From Sialomes to the Sialoverse. An Insight into Salivary Potion of Blood-Feeding Insects.

Advances in Insect Physiology

Volumn 37, Issue , 2009, Pages 59-118

  Ribeiro, José M C ^a   Arcà, Bruno ^b,c  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 76949090652     PISSN: 00652806     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2806(09)37002-2     Document Type: Review

References (318)

1. Abebe M., Cupp M.S., Champagne D., Cupp E.W. Simulidin: a black fly (Simulium vittatum) salivary gland protein with anti-thrombin activity. J. Insect Physiol. 1995, 41:1001-1006.
2. Abramson D.I. Dermal blood vessels and Lymphatics. Handbook of Experimental Pharmacology: The Pharmacology of the Skin 1989, Vol. 1:89-116. Springer-Verlag, Berlin.
3. Adler S., Theodor O. The mouthparts, alimentary tract and salivary apparatus of the female Phlebotomus papatasi. Ann. Trop. Med. Parasitol. 1926, 20:109-142.
4. Aksoy S., Rio R.V. Interactions among multiple genomes: tsetse, its symbionts and trypanosomes. Insect Biochem. Mol. Biol. 2005, 35:691-698.
5. Allen J.R. Tick resistance: basophil in skin reactions of resistant guinea pigs. Int. J. Parasitol. 1973, 3:195-200.
6. Altschul S.F., Madden T.L., Schaffer A.A., Zhang J., Zhang Z., Miller W., Lipman D.J. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997, 25:3389-3402.
7. Ameri M., Wang X., Wilkerson M.J., Kanost M.R., Broce A.B. An immunoglobulin binding protein (antigen 5) of the stable fly (Diptera: Muscidae) salivary gland stimulates bovine immune responses. J. Med. Entomol. 2008, 45:94-101.
8. Amino R., Porto R.M., Chammas R., Egami M.I., Schenkman S. Identification and characterization of a sialidase released by the salivary gland of the hematophagous insect Triatoma infestans. J. Biol. Chem. 1998, 273:24575-24582.
9. Amino R., Tanaka A.S., Schenkman S. Triapsin, an unusual activatable serine protease from the saliva of the hematophagous vector of Chagas' disease Triatoma infestans (Hemiptera: Reduviidae). Insect Biochem. Mol. Biol. 2001, 31:465-472.
10. Amino R., Martins R.M., Procopio J., Hirata I.Y., Juliano M.A., Schenkman S. Trialysin, a novel pore-forming protein from Saliva of haematophagous insects activated by limited proteolysis. J. Biol. Chem. 2002, 277:6207-6213.
11. Andersen J.F., Ribeiro J.M.C. A secreted salivary inositol polyphosphate 5-phosphatase from a blood-feeding insect: allosteric activation by soluble phosphoinositides and phosphatidylserine. Biochemistry 2006, 45:5450-5457.
12. Andersen J.F., Champagne D.E., Weichsel A., Ribeiro J.M.C., Balfour C.A., Dress V., Montfort W.R. Nitric oxide binding and crystallization of recombinant nitrophorin I, a nitric oxide transport protein from the blood-sucking bug Rhodnius prolixus. Biochemistry 1997, 36:4423-4428.
13. Andersen J.F., Weichsel A., Balfour C.A., Champagne D.E., Montfort W.R. The crystal structure of nitrophorin 4 at 1.5Å resolution: transport of nitric oxide by a lipocalin-based heme protein. Structure 1998, 6:1315-1327.
14. Andersen J.F., Francischetti I.M.B., Valenzuela J.G., Schuck P., Ribeiro J.M.C. Inhibition of hemostasis by a high affinity biogenic amine-binding protein from the saliva of a blood-feeding insect. J. Biol. Chem. 2003, 278:4611-4617.
15. Andersen J.F., Gudderra N.P., Francischetti I.M.B., Ribeiro J.M.C. The role of salivary lipocalins in blood feeding by Rhodnius prolixus. Arch. Insect Biochem. Physiol. 2005, 58:97-105.
