Phenyl N-tert-butylnitrone, a free radical scavenger, reduces mechanical allodynia in chemotherapy-induced neuropathic pain in rats

Anesthesiology

Volumn 112, Issue 2, 2010, Pages 432-439

  Kim, Hee Kee ^a   Zhang, Yan Ping ^a   Gwak, Young Seob ^b   Abdi, Salahadin ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; N TERT BUTYL ALPHA PHENYLNITRONE; PACLITAXEL; SCAVENGER; AMINE OXIDE; ANTINEOPLASTIC AGENT; HYPNOTIC SEDATIVE AGENT; NEUROPROTECTIVE AGENT; PHENYL-N-TERT-BUTYLNITRONE;

ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; MALE; MECHANICAL STIMULATION; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; OXIDATIVE STRESS; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RAT; ANIMAL; BODY WEIGHT; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; PAIN; PAIN ASSESSMENT; PSYCHOLOGICAL ASPECT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BEHAVIOR, ANIMAL; BODY WEIGHT; CYCLIC N-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; HYPNOTICS AND SEDATIVES; MALE; NEUROPROTECTIVE AGENTS; PACLITAXEL; PAIN; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77449134436     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3181ca31bd     Document Type: Article

References (48)

1. Vyas DM, Kadow JF: Paclitaxel: A unique tubulin interacting anticancer agent. Prog Med Chem 1995; 32:289-337
2. Wall JE, Mandrell BN, Jenkins JJ III, Smiley LM, Pratt CB: Effectiveness of paclitaxel in treating papillary serous carcinoma of the peritoneum in an adolescent. Am J Obstet Gynecol 1995; 172:1049-1052
3. Carlier MF, Pantaloni D: Taxol effect on tubulin polymerization and associated guanosine 5'-triphosphate hydrolysis. Biochemistry 1983; 22:4814-4822
4. Schiff PB, Fant J, Horwitz SB: Promotion of microtubule assembly in vitro by taxol. Nature 1979; 277:665-667
5. Dougherty PM, Cata JP, Cordella JV, Burton A, Weng HR: Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients. Pain 2004; 109:132-142
6. Wiernik PH, Schwartz EL, Strauman JJ, Dutcher JP, Lipton RB, Paietta E: Phase I clinical and pharmacokinetic study of taxol. Cancer Res 1987; 47:2486-2493
7. Forsyth PA, Balmaceda C, Peterson K, Seidman AD, Brasher P, DeAngelis LM: Prospective study of paclitaxel-induced peripheral neuropathy with quantitative sensory testing. J Neurooncol 1997; 35:47-53
8. Wolf S, Barton D, Kottschade L, Grothey A, Loprinzi C: Chemotherapy-induced peripheral neuropathy: Prevention and treatment strategies. Eur J Cancer 2008; 44:1507-1515
9. Jenner P: Oxidative damage in neurodegenerative disease. Lancet 1994; 344:796-798
10. Lewen A, Matz P, Chan PH: Free radical pathways in CNS injury. J Neurotrauma 2000; 17:871-890
11. Contestabile A: Oxidative stress in neurodegeneration: Mechanisms and therapeutic perspectives. Curr Top Med Chem 2001; 1:553-568
12. Kim HK, Park SK, Zhou JL, Taglialatela G, Chung K, Cog-geshall RE, Chung JM: Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain 2004; 111:116-124
13. Lee I, Kim HK, Kim JH, Chung K, Chung JM: The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. Pain 2007; 133:9-17
14. Hacimuftuoglu A, Handy CR, Goettl VM, Lin CG, Dane S, Stephens RL Jr: Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice. Behav Brain Res 2006; 173:211-216
15. Wang J, Cochran V, Abdi S, Chung JM, Chung K, Kim HK: Phenyl N-t-butylnitrone, a reactive oxygen species scavenger, reduces zymosan-induced visceral pain in rats. Neu-rosci Lett 2008; 439:216-219
16. Tal M: A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy. Neuroreport 1996; 7:1382-1384
17. Khalil Z, Khodr B: A role for free radicals and nitric oxide in delayed recovery in aged rats with chronic constriction nerve injury. Free Radic Biol Med 2001; 31:430-439
18. Kim HK, Kim JH, Gao X, Zhou JL, Lee I, Chung K, Chung JM: Analgesic effect of vitamin E is mediated by reducing central sensitization in neuropathic pain. Pain 2006; 122: 53-62
19. Schwartz ES, Lee I, Chung K, Chung JM: Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice. Pain 2008; 138:514-524
20. Dickenson A, Haley J, Schachter M, Chapman V: Electro-physiological approaches to the study of bradykinin and nitric oxide in inflammatory pain. Agents Actions Suppl 1992; 38(pt 2):358-365
