Recombinant Forms of Tetanus Toxin Engineered for Examining and Exploiting Neuronal Trafficking Pathways

Journal of Biological Chemistry

Volumn 276, Issue 33, 2001, Pages 31394-31401

  Li, Yan ^a   Foran, Patrick ^a   Lawrence, Gary ^a   Mohammed, Nadiem ^a   Chan Kwo Chion, Chan Ka Ning ^a   Lisk, Godfrey ^a   Aoki, Roger ^b   Dolly, Oliver ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ALLERGAN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; ENZYME KINETICS; NEUROLOGY; PROTEINS; TRANSPORT PROPERTIES;

BIOCHEMICAL PATHWAYS; INTOXICATION; NEUROPARALYSIS;

BIOCHEMICAL ENGINEERING;

ALANINE; ENTEROPEPTIDASE; GLUTAMIC ACID; NEUROTRANSMITTER; PROTEINASE; TETANUS TOXIN; TOXIN; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENZYME ACTIVITY; ESCHERICHIA COLI; GENETIC ENGINEERING; GENETIC RECOMBINATION; INTOXICATION; MOUSE; NERVE CELL; NERVE FIBER TRANSPORT; NEUROTRANSMISSION; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RETROGRADE NERVE FIBER TRANSPORT; SPASTIC PARESIS; TETANUS; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DRUG EFFECT; METABOLISM; MOLECULAR GENETICS; NEUROMUSCULAR SYNAPSE; NUCLEOTIDE SEQUENCE; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ANIMALIA; ESCHERICHIA COLI;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEUROMUSCULAR JUNCTION; NEURONS; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TETANUS TOXIN;

EID: 0035903198     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103517200     Document Type: Article

References (43)