16. Andersen J.F., Hinnebusch B.J., Lucas D.A., Conrads T.P., Veenstra T.D., Pham V.M., Ribeiro J.M.C. An insight into the sialome of the oriental rat flea, Xenopsylla cheopis (Rots). BMC Genomics 2007, 8:102.
17. Andersen J.F., Pham V.M., Meng Z., Champagne D.E., Ribeiro J.M.C. Insight into the sialome of the black fly, Simulium vittatum. J. Proteome Res. 2009, 8:1474-1488.
18. Anderson J.M., Oliveira F., Kamhawi S., Mans B.J., Reynoso D., Seitz A.E., Lawyer P., Garfield M., Pham M., Valenzuela J.G. Comparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis. BMC Genomics 2006, 7:52.
19. Andersson J.O. Lateral gene transfer in eukaryotes. Cell. Mol. Life Sci. 2005, 62:1182-1197.
20. Arcà B., Lombardo F., de Lara Capurro M., della Torre A., Dimopoulos G., James A.A., Coluzzi M. Trapping cDNAs encoding secreted proteins from the salivary glands of the malaria vector Anopheles gambiae. Proc. Natl. Acad. Sci. USA 1999, 96:1516-1521.
21. Arcà B., Lombardo F., Lanfrancotti A., Spanos L., Veneri M., Louis C., Coluzzi M. A cluster of four D7-related genes is expressed in the salivary glands of the African malaria vector Anopheles gambiae. Insect Mol. Biol. 2002, 11:47-55.
22. Arcà B., Lombardo F., Valenzuela J.G., Francischetti I.M.B., Marinotti O., Coluzzi M., Ribeiro J.M.C. An updated catalogue of salivary gland transcripts in the adult female mosquito, Anopheles gambiae. J. Exp. Biol. 2005, 208:3971-3986.
23. Arcà B., Lombardo F., Francischetti I.M.B., Pham V.M., Mestres-Simon M., Andersen J.F., Ribeiro J.M.C. An insight into the sialome of the adult female mosquito Aedes albopictus. Insect Biochem. Mol. Biol. 2007, 37:107-127.
24. Argentine J.A., James A.A. Characterization of a salivary gland-specific esterase in the vector mosquito, Aedes aegypti. Insect Biochem. Mol. Biol. 1995, 25:621-630.
25. Assumpção T.C., Francischetti I.M.B., Andersen J.F., Schwarz A., Santana J.M., Ribeiro J.M.C. An insight into the sialome of the blood-sucking bug Triatoma infestans, a vector of Chagas' disease. Insect Biochem. Mol. Biol. 2008, 38:213-232.
26. Baines S. The role of the symbiotic bacteria in the nutrition of Rhodnius prolixus. J. Exp. Biol. 1956, 33:533-541.
27. Bänziger H. The piercing mechanism of the fruit-piercing moth Calpe [Calyptra] thalictri Bkh. (noctuidae) with reference to the skin-piercing blood-sucking moth C. eustrigata Hmps. Acta Trop. 1970, 27:54-88.
28. Bänziger H. Skin-piercing blood-sucking moths I: ecological and ethological studies on Calpe eustrigata (Lepid., noctuidae). Acta Trop. 1975, 32:125-144.
29. Bänziger H. Skin-piercing blood-sucking moths II: studies on a further 3 adult Calyptra [Calpe] sp. (Lepid., Noctuidae). Acta Trop. 1979, 36:23-37.
30. Barral A., Honda E., Caldas A., Costa J., Vinhas V., Rowton E.D., Valenzuela J.G., Charlab R., Barral-Netto M., Ribeiro J.M.C. Human immune response to sand fly salivary gland antigens: a useful epidemiological marker?. Am. J. Trop. Med. Hyg. 2000, 62:740-745.
31. Beerntsen B.T., Champagne D.E., Coleman J.L., Campos Y.A., James A.A. Characterization of the Sialokinin I gene encoding the salivary vasodilator of the yellow fever mosquito, Aedes aegypti. Insect Mol. Biol. 1999, 8:459-467.
