure, function and relevance for radiation biology. Int J Radiat Biol 78:643-658
-
(2002)
Int J Radiat Biol
, vol.78
, pp. 643-658
-
-
Belka, C.1
Budach, W.2
-
5
-
-
0034708169
-
Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis
-
Belka C, Rudner J, Wesselborg S, Stepczynska A, Marini P, Lepple-Wienhues A, Faltin H, Bamberg M, Budach W, Schulze-Osthoff K (2000) Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis. Oncogene 19:1181-1190
-
(2000)
Oncogene
, vol.19
, pp. 1181-1190
-
-
Belka, C.1
Rudner, J.2
Wesselborg, S.3
Stepczynska, A.4
Marini, P.5
Lepple-Wienhues, A.6
Faltin, H.7
Bamberg, M.8
Budach, W.9
Schulze-Osthoff, K.10
-
6
-
-
0035912109
-
Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL
-
Belka C, Schmid B, Marini P, Durand E, Rudner J, Faltin H, Bamberg M, Schulze-Osthoff K, Budach W (2001) Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL. Oncogene 20:2190-2196
-
(2001)
Oncogene
, vol.20
, pp. 2190-2196
-
-
Belka, C.1
Schmid, B.2
Marini, P.3
Durand, E.4
Rudner, J.5
Faltin, H.6
Bamberg, M.7
Schulze-Osthoff, K.8
Budach, W.9
-
7
-
-
0141679399
-
Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model
-
Buchsbaum DJ, Zhou T, Grizzle WE, Oliver PG, Hammond CJ, Zhang S, Carpenter M, LoBuglio AF (2003) Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model. Clin Cancer Res 9:3731-3741
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3731-3741
-
-
Buchsbaum, D.J.1
Zhou, T.2
Grizzle, W.E.3
Oliver, P.G.4
Hammond, C.J.5
Zhang, S.6
Carpenter, M.7
Lobuglio, A.F.8
-
8
-
-
0037374470
-
Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappa B in tumor necrosis factor-related apoptosis-inducing ligand signaling
-
Chen XF, Kandasamy K, Srivastava RK (2003) Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappa B in tumor necrosis factor-related apoptosis-inducing ligand signaling. Cancer Res 63:1059-1066
-
(2003)
Cancer Res
, vol.63
, pp. 1059-1066
-
-
Chen, X.F.1
Kandasamy, K.2
Srivastava, R.K.3
-
9
-
-
0034652156
-
Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy
-
Chinnaiyan AM, Prasad U, Shankar S, Hamstra DA, Shanaiah M, Chenevert TL, Ross BD, Rehemtulla A (2000) Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. Proc Natl Acad Sci U S A 97:1754-1759
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 1754-1759
-
-
Chinnaiyan, A.M.1
Prasad, U.2
Shankar, S.3
Hamstra, D.A.4
Shanaiah, M.5
Chenevert, T.L.6
Ross, B.D.7
Rehemtulla, A.8
-
10
-
-
50549105199
-
HGS-ETR1, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: Results of a phase i and PK study
-
Chow LQ, Eckhardt SG, Gustafson DL, O'Bryant C, Hariharan S, Diab S, Fox NL, Corey A, Padavic K, Brown M et al (2006) HGS-ETR1, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase I and PK study. J Clin Oncol 24:103S
-
(2006)
J Clin Oncol
, vol.24
-
-
Chow, L.Q.1
Eckhardt, S.G.2
Gustafson, D.L.3
O'Bryant, C.4
Hariharan, S.5
Diab, S.6
Fox, N.L.7
Corey, A.8
Padavic, K.9
Brown, M.10
-
11
-
-
0035871757
-
Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4
-
Chuntharapai A, Dodge K, Grimmer K, Schroeder K, Marsters SA, Koeppen H, Ashkenazi A, Kim KJ (2001) Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4. J Immunol 166:4891-4898
-
(2001)
J Immunol
, vol.166
, pp. 4891-4898
-
-
Chuntharapai, A.1
Dodge, K.2
Grimmer, K.3
Schroeder, K.4
Marsters, S.A.5
Koeppen, H.6
Ashkenazi, A.7
Kim, K.J.8
-
12
-
-
0842281645
-
Cell death: Critical control points
-
Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116:205-219
-
(2004)
Cell
, vol.116
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
13
-
-
0037069929
-
Chemotherapy: Targeting the mitochondrial cell death pathway
-
Debatin KM, Poncet D, Kroemer G (2002) Chemotherapy: targeting the mitochondrial cell death pathway. Oncogene 21:8786-8803
-
(2002)
Oncogene
, vol.21
, pp. 8786-8803
-
-
Debatin, K.M.1
Poncet, D.2
Kroemer, G.3
-
14
-
-
0030869432
-
Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family
-
DegliEsposti MA, Smolak PJ, Walczak H, Waugh J, Huang CP, DuBose RF, Goodwin RG, Smith CA (1997) Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J Exp Med 186:1165-1170
-
(1997)
J Exp Med
, vol.186
, pp. 1165-1170
-
-
Degliesposti, M.A.1
Smolak, P.J.2
Walczak, H.3
Waugh, J.4
Huang, C.P.5
Dubose, R.F.6
Goodwin, R.G.7
Smith, C.A.8
-
15
-
-
0035353207
-
Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by selective up-regulation of TRAIL-R1
