Phosphorylation of Drosophila Jun by the MAP kinase Rolled regulates photoreceptor differentiation

EMBO Journal

Volumn 15, Issue 15, 1996, Pages 3943-3950

  Peverali, Fiorenzo A ^a   Isaksson, Anders ^a   Papavassiliou, Athanasios G ^a   Plastina, Pierfrancesco ^a   Staszewski, Lena M ^a   Mlodzik, Marek ^a   Bohmann, Dirk ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Drosophila development; Jun; MAP kinase; Signal transduction; Transcription factor

Indexed keywords

HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; ONCOPROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DROSOPHILA; ENZYME SUBSTRATE; EYE DEVELOPMENT; IMAGINAL DISC; NONHUMAN; ONCOGENE C JUN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALIA;

EID: 0029738257     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00768.x     Document Type: Article

References (37)

1. Angel, P. and Karin, M. (1991) The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochim. Biophys. Acta, 1072, 129-157.
2. Baichwal, V.R., Park, A. and Tjian, R. (1992) The cell-type-specific activator region of c-Jun juxtaposes constitutive and negatively regulated elements. Genes Dev., 6, 1493-1502.
3. Basler, K., Christen, B. and Hafen, E. (1991) Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell, 64, 1069-1081.
4. Biggs, W.H.I. and Zipursky, S.L. (1992) Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase. Proc. Natl Acad. Sci. USA, 89, 6295-6299.
5. Biggs, W.H.I., Zavitz, K.H., Dickson, B., van der Straten, A., Brunner, D., Hafen, E. and Zipursky, S.L. (1994) The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. EMBO J., 13, 1628-1635.
6. Binetruy, B., Smeal, T. and Karin, M. (1991) Ha-ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature, 351, 122-127.
7. Bohmann, D., Ellis, M.C., Staszewski, L.M. and Mlodzik, M. (1994) Drosophila Jun mediates Ras-dependent photoreceptor determination. Cell, 78, 973-86.
8. Brunner, D., Dücker, K., Oellers, N., Hafen, E., Scholz, H. and Klämbt, C. (1994a) The Ets-domain protein pointed P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature, 370, 386-389.
9. Brunner, D., Oellers, N., Szabad, J., Biggs, W.H.I., Zipursky, L.H. and Hafen, E. (1994b) A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell, 76, 875-888.
10. Coso, O.A., Chiariello, M., Yu, J.-C., Teramoto, H., Crespo, P., Xu, N., Miki, T. and Gutkind, S. (1995) The small GTP-binding proteins Rac 1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell, 81, 1137-1146.
11. Dérijard, B., Hibi, M., Wu, I., Barrett, T., Su, B., Deng, T., Karin, M. and Davis, R. (1994) JNK1: a protein kinase stimulated by UV-light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell, 76, 1025-1037.
12. Dickson, B., Sprenger, F., Morrison, D. and Hafen, E. (1992) Raf functions downstream of Ras1 in the sevenless signal transduction pathway. Nature, 360, 600-603.
13. Fortini, M.E., Simon, M.A. and Rubin, G.M. (1992) Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature, 355, 559-561.
14. Ham, J., Babij, C., Whitfield, J., Pfarr, C.M., Lallemand, D., Yaniv, M. and Rubin, L.M. (1995) A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron, 14, 927-939.
15. Hibi, M., Lin, A., Smeal, T., Minden, A. and Karin, M. (1993) Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev., 7, 2135-2148.
16. Hill, C.S. and Treisman, R. (1995) Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell, 80, 199-211.
17. Hilliker, A.J. (1976) Genetic analysis of the centromeric heterochromatin of chromosome 2 of Drosophila melanogaster: deficiency mapping of EMS-induced lethal complementation groups. Genetics, 83, 765-782.
18. Kyriakis, J.M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E.A., Ahmad, M.F., Avruch, J. and Woodgett, J.R. (1994) The stress-activated protein kinase subfamily of c-Jun kinases. Nature, 369, 156-160.
19. Landt, O., Grunert, H.-P. and Hahn, U. (1990) A general method for rapid site-directed mutagenesis using the polymerase chain reaction. Gene, 96, 125-128.
20. Marais, R., Wynne, J. and Treisman, R. (1993) The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell, 73, 381-393.
21. Melnick, M.B., Perkins, L.A., Lee, M., Ambrosio, L. and Perrimon, N. (1993) Developmental and molecular characterization of mutations in the Drosophila raf serine/threonine protein kinase. Development, 118, 127-138.
22. Minden, A., Lin, A., McMahon, M., Lange-Carter, C., Dérijard, B., Davis, R.J., Johnson, G.L. and Karin, M. (1994) Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science, 266, 1719-1723.
23. Minden, A., Lin, A., Claret, F.-X., Abo, A. and Karin, M. (1995) Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and CDC42Hs. Cell, 81, 1147-1157.
24. Mullins, M.C., Rio, D.C. and Rubin, G.M. (1990) Cis-acting DNA sequence requirements for P-element transposition. Genes Dev., 3, 729-738.
25. O'Farell, P.Z., Goodman, H.M. and O'Farrell, P.H. (1977) High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell, 12, 1133-1141.
26. O'Neill, E.M., Rebay, I., Tjian, R. and Rubin, G.M. (1994) The activities of Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell, 78, 137-147.
27. Papavassiliou, A.G. (1994) Preservation of protein phosphoryl groups in immunoprecipitation assays. J. Immunol. Methods, 170, 67-73.
28. Papavassiliou, A.G., Chavrier, C. and Bohmann, D. (1992) Phosphorylation state and DNA-binding activity of c-Jun depend on the intracellular concentration of binding sites. Proc. Natl Acad. Sci. USA, 89, 11562-11565.
29. Papavassiliou, A.G., Treier, M. and Bohmann, D. (1995) Intramolecular signal transduction in c-Jun. EMBO J., 14, 2014-2019.
30. Peverali, F.A., Ramqvist, T., Saffrich, R., Pepperkock, R., Barone, M.V. and Philipson, L. (1994) Regulation of G1 progression by E2A and Id helix-loop-helix proteins. EMBO J., 13, 4291-4301.
31. Pulverer, B.J., Kyriakis, J.M., Aruch, J., Nikolakaki, E. and Woodgett, J.R. (1991) Phosphorylation of c-Jun mediated by MAP kinase. Nature, 353, 670-674.
32. Sánchez, I., Hughes, R.T., Mayer, B.J., Yee, K., Woodgett, J.R., Avruch, J., Kyriakis, J.M. and Zon, L.I. (1994) Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature, 372, 794-798.
33. Smeal, T., Binetruy, B., Mercola, D.A., Birrer, M. and Karin, M. (1991) Oncogenic and transcriptional cooperation with Ha-ras requires phosphorylation of c-Jun on serines 63 and 73. Nature, 354, 494-496.
34. Spradling, A.C. and Rubin, G.M. (1982) Transposition of cloned P-elements into Drosophila germline chromosomes. Science, 218, 341-347.
35. Tomlinson, A. and Ready, D.F. (1987) Neuronal differentiation in the Drosophila ommatidium. Dev. Biol., 120, 183-193.
36. Treier, M., Bohmann, D. and Mlodzik, M. (1995) Jun cooperates with the Ets-domain protein Pointed to induce photoreceptor R7 fate in the Drosophila eye. Cell, 83, 753-760.
37. Yan, M., Dai, T., Deak, J.C., Kyriakis, J.M., Zon, L.I., Woodgett, J.R. and Templeton, D.J. (1994) Activation of stress-activated protein kinase by MEKK1 phophorylation of its activator SEK1. Nature, 372, 798-800.