Increased Dickkopf-1 expression accelerates bone cell apoptosis in femoral head osteonecrosis

Bone

Volumn 46, Issue 3, 2010, Pages 584-591

  Ko, Jih Yang ^a,b   Wang, Feng Sheng ^b   Wang, Ching Jen ^a,b   Wong, To ^a,b   Chou, Wen Yi ^a,b   Tseng, Shin Ling ^b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Apoptosis; Dickkopf 1; Glucocorticoids; Osteoblasts; Osteonecrosis

Indexed keywords

AXIN; CORTICOSTEROID; DICKKOPF 1 PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; PROTEIN BAD; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA; WNT3A PROTEIN; APOPTOSIS INDUCING FACTOR; DKK1 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ALCOHOLISM; APOPTOSIS; ARTICLE; BONE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMUR HEAD NECROSIS; FEMUR NECK FRACTURE; GENE EXPRESSION; HIP ARTHROPLASTY; HUMAN; HUMAN CELL; HUMAN TISSUE; MESENCHYME CELL; NICK END LABELING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; RNA INTERFERENCE; ADOLESCENT; ADULT; AGED; BIOSYNTHESIS; BLOOD; COMPARATIVE STUDY; FEMALE; GENETICS; MALE; METABOLISM; MIDDLE AGED; OSTEOCYTE; PATHOLOGY; PHYSIOLOGY; UPREGULATION; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; APOPTOSIS INDUCING FACTOR; FEMALE; FEMUR HEAD NECROSIS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; OSTEOCYTES; UP-REGULATION; YOUNG ADULT;

EID: 77649182876     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.10.030     Document Type: Article

References (54)