-
Di Pietro R, Secchiero P, Rana R, Gibellini D, Visani G, Bemis K, Zamai L, Miscia S, Zauli G (2001) Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by selective up-regulation of TRAIL-R1. Blood 97:2596-2603
-
(2001)
Blood
, vol.97
, pp. 2596-2603
-
-
Di Pietro, R.1
Secchiero, P.2
Rana, R.3
Gibellini, D.4
Visani, G.5
Bemis, K.6
Zamai, L.7
Miscia, S.8
Zauli, G.9
-
16
-
-
0033981577
-
Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
-
Eskes R, Desagher S, Antonsson B, Martinou JC (2000) Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol 20:929-935
-
(2000)
Mol Cell Biol
, vol.20
, pp. 929-935
-
-
Eskes, R.1
Desagher, S.2
Antonsson, B.3
Martinou, J.C.4
-
18
-
-
20044391426
-
DR5 knockout mice are compromised in radiation-induced apoptosis
-
Finnberg N, Gruber JJ, Fei PW, Rudolph D, Bric A, Kim SH, Burns TF, Ajuha H, Page R, Wu GS et al (2005) DR5 knockout mice are compromised in radiation-induced apoptosis. Mol Cell Biol 25:2000-2013
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2000-2013
-
-
Finnberg, N.1
Gruber, J.J.2
Fei, P.W.3
Rudolph, D.4
Bric, A.5
Kim, S.H.6
Burns, T.F.7
Ajuha, H.8
Page, R.9
Wu, G.S.10
-
19
-
-
38149139518
-
TRAU-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis
-
Finnberg N, Klein-Szanto AJP, El-Deiry WS (2008) TRAU-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. J Clin Invest 118:111-123
-
(2008)
J Clin Invest
, vol.118
, pp. 111-123
-
-
Finnberg, N.1
Klein-Szanto, A.J.P.2
El-Deiry, W.S.3
-
20
-
-
43049152921
-
Enhancement of glioma radiotherapy and chemotherapy response with targeted antibody therapy against death receptor 5
-
Fiveash JB, Gillespie GY, Oliver PG, Zhou T, Belenky ML, Buchsbaum DJ (2008) Enhancement of glioma radiotherapy and chemotherapy response with targeted antibody therapy against death receptor 5. Int J Radiat Oncol Biol Phys 71:507-516
-
(2008)
Int J Radiat Oncol Biol Phys
, vol.71
, pp. 507-516
-
-
Fiveash, J.B.1
Gillespie, G.Y.2
Oliver, P.G.3
Zhou, T.4
Belenky, M.L.5
Buchsbaum, D.J.6
-
21
-
-
77950270445
-
CD95 (Fas/APO-1)-dependence of T cell apoptosis induced by DNA damage
-
Fuchs EJ, Paik JE, Engstrom LE, Bedi A (1997) CD95 (Fas/APO-1)-dependence of T cell apoptosis induced by DNA damage. Blood 90: 225
-
(1997)
Blood
, vol.90
, pp. 225
-
-
Fuchs, E.J.1
Paik, J.E.2
Engstrom, L.E.3
Bedi, A.4
-
22
-
-
4344607589
-
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs
-
Ganten TM, Haas TL, Sykora J, Stahl H, Sprick MR, Fas SC, Krueger A, Weigand MA, Grosse-Wilde A, Stremmel W et al (2004) Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Cell Death Differ 11:S86-S96
-
(2004)
Cell Death Differ
, vol.11
-
-
Ganten, T.M.1
Haas, T.L.2
Sykora, J.3
Stahl, H.4
Sprick, M.R.5
Fas, S.C.6
Krueger, A.7
Weigand, M.A.8
Grosse-Wilde, A.9
Stremmel, W.10
-
23
-
-
24944458177
-
Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: Induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death
-
Georgakis GV, Li Y, Humphreys R, Andreeff M, O'Brien S, Younes M, Carbone A, Albert V, Younes A (2005) Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death. Br J Haematol 130:501-510
-
(2005)
Br J Haematol
, vol.130
, pp. 501-510
-
-
Georgakis, G.V.1
Li, Y.2
Humphreys, R.3
Andreeff, M.4
O'Brien, S.5
Younes, M.6
Carbone, A.7
Albert, V.8
Younes, A.9
-
24
-
-
0028879677
-
P53 point mutation and survival in colorectal-cancer patients
-
Goh HS, Yao J, Smith DR (1995) P53 point mutation and survival in colorectal-cancer patients. Cancer Res 55:5217-5221
-
(1995)
Cancer Res
, vol.55
, pp. 5217-5221
-
-
Goh, H.S.1
Yao, J.2
Smith, D.R.3
-
25
-
-
0034667482
-
Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells
-
Gong BD, Almasan A (2000) Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells. Cancer Res 60:5754-5760
-
(2000)
Cancer Res
, vol.60
, pp. 5754-5760
-
-
Gong, B.D.1
Almasan, A.2
-
26
-
-
0033761316
-
CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa
-
Grassme H, Kirschnek S, Riethmueller J, Riehle A, von Kurthy G, Lang F, Weller M, Gulbins E (2000) CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa. Science 290:527-530
-
(2000)
Science
, vol.290
, pp. 527-530
-
-
Grassme, H.1
Kirschnek, S.2
Riethmueller, J.3
Riehle, A.4
Von Kurthy, G.5
Lang, F.6
Weller, M.7
Gulbins, E.8
-
27
-
-
0032530612
-
Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