32. Belkaid Y., Valenzuela J.G., Kamhawi S., Rowton E., Sacks D.L., Ribeiro J.M.C. Delayed-type hypersensitivity to Phlebotomus papatasi sand fly bite: an adaptive response induced by the fly?. Proc. Natl. Acad. Sci. USA 2000, 97:6704-6709.
33. Billingsley P.F., Baird J., Mitchell J.A., Drakeley C. Immune interactions between mosquitoes and their hosts. Parasite Immunol. 2006, 28:143-153.
34. Borkent A. The frog-biting midges of the World (Corethrellidae: Diptera). Zootaxa 2008, 1804:1-456.
35. Bowman A.S., Sauer J.R. Tick salivary glands: function, physiology and future. Parasitology 2004, 129:S67-S81.
36. Bowman A.S., Dillwith J.W., Sauer J.R. Tick salivary prostaglandins: presence, origin and significance. Parasitol. Today 1996, 12:388-396.
37. 2 activity in saliva of the lone star tick, Amblyomma americanum (L.). Exp. Parasitol. 1997, 87:121-132.
38. Braun M., Schror K. Prostaglandin D2 relaxes bovine coronary arteries by endothelium-dependent nitric oxide-mediated cGMP formation. Circ. Res. 1992, 71:1305-1313.
39. Braverman I.M. The cutaneous microcirculation: ultrastructure and microanatomical organization. Microcirculation 1997, 4:329-340.
40. Brossard M., Wikel S.K. Tick immunobiology. Parasitology 2004, 129:S161-S176.
41. Caljon G., Van Den Abbeele J., Stijlemans B., Coosemans M., De Baetselier P., Magez S. Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response. Infect. Immun. 2006, 74:6324-6330.
42. Calvo E., Ribeiro J.M.C. A novel secreted endonuclease from Culex quinquefasciatus salivary glands. J. Exp. Biol. 2006, 209:2651-2659.
43. Calvo E., Andersen J., Francischetti I.M.B., de Lara Capurro M., de Bianchi A.G., James A.A., Ribeiro J.M.C., Marinotti O. The transcriptome of adult female Anopheles darlingi salivary glands. Insect Mol. Biol. 2004, 13:73-88.
44. Calvo E., Mans B.J., Andersen J.F., Ribeiro J.M.C. Function and evolution of a mosquito salivary protein family. J. Biol. Chem. 2006, 281:1935-1942.
45. Calvo E., Pham V.M., Lombardo F., Arcà B., Ribeiro J.M.C. The sialotranscriptome of adult male Anopheles gambiae mosquitoes. Insect Biochem. Mol. Biol. 2006, 36:570-575.
46. Calvo E., Dao A., Pham V.M., Ribeiro J.M.C. An insight into the sialome of Anopheles funestus reveals an emerging pattern in anopheline salivary protein families. Insect Biochem. Mol. Biol. 2007, 37:164-175.
47. Calvo E., Tokumasu F., Marinotti O., Villeval J.L., Ribeiro J.M.C., Francischetti I.M.B. Aegyptin, a novel mosquito salivary gland protein, specifically binds to collagen and prevents its interaction with platelet glycoprotein VI, integrin α2β1, and von Willebrand factor. J. Biol. Chem. 2007, 282:26928-26938.
48. Calvo E., Pham V.M., Ribeiro J.M.C. An insight into the sialotranscriptome of the non-blood feeding Toxorhynchites amboinensis mosquito. Insect Biochem. Mol. Biol. 2008, 38:499-507.
49. Calvo E., Mans B.J., Ribeiro J.M.C., Andersen J.F. Multifunctionality and mechanism of ligand binding in a mosquito antiinflammatory protein. Proc. Natl. Acad. Sci. USA 2009, 106:3728-3733.
50. Calvo E., Pham V.M., Marinotti O., Andersen J.F., Ribeiro J.M.C. The salivary gland transcriptome of the neotropical malaria vector Anopheles darlingi reveals accelerated evolution of genes relevant to hematophagy. BMC Genomics 2009, 10:57.
