Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contraction and results in postnatal death in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 47, 2008, Pages 18614-18618

  Chi, Mei ^a   Zhou, Yingbi ^a   Vedamoorthyrao, Srikanth ^a   Babu, Gopal J ^a   Periasamy, Muthu ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Contractility; Gene knockout; Isoform specific; Myofilament

Indexed keywords

ALPHA ACTIN; CARBACHOL; MYOSIN; MYOSIN HEAVY CHAIN; MYOSIN LIGHT CHAIN; SMOOTH MUSCLE MYOSIN 1; SMOOTH MUSCLE MYOSIN 2; TROPOMYOSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BLADDER DISTENSION; DEATH; DIGESTIVE SYSTEM; DOWN REGULATION; EXON; GENE TARGETING; HETEROZYGOTE; HOMOZYGOTE; HYDRONEPHROSIS; KIDNEY PELVIS; KNOCKOUT MOUSE; MOUSE; MULTIPLE ORGAN FAILURE; MYOFILAMENT; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION; URINE RETENTION;

ANIMALS; ANIMALS, NEWBORN; CARBACHOL; FEMALE; HETEROZYGOTE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE CONTRACTION; PHOSPHORYLATION; SMOOTH MUSCLE MYOSINS;

MUS;

EID: 57449098002     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808162105     Document Type: Article

References (28)

1. Rovner AS, Murphy RA, Owens GK (1986) Expression of smooth muscle and nonmuscle myosin heavy chains in cultured vascular smooth muscle cells. J Biol Chem 261:14740-14745.
2. Murphy RA, Walker JS, Strauss JD (1997) Myosin isoforms and functional diversity in vertebrate smooth muscle. Comp Biochem Physiol B Biochem Mol Biol 117:51-60.
3. Loukianov E, Loukianova T, Periasamy M (1997) Myosin heavy chain isoforms in smooth muscle. Comp Biochem Physiol B Biochem Mol Biol 117:13-18.
4. Craig R, Woodhead JL (2006) Structure and function of myosin filaments. Curr Opin Struct Biol 16:204-212.
5. Nagai R, Larson DM, Periasamy M (1988) Characterization of a mammalian smooth muscle myosin heavy chain cDNA clone and its expression in various smooth muscle types. Proc Natl Acad Sci USA 85:1047-1051.
6. Nagai R, Kuro-o M, Babij P, Periasamy M (1989) Identification of two types of smooth muscle myosin heavy chain isoforms by cDNA cloning and immunoblot analysis. J Biol Chem 264:9734-9737.
7. Babij P, Periasamy M (1989) Myosin heavy chain isoform diversity in smooth muscle is produced by differential RNA processing. J Mol Biol 210:673-679.
8. Miano JM, Cserjesi P, Ligon KL, Periasamy M, Olson EN (1994) Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis. Circ Res 75:803-812.
9. Lauzon AM, et al. (1998) A 7-amino acid insert in the heavy chain nucleotide binding loop alters the kinetics of smooth muscle myosin in the laser trap. J Muscle Res Cell Motil 19:825-837.
10. Kelley CA, Takahashi M, Yu JH, Adelstein RS (1993) An insert of seven amino acids confers functional differences between smooth muscle myosins from the intestines and vasculature. J Biol Chem 268:12848-12854.
11. Rovner AS, Freyzon Y, Trybus KM (1997) An insert in the motor domain determines the functional properties of expressed smooth muscle myosin isoforms. J Muscle Res Cell Motil 18:103-110.
12. Babu GJ, et al. (2001) Loss of SM-B myosin affects muscle shortening velocity and maximal force development. Nat Cell Biol 3:1025-1029.
13. Babu GJ, et al. (2004) Isoform switching from SM-B to SM-A myosin results in decreased contractility and altered expression of thin filament regulatory proteins. Am J Physiol 287:C723-C729.
14. White SL, Zhou MY, Low RB, Periasamy M (1998) Myosin heavy chain isoform expression in rat smooth muscle development. Am J Physiol 275:C581-C589.
15. Wang ZE, Gopalakurup SK, Levin RM, Chacko S (1995) Expression of smooth muscle myosin isoforms in urinary bladder smooth muscle during hypertrophy and regression. Lab Invest 73:244-251.
16. Cher ML, Abernathy BB, McConnell JD, Zimmern PE, Lin VK (1996) Smooth-muscle myosin heavy-chain isoform expression in bladder-outlet obstruction. World J Urol 14:295-300.
17. DiSanto ME, et al. (2003) Alteration in expression of myosin isoforms in detrusor smooth muscle following bladder outlet obstruction. Am J Physiol 285:C1397-C1410.
18. Packer CS, Roepke JE, Oberlies NH, Rhoades RA (1998) Myosin isoform shifts and decreased reactivity in hypoxia-induced hypertensive pulmonary arterial muscle. Am J Physiol 274:L775-L785.
19. Aikawa M, et al. (1993) Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. Circ Res 73:1000-1012.
20. Itoh S, et al. (2002) Importance of NAD(P)H oxidase-mediated oxidative stress and contractile type smooth muscle myosin heavy chain SM2 at the early stage of atherosclerosis. Circulation 105:2288-2295.
21. Martin AF, et al. (2007) Expression and function of COOH-terminal myosin heavy chain isoforms in mouse smooth muscle. Am J Physiol 293:C238-C245.
22. 2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83:1325-1358.
23. Morano I, et al. (2000) Smooth-muscle contraction without smooth-muscle myosin. Nat Cell Biol 2:371-375.
24. Lofgren M, Ekblad E, Morano I, Arner A (2003) Nonmuscle myosin motor of smooth muscle. J Gen Physiol 121:301-310.
25. Rovner AS, Fagnant PM, Lowey S, Trybus KM (2002) The carboxyl-terminal isoforms of smooth muscle myosin heavy chain determine thick filament assembly properties. J Cell Biol 156:113-123.
26. Hypolite JA, et al. (2001) Regional variation in myosin isoforms and phosphorylation at the resting tone in urinary bladder smooth muscle. Am J Physiol 280:C254-C264.
27. Zhou Y, Dirksen WP, Babu GJ, Periasamy M (2003) Differential vasoconstrictions induced by angiotensin II: Role of AT1 and AT2 receptors in isolated C57BL/6J mouse blood vessels. Am J Physiol 285:H2797-H2803.
28. 2+ sensitivity of porcine renal artery. J Physiol (London) 516:55-65.