1. J Jones L.C., Hungerford D.S. Osteonecrosis: etiology, diagnosis, and treatment. Curr. Opin. Rheumatol. 2004, 16:443-449.
2. Marciniak D., Furey C., Shaffer J.W. Osteonecrosis of the femoral head. A study of 101 hip treated with vascularized fibular grafting. J. Bone Joint Surg. Am. 2005, 87:742-747.
3. Roth J., Palm C., Scheunemann I., Raulse M.B., Schweizer R., Dannecker G.E. Musculoskeletal abnormalities of the formation in patients with juvenile idiopathic arthritis relate mainly to bone geometry. Arthritis Rheum. 2004, 50:1277-1285.
4. Chao Y.C., Wang S.J., Chu H.C., Chang W.K., Hsieh T.Y. Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver. Alcohol Alcohol. 2003, 38:431-436.
5. Zalavras C.G., Vartholomatos G., Dokou E., Mailzos K.N. Genetic background of osteonecrosis: association with thrombophilic mutations. Clin. Orthop. Relat. Res. 2004, 422:251-255.
6. Liu Y.F., Chen W.M., Lin Y.F., Yang R.C., Lin M.W., Lin L.H., et al. Type II collagen gene variants and inherited osteonecrosis of the femoral head. N. Engl. J. Med. 2005, 352:2294-2301.
7. Weinstein R.S., Nicholas R.W., Manolagas S.C. Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip. J. Clin. Endocrionol. Metab. 2000, 85:2907-2912.
8. Calder J.D., Pearse M.F., Revell P.A. The extent of osteocyte death in the proximal femur of patients with osteonecrosis of the femoral head. J. Bone Joint Surg. Br. 2001, 83:419-422.
9. Suh K.T., Kim S.W., Roh H.L., Youn M.S., Jung J.S. Decreased osteogenic differentiation of mesenchymal stem cells in alcohol-induced osteonecrosis. Clin. Orthop. Relat. Res. 2005, 431:220-225.
10. Lee J.S., Lee J.S., Roh H.L., Kim C.H., Jung J.S., Suh K.T. Alterations in the differentiation ability of mesenchymal stem cells in patients with nontraumatic osteonecrosis of the femoral head: comparative analysis according to the risk factor. J. Orthoptera Res. 2006, 24:604-609.
11. Gangji V., Hauzeur J.P., Schoutens A., Hinesenkamp M., Appelboom T., Egrise D. Abnormalities in the replicative capacity of osteoblastic cells in the proximal femurs of patients with osteonecrosis of the femoral head. J. Rheumatol. 2003, 30:348-351.
12. Motomura G., Yamamoto T., Miyanishi K., Yamashita A., Sueishi K., Iwamoto Y. Bone marrow fat-cell enlargement in early steroid-induced osteonecrosis-a histomorphometric study of autopsy cases. Pathol. Res. Pract. 2005, 200:807-811.
13. Calder J.D., Buttery L., Revell P.A., Pearse M., Polak J.M. Apoptosis-a significant cause of bone cell death in osteonecrosis of the femoral head. J. Bone Joint Surg. Br. 2004, 86:1209-1213.
14. Ichiseki T., Kaneuji A., Katsuda S., Ueda Y., Sugimori T., Matsumoto T. DNA oxidation injury in bone early after steroid administration is involved in the pathogenesis of steroid-induced osteonecrosis. Rheumatology 2005, 44:456-460.
15. Eberhardt A.W., Yeager-Jones A., Blair H.C. Regional trabecular bone matrix degeneration and osteocyte death in femora of glucocorticoid-treated rabbits. Endocrinology 2001, 142:1333-1340.
16. Kawano Y., Kypta R. Secreted antagonists of the Wnt signaling pathway. J. Cell. Sci. 2003, 116:2627-2634.
17. Krishan V., Bryant H.U., MacDougald O.A. Regulation of bone mass by Wnt signaling. J. Clin. Invest. 2006, 116:1202-1209.
18. Li J., Sarosi I., Cattley R.C., Pretorius J., Asuncion F., Grisanti M., et al. Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 2006, 39:754-766.
19. Diarra D., Stolina M., Polzer K., Zwerina J., Ominsky M.S., Dwyer D., et al. Dickkopf-1 is a master regulator of joint remodeling. Nat. Med. 2007, 13:156-163.
20. Tian E., Zhan F., Walker R., Rasmussen E., Ma Y., Barlogie B., et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N. Engl. J. Med. 2003, 349:2483-2494.
21. Hall C.L., Bafico A., Dai J., Aaronson S.A., Keller E.T. Prostate cancer cells promote osteoblastic bone metastases through Wnts. Cancer Res. 2005, 65:7554-7560.
22. Ohnaka K., Tanabe M., Kawate H., Nawata H., Takayanagi R. Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts. Biochem. Biophys. Res. Commun. 2005, 329:177-181.
23. Weng L.H., Wang C.J., Ko J.Y., Sun Y.C., Su Y.S., Wang F.S. Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint. Osteoarthr. Cartil. 2009, 17:919-929.
24. Wang F.S., Ko J.Y., Ke H.J., Ye D.W., Wu S.L. Modulation of Dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation and bone mass loss. Endocrinology 2008, 149:1793-1801.
25. Rubin J., Murphy T.C., Fan X., Goldschmidt M., Taylor W.R. Activation of extracellular signal-regulated kinase is involved in mechanical strain inhibition of RANKL expression in bone stromal cells. J. Bone Miner. Res. 2002, 17:1452-1460.
26. Min J.L., Meulenbelt I., Riyazi N., Kloppenbur M., Houwing-Duistermaat J.J., Seymour A.B., et al. Association of the frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis Rheum. 2005, 52:1077-1080.
27. Nakamura Y., Nawata M., Waitani S. Expression profiles and functional analyses of Wnt-related gene in human joint disorders. Am. J. Pathol. 2005, 167:97-105.
28. Loughlin J., Dowling B., Chapman K., Marcelline L., Mustafa Z., Southam L., Ferreira A., Ciesielski C., Carson D.A., Corr M. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:9757-9762.
