Polymorphisms of the dopamine D2 receptor, serotonin transporter, and GABAA receptor β3 subunit genes and alcoholism in Mexican-Americans

Alcohol

Volumn 32, Issue 1, 2004, Pages 45-52

  Konishi, Tamiko ^a   Calvillo, Maria ^a   Leng, Ai She ^a   Lin, Keh Ming ^a   Wan, Yu Jui Yvonne ^b  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol; Genetic risk factor; Mexican Americans; Neurotransmitter genes

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; DOPAMINE 2 RECEPTOR; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; SEROTONIN TRANSPORTER;

ADULT; ALCOHOLISM; BETA CHAIN; CONFERENCE PAPER; CONTROLLED STUDY; GENE FREQUENCY; GENE LINKAGE GROUP; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION GENETICS; RISK FACTOR; STATISTICAL SIGNIFICANCE;

ADULT; ALCOHOLISM; CARRIER PROTEINS; CHI-SQUARE DISTRIBUTION; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MEXICAN AMERICANS; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; PROTEIN SUBUNITS; RECEPTORS, DOPAMINE D2; RECEPTORS, GABA-A; RISK FACTORS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

INSERTION SEQUENCES;

EID: 1842585665     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.alcohol.2003.11.002     Document Type: Conference Paper

References (70)