-
Griffith TS, Chin WA, Jackson GC, Lynch DH, Kubin MZ (1998) Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. J Immunol 161:2833-2840
-
(1998)
J Immunol
, vol.161
, pp. 2833-2840
-
-
Griffith, T.S.1
Chin, W.A.2
Jackson, G.C.3
Lynch, D.H.4
Kubin, M.Z.5
-
28
-
-
38149122326
-
TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development
-
Grosse-Wilde A, Voloshanenko O, Bailey SL, Longton GM, Schaefer U, Csernok AI, Schutz G, Greiner EF, Kemp CJ, Walczak H (2008) TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development. J Clin Invest 118:100-110
-
(2008)
J Clin Invest
, vol.118
, pp. 100-110
-
-
Grosse-Wilde, A.1
Voloshanenko, O.2
Bailey, S.L.3
Longton, G.M.4
Schaefer, U.5
Csernok, A.I.6
Schutz, G.7
Greiner, E.F.8
Kemp, C.J.9
Walczak, H.10
-
29
-
-
0035008833
-
Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene
-
Guan BX, Yue P, Clayman GL, Sun SY (2001) Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene. J Cell Physiol 188:98-105
-
(2001)
J Cell Physiol
, vol.188
, pp. 98-105
-
-
Guan, B.X.1
Yue, P.2
Clayman, G.L.3
Sun, S.Y.4
-
30
-
-
18044369285
-
Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X rays and death receptor agonists
-
Hamasu T, Inanami O, Asanuma T, Kuwabara M (2005) Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X rays and death receptor agonists. J Radiat Res 46:103-110
-
(2005)
J Radiat Res
, vol.46
, pp. 103-110
-
-
Hamasu, T.1
Inanami, O.2
Asanuma, T.3
Kuwabara, M.4
-
31
-
-
33748684362
-
Irradiation-induced pneumonitis mediated by the CD95/CD95-ligand system
-
Heinzelmann F, Jendrossek V, Lauber K, Nowak K, Eldh T, Boras R, Handrick R, Henkel M, Martin C, Uhlig S et al (2006) Irradiation-induced pneumonitis mediated by the CD95/CD95-ligand system. J Natl Cancer Inst 98:1248-1251.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 1248-1251
-
-
Heinzelmann, F.1
Jendrossek, V.2
Lauber, K.3
Nowak, K.4
Eldh, T.5
Boras, R.6
Handrick, R.7
Henkel, M.8
Martin, C.9
Uhlig, S.10
-
32
-
-
33847167668
-
A phase i safety and pharmacokinetic (PK) study of recombinant Apo2L/TRAIL, an apoptosis-inducing protein in patients with advanced cancer
-
Herbst RS, Mendolson DS, Ebbinghaus S, Gordon MS, O'Dwyer P, Lieberman G, Ing J, Kurzrock R, Novotny W, Eckhardt G (2006) A phase I safety and pharmacokinetic (PK) study of recombinant Apo2L/TRAIL, an apoptosis-inducing protein in patients with advanced cancer. J Clin Oncol 24:124S
-
(2006)
J Clin Oncol
, vol.24
-
-
Herbst, R.S.1
Mendolson, D.S.2
Ebbinghaus, S.3
Gordon, M.S.4
O'Dwyer, P.5
Lieberman, G.6
Ing, J.7
Kurzrock, R.8
Novotny, W.9
Eckhardt, G.10
-
33
-
-
0035525733
-
Cellular stress response and apoptosis in cancer therapy
-
Herr I, Debatin KM (2001) Cellular stress response and apoptosis in cancer therapy. Blood 98:2603-2614
-
(2001)
Blood
, vol.98
, pp. 2603-2614
-
-
Herr, I.1
Debatin, K.M.2
-
34
-
-
17944376030
-
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity
-
Ichikawa K, Liu WM, Zhao LM, Wang Z, Liu D, Ohtsuka T, Zhang HG, Mountz JD, Koopman WJ, Kimberly RP et al (2001) Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med 7:954-960
-
(2001)
Nat Med
, vol.7
, pp. 954-960
-
-
Ichikawa, K.1
Liu, W.M.2
Zhao, L.M.3
Wang, Z.4
Liu, D.5
Ohtsuka, T.6
Zhang, H.G.7
Mountz, J.D.8
Koopman, W.J.9
Kimberly, R.P.10
-
35
-
-
34347237889
-
Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells
-
Ivanov N, Zhou HN, Hei TK (2007) Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Res 67:5397-5407
-
(2007)
Cancer Res
, vol.67
, pp. 5397-5407
-
-
Ivanov, N.1
Zhou, H.N.2
Hei, T.K.3
-
36
-
-
0037169358
-
Apoptosis: A link between cancer genetics and chemotherapy
-
Johnstone RW, Ruefli AA, Lowe SW (2002) Apoptosis: a link between cancer genetics and chemotherapy. Cell 108:153-164
-
(2002)
Cell
, vol.108
, pp. 153-164
-
-
Johnstone, R.W.1
Ruefli, A.A.2
Lowe, S.W.3
-
37
-
-
77950191194
-
Results of a phase 2 study of HGS-ETR1, a fully human agonistic monoclonal antibody to TRAIL Receptor 1, in subjects with relapsed or refractory colorectal cancer (CRC)
-
Kanzler S, Trarbach T, Heinemann V, Kohne CH, Sneller V, Bieber F, Galle PR, Seeber S (2005) Results of a phase 2 study of HGS-ETR1, a fully human agonistic monoclonal antibody to TRAIL Receptor 1, in subjects with relapsed or refractory colorectal cancer (CRC). EJC Suppl 3:178-178
-
(2005)
EJC Suppl
, vol.3
