The A1 allele of the human D2 dopamine receptor gene is associated with increased activity of striatal L-amino acid decarboxylase in healthy subjects

Pharmacogenetics and Genomics

Volumn 15, Issue 6, 2005, Pages 387-391

  Laakso, Aki ^a   Pohjalainen, Tiina ^a   Bergman, Jörgen ^b   Kajander, Jaana ^a,b   Haaparanta, Merja ^b   Solin, Olof ^b   Syvälahti, Erkka ^a   Hietala, Jarmo ^b,c  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU PET CENTRE   (Finland)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Association; DRD2; PET; Polymorphism; TaqIA RFLP; 18F fluorodopa

Indexed keywords

6 FLUORODOPA F 18; AMINE; AMINO ACID DECARBOXYLASE; AUTORECEPTOR; DOPA; DOPAMINE; DOPAMINE 2 RECEPTOR; LEVODOPA; PHENETHYLAMINE;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DOPAMINE METABOLISM; DOPAMINE UPTAKE; DRD2 GENE; ENZYME ACTIVITY; FEMALE; FINLAND; GENE; GENE EXPRESSION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HUMAN; HUMAN EXPERIMENT; ISOTOPE LABELING; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PUTAMEN; RECEPTOR DENSITY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; STRIATE CORTEX; TAQ1 GENE; VOLUNTEER;

EID: 20644453331     PISSN: 17446872     EISSN: None     Source Type: Journal    
DOI: 10.1097/01213011-200506000-00003     Document Type: Article

References (33)

1. 2 receptor gene in alcoholism. JAMA 1990; 263:2055-2060.
2. 2 dopamine receptor gene and alcoholism. JAMA 1993; 269:1673-1677.
3. Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJH, Comings DE. Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour. Pharmacogenetics 1995; 5: 121-141.
4. Comings DE. Why different rules are required for polygenic inheritance: lessons from studies of the DRD2 gene. Alcohol 1998; 16:61-70.
5. Noble EP. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet 2003; 1168:103-125.
6. Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, et al. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 2003; 12:205-216.
7. 2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 1991; 48:648-654.
8. Thompson J, Thomas N, Singleton A, Piggott M, Lloyd S, Perry EK, et al. D2 dopamine receptor gene (DRD2) Taq1A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics 1997; 7:479-484.
9. 2 receptor availability in healthy volunteers. Mol Psychiatry 1998; 3:256-260.
10. Jönsson EG, Nöthen MM, Grünhage F, Farde L, Nakashima Y, Propping P, et al. Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol Psychiatry 1999; 4:290-296.
11. Ritchie T, Noble EP. Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics. Neurochem Res 2003; 28:73-82.
12. 2 receptor gene. Mol Psychiatry 1998; 3:261-265.
13. Arinami T, Gao M, Hamaguchi H, Toru M. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum Mol Genet 1997; 6:577-582.
14. 2 receptor density in vivo. Pharmacogenetics 1999; 9:505-509.
15. Kehr W, Carlsson A, Lindqvist M, Magnusson T, Atack C. Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity. J Pharm Pharmacol 1972; 24:744-746.
16. Haubrich DR, Pflueger AB. The autoreceptor control of dopamine synthesis: an in vitro and in vivo comparison of dopamine agonists. Mol Pharmacol 1982; 21:114-120.
17. Zhu MY, Juorio AV, Paterson IA, Boulton AA. Regulation of aromatic L-amino acid decarboxylase by dopamine receptors in the rat brain. J Neurochem 1992; 58:637-641.
18. 3 receptor preferring antagonists differentially affect striatal dopamine release and metabolism in conscious rats. Eur J Pharmacol 1994; 261:327-331.
19. Cho S, Duchemin AM, Neff NH, Hadjiconstantinou M. Tyrosine hydroxylase, aromatic L-amino acid decarboxylase and dopamine metabolism after chronic treatment with dopaminergic drugs. Brain Res 1999; 830:237-245.
20. Cumming P, Gjedde A. Compartmental analysis of dopa decarboxylation in living brain from dynamic positron emission tomograms. Synapse 1998; 29:37-61.
21. 11C]dopa turnover in the rat striatum with infusion of L-tyrosine. J Neural Transm 1994; 95:1-15.
22. Hietala J, Syvälahti E, Vilkman H, Vuorio K, Räkkölä inen V, Bergman J, et al. Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia. Schizophr Res 1999; 35:41-50.
23. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983; 3:1-7.
24. Grandy DK, Zhang Y, Civelli O. PCR detection of the TaqA RFLP at the DRD2 locus. Hum Mol Genet 1993; 2:2197.
25. Laakso A, Vilkman H, Bergman J, Haaparanta M, Solin O, Syvälahti E, et al. Sex differences in striatal presynaptic dopamine synthesis capacity in healthy subjects. Biol Psychiatry 2002; 52:759-763.
26. Berry MD, Juorio AV, Li XM, Boulton AA. Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. Neurochem Res 1996; 21:1075-1087.
27. Barrio JR, Huang SC, Phelps ME. Biological imaging and the molecular basis of dopaminergic diseases. Biochem Pharmacol 1997; 54:341-348.
28. Premont RT, Gainetdinov RR, Caron MG. Following the trace of elusive amines. Proc Natl Acad Sci USA 2001; 98:9474-9475.
29. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, et al. Trace amines: Identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci USA 2001; 98:8966-8971.
30. Bunzow JR, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, Quigley DI, et al. Amphetamine 3,4-methylendioxyamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol Pharmacol 2001; 60: 1181-1188.
31. Comings DE, Blum K. Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog Brain Res 2000; 126:325-341.
32. Tiihonen J, Vilkman H, Räsänen P, Ryynänen OP, Hakko H, Bergman J, et al. Striatal presynaptic dopamine function in type 1 alcoholics measured with positron emission tomography. Mol Psychiatry 1998; 4:156-161.
33. Dubertret C, Gouya L, Hanoun N, Deybach JC, Ades J, Hamon M, et al. The 3′ region of the DRD2 gene is involved in genetic susceptibility to schizophrenia. Schizophr Res 2004; 67:75-85.