1. Amadeo S., Abbar M., Fourcade M.L., Waksman G., Leroux M.G., Madec A., Selin M., Champiat J.C., Brethome A., Leclaire Y., Castelnau D., Venisse J.-L., Mallet J. D2 dopamine receptor gene and alcoholism. J Psychiatr Res. 27:1993;173-179.
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. 1994;Author, Washington, DC.
3. Arinami T., Gao M., Hamaguchi H., Toru M. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum Mol Genet. 6:1997;577-582.
4. Arinami T., Itokawa M., Komiyama T., Mitsushio H., Mori H., Mifune H., Hamaguchi H., Toru M. Association between severity of alcoholism and the A1 allele of the dopamine D2 receptor gene TaqI A RFLP in Japanese. Biol Psychiatry. 33:1993;108-114.
5. Blomqvist O., Ericson M., Johnson D.H., Engel J.A., Söderpalm B. Voluntary ethanol intake in the rat: effects of nicotine acetylcholine receptor blockade or subchronic nicotine treatment. Eur J Pharmacol. 314:1996;257-267.
6. 2 dopamine receptor gene with severe alcoholism. Alcohol. 8:1991;409-416.
7. Blum K., Noble E.P., Sheridan P.J., Montgomery A., Ritchie T., Jagadeeswaran P., Nogami H., Briggs A.H., Cohn J.B. Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA. 263:1990;2055-2060.
8. Breen G., Brown J., Maude S., Fox H., Collier D., Li T., Arranz M., Shaw D., StClair D. -141 C del/ins polymorphism of the dopamine receptor 2 gene is associated with schizophrenia in a British population. Am J Med Genet. 88:1999;407-410.
9. Caetano R., Clark C.L. Trends in alcohol consumption patterns among whites, blacks and Hispanics: 1984 and 1995. J Stud Alcohol. 59:1998;659-668.
10. Castiglione C.M., Deinard A.S., Speed W.C., Sirugo G., Rosenbaum H.C., Zhang Y., Grandy D.K., Grigorenko E.L., Bonne-Tamir B., Pakstis A.J., Kidd J.R., Kidd K.K. Evolution of haplotypes at the DRD2 locus. Am J Hum Genet. 57:1995;1145-1156.
11. Chen W.J., Chen C.-H., Huang J., Hsu Y.-P., Seow S.-V., Chen C.-C., Cheng A.T.A. Genetic polymorphisms of the promoter region of dopamine D2 receptor and dopamine transporter genes and alcoholism among four aboriginal groups and Han Chinese in Taiwan. Psychiatr Genet. 11:2001;187-195.
12. Collier D.A., Stober G., Li T., Heils A., Catalano M., Di Bella D., Arranz M.J., Murray R.M., Vallada H.P., Bengel D., Muller C.R., Roberts G.W., Smeraldi E., Kirov G., Sham P., Lesch K.-P. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry. 1:1996;453-460.
13. Comings D.E., Comings B.G., Muhleman D., Dietz G., Shahbahrami B., Tast D., Knell E., Kocsis P., Baumgarten R., Kovacs B.W., Levy D.L., Smith M., Kane J.M., Lieberman J.A., Klein D.N., MacMurray J., Tosk J., Sverd J., Gysin R., Flanagan S. The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA. 266:1991;1793-1800.
14. Cruz C., Camarena B., Mejia J.M., Paez F., Eroza V., Ramon De La Fuente J., Kershenobich D., Nicolini H. The dopamine D2 receptor gene TaqI A1 polymorphism and alcoholism in a Mexican population. Arch Med Res. 26:1995;421-426.
15. Gelernter J., Kranzler H., Cubells J.F. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet. 101:1997;243-246.
16. Gelernter J., O'Malley S., Risch N., Kranzler H.R., Krystal J., Merikangas K., Kennedy J.L., Kidd K.K. No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. JAMA. 266:1991;1801-1807.
17. Goldman D., Brown G.L., Albaugh B., Robin R., Goodson S., Trunzo M., Akhtar L., Lucas-Derse S., Long J., Linnoila M., Dean M. DRD2 dopamine receptor genotype, linkage disequilibrium, and alcoholism in American Indians and other populations. Alcohol Clin Exp Res. 17:1993;199-204.
18. Goldman D., Dean M., Brown G.L., Bolos A.M., Tokola R., Virkkunen M., Linnoila M. D2 dopamine receptor genotype and cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenylglycol in alcoholics in Finland and the United States. Acta Psychiatr Scand. 86:1992;351-357.
19. Gorwood P., Batel P., Adès J., Hamon M., Boni C. Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior. Biol Psychiatry. 48:2000;259-264.
20. Grandy D.K., Zhang Y., Civelli O. PCR detection of the TaqA RFLP at the DRD2 locus. Hum Mol Genet. 2:1993;2197.
21. Hallikainen T., Saito T., Lachman H.M., Volavka J., Pohjalainen T., Ryynanen O.P., Kauhanen J., Syvalahti E., Hietala J., Tiihonen J. Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior. Mol Psychiatry. 4:1999;385-388.
