Fenretinide: A p53-independent way to kill cancer cells

Biochemical and Biophysical Research Communications

Volumn 331, Issue 3, 2005, Pages 810-815

  Corazzari, Marco ^a   Lovat, Penny E ^b   Oliverio, Serafina ^c   Di Sano, Federica ^c   Donnorso, Raffaele Perrone ^d   Redfern, Christopher P F ^b   Piacentini, Mauro ^a,c  

^a NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Ceramide; Gadd153; GD3; Glucosylceramide synthase; Retinoids

Indexed keywords

ANTINEOPLASTIC AGENT; ARACHIDONATE 12 LIPOXYGENASE; BAICALEIN; CARBOPLATIN; CASPASE; CERAMIDE; CISPLATIN; ETOPOSIDE; FENRETINIDE; GANGLIOSIDE GD3; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN BAK; PROTEIN BNIP3; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL; CYTOTOXICITY; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; ENZYME ACTIVATION; GENE EXPRESSION; GENE INDUCTION; HUMAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

EID: 18144378089     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.03.184     Document Type: Review

References (58)

1. J.F.R. Kerr, A.H. Wyllie, and A.R. Currie Apoptosis: a basic biological phenomenon with wide-ranging implication in tissue kinetics Br. J. Cancer 26 1972 239 257
2. M.O. Hengartner The biochemistry of apoptosis Nature 407 2000 770 776
3. D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
4. J.R. Marks, A.M. Davidoff, B.J. Kerns, P.A. Humphrey, J.D. Pence, R.K. Dodge, D.L. Clarke-Pearson, J.D. Iglehart, R.C. Bast Jr., and A. Berchuck Overexpression and mutation of p53 in epithelial ovarian cancer Cancer Res. 51 1991 2979 2984
5. D. Malkin, F.P. Li, L.C. Strong, J.F. Fraumeni Jr., C.E. Nelson, D.H. Kim, J. Kassel, M.A. Gryka, F.Z. Bischoff, and M.A. Tainsky Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasm Science 250 1990 1233 1238
6. L.A. Donehower, M. Harvey, B.L. Slagle, M.J. McArthur, C.A. Montgomery Jr., J.S. Butel, and A. Bradley Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours Nature 356 1992 215 221
7. C. Deng, P. Zhang, J.W. Harper, S.J. Elledge, and P. Leder Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control Cell 82 1995 675 684
8. P. Kastner, M. Mark, and P. Chambon Nonsteroid nuclear receptors: What are genetic studies telling us about their role in real life? Cell 83 1995 859 869
9. A.L. Means, and L.J. Gudas The role of retinoids in vertebrate development Annu. Rev. Biochem. 64 1995 201 233
10. R. Lotan Retinoids in cancer chemoprevention FASEB J. 10 1996 1031 1039
11. D. Simoni, and M. Tolomeo Retinoids, apoptosis and cancer Curr. Pharm. Des. 7 2001 1823 1837
12. A. Lasorella, A. Iavarone, and M.A. Israel Differentiation of neuroblastoma enhances Bcl-2 expression and induces alterations of apoptosis and drug resistance Cancer Res. 55 1995 4711 4716
13. B. Meister, F.M. Fink, A. Hittmair, C. Marth, and M. Widschwendter Antiproliferative activity and apoptosis induced by retinoic acid receptor-γ selectively binding retinoids in neuroblastoma Anticancer Res. 18 1998 1777 1786
14. B.J. Maurer, L.S. Metelitsa, R.C. Seeger, M.C. Cabot, and C.P. Reynolds Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)-retinamide in neuroblastoma cell lines J. Natl. Cancer Inst. 91 1999 1138 1146
15. T.W. Grunt, E. Dittrich, M. Offterdinger, S.M. Schneider, C.H. Dittrich, and H. Huber Effects of retinoic acid and fenretinide on the c-erbB-2 expression, growth and cisplatin sensitivity of breast cancer cells Br. J. Cancer 78 1998 70 87
16. G.P. Kalemkerian, and O. Xialolan Activity of fenretinide plus chemotherapeutic agents in small lung cancer cell lines Cancer Chemother. Pharmacol. 43 1999 145 150
17. P.E. Lovat, M. Ranalli, F. Bernassola, M.J. Tilby, A.J. Malcolm, A.D.J. Pearson, M. Piacentini, G. Melino, and C.P.F. Redfern Synergistic induction of apoptosis of neuroblastoma by fenretinide or CD437 in combination with chemotherapeutic drugs Int. J. Cancer 88 2000 977 985
18. P.E. Lovat, M. Ranalli, F. Bernassola, M. Tilby, A.J. Malcolm, A.D.J. Pearson, M. Piacentini, G. Melino, and C.P.F. Redfern Distinct properties of fenretinide and CD437 lead to synergistic responses with chemotherapeutic reagents Med. Pediatr. Oncol. 35 2000 663 668
