A role for free radicals and nitric oxide in delayed recovery in aged rats with chronic constriction nerve injury

Free Radical Biology and Medicine

Volumn 31, Issue 4, 2001, Pages 430-439

  Khalil, Zeinab ^a   Khodr, Bereha ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Ageing; Chronic constriction injury; Free radical activity; Hyperalgesia; Neurogenic vascular response; Nitric oxide

Indexed keywords

3 BROMO 7 NITROINDAZOLE; ANTIOXIDANT; FREE RADICAL; LIPID HYDROPEROXIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; REACTIVE OXYGEN METABOLITE; SUBSTANCE P; TIRILAZAD; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY MUSCLE; ARTICLE; BATH; BLOOD FLOW; BLOOD VESSEL INNERVATION; BLOOD VESSEL REACTIVITY; BODY TEMPERATURE; CHRONIC DISEASE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; HYPERALGESIA; MALE; NERVE COMPRESSION; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; TISSUE REPAIR; TREATMENT OUTCOME;

AGING; ANIMALS; ANTIOXIDANTS; CHRONIC DISEASE; CONSTRICTION, PATHOLOGIC; FREE RADICALS; HEAT; HYPERALGESIA; LIPID PEROXIDES; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PAIN; PREGNATRIENES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SCIATIC NERVE; XANTHINE OXIDASE;

EID: 0035882524     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00597-4     Document Type: Article

References (42)

1. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
2. Novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury
3. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
4. Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal in rats with chronic constriction injury
5. Wallerian degeneration and hyperalgesia after peripheral nerve injury are glutathione-dependent
6. Application of nitric oxide synthase inhibitor, N-omega-nitro-L-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats
7. Aging and neuropathic pain
8. The effect of aging on efferent nerve fibers regeneration in mice
9. Involvement of free radicals in ageing: A consequence or cause of senescence
10. CGRP and nitric oxide of neuronal origin mediate neurogenic vasodilatation in rat skin microvasculature
11. Responses of mitochondrial superoxide dismutase, catalase and glutathione peroxidase activities to aging
12. Relationship between superoxide anion radical generation and aging in the housefly, musca domestica
13. Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema
14. Peroxynitrite versus hydroxyl radical: The role of nitric oxide in superoxide-dependent cerebral injury
15. Modulation of inflammation by reactive oxygen species: Implications for aging and tissue repair
16. Skin vascular reactivity to the neuropeptide substance P in rats with peripheral mononeuropathy
17. Further evidence for "pain-related" behaviours in a model of unilateral peripheral mononeuropathy
18. Tachykinin-induced vasodilatation in rat skin measured with a laser Doppler flowmeter: Evidence for receptor mediator effects
19. Sequence of events in substance P-induced plasma extravasation in rat skin
20. Serotonin modulates substance P-induced extravasation and vasodilatation in rat skin by an action through capsaicin-sensitive primary afferent nerves
21. The etiological role of free radicals in human hematoma-induced flap necrosis
22. Secondary ischemia in rabbit skin flaps: The roles played by thromboxane and free radicals
23. Mechanisms of free radical oxidation of unsaturated lipids
24. Management of chronic pain
25. Age-related differences in the time course of capsaicin-induced hyperalgesia
26. Relationship between oxygen metabolism, aging and development
27. DNA strand break formation following exposure of bovine pulmonary artery and aortic endothelial cells to reactive oxygen products
28. Reactive oxygen-mediated protein oxidation in aging and disease
29. Role of oxidants in ischemic brain damage
30. Multiple-dose tolerability and pharmacokinetics of tirilazad mesylate at doses of up to 10 mg/kg/day administered over 5-10 days in healthy volunteers
31. The use of salicylate hydroxylation to detect hydroxyl radical generation in ischemic and traumatic brain injury. Reversal by tirilazad mesylate (U-74006F)
32. Ion transport ATPases as targets for free radical damage. Protection by an aminosteroid of the Ca2+ pump ATPase and Na+/K+ pump ATPase of human red blood cell membranes
33. Inhibition of lipid peroxidation in central nervous system trauma and ischemia
34. Local nitric oxide synthase activity in a model of neuropathic pain
35. Local expression of inducible nitric oxide synthase in an animal model of neuropathic pain
36. Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat
37. Marked increase in nitric oxide synthase mRNA in rat dorsal root ganglia after peripheral axotomy: In situ hybridization and functional studies
38. Nitric oxide mediates ongoing discharges in dorsal root ganglion cells after peripheral nerve injury
39. Nitrix oxide evokes pain at nociceptors of the paravascular tissue and veins in humans
40. Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan-induced thermal hyperalgesia
41. A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy
42. Effect of desmethyl tirilazad, dizocilpine maleate and nimodipine on brain nitric oxide synthase activity and cyclic guanosine monophosphate during cerebral ischemia in rats