A new isoquinolinium derivative, cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway

Journal of Biological Chemistry

Volumn 285, Issue 5, 2010, Pages 2986-2995

  Jang, Eun Ryoung ^a   Ryu, Minsook ^b   Park, Jeong Eun ^a   Kim, Jung Ho ^c   Lee, Jong Soo ^b   Song, Kiwon ^a  

^a Yonsei University   (South Korea)

^b Ajou University   (South Korea)

^c Hanwha Corporation   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROLIFERATIVE EFFECT; APOPTOSIS; APOPTOTIC EFFECTS; CANCER CELLS; CANCER CHEMOTHERAPEUTIC AGENTS; CARCINOMA CELLS; CASPASES; CHEMOSENSITIVITY; COLON CANCER CELLS; HEK-293; MISMATCH REPAIR; PRO-APOPTOTIC EFFECTS; SMALL-MOLECULE LIBRARY; STRESS-ACTIVATED KINASE;

CELL DEATH;

BERBERINE; CANCER SELECTIVE DEATH INDUCER 1; CASPASE; CHECKPOINT KINASE 2; ISOQUINOLINE DERIVATIVE; PROTEIN P53; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CADEIN1 COMPOUND; MITOGEN ACTIVATED PROTEIN KINASE P38; TP53 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL MUTANT; CELL PROLIFERATION; CELL STRAIN HEK293; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RESPONSE; DRUG SCREENING; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MISMATCH REPAIR; PRIORITY JOURNAL; BASE MISPAIRING; CELL CYCLE; CELL LINE; CHEMICAL MODEL; DNA REPAIR; DRUG EFFECT; METABOLISM; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BASE PAIR MISMATCH; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA REPAIR; DRUG SCREENING ASSAYS, ANTITUMOR; GENES, P53; HUMANS; ISOQUINOLINES; MODELS, CHEMICAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77449124806     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.070466     Document Type: Article

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