, pp. 178-178
-
-
Kanzler, S.1
Trarbach, T.2
Heinemann, V.3
Kohne, C.H.4
Sneller, V.5
Bieber, F.6
Galle, P.R.7
Seeber, S.8
-
38
-
-
17944380941
-
Ionizing radiation can overcome resistance to TRAIL in TRAIL-resistant cancer cells
-
Kim MR, Lee JY, Park MT, Chun YJ, Jang YJ, Kang CM, Kim HS, Cho CK, Lee YS, Jeong HY et al (2001) Ionizing radiation can overcome resistance to TRAIL in TRAIL-resistant cancer cells. FEBS Lett 505:179-184
-
(2001)
FEBS Lett
, vol.505
, pp. 179-184
-
-
Kim, M.R.1
Lee, J.Y.2
Park, M.T.3
Chun, Y.J.4
Jang, Y.J.5
Kang, C.M.6
Kim, H.S.7
Cho, C.K.8
Lee, Y.S.9
Jeong, H.Y.10
-
39
-
-
0141757451
-
Radiation and ceramide-induced apoptosis
-
Kolesnick R, Fuks Z (2003) Radiation and ceramide-induced apoptosis. Oncogene 22:5897-5906
-
(2003)
Oncogene
, vol.22
, pp. 5897-5906
-
-
Kolesnick, R.1
Fuks, Z.2
-
40
-
-
0035866369
-
Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis
-
Lacour S, Hammann A, Wotawa A, Corcos L, Solary E, Dimanche-Boitrel MT (2001) Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. Cancer Res 61:1645-1651
-
(2001)
Cancer Res
, vol.61
, pp. 1645-1651
-
-
Lacour, S.1
Hammann, A.2
Wotawa, A.3
Corcos, L.4
Solary, E.5
Dimanche-Boitrel, M.T.6
-
41
-
-
0037468930
-
Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells
-
Lacour S, Micheau O, Hammann A, Drouineaud V, Tschopp J, Solary E, Dimanche-Boitrel MT (2003) Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells. Oncogene 22:1807-1816
-
(2003)
Oncogene
, vol.22
, pp. 1807-1816
-
-
Lacour, S.1
Micheau, O.2
Hammann, A.3
Drouineaud, V.4
Tschopp, J.5
Solary, E.6
Dimanche-Boitrel, M.T.7
-
42
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li HL, Zhu H, Xu CJ, Yuan JY (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501
-
(1998)
Cell
, vol.94
, pp. 491-501
-
-
Li, H.L.1
Zhu, H.2
Xu, C.J.3
Yuan, J.Y.4
-
43
-
-
0030581151
-
Induction of apoptotic program in cellfree extracts: Requirement for dATP and cytochrome c
-
Liu XS, Kim CN, Yang J, Jemmerson R, Wang XD (1996) Induction of apoptotic program in cellfree extracts: requirement for dATP and cytochrome c. Cell 86:147-157
-
(1996)
Cell
, vol.86
, pp. 147-157
-
-
Liu, X.S.1
Kim, C.N.2
Yang, J.3
Jemmerson, R.4
Wang, X.D.5
-
44
-
-
0027451668
-
P53-dependent apoptosis modulates the cytotoxicity of anticancer agents
-
Lowe SW, Ruley HE, Jacks T, Housman DE (1993) P53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967
-
(1993)
Cell
, vol.74
, pp. 957-967
-
-
Lowe, S.W.1
Ruley, H.E.2
Jacks, T.3
Housman, D.E.4
-
45
-
-
0027944206
-
P53 status and the efficacy of cancer-therapy in-vivo
-
Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, Housman DE, Jacks T (1994) P53 status and the efficacy of cancer-therapy in-vivo. Science 266:807-810
-
(1994)
Science
, vol.266
, pp. 807-810
-
-
Lowe, S.W.1
Bodis, S.2
McClatchey, A.3
Remington, L.4
Ruley, H.E.5
Fisher, D.E.6
Housman, D.E.7
Jacks, T.8
-
46
-
-
0032555716
-
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
-
Luo X, Budihardjo I, Zou H, Slaughter C, Wang XD (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481-490
-
(1998)
Cell
, vol.94
, pp. 481-490
-
-
Luo, X.1
Budihardjo, I.2
Zou, H.3
Slaughter, C.4
Wang, X.D.5
-
47
-
-
51449113724
-
Targeting pro-apoptotic trail receptors sensitizes HeLa cervical cancer cells to irradiation-induced apoptosis
-
Maduro JH, de Vries EGE, Meersma GJ, Hougardy BMT, van der Zee AGJ, De Jong S (2008) Targeting pro-apoptotic trail receptors sensitizes HeLa cervical cancer cells to irradiation-induced apoptosis. Int J Radiat Oncol Biol Phys 72:543-552
-
(2008)
Int J Radiat Oncol Biol Phys
, vol.72
, pp. 543-552
-
-
Maduro, J.H.1
De Vries, E.G.E.2
Meersma, G.J.3
Hougardy, B.M.T.4
Van Der Zee, A.G.J.5
De Jong, S.6
-
48
-
-
0345933237
-
Molecular requirements for the combined effects of TRAIL and ionising radiation
-
Marini P, Jendrossek V, Durand E, Gruber C, Budach W, Belka C (2003) Molecular requirements for the combined effects of TRAIL and ionising radiation. Radiother Oncol 68:189-198
-
(2003)
Radiother Oncol
, vol.68
, pp. 189-198
-
-
Marini, P.1
Jendrossek, V.2
Durand, E.3
Gruber, C.4
Budach, W.5
Belka, C.6
-
49
-
-
13144280868
-
Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis
-
Marini P, Schmid A, Jendrossek V, Faltin H, Daniel PT, Budach W, Belka C (2005) Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis. BMC Cancer 5:5
