DNA oxidation injury in bone early after steroid administration is involved in the pathogenesis of steroid-induced osteonecrosis

Rheumatology

Volumn 44, Issue 4, 2005, Pages 456-460

  Ichiseki, T ^a   Kaneuji, A ^a   Katsuda, S ^a   Ueda, Y ^a   Sugimori, T ^a   Matsumoto, T ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

8 OHdG; Oxidation; Steroid induced osteonecrosis

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANTIOXIDANT; CORTICOSTEROID; DNA; METHYLPREDNISOLONE; MONOCLONAL ANTIBODY; 8-HYDROXY-2'-DEOXYGUANOSINE; DEOXYGUANOSINE; DRUG DERIVATIVE; GLUCOCORTICOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; BONE INJURY; BONE MARROW CELL; BONE NECROSIS; CALCULATION; CONTROLLED STUDY; DIAPHYSIS; DNA METABOLISM; EXPERIMENTAL MODEL; FEMALE; FEMUR; HEMATOPOIETIC CELL; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; JAPAN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RABBIT; SINGLE DRUG DOSE; STATISTICAL ANALYSIS; ANIMAL; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DNA DAMAGE; DRUG EFFECT; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATHOLOGY;

ANIMALS; DEOXYGUANOSINE; DIAPHYSES; DISEASE MODELS, ANIMAL; DNA DAMAGE; FEMALE; GLUCOCORTICOIDS; METHYLPREDNISOLONE; OSTEONECROSIS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RABBITS;

EID: 18744392271     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keh518     Document Type: Article

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