22. Hammoumi S., Payen A., Favre J.-D., Balmes J.-L., Benard J.-Y., Husson M., Ferrand J.-P., Martin J.-P., Daoust M. Does the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence? Alcohol. 17:1999;107-112.
23. Hanis C.L., Hewett-Emmett D., Bertin T.K., Schull W.J. Origins of U.S. Hispanics. Implications for diabetes. Diabetes Care. 14:1991;618-627.
24. A receptor β2 subunit. J Neurochem. 62:1994;10-16.
25. Hauge X.Y., Grandy D.K., Eubanks J.H., Evans G.A., Civelli O., Litt M. Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. Genomics. 10:1991;527-530.
26. Hornung J.P., De Tribolet N. Distribution of GABA-containing neurons in human frontal cortex: a quantitative immunocytochemical study. Anat Embryol (Berl). 189:1994;139-145.
27. Howard L.A., Micu A.L., Sellers E.M., Tyndale R.F. Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver. J Pharmacol Exp Ther. 299:2001;542-550.
28. Ishiguro H., Arinami T., Saito T., Akazawa S., Enomoto M., Mitushio H., Fujishiro H., Tada K., Akimoto Y., Mifune H., Shioduka S., Hamaguchi H., Toru M., Shibuya H. Association study between the -141C Ins/Del and TaqI A polymorphisms of the dopamine D2 receptor gene and alcoholism. Alcohol Clin Exp Res. 22:1998;845-848.
29. Ishiguro H., Saito T., Akazawa S., Mitushio H., Tada K., Enomoto M., Mifune H., Toru M., Shibuya H., Arinami T. Association between drinking-related antisocial behavior and a polymorphism in the serotonin transporter gene in a Japanese population. Alcohol Clin Exp Res. 23:1999;1281-1284.
30. Istvan J., Matarazzo J.D. Tobacco, alcohol, and caffeine use: a review of their interrelationships. Psychol Bull. 95:1984;301-326.
31. A receptor gamma 2-subunit in mice by alternative splicing. J Neurochem. 56:1991;713-715.
32. *2 and CYP2E1 c2 alleles increase the risk of alcoholism in Mexican American men. Exp Mol Pathol. 74:2003;183-189.
33. Konishi T., Smith J.L., Lin K.M., Wan Y.J. Influence of genetic admixture on polymorphisms of alcohol-metabolizing enzymes: analyses of mutations on the CYP2E1, ADH2, ADH3 and ALDH2 genes in a Mexican-American population living in the Los Angeles area. Alcohol Alcohol. 38:2003;93-94.
34. Koob G.F., Swerdlow N.R. The functional output of the mesolimbic dopamine system. Ann N Y Acad Sci. 537:1988;216-227.
35. Kranzler H., Lappalainen J., Nellissery M., Gelernter J. Association study of alcoholism subtypes with a functional promoter polymorphism in the serotonin transporter protein gene. Alcohol Clin Exp Res. 26:2002;1330-1335.
36. Lahiri D.K., Nurnberger J.I. Jr. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 19:1991;5444.
37. Lê A.D., Corrigall W.A., Harding J.W.S., Juzytsch W., Li T.-K. Involvement of nicotinic receptors in alcohol self-administration. Alcohol Clin Exp Res. 24:2000;155-163.
38. LeMarquand D., Pihl R.O., Benkelfat C. Serotonin and alcohol intake, abuse, and dependence: clinical evidence. Biol Psychiatry. 36:1994;326-337.
39. Lesch K.-P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Muller C.R., Hamer D.H., Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 274:1996;1527-1531.
40. A receptor heterogeneity. Nature. 335:1988;76-79.
41. Lichtermann D., Hranilovic D., Trixler M., Franke P., Jernej B., Delmo C.D., Knapp M., Schwab S.G., Maier W., Wildenauer D.B. Support for allelic association of a polymorphic site in the promoter region of the serotonin transporter gene with risk for alcohol dependence. Am J Psychiatry. 157:2000;2045-2047.
42. Matsushita S., Yoshino A., Murayama M., Kimura M., Muramatsu T., Higuchi S. Association study of serotonin transporter gene regulatory region polymorphism and alcoholism. Am J Med Genet. 105:2001;446-450.
43. Meltzer H., Arora R.C. Genetic control of serotonin uptake in blood platelets: a twin study. Psychiatry Res. 24:1988;263-269.
44. Mendoza R., Wan Y.-J.Y., Poland R.E., Smith M., Zheng Y., Berman N., Lin K.-M. CYP2D6 polymorphism in a Mexican American population. Clin Pharmacol Ther. 70:2001;552-560.
45. 3 (GABRβ3) locus in the Angelman/Prader-Willi region (AS/PWS) of chromosome 15. Hum Mol Genet. 1:1992;67.
46. Nakamura T., Muramatsu T., Ono Y., Matsushita S., Higuchi S., Muzushima H., Yoshimura K., Kanba S., Asai M. Serotonin transporter gene regulatory region polymorphism and anxiety-related traits in the Japanese. Am J Med Genet. 74:1997;544-545.