-
(2005)
BMC Cancer
, vol.5
, pp. 5
-
-
Marini, P.1
Schmid, A.2
Jendrossek, V.3
Faltin, H.4
Daniel, P.T.5
Budach, W.6
Belka, C.7
-
50
-
-
33747829837
-
Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: Enhanced effects in vitro and dose-dependent growth delay in vivo
-
Marini P, Denzinger S, Schiller D, Kauder S, Welz S, Humphreys R, Daniel PT, Jendrossek V, Budach W, Belka C (2006) Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo. Oncogene 25:5145-5154
-
(2006)
Oncogene
, vol.25
, pp. 5145-5154
-
-
Marini, P.1
Denzinger, S.2
Schiller, D.3
Kauder, S.4
Welz, S.5
Humphreys, R.6
Daniel, P.T.7
Jendrossek, V.8
Budach, W.9
Belka, C.10
-
51
-
-
13144265771
-
A novel receptor for Apo2L/TRAIL contains a truncated death domain
-
Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P et al (1997) A novel receptor for Apo2L/TRAIL contains a truncated death domain. Current Biology 7:1003-1006
-
(1997)
Current Biology
, vol.7
, pp. 1003-1006
-
-
Marsters, S.A.1
Sheridan, J.P.2
Pitti, R.M.3
Huang, A.4
Skubatch, M.5
Baldwin, D.6
Yuan, J.7
Gurney, A.8
Goddard, A.D.9
Godowski, P.10
-
52
-
-
33749164762
-
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2
-
Merino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O (2006) Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol 26:7046-7055
-
(2006)
Mol Cell Biol
, vol.26
, pp. 7046-7055
-
-
Merino, D.1
Lalaoui, N.2
Morizot, A.3
Schneider, P.4
Solary, E.5
Micheau, O.6
-
53
-
-
0028883179
-
Tumor-suppressor p53 is a direct transcriptional activator of the human bax gene
-
Miyashita T, Reed JC (1995) Tumor-suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
54
-
-
77950290186
-
Mapatumumab, a fully human agonistic monoclonal antibody that targets TRAIL-R1, in combination with gemcitabine and cisplatin: A phase 1 study in patients with advanced solid malignancies
-
Mom CH, Sleijfer S, Gietema JA, Fox NL, Piganeau C, Lo L, Uges DRA, Loos W, de Vries EGE, Verweij J (2006) Mapatumumab, a fully human agonistic monoclonal antibody that targets TRAIL-R1, in combination with gemcitabine and cisplatin: a phase 1 study in patients with advanced solid malignancies. EJC Suppl 4:202
-
(2006)
EJC Suppl
, vol.4
, pp. 202
-
-
Mom, C.H.1
Sleijfer, S.2
Gietema, J.A.3
Fox, N.L.4
Piganeau, C.5
Lo, L.6
Uges, D.R.A.7
Loos, W.8
De Vries, E.G.E.9
Verweij, J.10
-
55
-
-
33847609303
-
Synergistic cytotoxicity through the activation of multiple apoptosis pathways in human glioma cells induced by combined treatment with ionizing radiation and tumor necrosis factor-related apoptosis-inducing ligand
-
Nagane M, Cavenee WK, Shiokawa Y (2007) Synergistic cytotoxicity through the activation of multiple apoptosis pathways in human glioma cells induced by combined treatment with ionizing radiation and tumor necrosis factor-related apoptosis-inducing ligand. J Neurosurg 106:407-416
-
(2007)
J Neurosurg
, vol.106
, pp. 407-416
-
-
Nagane, M.1
Cavenee, W.K.2
Shiokawa, Y.3
-
56
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
Nakano K, Vousden KH (2001) PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7:683-694
-
(2001)
Mol Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
57
-
-
0028135715
-
FAS-mediated apoptosis in primary cultured mouse hepatocytes
-
Ni R, Tomita Y, Matsuda K, Ichihara A, Ishimura K, Ogasawara J, Nagata S (1994) FAS-mediated apoptosis in primary cultured mouse hepatocytes. Exp Cell Res 215:332-337
-
(1994)
Exp Cell Res
, vol.215
, pp. 332-337
-
-
Ni, R.1
Tomita, Y.2
Matsuda, K.3
Ichihara, A.4
Ishimura, K.5
Ogasawara, J.6
Nagata, S.7
-
58
-
-
2342459790
-
DNA damage-induced apoptosis
-
Norbury CJ, Zhivotovsky B (2004) DNA damage-induced apoptosis. Oncogene 23:2797-2808
-
(2004)
Oncogene
, vol.23
, pp. 2797-2808
-
-
Norbury, C.J.1
Zhivotovsky, B.2
-
59
-
-
0034640281
-
Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (2000) Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288:1053-1058
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
Ohki, R.2
Murasawa, H.3
Nemoto, J.4
Shibue, T.5
Yamashita, T.6
Tokino, T.7
Taniguchi, T.8
Tanaka, N.9
-
60
-
-
0027291205
-
Lethal effect of the anti-Fas antibody in mice
-
Ogasawara J, Watanabefukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, Suda T, Nagata S (1993) Lethal effect of the anti-Fas antibody in mice. Nature 364:806-809
-
(1993)
Nature
