PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the warburg effect

Science Signaling

Volumn 2, Issue 97, 2009, Pages

  Dang, Chi V ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 1; GLUTAMINE; LACTATE DEHYDROGENASE; PHOSPHOENOLPYRUVATE; PYRUVATE KINASE; PYRUVATE KINASE M 2; UNCLASSIFIED DRUG; TYROSINE;

CANCER CELL; CELL METABOLISM; CELL PROLIFERATION; CELL STIMULATION; CITRIC ACID CYCLE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SYNTHESIS; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HYPOXIC CELL; MUTATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; WARBURG EFFECT; WILD TYPE; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CHEMISTRY; METABOLISM; NEOPLASM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN MULTIMERIZATION;

ANIMALS; CELL PROLIFERATION; CITRIC ACID CYCLE; GLUTAMINE; GLYCOLYSIS; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PYRUVATE KINASE; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; SIGNAL TRANSDUCTION; TYROSINE;

EID: 77449160135     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.297pe75     Document Type: Review

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23. 23. I thank A. Le, L. Gardner, and R. DeBerardinis for comments. Supported by the Leukemia and Lymphoma Society, NIH grants CA51497 and CA57341, and the AACR Stand Up to Cancer (SU2C) initiative. C.V.D. is a consultant for Agios Pharmaceuticals Inc