Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: A preliminary study

BMC Medical Genetics

Volumn 11, Issue 1, 2010, Pages

  Prasad, Pushplata ^a   Ambekar, Atul ^a   Vaswani, Meera ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR;

ADULT; ALCOHOLISM; ALLELE; ARTICLE; CHROMOSOME 11P; CONTROLLED STUDY; DNA SEQUENCE; GENE DELETION; GENE INSERTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; INDIAN; MALE; SINGLE NUCLEOTIDE POLYMORPHISM; TREND STUDY; ADOLESCENT; CASE CONTROL STUDY; CHROMOSOME 11; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; GENETICS; GENOTYPE; INDIA; MIDDLE AGED; REGRESSION ANALYSIS; RETROSPECTIVE STUDY; RISK; RISK FACTOR;

ADOLESCENT; ADULT; ALCOHOLISM; ALLELES; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 11; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; GENOTYPE; HAPLOTYPES; HUMANS; INDIA; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, DOPAMINE D2; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 77649157894     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-11-24     Document Type: Article

References (50)

1. Florez G, Saiz P, Garcia-Portilla P, A' lvarez S, Nogue'ýras L, Morales B, Alvarez V, Coto E, Bobes J. Association between the STin2 VNTR polymorphism of the serotonin transporter gene and treatment outcome in alcohol-dependent patients. Alcohol Alcohol 2008, 43:516-22.
2. McGue M. The behavioral genetics of alcoholism. Curr Dir Psychol Sci 1999, 8:109-15.
3. Edenberg HJ, Foround T. The genetics of alcoholism: identifying specific genes through family studies. Addict Biol 2006, 11:386-96. 10.1111/j.1369-1600.2006.00035.x, 16961766.
4. Koob GF, Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 2001, 24:97-129. 10.1016/S0893-133X(00)00195-0, 11120394.
5. Lingford-Hughes A, Nutt D. Neurobiology of addiction and implications for treatment. Br J Psychiatry 2003, 182:97-100. 10.1192/bjp.182.2.97, 12562734.
6. Munafò M, Johnstone E, Murphy M, Walton R. New directions in the genetic mechanisms underlying nicotine addiction. Addict Biol 2001, 6:109-17. 10.1080/13556210020040181, 11341850.
7. Dick DM, Foroud T. Candidate genes for alcohol dependence: a review of genetic evidence from human studies. Alcohol Clin Exp Res 2003, 27:868-79. 10.1097/01.ALC.0000065436.24221.63, 12766633.
8. Tupala E, Tiihonen J. Dopamine and alcoholism: neurobiological basis of ethanol abuse. Prog Neuropsychopharmacol Biol Psychiatry 2004, 28:1221-47. 10.1016/j.pnpbp.2004.06.022, 15588749.
9. Kienast T, Heinz A. Dopamine and the diseased brain. CNS Neurol Disord Drug Targets 2006, 5:109-31. 10.2174/187152706784111560, 16613557.
10. Hesselbrock V, Higuchi S, Soyka M. Recent developments in the genetics of alcohol-related phenotypes. Alcohol Clin Exp Res 2005, 29:1321-24. 10.1097/01.ALC.0000171955.52431.E7, 16088995.
11. Ferguson RA, Goldberg DM. Genetic markers of alcohol abuse. Clin Chim Acta 1997, 257:199-250. 10.1016/S0009-8981(96)06444-3, 9118563.
12. Goldman D. Candidate genes in alcoholism. Clin Neurosci 1995, 3:174-81.
13. Wildenberg E, Janssen RG, Hutchison KE, van Breukelen GJ, Wiers RW. Polymorphisms of the dopamine D4 receptor gene (DRD4 VNTR) and cannabinoid CB1 receptor gene (CNR1) are not strongly related to cue-reactivity after alcohol exposure. Addict Biol 2007, 12:210-20. 10.1111/j.1369-1600.2007.00064.x, 17508995.
14. Huang SY, Lin WW, Wan FJ, Chang AJ, Ko HC, Wang TJ, Wu PL, Lu RB. Monoamine oxidase-A polymorphisms might modify the association between the dopamine D2 receptor gene and alcohol dependence. J Psychiatry Neurosci 2007, 32:185-92. 1863553, 17476365.