1. Stockel, K., Schwab, M., and Thoenen, H. (1975) Brain Res. 99, 1-16
2. Ugolini, G. (1995) in Viral Vectors: Gene Therapy and Neuroscience Applications (Loewy, A. D., and Kaplitt, M. G., eds) pp. 293-317, Academic Press, New York
3. Dolly, J. O. (1990) in Neuromuscular Transmission-Basic and Applied Aspects (Vincent, A., and Wray, D. W., eds) pp. 107-131, Manchester University Press, Manchester
4. Price, D. L., Griffin, J., Young, A., Peck, K., and Stocks, A. (1975) Science 188, 945-947
5. Wellhöner, H. H. (1992) in Handbook of Experimental Pharmacology (Herken, H., and Hucho, F., eds), Vol 102: Selective Neurotoxicity, pp. 357-417, Springer-Verlag, Berlin
6. Herreros, J., Lalli, G., Montecucco, C., and Schiavo, G. (2000) J. Neurochem. 74, 1941-1950
7. Lalli, G., Herreros, J., Osborne, S. L., Montecucco, C., Rossetto, O., and Schiavo, G. (1999) J. Cell Sci. 112, 2715-2724
8. Montecucco, C. (1986) Trends Biochem. Sci. 11, 314-317
9. Li, Y., Aoki, R., and Dolly, J. O. (1999) J. Biochem. 125, 1200-1208
10. Link, E., Edelmann, L., Chou, J. H., Binz, T., Yamasaki, S., Eisel, U., Baumert, M., Südhof, T. C., Niemann, H., and Jahn, R. (1992) Biochem. Biophys. Res. Commun. 189, 1017-1023
11. Schiavo, G., Benfenati, F., Poulain, B., Rossetto, O., Delaureto, P. P., DasGupta, B. R., and Montecucco, C. (1992) Nature 359, 832-835
12. Habig, W. H., Keinumer, J. G., and Hadegree, M. C. (1983) in Frontiers in Biochemical and Biophysical Studies of Proteins and Membranes (Lui, T. Y., ed) pp. 463-473, Elsevier, New York
13. Schwab, M. E., Suda, K., and Thoenen, H. (1979) J. Cell Biol. 82, 798-810
14. Li, Y., Foran, P., Fairweather, N. F., de Paiva, A., Weller, U., Dougan, G., and Dolly, J. O. (1994) Biochemistry 33, 7014-7020
15. Bizzini, B., Grob, P., and Akert, K. (1981) Brain Res. 210, 291-309
16. Coen, L., Osta, R., Maury, M., and Brulet, P. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 9400-9405
17. Figueiredo, D. M., Hallewell, R. A., Chen, L. L., Fairweather, N. F., Dougan, G., Savitt, J. M., Parks, D. A., and Fishman, P. S. (1997) Exp. Neurol. 145, 546-554
18. Fishman, P. S., Savitt, J. M., and Farrand, D. A. (1990) J. Neurol. Sci. 98, 311-325
19. Weller, U., Dauzenroth, M.-E., Meyer zu Heringdorf, D., and Habermann, E. (1989) Eur. J. Biochem. 182, 649-656
20. Fishman, P. S., Parks, D. A., Patwardhan, A. J., and Matthews, C. C. (1999) Nat. Toxins 7, 151-156
21. Schiavo, G., Matteoli, M., and Montecucco, C. (2000) Physiol. Rev. 80, 717-766
22. Simpson, L. L. (1986) Ann. Rev. Pharmacol. Toxicol. 26, 427-453
23. Matsuda, M., Sugimoto, N., Ozutsumi, K., and Hiria, T. (1982) Biochem. Biophys. Res. Commun. 104, 799-805
24. Figueiredo, D., Turcotte, C., Frankel, G., Li, Y., Dolly, O., Wilkin, G., Marriott, D., Fairweather, N., and Dougan, G. (1995) Infect. Immun. 63, 3218-3221
25. Hanahan, D. (1983) J. Mol. Biol. 166, 557-580
26. Foran, P., Shone, C. C., and Dolly, J. O. (1994) Biochemistry 33, 15365-15374
27. de Paiva, A., Ashton, A. C., Foran, P., Schiavo, G., Montecucco, C., and Dolly, J. O. (1993) J. Neurochem. 61, 2338-2341
28. Maisey, E. A., Wadsworth, J. D. F., Poulain, B., Shone, C. C., Melling, J., Gibbs, P., Tauc, L., and Dolly, J. O. (1988) Eur. J. Biochem. 177, 683-691
29. Cambray-Deakin, M. A. (1995) in Neural Cell Culture: A Practical Approach (Cohen, J., and Wilkin, G. P., eds) pp. 3-13, IRL Press, Oxford, UK
30. Gallo, V., Ciotti, M. T., Coletti, A., Aloisi, F., and Levi, G. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 7919-7923
31. Krieglstein, K. G., Henschen, A. H., Weller, U., and Habermann, E. (1991) Eur. J. Biochem. 202, 41-51
32. Fairweather, N. F., Sanders, D., Slater, D., Hudel, M., Habermann, E., and Weller, U. (1993) FEBS Lett. 323, 218-222
33. Montecucco, C., and Schiavo, G. (1993) Trends Biochem. Sci. 18, 324-327
34. Lacy, D. B., Tepp, W., Cohen, A. C., DasGupta, B. R., and Stevens, R. C. (1998) Nat. Struct. Biol. 5, 898-902
35. Habermann, E., Weller, U., and Hudel, M. (1991) Naunyn-Schmiedebergs Arch. Exp. Pharmacol. 343, 323-329
36. de Paiva, A., Poulain, B., Lawrence, G. W., Shone, C. C., Tauc, L., and Dolly, J. O. (1993) J. Biol. Chem. 268, 20838-20844
37. Dolly, J. O., de Paiva, A., Foran, P., Lawrence, G., Daniels-Holgate, P., and Ashton, A. C. (1994) Semin. Neurosci. 6, 149-158
38. Daniels-Holgate, P. U., and Dolly, J. O. (1996) J. Neurosci. Res. 44, 263-271
39. Hogy, B., Dauzenroth, M. E., Hudel, M., Weller, U., and Habermann, E. (1992) Toxicon 30, 63-76
40. Bizzini, B., Stoeckel, K., and Schwab, M. (1977) J. Neurochem. 28, 529-542
41. Francis, J. W., Hosler, B. A., Brown, R. H., Jr., and Fishman, P. S. (1995) J. Biol. Chem. 270, 15434-15442
42. Schiavo, G., Demel, R., and Montecucco, C. (1991) Eur. J. Biochem. 199, 705-711
43. Schiavo, G., Papini, E., Genna, G., and Montecucco, C. (1990) Infect. Immun. 58, 4136-4141