-
1
-
-
0003503759
-
-
National Institute of Occupational Safety and Health, R-TECS, National Institute of Occupational Safety and Health, Cincinnati, Ohio
-
National Institute of Occupational Safety and Health, Registry of Toxic Effects of Chemical Substances (R-TECS), National Institute of Occupational Safety and Health, Cincinnati, Ohio, 1996.
-
(1996)
Registry of Toxic Effects of Chemical Substances
-
-
-
2
-
-
23944472235
-
Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization
-
Smith T.J., Lou J., Geren I.N., Forsyth C.M., Tsai R., Laporte S.L., Tepp W.H., Bradshaw M., Johnson E.A., Smith L.A., and Marks J.D. Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization. Infect. Immun. 73 9 (2005) 5450-5457
-
(2005)
Infect. Immun.
, vol.73
, Issue.9
, pp. 5450-5457
-
-
Smith, T.J.1
Lou, J.2
Geren, I.N.3
Forsyth, C.M.4
Tsai, R.5
Laporte, S.L.6
Tepp, W.H.7
Bradshaw, M.8
Johnson, E.A.9
Smith, L.A.10
Marks, J.D.11
-
3
-
-
1342323663
-
Identification of the major steps in botulinum toxin action
-
Simpson L.L. Identification of the major steps in botulinum toxin action. Annu. Rev. Pharmacol. Toxicol. 44 (2004) 167-193
-
(2004)
Annu. Rev. Pharmacol. Toxicol.
, vol.44
, pp. 167-193
-
-
Simpson, L.L.1
-
4
-
-
0037222077
-
Translocation of botulinum neurotoxin light chain protease through the heavy chain channel
-
Koriazova L.K., and Montal M. Translocation of botulinum neurotoxin light chain protease through the heavy chain channel. Nat. Struct. Biol. 10 1 (2003) 13-18
-
(2003)
Nat. Struct. Biol.
, vol.10
, Issue.1
, pp. 13-18
-
-
Koriazova, L.K.1
Montal, M.2
-
5
-
-
0024443301
-
Botulinum neurotoxin type A radiolabeled at either the light or the heavy chain
-
Dekleva M.L., DasGupta B.R., and Sathyamoorthy V. Botulinum neurotoxin type A radiolabeled at either the light or the heavy chain. Arch. Biochem. Biophys. 274 1 (1989) 235-240
-
(1989)
Arch. Biochem. Biophys.
, vol.274
, Issue.1
, pp. 235-240
-
-
Dekleva, M.L.1
DasGupta, B.R.2
Sathyamoorthy, V.3
-
6
-
-
0028810969
-
Expression and purification of the light chain of botulinum neurotoxin A: a single mutation abolishes its cleavage of SNAP-25 and neurotoxicity after reconstitution with the heavy chain
-
Zhou L., de Paiva A., Liu D., Aoki R., and Dolly J.O. Expression and purification of the light chain of botulinum neurotoxin A: a single mutation abolishes its cleavage of SNAP-25 and neurotoxicity after reconstitution with the heavy chain. Biochemistry 34 46 (1995) 15175-15181
-
(1995)
Biochemistry
, vol.34
, Issue.46
, pp. 15175-15181
-
-
Zhou, L.1
de Paiva, A.2
Liu, D.3
Aoki, R.4
Dolly, J.O.5
-
7
-
-
18344376914
-
Development of a delivery vehicle for intracellular transport of botulinum neurotoxin antagonists
-
Goodnough M.C., Oyler G., Fishman P.S., Johnson E.A., Neale E.A., Keller J.E., Tepp W.H., Clark M., Hartz S., and Adler M. Development of a delivery vehicle for intracellular transport of botulinum neurotoxin antagonists. FEBS Lett. 513 (2002) 163-168
-
(2002)
FEBS Lett.
