메뉴 건너뛰기




Volumn 28, Issue 2, 2007, Pages 88-98

Statins and the vascular endothelial inflammatory response

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CERIVASTATIN; CHEMOKINE; CHEMOKINE RECEPTOR; COMPACTIN; FLUINDOSTATIN; GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEVINOLIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

EID: 33846639179     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2006.12.003     Document Type: Review
Times cited : (187)

References (90)
  • 1
    • 33646354412 scopus 로고    scopus 로고
    • Statin therapy and autoimmune disease: from protein prenylation to immunomodulation
    • Greenwood J., et al. Statin therapy and autoimmune disease: from protein prenylation to immunomodulation. Nat. Rev. Immunol. 6 (2006) 358-370
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 358-370
    • Greenwood, J.1
  • 2
    • 15944384675 scopus 로고    scopus 로고
    • Statins: immunomodulators for autoimmune rheumatic disease?
    • Jury E.C., and Ehrenstein M.R. Statins: immunomodulators for autoimmune rheumatic disease?. Lupus 14 (2005) 192-196
    • (2005) Lupus , vol.14 , pp. 192-196
    • Jury, E.C.1    Ehrenstein, M.R.2
  • 3
    • 11344277830 scopus 로고    scopus 로고
    • Statins for atherosclerosis - as good as it gets?
    • Ehrenstein M.R., et al. Statins for atherosclerosis - as good as it gets?. New Engl. J. Med. 352 (2005) 73-75
    • (2005) New Engl. J. Med. , vol.352 , pp. 73-75
    • Ehrenstein, M.R.1
  • 4
    • 0034948339 scopus 로고    scopus 로고
    • Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
    • Weitz-Schmidt G., et al. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat. Med. 7 (2001) 687-692
    • (2001) Nat. Med. , vol.7 , pp. 687-692
    • Weitz-Schmidt, G.1
  • 6
    • 28844506346 scopus 로고    scopus 로고
    • Potential vascular benefits of statins
    • Kinlay S. Potential vascular benefits of statins. Am. J. Med. 118 Suppl. 12A (2005) 62-67
    • (2005) Am. J. Med. , vol.118 , Issue.SUPPL. 12A , pp. 62-67
    • Kinlay, S.1
  • 7
    • 33745002232 scopus 로고    scopus 로고
    • The nonlipid effects of statins on endothelial function
    • Beckman J.A., and Creager M.A. The nonlipid effects of statins on endothelial function. Trends Cardiovasc. Med. 16 (2006) 156-162
    • (2006) Trends Cardiovasc. Med. , vol.16 , pp. 156-162
    • Beckman, J.A.1    Creager, M.A.2
  • 8
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature 420 (2002) 868-874
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 9
    • 0038366771 scopus 로고    scopus 로고
    • Endothelium-dependent effects of statins
    • Wolfrum S., et al. Endothelium-dependent effects of statins. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 729-736
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 729-736
    • Wolfrum, S.1
  • 10
    • 31844451010 scopus 로고    scopus 로고
    • Anti-inflammatory effects of statins: clinical evidence and basic mechanisms
    • Jain M.K., and Ridker P.M. Anti-inflammatory effects of statins: clinical evidence and basic mechanisms. Nat. Rev. Drug Discov. 4 (2005) 977-987
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 977-987
    • Jain, M.K.1    Ridker, P.M.2
  • 11
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation, atherosclerosis, and coronary artery disease
    • Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. New Engl. J. Med. 352 (2005) 1685-1695
    • (2005) New Engl. J. Med. , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 12
    • 0042376168 scopus 로고    scopus 로고
    • Statins and their role in vascular protection
    • Mason J.C. Statins and their role in vascular protection. Clin. Sci. (Lond.) 105 (2003) 251-266
    • (2003) Clin. Sci. (Lond.) , vol.105 , pp. 251-266
    • Mason, J.C.1
  • 13
    • 15944397265 scopus 로고    scopus 로고
    • Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases?