19. P.E. Lovat, M. Ranalli, M. Annichiarrico-Petruzzelli, F. Bernassola, M. Piacentini, A.J. Malcolm, A.D.J. Pearson, G. Melino, and C.P.F. Redfern Effector mechanisms of fenretinide-induced apoptosis in neuroblastoma Exp. Cell Res. 260 2000 50 60
20. M. Corazzari, P.E. Lovat, S. Oliverio, A.D.J. Pearson, M. Piacentini, and C.P.F. Redfern GADD153 mediates apoptosis in response to fenretinide but not synergy between fenretinide and chemotherapeutic drugs in neuroblastoma Mol. Pharmacol. 64 2003 1370 1378
21. P.E. Lovat, S. Oliverio, M. Ranalli, M. Corrazzari, C. Rodolfo, F. Bernassola, K. Aughton, M. Maccarrone, Q.D. Campbell Hewson, A.D.J. Pearson, G. Melino, M. Piacentini, and C.P.F. Redfern GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma Cancer Res. 62 2002 5158 5167
22. P.E. Lovat, S. Oliverio, M. Corazzari, C. Rodolfo, M. Ranalli, B. Goranov, G. Melino, C.P.F. Redfern, and M. Piacentini Bak: a downstream mediator of fenretinide-induced apoptosis of SH-SY5Y neuroblastoma cells Cancer Res. 63 2003 7310 7313
23. P.E. Lovat, M. Ranalli, M. Corazzari, L. Raffaghello, A.D.J. Pearson, M. Ponzoni, M. Piacentini, G. Melino, and C.P.F. Redfern Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma J. Cell. Biochem. 89 2003 698 708
24. I. Herr, and K.M. Debatin Cellular stress response and apoptosis in cancer therapy Blood 98 2001 2603 2614
25. M.O. Hengartner, and H.R. Horvitz Programmed cell death in Caenorhabditis elegans Curr. Opin. Genet. Dev. 4 1994 581 586
26. D.R. Green Apoptotic pathways: the road to ruin Cell 94 1998 696 698
27. G. Pagnan, G. Caridi, P.G. Montaldo, M. Bado, V. Chiesa, T.M. Allen, and M. Ponzoni Apoptosis of human neuroblastoma cells induced by liposome-capsulated fenretinide J. Liposome Res. 8 1998 401 423
28. R.R. Mehta, M.E. Hawthorne, J.M. Graves, and R.G. Mehta Metabolism of N-(4-hydroxyphenyl)retinamide (4-HPR) may serve as a biomarker for its efficacy against breast cancer and melanoma cells Eur. J. Cancer 34 1998 902 907
29. P. Boya, M.C. Morales, R.A. Gonzales-Polo, K. Andreau, I. Gourdier, J.L. Perfettini, N. Larochette, A. Deniaud, F. Baran-Marszak, R. Fagard, J. Feuillard, A. Asumendi, M. Raphael, B. Pau, C. Brenner, and G. Kroemer The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-3 family Oncogene 22 2003 6220 6230
30. P.G. Montaldo, G. Pagnan, F. Pastorino, V. Chiesa, L. Raffaghello, M. Kirckmeier, T.M. Allen, and M. Ponzoni N-(4-hydroxyphenyl)retinamide is cytotoxic to melanoma cells in vitro through induction of programmed cell death Int. J. Cancer 81 1999 262 267
31. D. Delia, A. Aiello, L. Meroni, M. Nicolini, J.C. Reed, and M.A. Pierotti Role of antioxidants and intracellular free radicals in retinamide-induced cell death Carcinogenesis 18 1997 943 948
32. A.N. Fanjul, D. Delia, M.A. Pierotti, D. Rideout, J. Qui, and M. Pfahl 4-Hydroxyphenyl retinamide is a highly selective activator of retinoid receptors J. Biol. Chem. 271 1996 22441 22446
33. A. Murakami, T. Ide, M. Susuki, T. Mochizuki, and T. Kadowaki Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha Biochem. Biophys. Res. Commun. 260 1999 609 613
34. J.L. Clifford, D.G. Menter, M. Wang, R. Lotan, and S.M. Lippman Retinoid receptor-dependent and independent effects of N-(4-hydroxyphenyl) retinamide in F9 embryonal carcinoma cells Cancer Res. 59 1999 14 18
35. D. Nie, K. Tang, C. Diglio, and K.V. Honn Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase Blood 95 2000 2304 2311
36. S.F. Abcouwer, C. Schwarz, and R.A. Meguid Glutamine deprivation induces the expression of GADD 45 and GADD 153 primarily by mRNA stabilization J. Biol. Chem. 274 1999 28645 28651
37. M.A. O'Reilly, R.J. Starversky, R.H. Watkins, W.M. Maniscalco, and P.C. Keng p53-independent induction of GADD 45 and GADD 153 in mouse lungs exposed to hypoxia Am. J. Physiol. Lung Cell Mol. Physiol. 278 2000 552 559
38. H. Zinszner, M. Kuroda, X.Z. Wang, N. Batchvarova, R.T. Lightfoot, H. Remotti, J.L. Stevens, and D. Ron CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum Genes Dev. 12 1998 982 995
39. M. Lauricella, M. Giuliano, S. Emanuele, R. Vento, and G. Tesoriere Apoptotic effects of different drugs on cultured retinoblastoma Y79 cells Tumour Biol. 19 1998 356 363
