Hsp40 chaperones promote degradation of the hERG potassium channel

Journal of Biological Chemistry

Volumn 285, Issue 5, 2010, Pages 3319-3329

  Walker, Valerie E ^a   Wong, Michael J H ^a   Atanasiu, Roxana ^a   Hantouche, Christine ^a   Young, Jason C ^a   Shrier, Alvin ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACES; CRITICAL POINTS; ENDOPLASMIC RETICULUM; FOLDING INTERMEDIATES; HERG POTASSIUM CHANNEL; HSP40 CHAPERONES; LACTACYSTIN; LONG QT SYNDROME; OVER-EXPRESSION; POTASSIUM CHANNELS; SECRETORY PATHWAYS; UBIQUITIN LIGASES;

CELL MEMBRANES; CUSTOMER SATISFACTION; EQUATIONS OF STATE; ETHERS; POTASSIUM; PROTEINS; TOTAL QUALITY MANAGEMENT;

DEGRADATION;

HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 40; LACTACYSTIN; MUTANT PROTEIN; POTASSIUM CHANNEL HERG; PROTEIN DJA1; PROTEIN DJA2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ACETYLCYSTEINE; CHAPERONE; CHAPERONIN; DNAJA1 PROTEIN, HUMAN; DNAJA2 PROTEIN, HUMAN; DRUG DERIVATIVE; KCNH1 PROTEIN, HUMAN; PROTEASOME;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TRANSPORT; CHEMISTRY; DENSITOMETRY; DRUG ANTAGONISM; ENDOPLASMIC RETICULUM; HELA CELL; LONG QT SYNDROME; METABOLISM; METHODOLOGY; MUTATION;

ACETYLCYSTEINE; CHAPERONINS; DENSITOMETRY; ENDOPLASMIC RETICULUM; ETHER-A-GO-GO POTASSIUM CHANNELS; HELA CELLS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; LONG QT SYNDROME; MOLECULAR CHAPERONES; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING;

EID: 77449092667     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.024000     Document Type: Article

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