    • McCarey D.W., et al. Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases?. Arthritis Res. Ther. 7 (2005) 55-61
    • (2005) Arthritis Res. Ther. , vol.7 , pp. 55-61
    • McCarey, D.W.1
  • 14
    • 9644303268 scopus 로고    scopus 로고
    • Atorvastatin reduces arterial stiffness in patients with rheumatoid arthritis
    • Van Doornum S., et al. Atorvastatin reduces arterial stiffness in patients with rheumatoid arthritis. Ann. Rheum. Dis. 63 (2004) 1571-1575
    • (2004) Ann. Rheum. Dis. , vol.63 , pp. 1571-1575
    • Van Doornum, S.1
  • 15
    • 19944433437 scopus 로고    scopus 로고
    • Simvastatin improves endothelial function in patients with rheumatoid arthritis
    • Hermann F., et al. Simvastatin improves endothelial function in patients with rheumatoid arthritis. J. Am. Coll. Cardiol. 45 (2005) 461-464
    • (2005) J. Am. Coll. Cardiol. , vol.45 , pp. 461-464
    • Hermann, F.1
  • 16
    • 0034533147 scopus 로고    scopus 로고
    • Statins as a newly recognised type of immunomodulator
    • Kwak B., et al. Statins as a newly recognised type of immunomodulator. Nat. Med. 6 (2000) 1399-1402
    • (2000) Nat. Med. , vol.6 , pp. 1399-1402
    • Kwak, B.1
  • 17
    • 0035872757 scopus 로고    scopus 로고
    • Inhibition of interferon-γ-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors
    • Sadeghi M.M., et al. Inhibition of interferon-γ-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors. Transplantation 71 (2001) 1262-1268
    • (2001) Transplantation , vol.71 , pp. 1262-1268
    • Sadeghi, M.M.1
  • 18
    • 0037408418 scopus 로고    scopus 로고
    • Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression
    • Muczynski K.A., et al. Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression. J. Am. Soc. Nephrol. 14 (2003) 1336-1348
    • (2003) J. Am. Soc. Nephrol. , vol.14 , pp. 1336-1348
    • Muczynski, K.A.1
  • 19
    • 33645647283 scopus 로고    scopus 로고
    • In vivo suppression of major histocompatibility complex class II expression on porcine vascular endothelial cells by an HMG-CoA reductase inhibitor
    • Geissler I., et al. In vivo suppression of major histocompatibility complex class II expression on porcine vascular endothelial cells by an HMG-CoA reductase inhibitor. Transplantation 81 (2006) 922-926
    • (2006) Transplantation , vol.81 , pp. 922-926
    • Geissler, I.1
  • 20
    • 17644412294 scopus 로고    scopus 로고
    • Statins and control of MHC2TA gene transcription
    • Kuipers H.F., and van den Elsen P.J. Statins and control of MHC2TA gene transcription. Nat. Med. 11 (2005) 365-366
    • (2005) Nat. Med. , vol.11 , pp. 365-366
    • Kuipers, H.F.1    van den Elsen, P.J.2
  • 21
    • 0036847338 scopus 로고    scopus 로고
    • 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells
    • Wagner A.H., et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 1784-1789
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 1784-1789
    • Wagner, A.H.1
  • 22
    • 33645882947 scopus 로고    scopus 로고
    • Lovastatin reduces apoptosis and downregulates the CD40 expression induced by TNF-α in cerebral vascular endothelial cells
    • Lin R., et al. Lovastatin reduces apoptosis and downregulates the CD40 expression induced by TNF-α in cerebral vascular endothelial cells. Curr. Neurovasc. Res. 3 (2006) 41-47
    • (2006) Curr. Neurovasc. Res. , vol.3 , pp. 41-47
    • Lin, R.1
  • 23
    • 0037016008 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells
    • Schonbeck U., et al. Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells. Circulation 106 (2002) 2888-2893
    • (2002) Circulation , vol.106 , pp. 2888-2893
    • Schonbeck, U.1
  • 24
    • 1642405502 scopus 로고    scopus 로고
    • Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells
    • Mulhaupt F., et al. Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells. Cardiovasc. Res. 59 (2003) 755-766
    • (2003) Cardiovasc. Res. , vol.59 , pp. 755-766
    • Mulhaupt, F.1
  • 25
    • 0033913583 scopus 로고    scopus 로고