, vol.364
, pp. 806-809
-
-
Ogasawara, J.1
Watanabefukunaga, R.2
Adachi, M.3
Matsuzawa, A.4
Kasugai, T.5
Kitamura, Y.6
Itoh, N.7
Suda, T.8
Nagata, S.9
-
61
-
-
33750621202
-
Phase i and pharmacokinetic study of HGS-ETR2, a human monoclonal antibody to TRAIL R2, in patients with advanced solid malignancies
-
Pacey S, Plummer RE, Attard G, Bale C, Calvert AH, Blagden S, Fox NL, Corey A, de Bono JS (2005) Phase I and pharmacokinetic study of HGS-ETR2, a human monoclonal antibody to TRAIL R2, in patients with advanced solid malignancies. J Clin Oncol 23: 205S
-
(2005)
J Clin Oncol
, vol.23
-
-
Pacey, S.1
Plummer, R.E.2
Attard, G.3
Bale, C.4
Calvert, A.H.5
Blagden, S.6
Fox, N.L.7
Corey, A.8
De Bono, J.S.9
-
62
-
-
0030762815
-
An antagonist decoy receptor and a death domain-containing receptor for TRAIL
-
Pan GH, Ni J, Wei YF, Yu GL, Gentz R, Dixit M (1997a) An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277:815-818
-
(1997)
Science
, vol.277
, pp. 815-818
-
-
Pan, G.H.1
Ni, J.2
Wei, Y.F.3
Yu, G.L.4
Gentz, R.5
Dixit, M.6
-
63
-
-
0030996297
-
The receptor for the cytotoxic ligand TRAIL
-
Pan GH, Orourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit M (1997b) The receptor for the cytotoxic ligand TRAIL. Science 276:111-113
-
(1997)
Science
, vol.276
, pp. 111-113
-
-
Pan, G.H.1
Orourke, K.2
Chinnaiyan, A.M.3
Gentz, R.4
Ebner, R.5
Ni, J.6
Dixit, M.7
-
64
-
-
21044441651
-
HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo
-
Pukac L, Kanakaraj P, Humphreys R, Alderson R, Bloom M, Sung C, Riccobene T, Johnson R, Fiscella M, Mahoney A et al (2005) HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. Br J Cancer 92:1430-1441
-
(2005)
Br J Cancer
, vol.92
, pp. 1430-1441
-
-
Pukac, L.1
Kanakaraj, P.2
Humphreys, R.3
Alderson, R.4
Bloom, M.5
Sung, C.6
Riccobene, T.7
Johnson, R.8
Fiscella, M.9
Mahoney, A.10
-
65
-
-
0037872265
-
Apoptosis induction in renal cell carcinoma by TRAIL and gamma-radiation is impaired by deficient caspase-9 cleavage
-
Ramp U, Caliskan E, Mahotka C, Krieg A, Heikaus S, Gabbert HE, Gerharz CD (2003) Apoptosis induction in renal cell carcinoma by TRAIL and gamma-radiation is impaired by deficient caspase-9 cleavage. Br J Cancer 88:1800-1807
-
(2003)
Br J Cancer
, vol.88
, pp. 1800-1807
-
-
Ramp, U.1
Caliskan, E.2
Mahotka, C.3
Krieg, A.4
Heikaus, S.5
Gabbert, H.E.6
Gerharz, C.D.7
-
66
-
-
58149268087
-
Ionizing radiation sensitizes leukemic MOLT-4 cells to TRAIL-induced apoptosis
-
Rezacova M, Vavrova J, Vokurkova D (2008) Ionizing radiation sensitizes leukemic MOLT-4 cells to TRAIL-induced apoptosis. Acta Medica (Hradec Kralove) 51:101-105
-
(2008)
Acta Medica (Hradec Kralove)
, vol.51
, pp. 101-105
-
-
Rezacova, M.1
Vavrova, J.2
Vokurkova, D.3
-
67
-
-
12444288591
-
Type i and type II reactions in TRAIL-induced apoptosis - Results from dose-response studies
-
Rudner J, Jendrossek V, Lauber K, Daniel PT, Wesselborg S, Belka C (2005) Type I and type II reactions in TRAIL-induced apoptosis - results from dose-response studies. Oncogene 24:130-140
-
(2005)
Oncogene
, vol.24
, pp. 130-140
-
-
Rudner, J.1
Jendrossek, V.2
Lauber, K.3
Daniel, P.T.4
Wesselborg, S.5
Belka, C.6
-
68
-
-
0032536771
-
Two CD95 (APO-1/Fas) signaling pathways
-
Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH, Peter ME (1998) Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17:1675-1687
-
(1998)
EMBO J
, vol.17
, pp. 1675-1687
-
-
Scaffidi, C.1
Fulda, S.2
Srinivasan, A.3
Friesen, C.4
Li, F.5
Tomaselli, K.J.6
Debatin, K.M.7
Krammer, P.H.8
Peter, M.E.9
-
69
-
-
0030707811
-
Characterization of two receptors for TRAIL
-
Schneider P, Bodmer JL, Thome M, Hofmann K, Holler N, Tschopp J (1997) Characterization of two receptors for TRAIL. FEBS Lett 416:329-334
-
(1997)
FEBS Lett
, vol.416
, pp. 329-334
-
-
Schneider, P.1
Bodmer, J.L.2
Thome, M.3
Hofmann, K.4
Holler, N.5
Tschopp, J.6
-
70
-
-
2942526515
-
The sequential treatment with ionizing radiation followed by TRAIL/Apo-2L reduces tumor growth and induces apoptosis of breast tumor xenografts in nude mice
-
Shankar S, Singh TR, Chen XF, Thakkar H, Firnin J, Srivastava RK (2004a) The sequential treatment with ionizing radiation followed by TRAIL/Apo-2L reduces tumor growth and induces apoptosis of breast tumor xenografts in nude mice. Int J Oncol 24:1133-1140
-
(2004)
Int J Oncol
, vol.24
, pp. 1133-1140
