New N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs as σ2 receptor ligands: Synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 3, 2009, Pages 1222-1231

  Chu, Wenhua ^a   Xu, Jinbin ^a   Zhou, Dong ^a   Zhang, Fanjie ^a   Jones, Lynne A ^a   Wheeler, Kenneth T ^b   Mach, Robert H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Chemosensitization; PET radiotracers; Sigma 2 ligands

Indexed keywords

9 AZABICYCLO[3.3.1]NONAN 3ALPHA YL PHENYLCARBAMATE DERIVATIVE; CARBAMIC ACID DERIVATIVE; DOXORUBICIN; FLUORINE 18; SIGMA 2 OPIATE RECEPTOR; SIGMA RECEPTOR LIGAND; UNCLASSIFIED DRUG; WC 26; WC 59;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST TUMOR; CHEMOSENSITIZATION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; TUMOR CELL DESTRUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOXORUBICIN; FLUORINE RADIOISOTOPES; HUMANS; LIGANDS; MICE; MICE, INBRED BALB C; PHENYLCARBAMATES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS, SIGMA;

MURINAE; MUS;

EID: 58949100861     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.025     Document Type: Article

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