메뉴 건너뛰기




Volumn 33, Issue 1, 2010, Pages 13-24

Heme oxygenase-1 in cardiovascular diseases: Molecular mechanisms and clinical perspectives

Author keywords

Bilirubin; Carbon monoxide; Clinical perspectives; Heme oxygenase 1

Indexed keywords

ACETYLSALICYLIC ACID; BILIRUBIN; BILIVERDIN; CARBON MONOXIDE; CURCUMIN; CYCLOSPORIN; FENOFIBRATE; HEME OXYGENASE 1; HEME OXYGENASE 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PROBUCOL; RAPAMYCIN; RESVERATROL; ROSIGLITAZONE; SIMVASTATIN; TROGLITAZONE; VASCULOTROPIN;

EID: 77649204284     PISSN: 20720939     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (34)

References (79)
  • 1
    • 0023731036 scopus 로고
    • Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications
    • Maines MD. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J 1988;2:2557-68.
    • (1988) FASEB J , vol.2 , pp. 2557-2568
    • Maines, M.D.1
  • 4
    • 0015118443 scopus 로고
    • Metabolism of hemoglobin and bile pigments
    • Orten JM. Metabolism of hemoglobin and bile pigments. Ann Clin Lab Sci 1971;1:113-24.
    • (1971) Ann Clin Lab Sci , vol.1 , pp. 113-124
    • Orten, J.M.1
  • 6
    • 0030886381 scopus 로고    scopus 로고
    • Heme oxygenase 1 is required for mammalian iron reutilization
    • Poss KD, Tonegawa S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci USA 1997;94:10919-24.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10919-10924
    • Poss, K.D.1    Tonegawa, S.2
  • 8
    • 0035957249 scopus 로고    scopus 로고
    • H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: A study with transgenic mice heterozygous for targeted disruption of the heme oxygenase-1 gene
    • Yoshida T, Maulik N, Ho YS, Alam J, Das DK. H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: A study with transgenic mice heterozygous for targeted disruption of the heme oxygenase-1 gene. Circulation 2001;103:1695-701.
    • (2001) Circulation , vol.103 , pp. 1695-1701
    • Yoshida, T.1    Maulik, N.2    Ho, Y.S.3    Alam, J.4    Das, D.K.5
  • 9
    • 14644400430 scopus 로고    scopus 로고
    • Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice
    • Liu X, Wei J, Peng DH, Layne MD, Yet SF. Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice. Diabetes 2005;54:778-84.
    • (2005) Diabetes , vol.54 , pp. 778-784
    • Liu, X.1    Wei, J.2    Peng, D.H.3    Layne, M.D.4    Yet, S.F.5
  • 13
    • 0042531793 scopus 로고    scopus 로고
    • Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway
    • Gong P, Cederbaum AI, Nieto N. Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway. J Biol Chem 2003;278:29693-700.
    • (2003) J Biol Chem , vol.278 , pp. 29693-29700
    • Gong, P.1    Cederbaum, A.I.2    Nieto, N.3
  • 14
    • 26244455871 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways
    • Chen JC, Huang KC, Lin WW. HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways. Cell Signal 2006;18:32-9.
    • (2006) Cell Signal , vol.18 , pp. 32-39
    • Chen, J.C.1    Huang, K.C.2    Lin, W.W.3
  • 15
    • 0036358038 scopus 로고    scopus 로고
    • MAPK-regulated transcription: A continuously variable gene switch?
    • Hazzalin CA, Mahadevan LC. MAPK-regulated transcription: a continuously variable gene switch? Nat Rev Mol Cell Biol 2002;3:30-40.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 30-40
    • Hazzalin, C.A.1    Mahadevan, L.C.2
  • 17
    • 33646699095 scopus 로고    scopus 로고
    • Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells
    • Harrison EM, McNally SJ, Devey L, Garden OJ, Ross JA, Wigmore SJ. Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells. FEBS J 2006;273:2345-56.