    • Inhibition of monocyte chemotactic protein-1 synthesis by statins
    • Romano M., et al. Inhibition of monocyte chemotactic protein-1 synthesis by statins. Lab. Invest. 80 (2000) 1095-1100
    • (2000) Lab. Invest. , vol.80 , pp. 1095-1100
    • Romano, M.1
  • 26
    • 33644680589 scopus 로고    scopus 로고
    • Modulatory effects of atorvastatin on endothelial cell-derived chemokines, cytokines, and angiogenic factors
    • Zineh I., et al. Modulatory effects of atorvastatin on endothelial cell-derived chemokines, cytokines, and angiogenic factors. Pharmacotherapy 26 (2006) 333-340
    • (2006) Pharmacotherapy , vol.26 , pp. 333-340
    • Zineh, I.1
  • 27
    • 33746473678 scopus 로고    scopus 로고
    • Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages
    • Veillard N.R., et al. Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages. Atherosclerosis 188 (2006) 51-58
    • (2006) Atherosclerosis , vol.188 , pp. 51-58
    • Veillard, N.R.1
  • 28
    • 0033398822 scopus 로고    scopus 로고
    • Simvastatin inhibits leukocyte-endothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats
    • Pruefer D., et al. Simvastatin inhibits leukocyte-endothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats. Arterioscler. Thromb. Vasc. Biol. 19 (1999) 2894-2900
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 2894-2900
    • Pruefer, D.1
  • 29
    • 0034753831 scopus 로고    scopus 로고
    • A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid
    • Stalker T.J., et al. A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br. J. Pharmacol. 133 (2001) 406-412
    • (2001) Br. J. Pharmacol. , vol.133 , pp. 406-412
    • Stalker, T.J.1
  • 30
    • 0036076620 scopus 로고    scopus 로고
    • Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1
    • Li D., et al. Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1. J. Pharmacol. Exp. Ther. 302 (2002) 601-605
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 601-605
    • Li, D.1
  • 31
    • 0037353629 scopus 로고    scopus 로고
    • Statins inhibit high glucose-mediated neutrophil-endothelial cell adhesion through decreasing surface expression of endothelial adhesion molecules by stimulating production of endothelial nitric oxide
    • Omi H., et al. Statins inhibit high glucose-mediated neutrophil-endothelial cell adhesion through decreasing surface expression of endothelial adhesion molecules by stimulating production of endothelial nitric oxide. Microvasc. Res. 65 (2003) 118-124
    • (2003) Microvasc. Res. , vol.65 , pp. 118-124
    • Omi, H.1
  • 32
    • 0034283671 scopus 로고    scopus 로고
    • Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein
    • Sadeghi M.M., et al. Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. J. Immunol. 165 (2000) 2712-2718
    • (2000) J. Immunol. , vol.165 , pp. 2712-2718
    • Sadeghi, M.M.1
  • 33
    • 0035587158 scopus 로고    scopus 로고
    • Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells
    • Rasmussen L.M., et al. Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells. Biochem. J. 360 (2001) 363-370
    • (2001) Biochem. J. , vol.360 , pp. 363-370
    • Rasmussen, L.M.1
  • 34
    • 0035996578 scopus 로고    scopus 로고
    • Lovastatin-stimulated superinduction of E-selectin, ICAM-1 and VCAM-1 in TNF-α activated human vascular endothelial cells
    • Schmidt A., et al. Lovastatin-stimulated superinduction of E-selectin, ICAM-1 and VCAM-1 in TNF-α activated human vascular endothelial cells. Atherosclerosis 164 (2002) 57-64
    • (2002) Atherosclerosis , vol.164 , pp. 57-64
    • Schmidt, A.1
  • 35
    • 12244275671 scopus 로고    scopus 로고
    • Effect of atorvastatin on adhesive phenotype of human endothelial cells activated by tumor necrosis factor α
    • Bernot D., et al. Effect of atorvastatin on adhesive phenotype of human endothelial cells activated by tumor necrosis factor α. J. Cardiovasc. Pharmacol. 41 (2003) 316-324
    • (2003) J. Cardiovasc. Pharmacol. , vol.41 , pp. 316-324
