메뉴 건너뛰기




Volumn 2, Issue 91, 2009, Pages

Apoptosis: Calling time on apoptosome activity

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 9; HOLOENZYME; PROTEINASE;

EID: 77449158449     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.291pe62     Document Type: Short Survey
Times cited : (9)

References (28)
  • 2
    • 33947426526 scopus 로고    scopus 로고
    • The CASBAH: A searchable database of caspase substrates
    • A. U. Luthi, S. J. Martin, The CASBAH: A searchable database of caspase substrates. Cell Death Differ. 14, 641-650 (2007).
    • (2007) Cell Death Differ. , vol.14 , pp. 641-650
    • Luthi, A.U.1    Martin, S.J.2
  • 3
    • 49549113643 scopus 로고    scopus 로고
    • Global mapping of the topography and magnitude of proteolytic events in apoptosis
    • M. M. Dix, G. M. Simon, B. F. Cravatt, Global mapping of the topography and magnitude of proteolytic events in apoptosis. Cell 134, 679-691 (2008).
    • (2008) Cell , vol.134 , pp. 679-691
    • Dix, M.M.1    Simon, G.M.2    Cravatt, B.F.3
  • 5
    • 39449093070 scopus 로고    scopus 로고
    • Caspase activation cascades in apoptosis
    • S. E. Logue, S. J. Martin, Caspase activation cascades in apoptosis. Biochem. Soc. Trans. 36, 1-9 (2008).
    • (2008) Biochem. Soc. Trans. , vol.36 , pp. 1-9
    • Logue, S.E.1    Martin, S.J.2
  • 7
    • 0035369143 scopus 로고    scopus 로고
    • The mitochondrial apoptosome: A killer unleashed by the cytochrome seas
    • DOI 10.1016/S0968-0004(01)01844-8, PII S0968000401018448
    • C. Adrain, S. J. Martin, The mitochondrial apoptosome: A killer unleashed by the cytochrome seas. Trends Biochem. Sci. 26, 390-397 (2001). (Pubitemid 32530658)
    • (2001) Trends in Biochemical Sciences , vol.26 , Issue.6 , pp. 390-397
    • Adrain, C.1    Martin, S.J.2
  • 8
    • 0344908231 scopus 로고    scopus 로고
    • Portrait of a killer: The mitochondrial apoptosome emerges from the shadows
    • M. M. Hill, C. Adrain, S. J. Martin, Portrait of a killer: The mitochondrial apoptosome emerges from the shadows. Mol. Interv. 3, 19-26 (2003).
    • (2003) Mol. Interv. , vol.3 , pp. 19-26
    • Hill, M.M.1    Adrain, C.2    Martin, S.J.3
  • 9
    • 67650455882 scopus 로고    scopus 로고
    • The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
    • S. Malladi, M. Challa-Malladi, H. O. Fearnhead, S. B. Bratton, The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J. 28, 1916-1925 (2009).
    • (2009) EMBO J. , vol.28 , pp. 1916-1925
    • Malladi, S.1    Challa-Malladi, M.2    Fearnhead, H.O.3    Bratton, S.B.4
  • 10
    • 41149152733 scopus 로고    scopus 로고
    • How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
    • J. E. Chipuk, D. R. Green, How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol. 18, 157-164 (2008).
    • (2008) Trends Cell Biol. , vol.18 , pp. 157-164
    • Chipuk, J.E.1    Green, D.R.2
  • 11
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • P. Li, D. Nijhawan, I. Budihardjo, S. M. Srinivasula, M. Ahmad, E. S. Alnemri, X.Wang, Cytochrome c and dATP-dependent formation of Apaf-1/caspase- 9 complex initiates an apoptotic protease cascade. Cell 91, 479-489 (1997). (Pubitemid 27508237)
    • (1997) Cell , vol.91 , Issue.4 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 12
  • 13
    • 33646024628 scopus 로고    scopus 로고
    • The apoptosome activates caspase-9 by dimerization
    • C. Pop, J. Timmer, S. Sperandio, G. S. Salvesen, The apoptosome activates caspase-9 by dimerization. Mol. Cell 22, 269-275 (2006).
    • (2006) Mol. Cell , vol.22 , pp. 269-275
    • Pop, C.1    Timmer, J.2    Sperandio, S.3    Salvesen, G.S.4
  • 14
    • 33845501864 scopus 로고    scopus 로고
    • Apoptosome: A platform for the activation of initiator caspases
    • DOI 10.1038/sj.cdd.4402028, PII 4402028
    • Q. Bao, Y. Shi, Apoptosome: A platform for the activation of initiator caspases. Cell Death Differ. 14, 56-65 (2007). (Pubitemid 44911894)
    • (2007) Cell Death and Differentiation , vol.14 , Issue.1 , pp. 56-65
    • Bao, Q.1    Shi, Y.2
  • 15
    • 34447565905 scopus 로고    scopus 로고
    • Caspase-9 cleavage, do you need it?
    • D. Twiddy, K. Cain, Caspase-9 cleavage, do you need it? Biochem. J. 405, e1-e2 (2007).
    • (2007) Biochem. J. , vol.405
    • Twiddy, D.1    Cain, K.2
  • 16
    • 0033573020 scopus 로고    scopus 로고
    • Caspase-9 and APAF-1 form an active holoenzyme
    • DOI 10.1101/gad.13.24.3179
    • J. Rodriguez, Y. Lazebnik, Caspase-9 and APAF- 1 form an active holoenzyme. Genes Dev. 13, 3179-3184 (1999). (Pubitemid 30030439)