, vol.513
, pp. 163-168
-
-
Goodnough, M.C.1
Oyler, G.2
Fishman, P.S.3
Johnson, E.A.4
Neale, E.A.5
Keller, J.E.6
Tepp, W.H.7
Clark, M.8
Hartz, S.9
Adler, M.10
-
8
-
-
68949124956
-
Extreme sensitivity of botulinum neurotoxin domains towards mild agitation
-
Toth S.I., Smith L.A., and Ahmed S.A. Extreme sensitivity of botulinum neurotoxin domains towards mild agitation. J. Pharm. Sci. 98 9 (2009) 3302-3311
-
(2009)
J. Pharm. Sci.
, vol.98
, Issue.9
, pp. 3302-3311
-
-
Toth, S.I.1
Smith, L.A.2
Ahmed, S.A.3
-
9
-
-
0030734570
-
Induction of an immune response by oral administration of recombinant botulinum toxin
-
Kiyatkin N., Maksymowych A.B., and Simpson L.L. Induction of an immune response by oral administration of recombinant botulinum toxin. Infect. Immun. 65 (1997) 4586-4591
-
(1997)
Infect. Immun.
, vol.65
, pp. 4586-4591
-
-
Kiyatkin, N.1
Maksymowych, A.B.2
Simpson, L.L.3
-
10
-
-
1242320307
-
C-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction
-
C-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction. Mol. Microbiol. 51 3 (2004) 631-643
-
(2004)
Mol. Microbiol.
, vol.51
, Issue.3
, pp. 631-643
-
-
Rummel, A.1
Mahrhold, S.2
Bigalke, H.3
Binz, T.4
-
11
-
-
3142735021
-
Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G
-
Rummel A., Karnath T., Henke T., Bigalke H., and Binz T. Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G. J. Biol. Chem. 279 29 (2004) 30865-30870
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.29
, pp. 30865-30870
-
-
Rummel, A.1
Karnath, T.2
Henke, T.3
Bigalke, H.4
Binz, T.5
-
12
-
-
10644230055
-
Botulinum neurotoxin type D enables cytosolic delivery of enzymatically active cargo proteins to neurons via unfolded translocation intermediates
-
Bade S., Rummel A., Reisinger C., Karnath T., Ahnert-Hilger G., Bigalke H., and Binz T. Botulinum neurotoxin type D enables cytosolic delivery of enzymatically active cargo proteins to neurons via unfolded translocation intermediates. J. Neurochem. 91 6 (2004) 1461-1472
-
(2004)
J. Neurochem.
, vol.91
, Issue.6
, pp. 1461-1472
-
-
Bade, S.1
Rummel, A.2
Reisinger, C.3
Karnath, T.4
Ahnert-Hilger, G.5
Bigalke, H.6
Binz, T.7
-
13
-
-
37749009074
-
Recombinant holotoxoid vaccine against botulism
-
Pier C.L., Tepp W.H., Bradshaw M., Johnson E.A., Barbieri J.T., and Baldwin M.R. Recombinant holotoxoid vaccine against botulism. Infect. Immun. 76 1 (2008) 437-442
-
(2008)
Infect. Immun.
, vol.76
, Issue.1
, pp. 437-442
-
-
Pier, C.L.1
Tepp, W.H.2
Bradshaw, M.3
Johnson, E.A.4
Barbieri, J.T.5
Baldwin, M.R.6
-
14
-
-
67649378415
-
Production of catalytically inactive BoNT/A1 holoprotein and comparison with BoNT/A1 subunit vaccines against toxin subtypes A1, A2, and A3
-
Webb R.P., Smith T.J., Wright P., Brown J., and Smith L.A. Production of catalytically inactive BoNT/A1 holoprotein and comparison with BoNT/A1 subunit vaccines against toxin subtypes A1, A2, and A3. Vaccine 27 33 (2009) 4490-4497
-
(2009)
Vaccine
, vol.27
, Issue.33
, pp. 4490-4497
-
-
Webb, R.P.1
Smith, T.J.2
Wright, P.3
Brown, J.4
Smith, L.A.5
-
15
-
-
0025319832
-
The complete amino acid sequence of the Clostridium botulinum type A neurotoxin, deduced by nucleotide sequence analysis of the encoding gene
-
Thompson D.E., Brehm J.K., Oultram J.D., Swinfield T.J., Shone C.C., Atkinson T., Melling J., and Minton N.P. The complete amino acid sequence of the Clostridium botulinum type A neurotoxin, deduced by nucleotide sequence analysis of the encoding gene. Eur. J. Biochem. 189 1 (1990) 73-81
-
(1990)
Eur. J. Biochem.