40. B.J. Maurer, L.S. Metelitsa, R.C. Seeger, M.C. Cabot, and C.P. Reynolds Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)-retinamide in neuroblastoma cell lines J. Natl. Cancer Inst. (Bethesda) 91 1999 1138 1146
41. B. Eymin, L. Dubrez, M. Allouche, and E. Solary Increased GADD 153 messenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide Cancer Res. 57 1997 686 695
42. G. Los, K. Benbatoul, D.P. Gatley, R. Barton, R. Christen, K.T. Robbins, D. Vicario, S. Kirmani, L.A. Orloff, H. Weis, and S.B. Howell Quantitation of the change in GADD 153 messenger RNA level as a molecular marker of tumor response in head and neck cancer Clin. Cancer Res. 7 1999 1610 1618
43. S. Siemer, D. Ornskov, B. Guerra, B. Boldyreff, and O.G. Issinger Determination of mRNA, and protein levels of p53. MDM2 and protein kinase CK2 subunits in F9 cells after treatment with the apoptosis-inducing drugs cisplatin and carboplatin Int. J. Biochem. Cell Biol. 31 1999 661 670
44. M.M. de las Alas, R.D. Christen, D.P. Gately, D.E. Weiner, K. Benbatoul, S. Kirmani, H.R. Dagostino, S.C. Plaxe, D. Darrah, E.F. McClay, S. Aebi, and G. Los Increase in tumor GADD153 mRNA level following treatment correlates with response to paclitaxel Cancer Chemother. Pharmacol. 45 2000 381 388
45. K.F. Macleod, N. Sherry, G. Hannon, D. Beach, T. Tokino, K. Kinzler, B. Vogelstein, and T. Jacks p53-dependent and -independent expression of p21 during cell growth, differentiation and cell damage Genes Dev. 9 1995 935 944
46. A.M. Rodriguez-Lopez, D. Xenaki, T.O. Eden, J.A. Hickman, and C.M. Chresta MDM2-mediated nuclear exclusion of p53 attenuates etoposide-induced apoptosis in neuroblastoma cells Mol. Pharmacol. 59 2001 135 143
47. S.J. Korsmeyer, WeiMC, M. Saito, S. Weiler, K.J. Oh, and P.H. Schlesinger Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c Cell Death Diff. 7 2000 1166 1173
48. B.J. Maurer, L. Melton, C. Billups, M.C. Cabot, and C.P. Reynolds Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl) retinamide and modulators of ceramide metabolism J. Natl. Cancer Inst. 92 2000 1897 1909
49. E. Gulbins, and R. Kolesnick Raft ceramide in molecular medicine Oncogene 22 2003 7070 7077
50. Y.A. Hannun, C. Luberto, and K.M. Argraves Enzymes of sphingolipid metabolism: from modular to integrative signaling Biochemistry 40 2001 4893 4903
51. A. Colell, A. Morales, J.C. Fernandez-Checa, and C. Garcia-Ruiz Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-α-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation. Possible role of ganglioside GD3 FEBS Lett. 526 2002 135 141
52. A. Erdreich-Epstein, L.B. Tran, N.N. Bowman, H. Wang, M.C. Cabot, D.L. Durden, J. Vlckova, C.P. Reynolds, M.F. Stins, S. Groshen, and M. Millard Ceramide signaling in fenretinide-induced endothelial cell apoptosis J. Biol. Chem. 277 2002 49531 49537
53. H. Wang, A.G. Charles, A.J. Frankel, and M.C. Cabot Increasing intracellular ceramide: an approach that enhances the cytotoxic response in prostate cancer cells Urology 61 2003 1047 1052
54. P.E. Lovat, F. Di Sano, M. Corazzari, B. Fazi, R. Perrone Donnorso, A.D.J. Pearson, A.G. Hall, C.P.F. Redfern, and M. Piacentini Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-Lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide J. Natl. Cancer Inst. 96 2004 1288 1298
55. B.J. Pettus, C.E. Chalfant, and Y.A. Hannun Ceramide in apoptosis: an overview and current perspectives Biochim. Biophys. Acta 1585 2002 114 125
56. V.V. Bezuglov, E.V. Fomina-Ageeva, N.M. Gretskaia, E.V. Kriukova, E.V. Diatlovitskaia, and L.D. Bergel'son Gangliosides modulate lipoxygenase oxidation in human lymphocytes Biokhimiia 56 1991 267 272
57. S.Y. Sun, P. Yue, G. Wu, W.S. El-Deiry, B. Shroot, W.K. Hong, and R. Lotan Implication of p53 in growth arrest and apoptosis induced by the synthetic retinoid CD437 in human lung cancer cells Cancer Res. 59 1999 2829 2833
58. J.Y. Liang, J.A. Fontana, J.N. Rao, J.V. Ordonez, M.I. Dawson, B. Shroot, J.F. Wilber, and P. Feng Synthetic retinoid CD437 induces S-phase arrest and apoptosis in human prostate cancer cells LNCaP and PC-3 Prostate 38 1999 228 236