    • Bernot, D.1
  • 36
    • 3042602228 scopus 로고    scopus 로고
    • Effects of statins on adhesion molecule expression in endothelial cells
    • Dimitrova Y., et al. Effects of statins on adhesion molecule expression in endothelial cells. J. Thromb. Haemost. 1 (2003) 2290-2299
    • (2003) J. Thromb. Haemost. , vol.1 , pp. 2290-2299
    • Dimitrova, Y.1
  • 37
    • 13844297745 scopus 로고    scopus 로고
    • Fluvastatin increases the expression of adhesion molecules, monocyte chemoattractant protein-1 and tissue factor in HUVEC stimulated by patient IgG fractions containing antiphospholipid antibodies
    • Dunoyer-Geindre S., et al. Fluvastatin increases the expression of adhesion molecules, monocyte chemoattractant protein-1 and tissue factor in HUVEC stimulated by patient IgG fractions containing antiphospholipid antibodies. Thromb. Haemost. 93 (2005) 339-345
    • (2005) Thromb. Haemost. , vol.93 , pp. 339-345
    • Dunoyer-Geindre, S.1
  • 38
    • 1342289577 scopus 로고    scopus 로고
    • Lovastatin inhibits Rho-regulated expression of E-selectin by TNFα and attenuates tumor cell adhesion
    • Nubel T., et al. Lovastatin inhibits Rho-regulated expression of E-selectin by TNFα and attenuates tumor cell adhesion. FASEB J. 18 (2004) 140-142
    • (2004) FASEB J. , vol.18 , pp. 140-142
    • Nubel, T.1
  • 39
    • 21344437272 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction
    • Prasad R., et al. Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction. J. Neurochem. 94 (2005) 204-214
    • (2005) J. Neurochem. , vol.94 , pp. 204-214
    • Prasad, R.1
  • 40
    • 0034607119 scopus 로고    scopus 로고
    • Cerivastatin suppresses lipopolysaccharide-induced ICAM-1 expression through inhibition of Rho GTPase in BAEC
    • Takeuchi S., et al. Cerivastatin suppresses lipopolysaccharide-induced ICAM-1 expression through inhibition of Rho GTPase in BAEC. Biochem. Biophys. Res. Commun. 269 (2000) 97-102
    • (2000) Biochem. Biophys. Res. Commun. , vol.269 , pp. 97-102
    • Takeuchi, S.1
  • 41
    • 0037207278 scopus 로고    scopus 로고
    • Statin inhibits interferon-γ-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells
    • Chung H.K., et al. Statin inhibits interferon-γ-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells. Exp. Mol. Med. 34 (2002) 451-461
    • (2002) Exp. Mol. Med. , vol.34 , pp. 451-461
    • Chung, H.K.1
  • 42
    • 0142230891 scopus 로고    scopus 로고
    • Cerivastatin ameliorates high insulin-enhanced neutrophil-endothelial cell adhesion and endothelial intercellular adhesion molecule-1 expression by inhibiting mitogen-activated protein kinase activation
    • Okouchi M., et al. Cerivastatin ameliorates high insulin-enhanced neutrophil-endothelial cell adhesion and endothelial intercellular adhesion molecule-1 expression by inhibiting mitogen-activated protein kinase activation. J. Diabetes Complications 17 (2003) 380-386
    • (2003) J. Diabetes Complications , vol.17 , pp. 380-386
    • Okouchi, M.1
  • 43
    • 0037339680 scopus 로고    scopus 로고
    • Simvastatin reduces the expression of adhesion molecules in circulating monocytes from hypercholesterolemic patients
    • Rezaie-Majd A., et al. Simvastatin reduces the expression of adhesion molecules in circulating monocytes from hypercholesterolemic patients. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 397-403
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 397-403
    • Rezaie-Majd, A.1
  • 44
    • 3042638413 scopus 로고    scopus 로고
    • Simvastatin modulates TNFα-induced adhesion molecules expression in human endothelial cells
    • Zapolska-Downar D., et al. Simvastatin modulates TNFα-induced adhesion molecules expression in human endothelial cells. Life Sci. 75 (2004) 1287-1302
    • (2004) Life Sci. , vol.75 , pp. 1287-1302
    • Zapolska-Downar, D.1
  • 45
    • 21244472282 scopus 로고    scopus 로고