, vol.189
, Issue.1
, pp. 73-81
-
-
Thompson, D.E.1
Brehm, J.K.2
Oultram, J.D.3
Swinfield, T.J.4
Shone, C.C.5
Atkinson, T.6
Melling, J.7
Minton, N.P.8
-
16
-
-
34347368946
-
Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases
-
Zhou Z., Cironi P., Lin A.J., Xu Y., Hrvatin S., Golan D.E., Silver P.A., Walsh C.T., and Yin J. Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases. ACS Chem. Biol. 2 5 (2007) 337-346
-
(2007)
ACS Chem. Biol.
, vol.2
, Issue.5
, pp. 337-346
-
-
Zhou, Z.1
Cironi, P.2
Lin, A.J.3
Xu, Y.4
Hrvatin, S.5
Golan, D.E.6
Silver, P.A.7
Walsh, C.T.8
Yin, J.9
-
17
-
-
34250670453
-
Site-specific protein labeling by Sfp phosphopantetheinyl transferase
-
Yin J., Lin A.J., Golan D.E., and Walsh C.T. Site-specific protein labeling by Sfp phosphopantetheinyl transferase. Nat. Protoc. 1 1 (2006) 280-285
-
(2006)
Nat. Protoc.
, vol.1
, Issue.1
, pp. 280-285
-
-
Yin, J.1
Lin, A.J.2
Golan, D.E.3
Walsh, C.T.4
-
18
-
-
10544244161
-
Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels
-
Shevchenko A., Jensen O.N., Podtelejnikov A.V., Sagliocco F., Wilm M., Vorm O., Mortensen P., Shevchenko A., Boucherie H., and Mann M. Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels. Proc. Natl. Acad. Sci. USA 93 25 (1996) 14440-14445
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, Issue.25
, pp. 14440-14445
-
-
Shevchenko, A.1
Jensen, O.N.2
Podtelejnikov, A.V.3
Sagliocco, F.4
Wilm, M.5
Vorm, O.6
Mortensen, P.7
Shevchenko, A.8
Boucherie, H.9
Mann, M.10
-
19
-
-
0037021429
-
Enhancement of protein expression in insect cells by a lobster tropomyosin cDNA leader sequence
-
Sano K., Maeda K., Oki M., and Maéda Y. Enhancement of protein expression in insect cells by a lobster tropomyosin cDNA leader sequence. FEBS Lett. 532 1-2 (2002) 143-146
-
(2002)
FEBS Lett.
, vol.532
, Issue.1-2
, pp. 143-146
-
-
Sano, K.1
Maeda, K.2
Oki, M.3
Maéda, Y.4
-
20
-
-
0028310454
-
Signals for protein targeting into and across membranes
-
von Heijne G. Signals for protein targeting into and across membranes. Subcell. Biochem. 22 (1994) 1-19
-
(1994)
Subcell. Biochem.
, vol.22
, pp. 1-19
-
-
von Heijne, G.1
-
21
-
-
3543058813
-
The C-terminus of botulinum neurotoxin type A light chain contributes to solubility, catalysis, and stability
-
Baldwin M.R., Bradshaw M., Johnson E.A., and Barbieri J.T. The C-terminus of botulinum neurotoxin type A light chain contributes to solubility, catalysis, and stability. Protein Expr. Purif. 37 1 (2004) 187-195
-
(2004)
Protein Expr. Purif.