15. Kim DJ, Park BL, Yoon S, Lee HK, Joe KH, Cheon YH, Gwon DH, Cho SN, Lee HW, NamGung S, Shin HD. 5' UTR polymorphism of dopamine receptor D1 (DRD1) associated with severity and temperament of alcoholism. Biochem Biophys Res Commun 2007, 357:1135-41. 10.1016/j.bbrc.2007.04.074, 17466946.
16. Sasabe T, Furukawa A, Matsusita S, Higuchi S, Ishiura S. Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients. Neurosci Lett 2007, 412:139-42. 10.1016/j.neulet.2006.10.064, 17196743.
17. Blomqvist O, Gelernter J, Kranzler HR. Family-based study of DRD2 alleles in alcohol and drug dependence. Am J Med Genet 2000, 96(Suppl 5):659-64. 10.1002/1096-8628(20001009)96:5<659::AID-AJMG12>3.0.CO;2-G, 11054774.
18. Gelernter J, Kranzler H. D2 dopamine receptor gene (DRD2) allele and haplotype frequencies in alcohol dependent and control subjects: no association with phenotype or severity of phenotype. Neuropsychopharmacology 1999, 20:640-49. 10.1016/S0893-133X(98)00110-9, 10327432.
19. Arinami T, Gao M, Hamaguchi H, Toru M. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum Mol Genet 1997, 6:577-82. 10.1093/hmg/6.4.577, 9097961.
20. Hauge XY, Grandy DK, Eubanks JH, Evans GA, Civelli O, Litt M. Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. Genomics 1991, 10:527-30. 10.1016/0888-7543(91)90431-D, 1679742.
21. Pohjalainen T, Rinne JO, Någren K, Lehikoinen P, Anttila K, Syvälahti EK, Hietala J. The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Mol Psychiatry 1998, 3:256-60. 10.1038/sj.mp.4000350, 9672901.
22. Laakso A, Pohjalainen T, Bergman J, Kajander J, Haaparante M, Solin O, Syvälahti E, Hietala J. The A1 allele of the human D2 dopamine receptor gene is associated with increased activity of striatal L-amino acid decarboxylase in healthy subjects. Pharmacogenet Genomics 2005, 15:387-91. 10.1097/01213011-200506000-00003, 15900211.
23. Ray R. The Extent Pattern and Trends of drug abuse in India: National Survey 2004, Ministry of Social Justice and Empowerment, Government of India and United Nations Office on Drugs and Crime, New Delhi.
24. Shaikh KJ, Naveen D, Sherrin T, Murthy A, Thennarasu K, Anand A, Benegal V, Jain S. Polymorphisms at the DRD2 locus in early-onset alcohol dependence in the Indian population. Addict Biol 2001, 6:331-35. 10.1080/13556210020077055, 11900611.
25. American Psychiatric Association Diagnostic and statistical manual of mental disorders 1994, American Psychiatric Press, Washington, DC, 4, American Psychiatric Association.
26. Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. Addiction 1993, 88(Suppl 6):791-804. 10.1111/j.1360-0443.1993.tb02093.x, 8329970.
27. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988, 16:1215. 10.1093/nar/16.3.1215, 334765, 3344216.
28. Itokawa M, Arinami T, Futamura N, Hamaguchi H, Toru M. A structural polymorphism of human dopamine D2 receptor, D2(Ser311-->Cys). Biochem Biophys Res Commun 1993, 196:1369-75. 10.1006/bbrc.1993.2404, 7902708.
29. Grandy DK, Zhang Y, Civelli O. PCR detection of the TaqA RFLP at the DRD2 locus. Hum Mol Genet 1993, 12:2197.
30. Gordon D, Finch SJ, Nothnagel M, Ott J. Power and sample size calculations for case-control genetic association tests when errors present: application to single nucleotide polymorphisms. Human Heredity 2002, 54:22-33. 10.1159/000066696, 12446984.
31. Gordon D, Levenstien MA, Finch SJ, Ott J. Errors and linkage disequilibrium interact multiplicatively when computing sample sizes for genetic case-control association studies. Pac Symp Biocomput 2003, 490-501.
32. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001, 68:978-89. 10.1086/319501, 1275651, 11254454.
33. Stephens M, Donnelly PP. Comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003, 73:1162-69. 10.1086/379378, 1180495, 14574645.