    • Nitric oxide mediates the effect of fluvastatin on intercellular adhesion molecule-1 and platelet endothelial cell adhesion molecule-1 expression on human endothelial cells
    • Xenos E.S., et al. Nitric oxide mediates the effect of fluvastatin on intercellular adhesion molecule-1 and platelet endothelial cell adhesion molecule-1 expression on human endothelial cells. Ann. Vasc. Surg. 19 (2005) 386-392
    • (2005) Ann. Vasc. Surg. , vol.19 , pp. 386-392
    • Xenos, E.S.1
  • 46
    • 33845447292 scopus 로고    scopus 로고
    • Cerivastatin reduces cytokine-induced surface expression of ICAM-1 via increased shedding in human endothelial cells
    • Landsberger M., et al. Cerivastatin reduces cytokine-induced surface expression of ICAM-1 via increased shedding in human endothelial cells. Atherosclerosis 190 (2007) 43-52
    • (2007) Atherosclerosis , vol.190 , pp. 43-52
    • Landsberger, M.1
  • 47
    • 0034886768 scopus 로고    scopus 로고
    • Fluvastatin inhibits O2- and ICAM-1 levels in a rat model with aortic remodeling induced by pressure overload
    • Katoh M., et al. Fluvastatin inhibits O2- and ICAM-1 levels in a rat model with aortic remodeling induced by pressure overload. Am. J. Physiol. Heart Circ. Physiol. 281 (2001) H655-H660
    • (2001) Am. J. Physiol. Heart Circ. Physiol. , vol.281
    • Katoh, M.1
  • 48
    • 18044385575 scopus 로고    scopus 로고
    • Rosuvastatin attenuates monocyte-endothelial cell interactions and vascular free radical production in hypercholesterolemic mice
    • Li W., et al. Rosuvastatin attenuates monocyte-endothelial cell interactions and vascular free radical production in hypercholesterolemic mice. J. Pharmacol. Exp. Ther. 313 (2005) 557-562
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , pp. 557-562
    • Li, W.1
  • 49
    • 13844276528 scopus 로고    scopus 로고
    • Statin-inhibited endothelial permeability could be associated with its effect on PECAM-1 in endothelial cells
    • Wei H., et al. Statin-inhibited endothelial permeability could be associated with its effect on PECAM-1 in endothelial cells. FEBS Lett. 579 (2005) 1272-1278
    • (2005) FEBS Lett. , vol.579 , pp. 1272-1278
    • Wei, H.1
  • 50
    • 0036627483 scopus 로고    scopus 로고
    • Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier
    • Greenwood J., et al. Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier. Vascul. Pharmacol. 38 (2002) 315-322
    • (2002) Vascul. Pharmacol. , vol.38 , pp. 315-322
    • Greenwood, J.1
  • 51
    • 0037166942 scopus 로고    scopus 로고
    • Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes
    • Barreiro O., et al. Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J. Cell Biol. 157 (2002) 1233-1245
    • (2002) J. Cell Biol. , vol.157 , pp. 1233-1245
    • Barreiro, O.1
  • 52
    • 7244248569 scopus 로고    scopus 로고
    • A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them
    • Carman C.V., and Springer T.A. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J. Cell Biol. 167 (2004) 377-388
    • (2004) J. Cell Biol. , vol.167 , pp. 377-388
    • Carman, C.V.1    Springer, T.A.2
  • 53
    • 0038322504 scopus 로고    scopus 로고
    • Lovastatin inhibits brain endothelial Rho-dependent lymphocyte migration and attenuates experimental autoimmune encephalomyelitis
    • Greenwood J., et al. Lovastatin inhibits brain endothelial Rho-dependent lymphocyte migration and attenuates experimental autoimmune encephalomyelitis. FASEB J. 17 (2003) 905-907
    • (2003) FASEB J. , vol.17 , pp. 905-907
    • Greenwood, J.1
  • 54
    • 13544255743 scopus 로고    scopus 로고
    • Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction
    • Gegg M.E., et al. Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. J. Immunol. 174 (2005) 2327-2335
    • (2005) J. Immunol. , vol.174 , pp. 2327-2335
    • Gegg, M.E.1
  • 55
    • 1642289214 scopus 로고    scopus 로고
    • Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity
    • Cook-Mills J.M., et al. Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity. Biochem. J. 378 (2004) 539-547
