Cell differentiation: Reciprocal regulation of Apaf-1 and the inhibitor of apoptosis proteins

Journal of Cell Biology

Volumn 167, Issue 2, 2004, Pages 193-195

  Lindholm, Dan ^a,b,c   Arumäe, Urmas ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; INHIBITOR OF APOPTOSIS PROTEIN;

BONE MARROW CELL; BRAIN; CELL DAMAGE; CELL DEATH; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; FEEDBACK SYSTEM; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GLIA CELL; HUMAN; MITOCHONDRION; MITOSIS; MOLECULAR MECHANICS; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; REGULATORY MECHANISM; REVIEW; TUMOR CELL;

ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 9; CASPASES; CELL DIFFERENTIATION; CYTOCHROMES C; HUMANS; MODELS, BIOLOGICAL; NEURONS; PROTEINS;

INTRACISTERNAL A-PARTICLES;

EID: 7244223248     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200409171     Document Type: Review

References (23)

1. Acehan, D., X. Jiang, D. Gene Morgan, J.E. Heuser, X. Wang, and C.W. Akey. 2002. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol. Cell. 9:423-432
2. Cao, G., M. Xiao, F. Sun, X. Xiao, W. Pei, J. Li, S.U. Graham, R.P. Simon, and J. Chen. 2004. Cloning of a novel Apaf-1-interacting protein: a potent suppressor of apoptosis and ischemic neuronal cell death. J. Neurosci. 24:6189-6201.
3. Cecconi, F., G. Alvarez-Bolado, B.I. Meyer, K.A. Roth, and P. Gruss. 1998. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell. 94:727-737.
4. Cozzolino, M., E. Ferraro, A. Ferri, D. Rigamonti, F. Quondamatteo, H. Ding, Z.S. Xu, F. Ferrari, D.F. Angelini, G. Rotilio, et al. 2004. Apoptosome inactivation rescues proneural and neural cells from neurodegeneration. Cell Death Differ. In press.
5. Danial, N., and S.J. Korsmeyer. 2004. Cell death: critical control points. Cell. 116:205-219.
6. Deshmukh, M., C. Du, X. Wang, and E.M. Johnson Jr. 2002. Exogenous Smac induces competence and permits caspase activation in sympathetic neurons. J. Neurosci. 22:8018-8027.
7. Du, C., M. Fang, Y. Li, L. Li, and X. Wang. 2000. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 102:33-42.
8. Ekert, P.G., S.H. Read, J. Silke, V.S. Marsden, H. Kaufmann, C.J. Hawkins, R. Gerl, S. Kumar, and D.L. Vaux. 2004. Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die. J. Cell Biol. 165:835-842.
9. Harlin, H., S.B. Reffey, C.S. Duckett, T. Lindsten, and C.B. Thompson. 2001. Characterization of XIAP-deficient mice. Mol. Cell. Biol. 21:3604-3608.
10. Hill, M.M., C. Adrain, P.J. Duriez, E.M. Creagh, and S. Martin. 2004. Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes. EMBO J. 23:2134-2145.
11. Li, P., D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri, and X. Wang. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:479-489.
12. Lindholm, D., O. Eriksson, and L. Korhonen. 2004. Mitochondrial proteins in neuronal degeneration. Biochem. Biophys. Res. Commun. 321:753-758.
13. Marsden, V.S., L. O'Connor, L.A. O'Reilly, J. Silke, D. Metcalf, P.G. Ekert, D.C. Huang, F. Cecconi, K. Kuida, K.J. Tomaselli, et al. 2002. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature. 419:634-637.
14. Okada, H., W.K. Suh, J. Jin, M. Woo, C. Du, A. Elia, G.S. Duncan, A. Wakeham, A. Itie, S.W. Lowe, et al. 2002. Generation and characterization of Smac/DIABLO-deficient mice. Mol. Cell. Biol. 22:3509-3517.
15. Perrelet, D., A. Ferri, P. Liston, P. Muzzin, R.G. Korneluk, and A.C. Kato. 2002. IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo. Nat. Cell Biol. 4:175-179.
16. Potts, P.R., S. Singh, M. Knezek, C.B. Thompson, and M. Deshmukh. 2003. Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J. Cell Biol. 163:789-799.
17. Schimmer, A., K. Welsh, C. Pinilla, Z. Wang, M. Krajewska, M.-J. Bonneau, I.M. Pedersen, S. Kitada, F.L. Scott, B. Bailly-Maitre, et al. 2004. Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell. 5:25-35.
18. Trapp, T., L. Korhonen, M. Besselmann, R. Martinez, E.A. Mercer, and D. Lindholm. 2003. Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia. Mol. Cell. Neurosci. 23:302-313.
19. Vyas, S., P. Juin, D. Hancock, Y. Suzuki, R. Takahashi, A. Triller, and G. Evan. 2004. Differentiation dependent sensitivity to apoptogenic factors in PC12 cells. J. Biol. Chem. 279:30983-30993.
20. Wright, K.M., M.W. Linhoff, P. Ryan Potts, and M. Deshmukh. 2004. Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis. J. Cell Biol. 167:303-313.
21. Yoshida, H., Y.Y. Kong, R. Yoshida, A.J. Elia, A. Hakem, R. Hakem, J.M. Penninger, and T.W. Mak. 1998. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell. 94:739-750.
22. Yu, L.-Y., E. Jokitalo, Y.-F. Sun, P. Mehlen, D. Lindholm, M. Saarma, and U. Arumae. 2003. GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway. J. Cell Biol. 163:987-997.
23. Zhou, H., W.J. Henzel, X. Liu, A. Lutschg, and X. Wang. 1997. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 90:405-413.