    • (2006) FEBS J , vol.273 , pp. 2345-2356
    • Harrison, E.M.1    McNally, S.J.2    Devey, L.3    Garden, O.J.4    Ross, J.A.5    Wigmore, S.J.6
  • 19
    • 29344457837 scopus 로고    scopus 로고
    • Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways
    • Wung BS, Hsu MC, Wu CC, Hsieh CW. Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. Pharmacol Res 2006;53:113-22.
    • (2006) Pharmacol Res , vol.53 , pp. 113-122
    • Wung, B.S.1    Hsu, M.C.2    Wu, C.C.3    Hsieh, C.W.4
  • 21
    • 48949115122 scopus 로고    scopus 로고
    • Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cdelta and Nrf2
    • Ogborne RM, Rushworth SA, O'Connell MA. Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cdelta and Nrf2. Biochem Biophys Res Commun 2008;373:584-8.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 584-588
    • Ogborne, R.M.1    Rushworth, S.A.2    O'Connell, M.A.3
  • 22
    • 0028307310 scopus 로고
    • Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene
    • Lavrovsky Y, Schwartzman ML, Levere RD, Kappas A, Abraham NG. Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc Natl Acad Sci USA 1994;91:5987-91.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5987-5991
    • Lavrovsky, Y.1    Schwartzman, M.L.2    Levere, R.D.3    Kappas, A.4    Abraham, N.G.5
  • 23
    • 0028039868 scopus 로고
    • Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5′ sequences are required for induction by heme or heavy metals
    • Alam J, Cai J, Smith A. Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5′ sequences are required for induction by heme or heavy metals. J Biol Chem 1994;269:1001-9.
    • (1994) J Biol Chem , vol.269 , pp. 1001-1009
    • Alam, J.1    Cai, J.2    Smith, A.3
  • 24
    • 0032878565 scopus 로고    scopus 로고
    • Heme oxygenase: Recent advances in understanding its regulation and role
    • Elbirt KK, Bonkovsky HL. Heme oxygenase: recent advances in understanding its regulation and role. Proc Assoc Am Physicians 1999;111:438-47.
    • (1999) Proc Assoc Am Physicians , vol.111 , pp. 438-447
    • Elbirt, K.K.1    Bonkovsky, H.L.2
  • 25
    • 50849145160 scopus 로고    scopus 로고
    • Ubiquitin-proteasome system mediates heme oxygenase-1 degradation through endoplasmic reticulum-associated degradation pathway
    • Lin PH, Chiang MT, Chau LY. Ubiquitin-proteasome system mediates heme oxygenase-1 degradation through endoplasmic reticulum-associated degradation pathway. Biochim Biophys Acta 2008;1783:1826-34.
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 1826-1834
    • Lin, P.H.1    Chiang, M.T.2    Chau, L.Y.3
  • 26
    • 22144481954 scopus 로고    scopus 로고
    • Increasing expression of heme oxygenase-1 by proteasome inhibition protects astrocytes from heme-mediated oxidative injury
    • Chen J, Regan RF. Increasing expression of heme oxygenase-1 by proteasome inhibition protects astrocytes from heme-mediated oxidative injury. Curr Neurovasc Res 2005;2:189-96.
    • (2005) Curr Neurovasc Res , vol.2 , pp. 189-196
    • Chen, J.1    Regan, R.F.2
  • 27
    • 41149177025 scopus 로고    scopus 로고
    • Pharmacological and clinuical aspects of heme oxygenase
    • Abraham NG, Kappas A. Pharmacological and clinuical aspects of heme oxygenase. Pharmacol Rev 2008;60:79-127.
    • (2008) Pharmacol Rev , vol.60 , pp. 79-127
    • Abraham, N.G.1    Kappas, A.2
  • 28
    • 38049132217 scopus 로고    scopus 로고
    • Heme oxygenase-1 and carbon monoxide in vascular pathobiology: Focus on angiogenesis
    • Dulak J, Deshane J, Jozkowicz A, Agarwal A. Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis. Circulation 2008;117:231-41.
    • (2008) Circulation , vol.117 , pp. 231-241
    • Dulak, J.1    Deshane, J.2    Jozkowicz, A.3    Agarwal, A.4
  • 29
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular disease: From marvel to menace
    • Forstermann U, Munzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006;113:1708-14.