    • (2004) Biochem. J. , vol.378 , pp. 539-547
    • Cook-Mills, J.M.1
  • 56
    • 0036558283 scopus 로고    scopus 로고
    • Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells
    • van Wetering S., et al. Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells. J. Cell Sci. 115 (2002) 1837-1846
    • (2002) J. Cell Sci. , vol.115 , pp. 1837-1846
    • van Wetering, S.1
  • 57
    • 0043245204 scopus 로고    scopus 로고
    • VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration
    • van Wetering S., et al. VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration. Am. J. Physiol. Cell Physiol. 285 (2003) C343-C352
    • (2003) Am. J. Physiol. Cell Physiol. , vol.285
    • van Wetering, S.1
  • 58
    • 0343048978 scopus 로고    scopus 로고
    • Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation
    • Wagner A.H., et al. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 61-69
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 61-69
    • Wagner, A.H.1
  • 59
    • 0035673283 scopus 로고    scopus 로고
    • Statins prevent endothelial cell activation induced by antiphospholipid (anti-β2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype
    • Meroni P.L., et al. Statins prevent endothelial cell activation induced by antiphospholipid (anti-β2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype. Arthritis Rheum. 44 (2001) 2870-2878
    • (2001) Arthritis Rheum. , vol.44 , pp. 2870-2878
    • Meroni, P.L.1
  • 60
    • 0037233913 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells
    • Dichtl W., et al. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 58-63
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 58-63
    • Dichtl, W.1
  • 61
    • 33644550593 scopus 로고    scopus 로고
    • Statins prevent NF-κB transactivation independently of the IKK-pathway in human endothelial cells
    • Holschermann H., et al. Statins prevent NF-κB transactivation independently of the IKK-pathway in human endothelial cells. Atherosclerosis 185 (2006) 240-245
    • (2006) Atherosclerosis , vol.185 , pp. 240-245
    • Holschermann, H.1
  • 62
    • 20144368777 scopus 로고    scopus 로고
    • Vascular implications of the Kruppel-like family of transcription factors
    • Suzuki T., et al. Vascular implications of the Kruppel-like family of transcription factors. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 1135-1141
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 1135-1141
    • Suzuki, T.1
  • 63
    • 22844434684 scopus 로고    scopus 로고
    • Statins exert endothelial atheroprotective effects via the KLF2 transcription factor
    • Parmar K.M., et al. Statins exert endothelial atheroprotective effects via the KLF2 transcription factor. J. Biol. Chem. 280 (2005) 26714-26719
    • (2005) J. Biol. Chem. , vol.280 , pp. 26714-26719
    • Parmar, K.M.1
  • 64
    • 23244457776 scopus 로고    scopus 로고
    • Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells
    • Sen-Banerjee S., et al. Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells. Circulation 112 (2005) 720-726
    • (2005) Circulation , vol.112 , pp. 720-726
    • Sen-Banerjee, S.1
  • 65
    • 33749426332 scopus 로고    scopus 로고
    • Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization
    • van Thienen J.V., et al. Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization. Cardiovasc. Res. 72 (2006) 231-240
    • (2006) Cardiovasc. Res. , vol.72 , pp. 231-240
    • van Thienen, J.V.1
  • 66
    • 0034647595 scopus 로고    scopus 로고
    • Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: reduction of mRNA levels for interleukin-1β, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor α (PPARα) in primary endothelial cells
    • Inoue I., et al. Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: reduction of mRNA levels for interleukin-1β, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor α (PPARα) in primary endothelial cells. Life Sci. 67 (2000) 863-876
