Botulinum neurotoxin type D enables cytosolic delivery of enzymatically active cargo proteins to neurones via unfolded translocation intermediates

Journal of Neurochemistry

Volumn 91, Issue 6, 2004, Pages 1461-1472

  Bade, Steffen ^a,c   Rummel, Andreas ^a   Reisinger, Clemens ^b   Karnath, Tino ^a   Ahnert Hilger, Gudrun ^b   Bigalke, Hans ^a   Binz, Thomas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Dihydrofolate reductase; Fusion protein; Green fluorescent protein; Luciferase; Neuronal transporter protein; Recombinant botulinum neurotoxin

Indexed keywords

BACTERIAL PROTEIN; BOTULINUM TOXIN; BOTULINUM TOXIN D; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; LUCIFERASE; NEUROTOXIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOTULISM; BRAIN SYNAPTOSOME; CELL FRACTIONATION; CHICKEN; CONTROLLED STUDY; CYTOSOL; ENZYME ASSAY; HIPPOCAMPUS; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PHRENIC NERVE; PLASMID; PRIORITY JOURNAL; PROTEIN PURIFICATION; RAT; SPINAL CORD; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BOTULINUM TOXIN TYPE A; BOTULINUM TOXINS; CELLS, CULTURED; CYTOSOL; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; LUCIFERASES; LUMINESCENT AGENTS; MICE; NEUROMUSCULAR AGENTS; PHRENIC NERVE; RATS; RATS, WISTAR; RECOMBINANT FUSION PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE;

ANIMALIA; BACTERIA (MICROORGANISMS); GALLUS GALLUS;

EID: 10644230055     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02844.x     Document Type: Article

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