Do sodium channel blockers have neuroprotective effect after onset of ischemic insult?

Neurological Research

Volumn 29, Issue 3, 2007, Pages 317-323

  Ates, Ozkan ^a   Cayli, Suleyman R ^a   Gurses, Iclal ^a   Karabulut, Aysun Bay ^a   Yucel, Neslihan ^a   Kocak, Ayhan ^a   Cakir, Celal Ozbek ^a   Yologlu, Saim ^a  

^a INONU UNIVERSITY   (Turkey)

Author keywords

Cerebral edema; Ischemia; Lipid peroxidation; Mexiletine; Phenytoin; Riluzole

Indexed keywords

MALONALDEHYDE; MEXILETINE; PHENYTOIN; RILUZOLE; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN NERVE CELL; BRAIN WATER; CELL SURVIVAL; COMMON CAROTID ARTERY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; HIPPOCAMPUS; HISTOPATHOLOGY; LIPID PEROXIDATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PYRAMIDAL NERVE CELL; RAT; REPERFUSION; SINGLE DRUG DOSE; STATISTICAL ANALYSIS; WATER CONTENT;

ANIMALS; BRAIN EDEMA; DISEASE MODELS, ANIMAL; ISCHEMIC ATTACK, TRANSIENT; LIPID PEROXIDATION; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION; SODIUM CHANNEL BLOCKERS; STATISTICS, NONPARAMETRIC;

EID: 34249035131     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164107X159225     Document Type: Article

References (54)

1. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 1982; 239: 57-69
2. Kirino T, Sano K. Selective vulnerability in the gerbil hippocampus following transient ischemia. Acta Neuropathol (Berl) 1984; 62: 201-208
3. Pulsinelli WA, Brierley LB, Plum FC. Temporal profile of neuronal damage in a model of transient ischemia. Ann Neurol 1982; 11: 491-498
4. Schmidt-Kastner R, Freund TF. Selective vulnerability of the hippocampus in brain ischemia. Neuroscience 1991; 40: 599-636
5. Crews FT, Steck JC, Chandler LJ. Ethanol, stroke, brain damage, and excitotoxicity. Pharmacol Biochem Behav 1998; 59: 981-991
6. Ikemune I, Mitani A, Namba S, et al. Functional changes of N-methyl-D-Aspartic acid and alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionate channels in gerbil hippocampal CA1, in relation to postischemic enhancement of glutamate receptor-mediated responses. Neurosci Lett 1999; 275: 125-128
7. Rasool N, Faroqui M, Rubinstein EH. Lidocaine accelerates neuroelectrical recovery after incomplete global ischemia in rabbits. Stroke 1990; 21: 929-935
8. Schwartz GW, Fehlings MG. Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: Improved behavioral and neuroanatomical recovery with riluzole. J Neurosurg 2001; 94: 245-256
9. Reitmeier RA. Mammalian exchangers and co-transporters. Curr Opin Cell Biol 1994; 6: 583-594
10. 2+ influx during anoxia in mammalian central nervous system white matter. Ann Neurol 1991; 30: 375-380
11. 2+ exchanger. J Neurosci 1990; 12: 430-439
12. Regan RF, Choi DW. Glutamate neurotoxicity in spinal cord cell culture. Neuroscience 1991; 43: 585-594
13. Taylor CP, Geer JJ, Burke SP. Endogenous extracellular glutamate accumulation in rat neocortical cultures by reversal of transmembrane sodium gradient. Neurosci Lett 1992; 145: 197-200
14. Hewitt KE, Stys PK, Lesiuk HJ. The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury. Brain Res 2001; 898: 281-287
15. Chang CZ, Winardi D, Loh JK, et al. Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine. Acta Neurochir (Wien) 2002; 144: 189-193
16. Lee EJ, Ayoub IA, Harris FB, et al. Mexiletine and magnesium independently, but not combined, protect against permanent, focal cerebral ischemia in Wistar rats. J Neurosci Res 1999; 58: 442-448
17. Bae HJ, Lee YS, Kang DW, et al. Neuroprotective effect of low dose riluzole in gerbil model of transient global ischemia. Neurosci Lett 2000; 294: 29-32
18. Pratt J, Rataud J, Bardot F, et al. Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischemia. Neurosci Lett 1992; 140: 225-230
19. Shokunbi MT, Gelb AW, Wu XM, et al. Continuous lidocaine infusion and focal cerebral ischemia in rats. Stroke 1990; 21: 107-111
20. Sutherland G, Ong BY, Louw D, et al. Effect of Idocaine on forebrain ischemia in rats. Stroke 1989; 20: 119-122
21. Boxer PA, Cordon JJ, Mann ME, et al. Comparison of phenytoin with non-competitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat. Stroke 1990; 21 (Suppl. III): 47-51
22. Burke SP, Taylor CP. Hippocampal glutamate release during 'in vitro ischemia' is calcium-independent and TTX-sensitive. Soc Neurosci Abstr 1991; 17: 1267
23. + channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia. Stroke 1994; 25: 2476-2482
24. Menkü A, Koç RK, Tayfur V, et al. Effects of mexiletine, ginkgo biloba extract (EGb 761), and their combination on experimental head injury. Neurosurg Rev 2003; 26: 288-291
25. Prenen GH, Go KG, Postema F, et al. Cerebral cation shifts in hypoxic-ischemic brain damage are prevented by the sodium channel blocker tetrodotoxin. Exp Neurol 1988; 99: 118-132
26. Galvao RIM, Diogenes JPL, Maia GCL, et al. Tenoxicam exerts a neuroprotective action after cerebral ischemia in rats. Neurochem Res 2005; 30: 39-46
27. Okiyama K, Smith DH, Gennarelli TA, et al. The sodium channel blocker and glutamate release inhibitor BW1003C87 and magnesium attenuate regional cerebral edema following experimental brain injury in the rat. J Neurochem 1995; 64: 802-809
28. Uchiyama M, Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 86: 271-278
29. Lee SR, Suh S, Kim SP. Protective effects of green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci Lett 2000; 287: 191-194
30. Sharma BK, Kumar K. Role of proinflammatory cytokines in cerebral ischemia: A review. Metabol Brain Dis 1998; 13: 1-8
31. He Z, Ibayashi S, Sugimori H, et al. Age-related ischemia in the brain following bilateral carotid artery occlusion - collateral blood flow and brain metabolism. Neurochem Res 1997; 22: 37-42
32. Shapira S, Sapir M, Wengier A, et al. Aging has a complex effect on a rat model of ischemic stroke. Brain Res 2002; 925: 148-158
33. Choi DW. Ionic dependence of glutamate neurotoxicity. J Neurosci 1987; 7: 369-379
34. Choi DW. Cerebral hypoxia: Some new approaches and unanswered questions. J Neurosci 1990; 10: 2493-2501
35. Sims NR, Zaidan E. Biochemical changes associated with selective neuronal death following short-term cerebral ischemia. Int J Biochem Cell Biol 1995; 27: 531-550
36. Yamasaki Y, Kogure K, Hara H, et al. The possible involvement of tetrodotoxin-sensitive ion channels in ischemic neuronal damage in the rat hippocampus. Neurosci Lett 1991; 121: 251-254
37. Bensimon G, Lacomblez L, Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Eng J Med 1994; 330: 585-591
38. Doble A. The pharmacology and mechanism of action of riluzole. Neurology 1996; 47 (Suppl. 4): 233-241
39. Huang CS, Song JH, Nagata K, et al. Effects of the neuroprotective agent riluzole on the high voltage-activated calcium channels of rat dorsal root ganglion neurons. J Pharmacol Exp Ther 1997; 282: 1280-1290
40. Peluffo H, Estevez A, Barbeito L, et al. Riluzole promotes survival of rat motoneurons in vitro by stimulating trophic activity produced by spinal astrocyte monolayers. Neurosci Lett 1997; 228: 207-211
41. Pratt J, Archambaud C, Böhme GA, et al. The effect of riluzole and mannitol on cerebral oedema after cryogenic injury in the mouse. Neurosci Lett 1999; 272: 143-145
42. Kwon JY, Bacher A, Zornow MH. Riluzole does not attenuate increases in hippocampal glutamate concentrations in a rabbit model of repeated transient global cerebral ischemia. Anesth Analg 1998; 86: 128-133
43. Bryson HM, Fulton B, Benfiald P. Riluzole. A review of its, pharmacodynamic and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis. Drugs 1996; 52: 549-563
44. Stefani A, Spadoni F, Bernardi G. Differential inhibition by riluzole, lamotrigine, and phenytoin of sodium and calcium currents in cortical neurons: implication for neuroprotective strategies. Exp Neurol 1997; 147: 115-122
45. Stys PK, Waxman SG. Activity dependent modulation of excitability: Implications for axonal physiology and pathophysiology. Muscle Nerve 1994; 17: 969-974
46. + channel of rat skeletal muscle fibres: A state dependent mechanism of action. Br J Pharmacol 1988; 125: 858-864
47. Schwab M, Bauer R, Zwiener U. The distribution of normal brain water content in Wistar rats and its increase due to ischemia. Brain Res 1997; 749: 82-87
48. 2+ exchanger.
49. Calabresi P, Marfia GA, Centonze D. Sodium influx plays a major role in the membrane depolarization induced by oxygen and glucose deprivation in striatal spiny neurons. Stroke 1999; 30: 171-179
50. Friedman JE, Haddad GG. Anoxia induces an increase in intracellular sodium in rat central neurons in vitro. Brain Res 1994; 663: 329-334
51. Globus MYT, Busto R, Dietrich WD, et al. Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and aminobutyric acid studied by intracerebral microdialysis. J Neurochem 1988; 51: 1455-1464
52. Kawase M, Murakami K, Fujimura M, et al. Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency. Stroke 1999; 30: 1962-1968
53. Demirpençe E, Caner H, Bavbek M, et al. Antioxidant action of the antiarrhythmic drug mexiletine in brain membranes. Jpn J Pharmacol 1999; 81: 7-11
54. Kaptanoǧlu E, Caner H, Sürücü S, et al. Effect of mexiletine on lipid peroxidation and early ultrastructural findings in experimental spinal cord injury. J Neurosurg 1999; 91: 200-204