    • (2000) Life Sci. , vol.67 , pp. 863-876
    • Inoue, I.1
  • 67
    • 0034994075 scopus 로고    scopus 로고
    • Statin-induced inhibition of the Rho-signaling pathway activates PPARα and induces HDL apoA-I
    • Martin G., et al. Statin-induced inhibition of the Rho-signaling pathway activates PPARα and induces HDL apoA-I. J. Clin. Invest. 107 (2001) 1423-1432
    • (2001) J. Clin. Invest. , vol.107 , pp. 1423-1432
    • Martin, G.1
  • 68
    • 33646817773 scopus 로고    scopus 로고
    • Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-α via inhibition of the protein kinase C signaling pathway
    • Paumelle R., et al. Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-α via inhibition of the protein kinase C signaling pathway. Circ. Res. 98 (2006) 361-369
    • (2006) Circ. Res. , vol.98 , pp. 361-369
    • Paumelle, R.1
  • 69
    • 0037353970 scopus 로고    scopus 로고
    • Beyond lipid-lowering: effects of statins on endothelial nitric oxide
    • Laufs U. Beyond lipid-lowering: effects of statins on endothelial nitric oxide. Eur. J. Clin. Pharmacol. 58 (2003) 719-731
    • (2003) Eur. J. Clin. Pharmacol. , vol.58 , pp. 719-731
    • Laufs, U.1
  • 70
    • 33644694919 scopus 로고    scopus 로고
    • Rho GTPases, statins, and nitric oxide
    • Rikitake Y., and Liao J.K. Rho GTPases, statins, and nitric oxide. Circ. Res. 97 (2005) 1232-1235
    • (2005) Circ. Res. , vol.97 , pp. 1232-1235
    • Rikitake, Y.1    Liao, J.K.2
  • 71
    • 0036322869 scopus 로고    scopus 로고
    • Isoprenoids as mediators of the biological effects of statins
    • Liao J.K. Isoprenoids as mediators of the biological effects of statins. J. Clin. Invest. 110 (2002) 285-288
    • (2002) J. Clin. Invest. , vol.110 , pp. 285-288
    • Liao, J.K.1
  • 72
    • 0036892061 scopus 로고    scopus 로고
    • Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells
    • Ming X.F., et al. Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol. Cell. Biol. 22 (2002) 8467-8477
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 8467-8477
    • Ming, X.F.1
  • 73
    • 25644440587 scopus 로고    scopus 로고
    • Blockade of geranylgeranylation by rosuvastatin upregulates eNOS expression in human venous endothelial cells
    • Landsberger M., et al. Blockade of geranylgeranylation by rosuvastatin upregulates eNOS expression in human venous endothelial cells. Biochem. Biophys. Res. Commun. 336 (2005) 1005-1009
    • (2005) Biochem. Biophys. Res. Commun. , vol.336 , pp. 1005-1009
    • Landsberger, M.1
  • 74
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y., et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat. Med. 6 (2000) 1004-1010
    • (2000) Nat. Med. , vol.6 , pp. 1004-1010
    • Kureishi, Y.1
  • 75
    • 0037023634 scopus 로고    scopus 로고
    • Double-edged role of statins in angiogenesis signaling
    • Urbich C., et al. Double-edged role of statins in angiogenesis signaling. Circ. Res. 90 (2002) 737-744
    • (2002) Circ. Res. , vol.90 , pp. 737-744
    • Urbich, C.1
  • 76
    • 0038179586 scopus 로고    scopus 로고
    • -/- mice in vivo
    • -/- mice in vivo. Circulation 107 (2003) 2480-2486
    • (2003) Circulation , vol.107 , pp. 2480-2486
    • Pelat, M.1
  • 77
    • 33746558058 scopus 로고    scopus 로고
    • Protective effect of pravastatin on vascular endothelium in patients with systemic sclerosis: a pilot study
    • Furukawa S., et al. Protective effect of pravastatin on vascular endothelium in patients with systemic sclerosis: a pilot study. Ann. Rheum. Dis. 65 (2006) 1118-1120
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 1118-1120
    • Furukawa, S.1
  • 78
    • 33745700412 scopus 로고    scopus 로고
    • Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis
    • Ifergan I., et al. Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. Ann. Neurol. 60 (2006) 45-55
    • (2006) Ann. Neurol. , vol.60 , pp. 45-55
    • Ifergan, I.1
  • 79
    • 0344465840 scopus 로고    scopus 로고
    • Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase
    • Stamatovic S.M., et al. Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase. J. Cell Sci. 116 (2003) 4615-4628
    • (2003) J. Cell Sci. , vol.116 , pp. 4615-4628
    • Stamatovic, S.M.1
  • 80
    • 27744472350 scopus 로고    scopus 로고
    • HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation
    • Zeng L., et al. HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. FASEB J. 19 (2005) 1845-1847
    • (2005) FASEB J. , vol.19 , pp. 1845-1847
    • Zeng, L.1
  • 81
    • 25844495838 scopus 로고    scopus 로고
    • Statins ameliorate endothelial barrier permeability changes in the cerebral tissue of streptozotocin-induced diabetic rats
    • Mooradian A.D., et al. Statins ameliorate endothelial barrier permeability changes in the cerebral tissue of streptozotocin-induced diabetic rats. Diabetes 54 (2005) 2977-2982
    • (2005) Diabetes , vol.54 , pp. 2977-2982
    • Mooradian, A.D.1
  • 82
    • 23944445364 scopus 로고    scopus 로고
    • Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol
    • Liao J.K. Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol. Am. J. Cardiol. 96 (2005) 24F-33F
    • (2005) Am. J. Cardiol. , vol.96
    • Liao, J.K.1
  • 83
    • 0036162113 scopus 로고    scopus 로고
    • Cellular antioxidant effects of atorvastatin in vitro and in vivo
    • Wassmann S., et al. Cellular antioxidant effects of atorvastatin in vitro and in vivo. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 300-305
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 300-305
    • Wassmann, S.1
  • 84
    • 33645944368 scopus 로고    scopus 로고
    • Tissue-specific effects of statins on the expression of heme oxygenase-1 in vivo
    • Hsu M., et al. Tissue-specific effects of statins on the expression of heme oxygenase-1 in vivo. Biochem. Biophys. Res. Commun. 343 (2006) 738-744
    • (2006) Biochem. Biophys. Res. Commun. , vol.343 , pp. 738-744
    • Hsu, M.1
  • 85
    • 0037192331 scopus 로고    scopus 로고
    • Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering
    • Wilson S.H., et al. Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering. Circulation 105 (2002) 415-418
    • (2002) Circulation , vol.105 , pp. 415-418
    • Wilson, S.H.1
  • 86
    • 0037178764 scopus 로고    scopus 로고
    • Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice
    • Vecchione C., and Brandes R.P. Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice. Circ. Res. 91 (2002) 173-179
    • (2002) Circ. Res. , vol.91 , pp. 173-179
    • Vecchione, C.1    Brandes, R.P.2
  • 87
    • 0037131289 scopus 로고    scopus 로고
    • Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury
    • Mason J.C., et al. Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury. Circ. Res. 91 (2002) 696-703
    • (2002) Circ. Res. , vol.91 , pp. 696-703
    • Mason, J.C.1
  • 88
    • 70350593605 scopus 로고    scopus 로고
    • Statin-induced expression of CD59 on vascular endothelium in hypoxia. A potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis
    • Kinderlerer A.R., et al. Statin-induced expression of CD59 on vascular endothelium in hypoxia. A potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. Arthritis Res. Ther. 8 (2006) R130-R141
    • (2006) Arthritis Res. Ther. , vol.8
    • Kinderlerer, A.R.1
  • 89
    • 20844463066 scopus 로고    scopus 로고
    • Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans
    • Landmesser U., et al. Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans. Circulation 111 (2005) 2356-2363
    • (2005) Circulation , vol.111 , pp. 2356-2363
    • Landmesser, U.1
  • 90
    • 2942705774 scopus 로고    scopus 로고
    • Safety of statins: focus on clinical pharmacokinetics and drug interactions
    • Bellosta S., et al. Safety of statins: focus on clinical pharmacokinetics and drug interactions. Circulation 109 Suppl. 1 (2004) III-50-III-57
    • (2004) Circulation , vol.109 , Issue.SUPPL. 1 , pp. 50-57
    • Bellosta, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.