21. Coderre TJ, Xanthos DN, Francis L, Bennett GJ: Chronic post-ischemia pain (CPIP): A novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat. Pain 2004; 112:94-105
22. Polomano RC, Mannes AJ, Clark US, Bennett GJ: A painful peripheral neuropathy in the rat produced by the chemo-therapeutic drug, paclitaxel. Pain 2001; 94:293-304
23. Kirk RE: Experimental designs: An overview. In: Experimental Design: Procedures for the Behavioral Sciences, 3rd edition. Edited by Anonymous. Pacific Grove, California, Brooks-Cole, 1995, pp 37-40
24. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL: Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53:55-63
25. Dixon WJ: Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 1980; 20:441-462
26. Devor M, Zalkind V: Reversible analgesia, atonia, and loss of consciousness on bilateral intracerebral microinjection of pentobarbital. Pain 2001; 94:101-112
27. Wagner R, Heckman HM, Myers RR: Wallerian degeneration and hyperalgesia after peripheral nerve injury are glutathione-dependent. Pain 1998; 77:173-179
28. Coyle JT, Puttfarcken P: Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993; 262:689-695
29. Gotz ME, Kunig G, Riederer P, Youdim MB: Oxidative stress: Free radical production in neural degeneration. Pharmacol Ther 1994; 63:37-122
30. Khalil Z, Liu T, Helme RD: Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal hyperalgesia in rats with chronic constriction injury. Pain 1999; 79:31-37
31. Cizkova D, Lukacova N, Marsala M, Marsala J: Neuropathic pain is associated with alterations of nitric oxide synthase immunoreactivity and catalytic activity in dorsal root ganglia and spinal dorsal horn. Brain Res Bull 2002; 58:161-171
32. Twining CM, Sloane EM, Milligan ED, Chacur M, Martin D, Poole S, Marsh H, Maier SF, Watkins LR: Peri-sciatic proin-flammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats. Pain 2004; 110:299-309
33. Park ES, Gao X, Chung JM, Chung K: Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn neurons. Neurosci Lett 2006; 391:108-111
34. Ali DW, Salter MW: NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity. Curr Opin Neurobiol 2001; 11:336-342
35. Zhang X, Wu J, Fang L, Willis WD: The effects of protein phosphatase inhibitors on nociceptive behavioral responses of rats following intradermal injection of capsa-icin. Pain 2003; 106:443-451
36. Raghavendra V, Tanga F, Rutkowski MD, DeLeo JA: Anti-hyperalgesic and morphine-sparing actions of propentofyl-line following peripheral nerve injury in rats: Mechanistic implications of spinal glia and proinflammatory cytokines. Pain 2003; 104:655-664
37. Lander HM: An essential role for free radicals and derived species in signal transduction. FASEB J 1997; 11:118-124
38. Floyd RA: Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 1999; 222: 236-245
39. Floyd RA, Hensley K: Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 2002; 23:795-807
40. Willis WD: Role of neurotransmitters in sensitization of pain responses. Ann N Y Acad Sci 2001; 933:142-156
41. Selimovic D, Hassan M, Haikel Y, Hengge UR: Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2. Cell Signal 2008; 20:311-322
42. Tsuji M, Inanami O, Kuwabara M: Neuroprotective effect of alpha-phenyl-N-tert-butylnitrone in gerbil hippocampus is mediated by the mitogen-activated protein kinase pathway and heat shock proteins. Neurosci Lett 2000; 282: 41-44
43. Chen G, Griffin M, Poyer JL, McCay PB: HPLC procedure for the pharmacokinetic study of the spin-trapping agent, alpha-phenyl-N-tert-butyl nitrone (PBN). Free Radic Biol Med 1990; 9:93-98
44. Chung JM, Chung K: Importance of hyperexcitability of DRG neurons in neuropathic pain. Pain Pract 2002; 2:87-97
45. Liu CN, Amir R, Devor M: Effect of age and nerve injury on cross-excitation among sensory neurons in rat dorsal root ganglia. Neurosci Lett 1999; 259:95-98 (Pubitemid 29064138)
46. Liu CN, Raber P, Ziv-Sefer S, Devor M: Hyperexcitability in sensory neurons of rats selected for high versus low neuropathic pain phenotype. Neuroscience 2001; 105:265-275
47. Xiao W, Naso L, Bennett GJ: Experimental studies of potential analgesics for the treatment of chemotherapy-evoked painful peripheral neuropathies. Pain Med 2008; 9:505-517
48. Kotake Y: Pharmacologic properties of phenyl N-tert-bu-tylnitrone. Antioxid Redox Signal 1999; 1:481-499