-
-
Shankar, S.1
Singh, T.R.2
Chen, X.F.3
Thakkar, H.4
Firnin, J.5
Srivastava, R.K.6
-
71
-
-
4143083851
-
Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo: Intracellular mechanisms
-
Shankar S, Singh TR, Srivastava RK (2004b) Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo: intracellular mechanisms. Prostate 61:35-49
-
(2004)
Prostate
, vol.61
, pp. 35-49
-
-
Shankar, S.1
Singh, T.R.2
Srivastava, R.K.3
-
72
-
-
11844293509
-
Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo
-
Shankar S, Chen XF, Srivastava RK (2005) Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo. Prostate 62:165-186
-
(2005)
Prostate
, vol.62
, pp. 165-186
-
-
Shankar, S.1
Chen, X.F.2
Srivastava, R.K.3
-
73
-
-
0030792712
-
Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
-
Sheridan JP, Marsters SA, Pitti RM, Gurney A, Skubatch M, Baldwin D, Ramakrishnan L, Gray CL, Baker K, Wood WI et al (1997) Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277:818-821
-
(1997)
Science
, vol.277
, pp. 818-821
-
-
Sheridan, J.P.1
Marsters, S.A.2
Pitti, R.M.3
Gurney, A.4
Skubatch, M.5
Baldwin, D.6
Ramakrishnan, L.7
Gray, C.L.8
Baker, K.9
Wood, W.I.10
-
74
-
-
0141705424
-
Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo
-
Singh TR, Shankar S, Chen WF, Asim M, Srivastava RK (2003) Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo. Cancer Res 63:5390-5400
-
(2003)
Cancer Res
, vol.63
, pp. 5390-5400
-
-
Singh, T.R.1
Shankar, S.2
Chen, W.F.3
Asim, M.4
Srivastava, R.K.5
-
75
-
-
0037009370
-
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
-
Sprick MR, Rieser E, Stahl H, Grosse-Wilde A, Weigand MA, Walczak H (2002) Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8. EMBO J 21:4520-4530
-
(2002)
EMBO J
, vol.21
, pp. 4520-4530
-
-
Sprick, M.R.1
Rieser, E.2
Stahl, H.3
Grosse-Wilde, A.4
Weigand, M.A.5
Walczak, H.6
-
76
-
-
0035912060
-
Intracellular mechanisms of TRAIL: Apoptosis through mitochondrial- dependent and -independent pathways
-
Suliman A, Lam A, Datta R, Srivastava RK (2001) Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways. Oncogene 20:2122-2133
-
(2001)
Oncogene
, vol.20
, pp. 2122-2133
-
-
Suliman, A.1
Lam, A.2
Datta, R.3
Srivastava, R.K.4
-
77
-
-
41549146659
-
X irradiation combined with TNF alpha-related apoptosis-inducing ligand (TRAIL) reduces hypoxic regions of human gastric adenocarcinoma xenografts in SCID mice
-
Takahashi M, Yasui H, Ogura A, Asanuma T, Kubota N, Tsujitan M, Kuwabara M, Inanami O (2008) X irradiation combined with TNF alpha-related apoptosis-inducing ligand (TRAIL) reduces hypoxic regions of human gastric adenocarcinoma xenografts in SCID mice. J Radiat Res 49:153-161
-
(2008)
J Radiat Res
, vol.49
, pp. 153-161
-
-
Takahashi, M.1
Yasui, H.2
Ogura, A.3
Asanuma, T.4
Kubota, N.5
Tsujitan, M.6
Kuwabara, M.7
Inanami, O.8
-
78
-
-
34248187996
-
Phase i pharmacokinetic and biologic correlative study of mapatumu mab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
-
Tolcher AW, Mita M, Meropol NJ, von Mehren M, Patnaik A, Padavic K, Hill M, Mays T, McCoy T, Fox NL et al (2007) Phase I pharmacokinetic and biologic correlative study of mapatumu mab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J Clin Oncol 25:1390-1395
-
(2007)
J Clin Oncol
, vol.25
, pp. 1390-1395
-
-
Tolcher, A.W.1
Mita, M.2
Meropol, N.J.3
Von Mehren, M.4
Patnaik, A.5
Padavic, K.6
Hill, M.7
Mays, T.8
McCoy, T.9
Fox, N.L.10
-
79
-
-
38549166571
-
Ionizing radiation modulates the TRAIL death-inducing signaling complex, allowing bypass of the mitochondrial apoptosis pathway
-
Verbrugge I, de Vries E, Tait SWG, Wissink EHJ, Walczak H, Verheij M, Borst J (2008) Ionizing radiation modulates the TRAIL death-inducing signaling complex, allowing bypass of the mitochondrial apoptosis pathway. Oncogene 27:574-584
-
(2008)
Oncogene
, vol.27
, pp. 574-584
-
-
Verbrugge, I.1
De Vries, E.2
Tait, S.W.G.3
Wissink, E.H.J.4
Walczak, H.5
Verheij, M.6
Borst, J.7
-
80
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10:789-799
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
81
-
-
8844245663
-
Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway
-
von Haefen C, Gillissen B, Hemmati PG, Wendt J, Guner D, Mrozek A, Belka C, Dorken B, Daniel PT (2004) Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway. Oncogene 23:8320-8332
-
(2004)
Oncogene
, vol.23