47. A receptor determined by electron microscopic image analysis. J Neurochem. 62:1994;815-818.
48. Noble E.P. DRD2 gene and alcoholism. Science. 281:1998;1287-1288.
49. Noble E.P., Syndulko K., Fitch R.J., Ritchie T., Bohlman M.C., Guth P., Sheridan P.J., Montgomery A., Heinzmann C., Sparkes R.S. D2 dopamine receptor TaqI A alleles in medically ill alcoholic and nonalcoholic patients. Alcohol Alcohol. 29:1994;729-744.
50. 3 subunit genes and alcoholism. Psychiatry Res. 81:1998;133-147.
51. O'Hara B.F., Smith S.S., Bird G., Persico A.M., Suarez B.K., Cutting G.R., Uhl G.R. Dopamine D2 receptor RFLPs, haplotypes and their association with substance use in black and Caucasian research volunteers. Hum Hered. 43:1993;209-218.
52. Oliveri R.L., Annesi G., Zappia M., Civitelli D., De Marco E.V., Pasqua A.A., Annesi F., Spadafora P., Gambardella A., Nicoletti G., Branca D., Caracciolo M., Aguglia U., Quattrone A. The dopamine D2 receptor gene is a susceptibility locus for Parkinson's disease. Mov Disord. 15:2000;127-131.
53. Owens M.J., Nemeroff C.B. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem. 40:1994;288-295.
54. Parsian A., Cloninger C.R. Serotonergic pathway genes and subtypes of alcoholism: association studies. Psychiatr Genet. 11:2001;89-94.
55. Parsian A., Cloninger C.R., Zhang Z.H. Functional variant in the DRD2 receptor promoter region and subtypes of alcoholism. Am J Med Genet. 96:2000;407-411.
56. Parsian A., Todd R.D., Devor E.J., O'Malley K.L., Suarez B.K., Reich T., Cloninger C.R. Alcoholism and alleles of the human D2 dopamine receptor locus. Studies of association and linkage. Arch Gen Psychiatry. 48:1991;655-663.
57. Potthoff A.D., Ellison G., Nelson L. Ethanol intake increases during continuous administration of amphetamine and nicotine, but not several other drugs. Pharmacol Biochem Behav. 18:1983;489-493.
58. Radel M., Goldman D. Pharmacogenetics of alcohol response and alcoholism: the interplay of genes and environmental factors in thresholds for alcoholism. Drug Metab Dispos. 29:(4 Pt 2):2001;489-494.
59. Sander T., Harms H., Dufeu P., Kuhn S., Hoehe M., Lesch K.-P., Rommelspacher H., Schmidt L.G. Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. Biol Psychiatry. 43:1998;908-912.
60. Sander T., Harms H., Lesch K.-P., Dufeu P., Kuhn S., Hoehe M., Rommelspacher H., Schmidt L.G. Association analysis of a regulatory variation of the serotonin transporter gene with severe alcohol dependence. Alcohol Clin Exp Res. 21:1997;1356-1359.
61. Sander T., Ladehoff M., Samochowiec J., Finckh U., Rommelspacher H., Schmidt L.G. Lack of an allelic association between polymorphisms of the dopamine D2 receptor gene and alcohol dependence in the German population. Alcohol Clin Exp Res. 23:1999;578-581.
62. Smith S.S., O'Hara B.F., Persico A.M., Gorelick D.A., Newlin D.B., Vlahov D., Solomon L., Pickens R., Uhl G.R. Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers. Arch Gen Psychiatry. 49:1992;723-727.
63. Sobell L.C., Sobell M.B., Kozlowski L.T., Toneatto T. Alcohol or tobacco research versus alcohol and tobacco research. Br J Addict. 85:1990;263-269.
64. Takahashi T., Lasker J.M., Rosman A.S., Lieber C.S. Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology. 17:1993;236-245.
65. Thompson M.D., Gonzalez N., Nguyen T., Comings D.E., George S.R., O'Dowd B.F. Serotonin transporter gene polymorphisms in alcohol dependence. Alcohol. 22:2000;61-67.
66. Turner E., Ewing J., Shilling P., Smith T.L., Irwin M., Schuckit M., Kelsoe J.R. Lack of association between an RFLP near the D2 dopamine receptor gene and severe alcoholism. Biol Psychiatry. 31:1992;285-290.
67. Twitchell G.R., Hanna G.L., Cook E.H., Stoltenberg S.F., Fitzgerald H.E., Zucker R.A. Serotonin transporter promoter polymorphism genotype is associated with behavioral disinhibition and negative affect in children of alcoholics. Alcohol Clin Exp Res. 25:2001;953-959.
68. 3 subunit to the Angelman/Prader-Willi region of human chromosome 15. Am J Hum Genet. 49:1991;330-337.
69. Wan Y.J., Poland R.E., Lin K.M. Genetic polymorphism of CYP2E1, ADH2, and ALDH2 in Mexican-Americans. Genet Test. 2:1998;79-83.
70. A/benzodiazepine receptors. EMBO J. 9:1990;3261-3267.