Riluzole interacts with voltage-activated sodium and potassium currents in cultured rat cortical neurons

Neuroscience

Volumn 85, Issue 3, 1998, Pages 931-938

  Zona, C ^b,c   Siniscalchi, A ^c   Mercuri, N B ^a,c   Bernardi, G ^a,c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Cortex; Epilepsy; Neuroprotection; Patch clamp; Voltage activated currents

Indexed keywords

ANIMAL CELL; ARTICLE; BRAIN CORTEX; DEPOLARIZATION; DOSE RESPONSE; EMBRYO; NERVE CELL MEMBRANE POTENTIAL; NEUROPROTECTION; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SODIUM CURRENT;

4-AMINOPYRIDINE; ANIMALS; CADMIUM; CELLS, CULTURED; CEREBRAL CORTEX; ELECTRIC STIMULATION; ION CHANNEL GATING; NEURONS; NEUROPROTECTIVE AGENTS; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS; RATS; RATS, WISTAR; RILUZOLE; SODIUM; SODIUM CHANNELS; TETRAETHYLAMMONIUM;

EID: 0031901783     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00604-0     Document Type: Article

References (29)

1. Benavides J., Camelin J. C., Mitrani N., Flamand F., Uzan A., Legrand J. J., Gueremy C., Le Fur G. 2-Amino-6-trifluoromethoxy benzothiazole. A possible antagonist of excitatory amino acid neurotransmission II. Neuropharmacology. 24:1985;1085-1092.
2. Benoit E., Escande D. Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre. Eur. J. Physiol. 419:1991;603-609.
3. Bensimon G., Laclombez L., Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N. Engl. J. Med. 330:1994;585-591.
4. Chéramy A., Barbeito L., Godeheu G., Glowinski J. Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo. Neurosci. Lett. 147:1992;209-212.
5. Debono M. W., Le Guern J., Canton T., Doble A., Pradier L. Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes. J. Pharmac. 235:1993;283-289.
6. Dichter M. A. Rat cortical neurons in cell culture: culture methods, cell morphology, electrophysiology and synapse formation. Brain Res. 149:1978;279-293.
7. Dichter M. A., Zona C. Calcium currents in cultured rat cortical neurons. Brain Res. 492:1989;219-229.
8. Doble A., Hebert J. P., Blanchard J. C. Pertussis toxin pretreatment abolishes the inhibitory effect of riluzole and carbachol on D-aspartate release from cultured cerebellar granule cells. Neurosci. Lett. 140:1992;251-254.
9. Drejer J., Honore T., Meier E., Schousboe A. Pharmacologically distinct glutamate receptors on cerebellar granule cells. Life Sci. 38:1988;2077-2085.
10. Hamill O. P., Marty A., Neher E., Sakmann B., Sigworth F. J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Eur. J. Physiol. 391:1981;85-100.
11. Hebert T., Drapeau P., Pradier L., Dunn R. J. Block of the rat brain IIA sodium channel α subunit by the neuroprotective drug riluzole. Molec. Pharmac. 45:1994;1055-1060.
12. Hubert J. P., Doble A. Ibotenic acid stimulates D-H-aspartate release from cultured cerebellar granule cells. Neurosci. Lett. 96:1989;345-350.
13. Hubert J. P., De Lumeau J. C., Glowinski J., Premont J., Doble A. Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action. Br. J. Pharmac. 113:1994;261-267.
14. Malgouris C., Bardot F., Daniel M., Pellis F., Rataud J., Uzan A., Blanchard J. C., Laduron P. M. Riluzole, a novel antiglutamate, prevents memory loss and hippocampal neuronal damage in ischemic gerbils. J. Neurosci. 9:1989;3720-3772.
15. Martin D., Thompson M. A., Nadler J. V. The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur. J. Pharmac. 250:1993;473-476.
16. Matsuki N., Quandt F. R., Ten Eick R. E., Yeh J. Z. Characterization of the block of sodium channels by phenytoin in mouse neuroblastoma cells. J. Pharmac. exp. Ther. 228:1984;523-530.
17. Mizoule J., Meldrum B., Mazadier M., Croucher M., Ollat C., Uzan A., Legrand J. J., Gueremy C., Le Fur G. 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid transmission I. Anticonvulsant properties. Neuropharmacology. 24:1985;767-771.
18. Pratt J., Rataud F., Bardot F., Roux M., Blanchard J. C., Laduron P. M., Stutzmann J. M. Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia. Neurosci. Lett. 140:1992;225-228.
19. Romettino S., Lazdunski M., Gottesmann C. Anticonvulsant and sleep-waking influences of riluzole in a rat model of absence epilepsy. Eur. J. Pharmac. 9:1993;371-373.
20. Rowland L. P. Amyotrophic lateral sclerosis. Curr. Opin. Neurol. 7:1994;310-315.
21. Siniscalchi A., Bonci A., Mercuri N. B., Bernardi G. Effects of riluzole on rat cortical neurons: an in vitro electrophysiological study. Br. J. Pharmac. 120:1997;225-230.
22. Stutzmann J. M., Bhome G. A., Gandolfo G., Gottesmann C., Lafforgue J., Blanchard J. C., Laduron P. M., Ladzunski M. Riluzole prevents hyperexcitability produced by mast cell degranulating peptide and dendrotoxin I in the rat. Eur. J. Pharmac. 193:1991;223-229.
23. + channels as targets for neuroprotective drugs. Trends pharmac. Sci. 16:1995;309-316.
24. Umemiya M., Berger A. J. Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones. Br. J. Pharmac. 116:1995;3227-3230.
25. Willow M., Gonoi T., Catteral W. A. Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells. Molec. Pharmac. 27:1985;1549-1558.
26. + channels. Neuroscience. 73:1996;951-962.
27. Yaari Y., Selzer M. E., Pincus J. H. Phenytoin: mechanisms of it's anticonvulsant action. Ann. Neurol. 20:1986;171-184.
28. Zona C., Pirrone G., Avoli M., Dichter M. Delayed and fast transient potassium currents in rat neocortical neurons in cell culture. Neurosci. Lett. 94:1988;285-290.
29. Zona C., Avoli M. Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia. 38:1997;522-525.