, vol.37
, Issue.1
, pp. 187-195
-
-
Baldwin, M.R.1
Bradshaw, M.2
Johnson, E.A.3
Barbieri, J.T.4
-
22
-
-
34848840291
-
Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain
-
e113
-
Brunger A.T., Breidenbach M.A., Jin R., Fischer A., Santos J.S., and Montal M. Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain. PLoS Pathog. 3 9 (2007) 1191-1194 e113
-
(2007)
PLoS Pathog.
, vol.3
, Issue.9
, pp. 1191-1194
-
-
Brunger, A.T.1
Breidenbach, M.A.2
Jin, R.3
Fischer, A.4
Santos, J.S.5
Montal, M.6
-
23
-
-
58149252452
-
Botulinum neurotoxin devoid of receptor binding domain translocates active protease
-
e1000245
-
Fischer A., Mushrush D.J., Lacy D.B., and Montal M. Botulinum neurotoxin devoid of receptor binding domain translocates active protease. PLoS Pathog. 4 12 (2008) 1-9 e1000245
-
(2008)
PLoS Pathog.
, vol.4
, Issue.12
, pp. 1-9
-
-
Fischer, A.1
Mushrush, D.J.2
Lacy, D.B.3
Montal, M.4
-
24
-
-
0034521658
-
Light chain of botulinum A neurotoxin expressed as an inclusion body from a synthetic gene is catalytically and functionally active
-
Ahmed S.A., and Smith L.A. Light chain of botulinum A neurotoxin expressed as an inclusion body from a synthetic gene is catalytically and functionally active. J. Protein Chem. 19 6 (2000) 475-487
-
(2000)
J. Protein Chem.
, vol.19
, Issue.6
, pp. 475-487
-
-
Ahmed, S.A.1
Smith, L.A.2
-
25
-
-
1442289359
-
6-tagged recombinant type B botulinum neurotoxin heavy chain transmembrane and binding domain
-
6-tagged recombinant type B botulinum neurotoxin heavy chain transmembrane and binding domain. Protein Expr. Purif. 34 1 (2004) 8-16
-
(2004)
Protein Expr. Purif.
, vol.34
, Issue.1
, pp. 8-16
-
-
Zhou, Y.1
Singh, B.R.2
-
26
-
-
0031282024
-
Recombinant expression and purification of the botulinum neurotoxin type A translocation domain
-
Lacy D.B., and Stevens R.C. Recombinant expression and purification of the botulinum neurotoxin type A translocation domain. Protein Expr. Purif. 11 2 (1997) 195-200
-
(1997)
Protein Expr. Purif.
, vol.11
, Issue.2
, pp. 195-200
-
-
Lacy, D.B.1
Stevens, R.C.2
-
27
-
-
65649126185
-
Full-length Clostridium botulinum serotype A derivatives with native structure and properties
-
Ichtchenko K., and Band P.A. Full-length Clostridium botulinum serotype A derivatives with native structure and properties. Neurotox. Res. 9 (2006) 234
-
(2006)
Neurotox. Res.
