Inverse correlation of thermal lability and conversion efficiency for five prion protein polymorphic variants

Biochemistry

Volumn 49, Issue 7, 2010, Pages 1448-1459

  Kirby, Louise ^a   Agarwal, Sonya ^a   Graham, James F ^a   Goldmann, Wilfred ^b   Gill, Andrew C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; CONFORMATIONAL CHANGE; DISEASE SUSCEPTIBILITY; EXTREME CASE; IN-VITRO; INVERSE CORRELATION; ISOFORMS; LOOP REGIONS; MISFOLDING; MOLECULAR DYNAMICS SIMULATIONS; POLYMORPHIC VARIANT; PRION PROTEIN; PROTEIN STABILITY; PROTEIN VARIANTS; SINGLE RESIDUE; THERMAL DENATURATIONS; THERMAL STABILITY; TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES;

AMINO ACIDS; ANIMALS; ASSAYS; CONVERSION EFFICIENCY; MOLECULAR DYNAMICS; OLIGOMERIZATION; ORGANIC ACIDS; POLYMORPHISM; PYROLYSIS; SCANDIUM; THERMODYNAMIC STABILITY;

PROTEINS;

PRION PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CORRELATION ANALYSIS; DISEASE PREDISPOSITION; MOLECULAR DYNAMICS; OLIGOMERIZATION; PRION DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN VARIANT; THERMOSTABILITY;

AMINO ACID SUBSTITUTION; ANIMALS; CELL-FREE SYSTEM; DEER; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; IMMUNITY, INNATE; LEUCINE; MICE; PEPTIDE FRAGMENTS; POLYMORPHISM, GENETIC; PRION DISEASES; PRIONS; PROLINE; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STABILITY; SHEEP; TEMPERATURE;

ANIMALIA; OVIS ARIES;

EID: 77449100647     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi901855z     Document Type: Article

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