34. Dick DM, Rose RJ, Kaprio J. The next challenge for psychiatric genetics: characterizing the risk associated with identified genes. Ann Clin Psychiatry 2006, 18:223-31. 10.1080/10401230600948407, 1764634, 17162621.
35. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs AH, Cohn JB. Allelic association of human dopamine D2 receptor gene in alcoholism. J Am Med Assoc 1990, 263:2055-60.
36. Konishi T, Calvillo M, Leng AS, Lin KM, Wan YJ. Polymorphisms of the dopamine D2 receptor, serotonin transporter, and GABA(A) receptor beta(3) subunit genes and alcoholism in Mexican-Americans. Alcohol 2004, 32:45-52. 10.1016/j.alcohol.2003.11.002, 15066703.
37. Wiesbeck GA, Dürsteler-MacFarland KM, Wurst FM, Walter M, Petitjean S, Müller S, Wodarz N, Böning J. No association of dopamine receptor sensitivity in vivo with genetic predisposition for alcoholism and DRD2/DRD3 gene polymorphisms in alcohol dependence. Addict Biol 2006, 11:72-75. 10.1111/j.1369-1600.2006.00003.x, 16759339.
38. Jönsson EG, Nöthen MM, Grünhage F, Farde L, Nakashima Y, Propping P, Sedvall GC. Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol Psychiatry 1999, 4:290-96. 10.1038/sj.mp.4000532, 10395223.
39. Samochowiec J, Ladehoff M, Pelz J, Smolka M, Schmidt LG, Rommelspacher H, Finckh U. Predominant influence of the 3'-region of dopamine D2 receptor gene (DRD2) on the clinical phenotype in German alcoholics. Pharmacogenetics 2000, 10:471-5. 10.1097/00008571-200007000-00010, 10898116.
40. Samochowiec J, Kucharska-Mazur J, Grzywacz A, Jabłoński M, Rommelspacher H, Samochowiec A, Sznabowicz M, Horodnicki J, Sagan L, Pełka-Wysiecka J. Family-based and case-control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence. Neurosci Lett 2006, 410:1-5. 10.1016/j.neulet.2006.05.005, 17079080.
41. Johann M, Putzhammer A, Eichhammer P, Wodarz N. Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. Am J Med Genet B Neuropsychiatr Genet 2005, 132B:46-49. 10.1002/ajmg.b.30085, 15389757.
42. Hirvonen MM, Lumme V, Hirvonen J, Pesonen U, Någren K, Vahlberg T, Scheinin H, Hietala J. C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33(Suppl 4):630-6. 10.1016/j.pnpbp.2009.02.021, 19285111.
43. Konishi T, Luo HR, Calvillo M, Mayo MS, Lin KM, Wan YJ. ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles. Alcohol Clin Exp Res 2004, 28:1145-52. 10.1097/01.ALC.0000134231.48395.42, 15318112.
44. Neville MJ, Johnstone EC, Walton RT. Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum Mutat 2004, 23:540-45. 10.1002/humu.20039, 15146457.
45. Lucht M, Barnow S, Schroeder W, Grabe HJ, Rosskopf D, Brummer C, John U, Freyberger HJ, Herrmann FH. Alcohol consumption is associated with an interaction between DRD2 exon 8 A/A genotype and self-directedness in males. Neuropsychobiology 2007, 56:24-31. 10.1159/000109974, 17943029.
46. Noble EP. The D2 dopamine receptor gene: a review of association studies in alcoholism and phenotypes. Alcohol 1998, 16(Suppl1):33-45. 10.1016/S0741-8329(97)00175-4, 9650634.
47. Laruelle M, Gelernter J, Innis RB. D2 receptors binding potential is not affected by TaqI polymorphism at the D2 receptor gene. Mol Psychiatry 1998, 3:261-65. 10.1038/sj.mp.4000343, 9672902.
48. Munafo MR, Matheson IJ, Flint J. Association of the DRD2 gene TaqIA polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias. Mol Psychiatry 2007, 12:454-61.
49. Kidd KK, Morar B, Castiglione CM, Zhao H, Pakstis AJ, Speed WC, Bonne-Tamir B, Lu RB, Goldman D, Lee C, Nam YS, Grandy DK, Jenkins T, Kidd JR. A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus. Hum Genet 1998, 103:211-27. 10.1007/s004390050809, 9760208.
50. Prasad P, Thelma BK. Normative genetic profiles of some commonly investigated polymorphisms in candidate genes from north Indian and south Indian populations. Hum Biol 2007, 79:241-54. 10.1353/hub.2007.0033, 18027817.