, vol.9
, pp. 234
-
-
Ichtchenko, K.1
Band, P.A.2
-
28
-
-
0035903198
-
Recombinant forms of tetanus toxin engineered for examining and exploiting neuronal trafficking pathways
-
Li Y., Foran P., Lawrence G., Mohammed N., Chan-Kwo-Chion C.K., Lisk G., Aoki R., and Dolly O. Recombinant forms of tetanus toxin engineered for examining and exploiting neuronal trafficking pathways. J. Biol. Chem. 276 33 (2001) 31394-31401
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.33
, pp. 31394-31401
-
-
Li, Y.1
Foran, P.2
Lawrence, G.3
Mohammed, N.4
Chan-Kwo-Chion, C.K.5
Lisk, G.6
Aoki, R.7
Dolly, O.8
-
29
-
-
0025167248
-
Botulinum neurotoxin type A: sequence of amino acids at the N-terminus and around the nicking site
-
DasGupta B.R., and Dekleva M.L. Botulinum neurotoxin type A: sequence of amino acids at the N-terminus and around the nicking site. Biochimie 72 9 (1990) 661-664
-
(1990)
Biochimie
, vol.72
, Issue.9
, pp. 661-664
-
-
DasGupta, B.R.1
Dekleva, M.L.2
-
30
-
-
0028204552
-
Covalent structure of botulinum neurotoxin type A: location of sulfhydryl groups, and disulfide bridges and identification of C-termini of light and heavy chains
-
Krieglstein K.G., DasGupta B.R., and Henschen A.H. Covalent structure of botulinum neurotoxin type A: location of sulfhydryl groups, and disulfide bridges and identification of C-termini of light and heavy chains. J. Protein Chem. 13 1 (1994) 49-57
-
(1994)
J. Protein Chem.
, vol.13
, Issue.1
, pp. 49-57
-
-
Krieglstein, K.G.1
DasGupta, B.R.2
Henschen, A.H.3
-
31
-
-
0022416338
-
Inactivation of Clostridium botulinum type A neurotoxin by trypsin and purification of two tryptic fragments. Proteolytic action near the COOH-terminus of the heavy subunit destroys toxin-binding activity
-
Shone C.C., Hambleton P., and Melling J. Inactivation of Clostridium botulinum type A neurotoxin by trypsin and purification of two tryptic fragments. Proteolytic action near the COOH-terminus of the heavy subunit destroys toxin-binding activity. Eur. J. Biochem. 151 1 (1985) 75-82
-
(1985)
Eur. J. Biochem.
, vol.151
, Issue.1
, pp. 75-82
-
-
Shone, C.C.1
Hambleton, P.2
Melling, J.3
-
32
-
-
0036426323
-
Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A
-
Chaddock J.A., Herbert M.H., Ling R.J., Alexander F.C., Fooks S.J., Revell D.F., Quinn C.P., Shone C.C., and Foster K.A. Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A. Protein Expr. Purif. 25 2 (2002) 219-228
-
(2002)
Protein Expr. Purif.
, vol.25
, Issue.2
, pp. 219-228
-
-
Chaddock, J.A.1
Herbert, M.H.2
Ling, R.J.3
Alexander, F.C.4
Fooks, S.J.5
Revell, D.F.6
Quinn, C.P.7
Shone, C.C.8
Foster, K.A.9
-
33
-
-
0035900618
-
Site-directed mutagenesis identifies active-site residues of the light chain of botulinum neurotoxin type A
-
Rigoni M., Caccin P., Johnson E.A., Montecucco C., and Rossetto O. Site-directed mutagenesis identifies active-site residues of the light chain of botulinum neurotoxin type A. Biochem. Biophys. Res. Commun. 288 5 (2001) 1231-1237
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.288
, Issue.5
, pp. 1231-1237
-
-
Rigoni, M.1
Caccin, P.2
Johnson, E.A.3
Montecucco, C.4
Rossetto, O.5
-
34
-
-
0034008947
-
Probing the mechanistic role of glutamate residue in the zinc-binding motif of type A botulinum neurotoxin light chain
-
Li L., Binz T., Niemann H., and Singh B.R. Probing the mechanistic role of glutamate residue in the zinc-binding motif of type A botulinum neurotoxin light chain. Biochemistry 39 9 (2000) 2399-2405
-
(2000)
Biochemistry
, vol.39
, Issue.9
, pp. 2399-2405
-
-
Li, L.1
Binz, T.2
Niemann, H.3
Singh, B.R.4
-
35
-
-
0031712779
-
Crystal structure of botulinum neurotoxin type A and implications for toxicity
-
Lacy D.B., Tepp W., Cohen A.C., DasGupta B.R., and Stevens R.C. Crystal structure of botulinum neurotoxin type A and implications for toxicity. Nat. Struct. Biol. 5 10 (1998) 898-902
-
(1998)
Nat. Struct. Biol.