29. Brien C.A.O., Jia D., Plotkin L.I., Bellido T., Powers C.C., Stewart S.A., et al. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduced bone formation and strength. Endocrinology 2004, 145:1835-1841.
30. Mottcetti P., Silvestrinin G., Ballanti P., Patacchioli F.R., Di Grezia R., Angelucci L., et al. Bcl-2 and Bax expression in cartilage and bone cells after high-dose corticosterone treatment in rats. Tissue Cell. 2001, 33:1-7.
31. Zalavras C., Shah S., Birbaum M.J., Frenkel B. Role of apoptosis in glucocorticoid-induced osteoporosis and osteonecrosis. Crit. Rev. Eukaryot. Gene Expr. 2003, 13:221-235.
32. Caricasole A., Copani A., Caraci F., Aronica E., Rozemuller A.J., Caruso A., et al. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J. Nieurosci. 2004, 24:6021-6027.
33. Khosla S., Westendorf J.J., Oarsler M.J. Building bone to reverse osteoporosis and repair fractures. J. Clin. Invest. 2008, 118:421-428.
34. Knobloch J., Shaughnessy J.D., Ruther U. Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway. FASEB J. 2007, 21:1410-1421.
35. Kwack M.H., Sung Y.K., Chung E.J., Im S.U., Ahn J.S., Kim M.K., et al. Dihyrotesterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes. J. Invest. Dermatol. 2008, 128:262-279.
36. Gunn W.G., Conley A., Deininger L., Oslon S.D., Prockop D.J., Gregory C.A. A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and IL-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cell 2006, 24:986-991.
37. Hall C.L., Kang S., MacDougald O.A., Keller E.T. Role of Wnts in prostate cancer bone metastases. J. Cell. Biochem. 2006, 97:661-672.
38. Ai M., Holmen S.L., Van Hul W., Williams B.O., Warman M.L. Reduced affinity and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutation in LRP5 affect canonical Wnt signaling. Mol. Cell. Biol. 2005, 25:4946-4955.
39. Seguin C., Kassis J., Busque L., Bestawros A., Theodoropoulos J., Alonso M.L., Harvey E.J. Non-traumatic necrosis of bone (ostoenecrosis) is associated with endothelial cell activation but not thrombophilia. Rheumatology 2008, 47:1151-1155.
40. Hirata T., Fujioka M., Takahashi K.A., Asano T., Ishida M., Akioka K., et al. Low molecular weight phenotype of Apo(a) is a risk factor of corticosteroid-induced osteonecrosis of the femoral head after renal transplantation. J. Rhemuatol. 2007, 34:516-522.
41. Tan X., Cai D., Wu Y., Liu B., Rong L., Chen Z., Zhao Q. Comparative analysis of serum proteomes: discovery of proteins associated with osteonecrosis of the femoral head. Transl. Res. 2006, 148:114-149.
42. Wu R.W., Wang F.S., Ko J.Y., Wang C.J., Wu S.L. Comparative serum proteomic expression of osteonecrosis of the femoral head in adults. Bone 2008, 43:561-566.
43. Lane N.E., Nevitt M.C., Lui L.Y., de Leon P., Corr M. Study of the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum. 2007, 56:3319-3325.
44. Garnero P., Tabassi N.C., Voorzanger-Rousselot N. Circulating Dickkopf-1 and radiographical progression in patients with early rheumatic arthritis treatment with etanercept. J. Rheumatol. 2008, 35:2313-2315.
45. Fleissner C., Brandle E., Peters M., Stover D., Sezer O., Heider U. Serum concentration of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma. Eur. J. Haematol. 2008, 80:490-494.
46. Yao W., Cheng Z., Busse C., Pham A., Nakamura M.C., Lane N.E. Glucocorticoid excess in mice results in early activation of osteoclastogenesis and adipogenesis and prolonged suppression of osteogenesis: a longitudinal study of gene expression in bone tissue from glucocorticoid-treated mice. Arthritis Rheum. 2008, 58:1674-1684.
47. Uderhardt S., Diarra D., Katzenbeisser J., David J.P., Zwerina J., Richards W.G., et al. Blockade of Dickkopf-1 induces fusion of sacroiliac joints. Ann. Rheum. Dis. 2009, doi:10.1136/ard.2008.102046.
48. Gonzalez-Quintela A., Campos J., Loidi L., Quinteiro C., Perez L.F., Gude F. Serum TNF-alpha levels in relation to alcohol consumption and common TNF gene polymorphism. Alcohol 2008, 42:513-518.
49. Okazaki S., Nishitani Y., Nagoya S., Kaya M., Yamashita T.Y., Matsumoto H. Femoral head osteonecrosis can be caused by disruption of the systemic immune response via the toll-like receptor 4 signaling pathway. Rheumatology 2009, 48:227-232.
50. Yeh C.H., Chang J.K., Wang Y.H., Ho H.L., Wang G.J. Ethanol may suppress Wnt/beta-catenin signaling on human bone marrow stromal cells: a preliminary study. Clin. Orthop. Relat. Res. 2008, 466:1047-1053.
51. Yeh C.H., Chang J.K., Ho M.L., Chen C.H., Wang C.J. Different differentiation of stromal cells from patients with osteonecrosis: a pilot study. Clin. Orthop. Relat. Res. 2009, 467:2159-2167.
52. Rauner M., Sipos W., Pietchmann P. Age-dependent Wnt gene expression in bone and during the course of osteoblast differentiation. Age 2008, 30:273-282.
53. Cappuccio I., Calderone A., Busceti C.L., Niagioni F., Pontarelli F., Bruno V., et al. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death. J. Neurosci. 2005, 25:2647-2657.
54. Colla S., Zhan F., Xiong W., Wu X., Xu H., Stephens O., et al. The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells. Blood 2007, 109:4470-4477.