, pp. 8320-8332
-
-
Von Haefen, C.1
Gillissen, B.2
Hemmati, P.G.3
Wendt, J.4
Guner, D.5
Mrozek, A.6
Belka, C.7
Dorken, B.8
Daniel, P.T.9
-
82
-
-
34948894931
-
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
-
Wagner KW, Punnoose EA, Januario T, Lawrence DA, Pitti RM, Lancaster K, Lee D, von Goetz M, Yee SF, Totpal K et al (2007) Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med 13:1070-1077
-
(2007)
Nat Med
, vol.13
, pp. 1070-1077
-
-
Wagner, K.W.1
Punnoose, E.A.2
Januario, T.3
Lawrence, D.A.4
Pitti, R.M.5
Lancaster, K.6
Lee, D.7
Von Goetz, M.8
Yee, S.F.9
Totpal, K.10
-
83
-
-
0032929520
-
Tumoricidal activity of tumor necrosis factor related apoptosis-inducing ligand in vivo
-
Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, Chin W, Jones J, Woodward A, Le T et al (1999) Tumoricidal activity of tumor necrosis factor related apoptosis-inducing ligand in vivo. Nat Med 5:157-163
-
(1999)
Nat Med
, vol.5
, pp. 157-163
-
-
Walczak, H.1
Miller, R.E.2
Ariail, K.3
Gliniak, B.4
Griffith, T.S.5
Kubin, M.6
Chin, W.7
Jones, J.8
Woodward Le A, T.9
-
84
-
-
4644245083
-
Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil
-
Wang SL, El-Deiry WS (2004) Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil. Cancer Res 64:6666-6672
-
(2004)
Cancer Res
, vol.64
, pp. 6666-6672
-
-
Wang, S.L.1
El-Deiry, W.S.2
-
85
-
-
0029807585
-
BID: A novel BH3 domain-only death agonist
-
Wang K, Yin XM, Chao DT, Milliman CL, Korsmeyer SJ (1996) BID: a novel BH3 domain-only death agonist. Genes Dev 10:2859-2869
-
(1996)
Genes Dev
, vol.10
, pp. 2859-2869
-
-
Wang, K.1
Yin, X.M.2
Chao, D.T.3
Milliman, C.L.4
Korsmeyer, S.J.5
-
86
-
-
0030683517
-
Treatment of the P815 murine mastocytoma with cisplatin or etoposide up-regulates cell-surface Fas (CD95) expression and increases sensitivity to anti-Fas antibody-mediated cytotoxicity and to lysis by anti-CD3-activated killer-T cells
-
Williams BA, Makrigiannis AP, Blay J, Hoskin DW (1997) Treatment of the P815 murine mastocytoma with cisplatin or etoposide up-regulates cell-surface Fas (CD95) expression and increases sensitivity to anti-Fas antibody-mediated cytotoxicity and to lysis by anti-CD3-activated killer-T cells. Int J Cancer 73:416-423
-
(1997)
Int J Cancer
, vol.73
, pp. 416-423
-
-
Williams, B.A.1
Makrigiannis, A.P.2
Blay, J.3
Hoskin, D.W.4
-
87
-
-
33748056488
-
TRAIL enhances efficacy of radiotherapy in a p53 mutant, Bcl-2 overexpressing lymphoid malignancy
-
Wissink EHJ, Verbrugge I, Vink SR, Schader MB, Schaefer U, Walczak H, Borst J, Verheij M (2006) TRAIL enhances efficacy of radiotherapy in a p53 mutant, Bcl-2 overexpressing lymphoid malignancy. Radiother Oncol 80:214-222
-
(2006)
Radiother Oncol
, vol.80
, pp. 214-222
-
-
Wissink, E.H.J.1
Verbrugge, I.2
Vink, S.R.3
Schader, M.B.4
Schaefer, U.5
Walczak, H.6
Borst, J.7
Verheij, M.8
-
88
-
-
0031253977
-
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
-
Wu GS, Burns TF, McDonald ER, Jiang W, Meng R, Krantz D, Kao G, Gan DD, Zhou JY, Muschel R et al (1997) KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat Genet 17:141-143
-
(1997)
Nat Genet
, vol.17
, pp. 141-143
-
-
Wu, G.S.1
Burns, T.F.2
McDonald, E.R.3
Jiang, W.4
Meng, R.5
Krantz, D.6
Kao, G.7
Gan, D.D.8
Zhou, J.Y.9
Muschel, R.10
-
89
-
-
0031036872
-
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
-
Yang J, Liu XS, Bhalla K, Kim CN, Ibrado AM, Cai JY, Peng TI, Jones DP, Wang XD (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275:1129-1132
-
(1997)
Science
, vol.275
, pp. 1129-1132
-
-
Yang, J.1
Liu, X.S.2
Bhalla, K.3
Kim, C.N.4
Ibrado, A.M.5
Cai, J.Y.6
Peng, T.I.7
Jones, D.P.8
Wang, X.D.9
-
90
-
-
0033607006
-
Biddeficient mice are resistant to Fas-induced hepatocellular apoptosis
-
Yin XM, Wang K, Gross A, Zhao YG, Zinkel S, Klocke B, Roth KA, Korsmeyer SJ (1999) Biddeficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400:886-891
-
(1999)
Nature
, vol.400
, pp. 886-891
-
-
Yin, X.M.1
Wang, K.2
Gross, A.3
Zhao, Y.G.4
Zinkel, S.5
Klocke, B.6
Roth, K.A.7
Korsmeyer, S.J.8
-
91
-
-
0035798180
-
Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL-R2 gene
-
Yoshida T, Maeda A, Tani N, Sakai T (2001) Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL-R2 gene. FEBS Lett 507:381-385
-
(2001)
FEBS Lett
, vol.507
, pp. 381-385
-
-
Yoshida, T.1
Maeda, A.2
Tani, N.3
Sakai, T.4
|