    • (2006) Circulation , vol.113 , pp. 1708-1714
    • Forstermann, U.1    Munzel, T.2
  • 30
    • 0027280271 scopus 로고
    • Carbon monoxide and dilation of blood vessels
    • Coceani F. Carbon monoxide and dilation of blood vessels. Science 1993;260:739.
    • (1993) Science , vol.260 , pp. 739
    • Coceani, F.1
  • 31
    • 0028838293 scopus 로고
    • Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide
    • Morita T, Kourembanas S. Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide. J Clin Invest 1995;96:2676-82.
    • (1995) J Clin Invest , vol.96 , pp. 2676-2682
    • Morita, T.1    Kourembanas, S.2
  • 35
    • 0035949615 scopus 로고    scopus 로고
    • Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice
    • Juan SH, Lee TS, Tseng KW, Liou JY, Shyue SK, Wu KK, Chau LY. Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. Circulation 2001;104:1519-25.
    • (2001) Circulation , vol.104 , pp. 1519-1525
    • Juan, S.H.1    Lee, T.S.2    Tseng, K.W.3    Liou, J.Y.4    Shyue, S.K.5    Wu, K.K.6    Chau, L.Y.7
  • 37
  • 38
    • 33749361935 scopus 로고    scopus 로고
    • Carbon monoxide-induced earlythrombolysis contributes to heme oxygenase-1-mediated inhibition of neointimal growth after vascular injury in hypercholesterolemic mice
    • Chen YH, Tsai HL, Chiang MT, Chau LY. Carbon monoxide-induced earlythrombolysis contributes to heme oxygenase-1-mediated inhibition of neointimal growth after vascular injury in hypercholesterolemic mice. J Biomed Sci 2006;13:721-30.
    • (2006) J Biomed Sci , vol.13 , pp. 721-730
    • Chen, Y.H.1    Tsai, H.L.2    Chiang, M.T.3    Chau, L.Y.4
  • 39
    • 14444268977 scopus 로고    scopus 로고
    • Gene transfer of human heme oxygenase into coronary endothelial cells potentially promotes angiogenesis
    • Deramaudt BM, Braunstein S, Remy P, Abraham NG. Gene transfer of human heme oxygenase into coronary endothelial cells potentially promotes angiogenesis. J Cell Biochem 1998;68:121-7.
    • (1998) J Cell Biochem , vol.68 , pp. 121-127
    • Deramaudt, B.M.1    Braunstein, S.2    Remy, P.3    Abraham, N.G.4
  • 42
    • 1642531778 scopus 로고    scopus 로고
    • Heme oxygenase and angiogenic activity of endothelial cells: Stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX
    • Jozkowicz A, Huk I, Nigisch A, Weigel G, Dietrich W, Motterlini R, Dulak J. Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX. Antioxid Redox Signal 2003;5:155-62.
    • (2003) Antioxid Redox Signal , vol.5 , pp. 155-162
    • Jozkowicz, A.1    Huk, I.2    Nigisch, A.3    Weigel, G.4    Dietrich, W.5    Motterlini, R.6    Dulak, J.7
  • 43
    • 1642581763 scopus 로고    scopus 로고
    • Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: Induction of angiogenesis and inhibition of leukocytic infiltration
    • Bussolati B, Ahmed A, Pemberton H, Landis RC, Di Carlo F, Haskard DO, Mason JC. Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration. Blood 2004;103:761-6.
    • (2004) Blood , vol.103 , pp. 761-766
    • Bussolati, B.1    Ahmed, A.2    Pemberton, H.3    Landis, R.C.4    Di Carlo, F.5    Haskard, D.O.6    Mason, J.C.7
  • 45
    • 0033781721 scopus 로고    scopus 로고
    • Coexpression of thymidine phosphorylase and heme oxygenase-1 in macrophages in human malignant vertical growth melanomas
    • Torisu-Itakura H, Furue M, Kuwano M, Ono M. Coexpression of thymidine phosphorylase and heme oxygenase-1 in macrophages in human malignant vertical growth melanomas. Jpn J Cancer Res 2000;91:906-10.