    • (1999) Genes and Development , vol.13 , Issue.24 , pp. 3179-3184
    • Rodriguez, J.1    Lazebnik, Y.2
  • 18
    • 34347209876 scopus 로고    scopus 로고
    • Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9
    • DOI 10.1042/BJ20070288
    • J. B. Denault, B. P. Eckelman, H. Shin, C. Pop, G. S. Salvesen, Caspase 3 attenuates XIAP (Xlinked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem. J. 405, 11-19 (2007). (Pubitemid 46999920)
    • (2007) Biochemical Journal , vol.405 , Issue.1 , pp. 11-19
    • Denault, J.-B.1    Eckelman, B.P.2    Shin, H.3    Pop, C.4    Salvesen, G.S.5
  • 19
    • 0034105784 scopus 로고    scopus 로고
    • Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes
    • K. Cain, S. B. Bratton, C. Langlais, G. Walker, D. G. Brown, X. M. Sun, G. M. Cohen, Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. J. Biol. Chem. 275, 6067-6070 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 6067-6070
    • Cain, K.1    Bratton, S.B.2    Langlais, C.3    Walker, G.4    Brown, D.G.5    Sun, X.M.6    Cohen, G.M.7
  • 20
    • 25444528729 scopus 로고    scopus 로고
    • The GAPs, GEFs, and GDIs of heterotrimeric G-protein á subunits
    • D. P. Siderovski, F. S. Willard, The GAPs, GEFs, and GDIs of heterotrimeric G-protein á subunits. Int. J. Biol. Sci. 1, 51-66 (2005).
    • (2005) Int. J. Biol. Sci. , vol.1 , pp. 51-66
    • Siderovski, D.P.1    Willard, F.S.2
  • 21
    • 7244223248 scopus 로고    scopus 로고
    • Cell differentiation: Reciprocal regulation of Apaf-1 and the inhibitor of apoptosis proteins
    • D. Lindholm, U. Arumae, Cell differentiation: Reciprocal regulation of Apaf-1 and the inhibitor of apoptosis proteins. J. Cell Biol. 167, 193-195 (2004).
    • (2004) J. Cell Biol. , vol.167 , pp. 193-195
    • Lindholm, D.1    Arumae, U.2
  • 22
    • 33646087420 scopus 로고    scopus 로고
    • The apoptosome: Physiological, developmental, and pathological modes of regulation
    • Z. T. Schafer, S. Kornbluth, The apoptosome: Physiological, developmental, and pathological modes of regulation. Dev. Cell 10, 549-561 (2006).
    • (2006) Dev. Cell , vol.10 , pp. 549-561
    • Schafer, Z.T.1    Kornbluth, S.2
  • 23
    • 27944469109 scopus 로고    scopus 로고
    • Regulation of caspase 9 through phosphorylation by protein kinase C ζ in response to hyperosmotic stress
    • S. C. Brady, L. A. Allan, P. R. Clarke, Regulation of caspase 9 through phosphorylation by protein kinase C ζ in response to hyperosmotic stress. Mol. Cell. Biol. 25, 10543-10555 (2005).
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 10543-10555
    • Brady, S.C.1    Allan, L.A.2    Clarke, P.R.3
  • 25
    • 0036187036 scopus 로고    scopus 로고
    • Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
    • D. Acehan, X. Jiang, D. G. Morgan, J. E. Heuser, X.Wang, C.W. Akey, Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation. Mol. Cell 9, 423-432 (2002).
    • (2002) Mol. Cell , vol.9 , pp. 423-432
    • Acehan, D.1    Jiang, X.2    Morgan, D.G.3    Heuser, J.E.4    Wang, X.5    Akey, C.W.6
  • 26
    • 27644483812 scopus 로고    scopus 로고
    • A structure of the human apoptosome at 12.8 Å resolution provides insights into this cell death platform
    • X.Yu, D. Acehan, J. F. Menetret, C. R. Booth, S. J. Ludtke, S. J. Riedl, Y. Shi, X.Wang, C.W. Akey, A structure of the human apoptosome at 12.8 Å resolution provides insights into this cell death platform. Structure 13, 1725-1735 (2005).
    • (2005) Structure , vol.13 , pp. 1725-1735
    • Yu, X.1    Acehan, D.2    Menetret, J.F.3    Booth, C.R.4    Ludtke, S.J.5    Riedl, S.J.6    Shi, Y.7    Wang, X.8    Akey, C.W.9
  • 27
    • 0033596980 scopus 로고    scopus 로고
    • An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
    • H. Zou, Y. Li, X. Liu, X. Wang, An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 274, 11549-11556 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 11549-11556
    • Zou, H.1    Li, Y.2    Liu, X.3    Wang, X.4
  • 28
    • 77953659279 scopus 로고    scopus 로고
    • Work in the Martin laboratory is supported by grants from Science Foundation Ireland (SRCG20336 and 08/IN.1/B2031) and the Wellcome Trust UK (082749). C.A. is supported by a longterm fellowship from The International Human Frontier Science Program Organization
    • Work in the Martin laboratory is supported by grants from Science Foundation Ireland (SRCG20336 and 08/IN.1/B2031) and the Wellcome Trust UK (082749). C.A. is supported by a longterm fellowship from The International Human Frontier Science Program Organization.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.