, vol.5
, Issue.10
, pp. 898-902
-
-
Lacy, D.B.1
Tepp, W.2
Cohen, A.C.3
DasGupta, B.R.4
Stevens, R.C.5
-
36
-
-
12144291021
-
Plasma membrane localization signals in the light chain of botulinum neurotoxin
-
Fernandez-Salas E., Steward L.E., Ho H., Garay P.E., Sun S.W., Gilmore M.A., Ordas J.V., Wang J., Francis J., and Aoki K.R. Plasma membrane localization signals in the light chain of botulinum neurotoxin. Proc. Natl. Acad. Sci. USA 101 9 (2004) 3208-3213
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.9
, pp. 3208-3213
-
-
Fernandez-Salas, E.1
Steward, L.E.2
Ho, H.3
Garay, P.E.4
Sun, S.W.5
Gilmore, M.A.6
Ordas, J.V.7
Wang, J.8
Francis, J.9
Aoki, K.R.10
-
37
-
-
26444459396
-
Internalization and mechanism of action of clostridial toxins in neurons
-
Grumelli C., Verderio C., Pozzi D., Rossetto O., Montecucco C., and Matteoli M. Internalization and mechanism of action of clostridial toxins in neurons. Neurotoxicology 26 5 (2005) 761-767
-
(2005)
Neurotoxicology
, vol.26
, Issue.5
, pp. 761-767
-
-
Grumelli, C.1
Verderio, C.2
Pozzi, D.3
Rossetto, O.4
Montecucco, C.5
Matteoli, M.6
-
38
-
-
27744456489
-
Visualization of binding and transcytosis of botulinum toxin by human intestinal epithelial cells
-
Ahsan C.R., Hajnóczky G., Maksymowych A.B., and Simpson L.L. Visualization of binding and transcytosis of botulinum toxin by human intestinal epithelial cells. J. Pharmacol. Exp. Ther. 315 3 (2005) 1028-1035
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.315
, Issue.3
, pp. 1028-1035
-
-
Ahsan, C.R.1
Hajnóczky, G.2
Maksymowych, A.B.3
Simpson, L.L.4
-
39
-
-
1842815920
-
Transglutaminase-mediated N- and C-terminal fluorescein labeling of a protein can support the native activity of the modified protein
-
Taki M., Shiota M., and Taira K. Transglutaminase-mediated N- and C-terminal fluorescein labeling of a protein can support the native activity of the modified protein. Protein Eng. Des. Sel. 17 2 (2004) 119-126
-
(2004)
Protein Eng. Des. Sel.
, vol.17
, Issue.2
, pp. 119-126
-
-
Taki, M.1
Shiota, M.2
Taira, K.3
-
40
-
-
0142059619
-
Identifying and modulating disulfide formation in the biopharmaceutical production of a recombinant protein vaccine candidate
-
Bouvier A., Chapline J., Boerner R., Jeyarajah S., Cook S., Acharya P.S., Henderson I., Schrimsher J.L., and Shepard S.R. Identifying and modulating disulfide formation in the biopharmaceutical production of a recombinant protein vaccine candidate. J. Biotechnol. 103 3 (2003) 257-271
-
(2003)
J. Biotechnol.
, vol.103
, Issue.3
, pp. 257-271
-
-
Bouvier, A.1
Chapline, J.2
Boerner, R.3
Jeyarajah, S.4
Cook, S.5
Acharya, P.S.6
Henderson, I.7
Schrimsher, J.L.8
Shepard, S.R.9
|