    • (2000) Jpn J Cancer Res , vol.91 , pp. 906-910
    • Torisu-Itakura, H.1    Furue, M.2    Kuwano, M.3    Ono, M.4
  • 46
    • 0031041377 scopus 로고    scopus 로고
    • Hypoxiainducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
    • Lee PJ, Jiang BH, Chin BY, Iyer NV, Alam J, Semenza GL, Choi AM. Hypoxiainducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem 1997;272:5375-81.
    • (1997) J Biol Chem , vol.272 , pp. 5375-5381
    • Lee, P.J.1    Jiang, B.H.2    Chin, B.Y.3    Iyer, N.V.4    Alam, J.5    Semenza, G.L.6    Choi, A.M.7
  • 47
    • 18844406447 scopus 로고    scopus 로고
    • Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue
    • Ceradini DJ, Gurtner GC. Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue. Trends Cardiovasc Med 2005;15:57-63.
    • (2005) Trends Cardiovasc Med , vol.15 , pp. 57-63
    • Ceradini, D.J.1    Gurtner, G.C.2
  • 50
    • 45549097135 scopus 로고    scopus 로고
    • Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1
    • Lin HH, Chen YH, Chang PF, Lee YT, Yet SF, Chau LY. Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1. J Mol Cell Cardiol 2008;45:44-55.
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 44-55
    • Lin, H.H.1    Chen, Y.H.2    Chang, P.F.3    Lee, Y.T.4    Yet, S.F.5    Chau, L.Y.6
  • 52
    • 67949099048 scopus 로고    scopus 로고
    • After vascular injury, heme oxygenase-1/carbon monoxide enhances re-endothelialization via promoting mobilization of circulating endothelial progenitor cells
    • Lin HH, Chen YH, Chau LY. After vascular injury, heme oxygenase-1/carbon monoxide enhances re-endothelialization via promoting mobilization of circulating endothelial progenitor cells. J Thromb Haemost 2009;7:1401-8.
    • (2009) J Thromb Haemost , vol.7 , pp. 1401-1408
    • Lin, H.H.1    Chen, Y.H.2    Chau, L.Y.3
  • 55
    • 3242661655 scopus 로고    scopus 로고
    • Heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo
    • Hu CM, Chen YH, Chiang MT, Chau LY. Heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo. Circulation 2004;110:309-16.
    • (2004) Circulation , vol.110 , pp. 309-316
    • Hu, C.M.1    Chen, Y.H.2    Chiang, M.T.3    Chau, L.Y.4
  • 57
  • 58
    • 65249113865 scopus 로고    scopus 로고
    • Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants
    • Weis N, Weigert A, von Knethen A, Brüne B. Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants. Mol Biol Cell 2009;20:1280-8.
    • (2009) Mol Biol Cell , vol.20 , pp. 1280-1288
    • Weis, N.1    Weigert, A.2    von Knethen, A.3    Brüne, B.4
  • 60
    • 65449130775 scopus 로고    scopus 로고
    • The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1
    • Wang XM, Kim HP, Nakahira K, Ryter SW, Choi AM. The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. J Immunol 2009;182:3809-18.
    • (2009) J Immunol , vol.182 , pp. 3809-3818
    • Wang, X.M.1    Kim, H.P.2    Nakahira, K.3    Ryter, S.W.4    Choi, A.M.5
  • 61
    • 0036127426 scopus 로고    scopus 로고
    • Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
    • Lee TS, Chau LY. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 2002;8:240-6.
    • (2002) Nat Med , vol.8 , pp. 240-246
    • Lee, T.S.1    Chau, L.Y.2
  • 63
    • 16344369210 scopus 로고    scopus 로고
    • Study on changes of heme oxygenase-1 expression in patients with coronary heart disease
    • Chen SM, Li YG, Wang DM. Study on changes of heme oxygenase-1 expression in patients with coronary heart disease. Clin Cardiol 2005;28:197-201.
    • (2005) Clin Cardiol , vol.28 , pp. 197-201
    • Chen, S.M.1    Li, Y.G.2    Wang, D.M.3
  • 64
    • 33745763562 scopus 로고    scopus 로고
    • Haem oxygenase-1 expression and coronary heart disease - association between levels of haem oxygenase-1 expression and angiographic morphology as well as the quantity of coronary lesions
    • Li YG, Wang DM, Chen SM, Tan XR, Fang XY, Wu JW, Zhang GH, Mai RQ. Haem oxygenase-1 expression and coronary heart disease - association between levels of haem oxygenase-1 expression and angiographic morphology as well as the quantity of coronary lesions. Acta Cardiol 2006;61:295-300.
