Haem oxygenase-1 genotype and cardiovascular adverse events in patients with peripheral artery disease

European Journal of Clinical Investigation

Volumn 35, Issue 12, 2005, Pages 731-737

  Dick, P ^a   Schillinger, M ^a   Minar, E ^a   Mlekusch, W ^a   Amighi, J ^a   Sabeti, S ^a   Schlager, O ^a   Raith, M ^a,b   Endler, G ^a,b   Mannhalter, C ^a,b   Wagner, O ^a,b   Exner, M ^a,b  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Atherosclerosis; Cardiovascular outcome; Genotype; Haem oxygenase; Polymorphism

Indexed keywords

DINUCLEOTIDE; GUANINE; HEME OXYGENASE 1; THYMIDINE;

ADULT; AGED; ALLELISM; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTERY DISEASE; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAROTID ARTERY; CEREBROVASCULAR DISEASE; CORONARY ARTERY BYPASS GRAFT; DNA DETERMINATION; FEMALE; GENOTYPE; HAZARD ASSESSMENT; HEART INFARCTION; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INJURY; MAJOR CLINICAL STUDY; MALE; MORTALITY; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; PROMOTER REGION; PROTECTION; REVASCULARIZATION; SEQUENCE ANALYSIS; STROKE; UPREGULATION;

EID: 28944448437     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2005.01580.x     Document Type: Article

References (25)

1. Tulis DA, Durante W, Peyton KJ, Evans AJ, Schafer AI. Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries. Atherosclerosis 2001;155:113-22.
2. Duckers HJ, Boehm M, True A, Yet SF, San H, Park JL et al. Heme oxygenase-1 protects against vascular constriction and proliferation. Nat Med 2001;7:693-8.
3. Ishikawa K, Sugawara D, Wang XP, Suzuki K, Itabe B, Maruyama Y, et al. Heme oxygenase-1 inhibits atherosclerotic lesion formation in 1dl-receptor knockout mice. Circ Res 2001;88:506-12.
4. Maines MD. Heme oxygenase: function, multiplicity, regulatory mechanisms and clinical application. FASEB J 1988;2:2557-68.
5. Tenhunen R, Marver HS, Schmid R. Microsomal heme oxygenase. Characterization of the enzyme. J Biol Chem 1969;244:6388-94.
6. Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, Shibahara S et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 2000;66:187-95.
7. Hirai H, Kubo H, Yamaya M, Nakayama K, Numasaki M, Kobayashi S et al. Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood 2003;102:1619-21.
8. Exner M, Schillinger M, Minar E, Mlekusch W, Schlerka G, Haumer M et al. Heme oxygenase-1 microsatellite gene promoter polymorphism is associated with restenosis after percutaneous transluminal angioplasty. J Endovasc Ther 2001;8:433-40.
9. Schillinger M, Exner M, Minar E, Mlekusch W, Müllner M, Mannhalter C et al. Heme oxygenase-1 genotype and restenosis after femoropopliteal PTA: a novel vascular protective factor. J Am Coll Cardiol 2004;43:950-7.
10. Chen YH, Lin SJ, Lin MW, Tsai HL, Kuo SS, Chen JW et al. Microsatellite polymorphism in promoter of heme oxygenase gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum Genet 2002;111:1-8.
11. Chen YH, Chau LY, Lin MW, Chen LC, Yo MH, Chen JW et al. Heme oxygenase-1 promoter microsatellite polymorphism is associated with angiographic restenosis after coronary stenting. Eur Heart J 2004;25:39-47.
12. Kaneda H, Ohno M, Taguchi J, Togo M, Hashimoto H, Ogasawara K et al. Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors. Arterioscler Thromb Vasc Biol 2002;22:1680-5.
13. Criqui MH, Langer RD, Fronek A, Feigelson HS, Klauber MR, McCann TJ et al. Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med 1992;326:381-6.
14. Schillinger M, Exner M, Amighi J, Mlekusch W, Sabeti S, Rumpold H et al. Joint effects of C-reactive protein and glycated haemoglobin in predicting future cardiovascular events in patients with advanced atherosclerosis. Circulation 2003;108:2323-8.
15. Kimpara T, Takeda A, Watanabe K, Itoyama Y, Ikawa S, Watanabe M et al. Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease. Hum Genet 1997;100:145-7.
16. Dormandy JA, Rutherford B. Management of peripheral arterial disease (PAD). TASC Working Group. Trans-Atlantic Inter-Society Consensus (TASC). J Vasc Surg 2000;31:S1-S296.
17. Campeau L. Grading of angina pectoris. Circulation 1976;54:522-3.
18. Antman E, Bassand JP, Klein W, Ohman M, Sendon JLL, Ryden L et al. Myocardial infarction redefined - a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction: The Joint European Society of Cardiology/American College of Cardiology Committee. J Am Coll Cardiol 2000;36:959-69.
19. Brott T, Adams HP, Olinger CP, Marler JR, Barsan WG, Biller J et al. Measurements of acute cerebral infarction: a clinical examination scale. Stroke 1989;20:864-70.
20. Schillinger M, Exner M, Mlekusch W, Ahmadi R, Rumpold H, Mannhalter C et al. Heme oxygenase-1 genotype is a vascular anti-inflammatory factor following balloon angioplasty. J Endovasc Ther 2002;9:385-94.
21. Exner M, Bohmig GA, Schillinger M, Regele H, Watschinger B, Hörl WH et al. Donor heme oxygenase-1 genotype is associated with renal allograft function. Transplantation 2004;77:538-42.
22. Baan C, Peeters A, Lemos F, Uitterlinden A, Doxiadis I, Claas F et al. Fundamental role for HO-1 in the self protection of renal allografts. Am J Transplant 2004;4:811-8.
23. Exner M, Minar E, Wagner O, Schillinger M. The role of heme oxygenase 1 promoter polymorphisms in human disease. Free Radic Biol Med 2004;37:1097-104.
24. Endler G, Exner M, Schillinger M, Marculescu R, Sunder-Plassmann R, Raith M et al. A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with increased bilirubin and HDL levels but not with coronary artery disease. Thromb Haemost 2004;91:155-61.
25. Funk M, Endler G, Schillinger M, Mustafa S, Hsieh K, Exner M et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter and ischemic cerebrovascular events - interrelation with traditional cardiovascular risk factors. Thromb Res 2004;113:217-23.