Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino-(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases

Journal of Medicinal Chemistry

Volumn 53, Issue 2, 2010, Pages 734-744

  Anzini, Maurizio ^a   Chelini, Alessia ^a   Mancini, Alessandra ^a   Cappelli, Andrea ^a   Frosini, Maria ^a   Ricci, Lorenzo ^a   Valoti, Massimo ^a   Magistretti, Jacopo ^b   Castelli, Loretta ^b   Giordani, Antonio ^c   Makovec, Francesco ^c   Vomero, Salvatore ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c Rotta Research Laboratorium   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 BUTYL 3 [6 (TRIFLUOROMETHOXY)BENZOTHIAZOL 2 YL]THIOUREA; 1 ETHYL 3 [6 (TRIFLUOROMETHOXY)BENZOTHIAZOL 2 YL]THIOUREA; 1 ISOPROPYL 3 [6 (TRIFLUOROMETHOXY)BENZOTHIAZOL 2 YL]THIOUREA; 1 PROPYL 3 [6 (TRIFLUOROMETHOXY)BENZOTHIAZOL 2 YL]THIOUREA; 2 AMINO 6 (TRIFLUOROMETHOXY)BENZOTHIAZOLE; AMIDINE; BENZOTHIAZOLE DERIVATIVE; EBSELEN; GLUTAMIC ACID; GUANIDINE DERIVATIVE; LACTATE DEHYDROGENASE; N,N DIMETHYL N' [6 (TRIFLUOROMETHOXY)BENZOTHIAZOL 2 YL]ACETAMIDINE; NEURONAL NITRIC OXIDE SYNTHASE; NEUROPROTECTIVE AGENT; RILUZOLE; THIOUREA DERIVATIVE; TROLOX C; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN DISEASE; BRAIN ISCHEMIA; BRAIN SLICE; CALCIUM CURRENT; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME RELEASE; IN VITRO STUDY; NEUROPROTECTION; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PATCH CLAMP; PROTON NUCLEAR MAGNETIC RESONANCE; PYRIFORM CORTEX; RAT; REPERFUSION INJURY; SODIUM CURRENT;

AMIDINES; ANIMALS; ANTIOXIDANTS; BENZOTHIAZOLES; BRAIN DISEASES; CALCIUM; GUANIDINES; ION TRANSPORT; NEURONS; NEUROPROTECTIVE AGENTS; RATS; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; SODIUM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

EID: 77249093092     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901375r     Document Type: Article

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