    • (2006) Acta Cardiol , vol.61 , pp. 295-300
    • Li, Y.G.1    Wang, D.M.2    Chen, S.M.3    Tan, X.R.4    Fang, X.Y.5    Wu, J.W.6    Zhang, G.H.7    Mai, R.Q.8
  • 65
    • 0033925281 scopus 로고    scopus 로고
    • Microsatellite polymorphism in the hem oxygenase-1 gene promoter is associated with susceptibility to emphysema
    • Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, Shibahara S, Sasaki H. Microsatellite polymorphism in the hem oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 2000;66:187-95.
    • (2000) Am J Hum Genet , vol.66 , pp. 187-195
    • Yamada, N.1    Yamaya, M.2    Okinaga, S.3    Nakayama, K.4    Sekizawa, K.5    Shibahara, S.6    Sasaki, H.7
  • 67
    • 4644226200 scopus 로고    scopus 로고
    • The role of heme oxygenasae-1 promoter polymorphisms in human disease
    • Exner M, Minar E, Wagner O, Sćhillinger M. The role of heme oxygenasae-1 promoter polymorphisms in human disease. Free Radic Biol Med 2004;37:1097-104.
    • (2004) Free Radic Biol Med , vol.37 , pp. 1097-1104
    • Exner, M.1    Minar, E.2    Wagner, O.3    Sćhillinger, M.4
  • 72
    • 38049034068 scopus 로고    scopus 로고
    • Pleiotropic effects of statin therapy: Molecular mechanisms and clinical results
    • Wang CY, Liu PY, Liao JK. Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. Trends Mol Med 2008;14:37-44.
    • (2008) Trends Mol Med , vol.14 , pp. 37-44
    • Wang, C.Y.1    Liu, P.Y.2    Liao, J.K.3
  • 73
    • 33646354412 scopus 로고    scopus 로고
    • Statin therapy and autoimmune disease: From protein prenylation to immunomodulation
    • Greenwood J, Steinman L, Zamvil SS. Statin therapy and autoimmune disease: from protein prenylation to immunomodulation. Nat Rev 2006;6:358-70.
    • (2006) Nat Rev , vol.6 , pp. 358-370
    • Greenwood, J.1    Steinman, L.2    Zamvil, S.S.3
  • 74
    • 33846639179 scopus 로고    scopus 로고
    • Statins and the vascular endothelial inflammatory response
    • Greenwood J, Mason JC. Statins and the vascular endothelial inflammatory response. Trends Immunol 2007;28:88-98.
    • (2007) Trends Immunol , vol.28 , pp. 88-98
    • Greenwood, J.1    Mason, J.C.2
  • 75
    • 33846049673 scopus 로고    scopus 로고
    • Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: A nested case-control study
    • Brouilette SW, Moore JS, McMahon AD, Thompson JR, Ford I, Shepherd J, Packard CJ, Samani NJ. Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet 2007;369:107-14.
    • (2007) Lancet , vol.369 , pp. 107-114
    • Brouilette, S.W.1    Moore, J.S.2    McMahon, A.D.3    Thompson, J.R.4    Ford, I.5    Shepherd, J.6    Packard, C.J.7    Samani, N.J.8
  • 76
    • 4444369432 scopus 로고    scopus 로고
    • Simvastatin induces heme oxygenase-1: A novel mechanism of vessel protection
    • Lee TS, Chang CC, Zhu Y, Shyy JY. Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection. Circulation 2004;110:1296-302.
    • (2004) Circulation , vol.110 , pp. 1296-1302
    • Lee, T.S.1    Chang, C.C.2    Zhu, Y.3    Shyy, J.Y.4
  • 78
    • 1942518840 scopus 로고    scopus 로고
    • PPARs and the complex journey to obesity
    • Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med 2004;10:355-61.
    • (2004) Nat Med , vol.10 , pp. 355-361
    • Evans, R.M.1    Barish, G.D.2    Wang, Y.X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.