51. Campbell C.L., Vandyke K.A., Letchworth G.J., Drolet B.S., Hanekamp T., Wilson W.C. Midgut and salivary gland transcriptomes of the arbovirus vector Culicoides sonorensis (Diptera: Ceratopogonidae). Insect Mol. Biol. 2005, 14:121-136.
52. Cappello M., Li S., Chen X., Li C.B., Harrison L., Narashimhan S., Beard C.B., Aksoy S. Tsetse thrombin inhibitor: bloodmeal-induced expression of an anticoagulant in salivary glands and gut tissue of Glossina morsitans morsitans. Proc. Natl. Acad. Sci. USA 1998, 95:14290-14295.
53. Carroll P.R., Neering I.R. Relationship between vasoconstriction and histamine induced vasodilation. Aust. J. Exp. Biol. Med. Sci. 1976, 54:197-202.
54. Cavalcante R.R., Pereira M.H., Gontijo N.F. Anti-complement activity in the saliva of phlebotomine sand flies and other haematophagous insects. Parasitology 2003, 127:87-93.
55. Cerna P., Mikes L., Volf P. Salivary gland hyaluronidase in various species of phlebotomine sand flies (Diptera: Psychodidae). Insect Biochem. Mol. Biol. 2002, 32:1691-1697.
56. Champagne D.E. Antihemostatic strategies of blood-feeding arthropods. Curr. Drug Targets Cardiovasc. Haematol. Disord. 2004, 4:375-396.
57. Champagne D.E., Ribeiro J.M.C. Sialokinins I and II: two salivary tachykinins from the Yellow Fever mosquito, Aedes aegypti. Proc. Natl. Acad. Sci. USA 1994, 91:138-142.
58. Champagne D.E., Nussenzveig R.H., Ribeiro J.M.C. Purification, characterization, and cloning of nitric oxide-carrying heme proteins (nitrophorins) from salivary glands of the blood sucking insect Rhodnius prolixus. J. Biol. Chem. 1995, 270:8691-8695.
59. Champagne D.E., Smartt C.T., Ribeiro J.M.C., James A.A. The salivary gland-specific apyrase of the mosquito Aedes aegypti is a member of the 5'-nucleotidase family. Proc. Natl. Acad. Sci. USA 1995, 92:694-698.
60. Charlab R., Valenzuela J.G., Rowton E.D., Ribeiro J.M.C. Toward an understanding of the biochemical and pharmacological complexity of the saliva of a hematophagous sand fly Lutzomyia longipalpis. Proc. Natl. Acad. Sci. USA 1999, 96:15155-15160.
61. Charlab R., Rowton E.D., Ribeiro J.M.C. The salivary adenosine deaminase from the sand fly Lutzomyia longipalpis. Exp. Parasitol. 2000, 95:45-53.
62. Cheeseman M.T. Characterization of apyrase activity from the salivary glands of the cat flea Ctenocephalides felis. Insect Biochem. Mol. Biol. 1998, 28:1025-1030.
63. Cheeseman M.T., Bates P.A., Crampton J.M. Preliminary characterisation of esterase and platelet-activating factor (PAF)-acetylhydrolase activities from cat flea (Ctenocephalides felis) salivary glands. Insect Biochem. Mol. Biol. 2001, 31:157-164.
64. Cobben R.H. On the original feeding habits of the Hemiptera (Insecta): a reply to Merrill Sweet. Ann. Entomol. Soc. Am. 1979, 72:711-715.
65. A Translation of the Eight Books of Aulus Cornelius Celsus on Medicine (1831) 2008, Kessinger Publishing, LLC, Whitefish, MT. G.F. Collier (Ed.).
66. Collis M.G. The vasodilator role of adenosine. Pharmacol. Ther. 1989, 41:143-162.
67. Hemostasis and Thrombosis: Basic Principles and Clinical Practice 2005, Lippincott Williams & Wilkins, Philadelphia, PA. 5th ed. R.W. Colman, V.J. Marder, A.W. Clowes, J.N. George, S.Z. Goldhaber (Eds.).
68. Cornwall J.W., Patton W.S. Some observations on the salivary secretion of the common blood-sucking insects and ticks. Indian J. Med. Res. 1914, 2:569-593.
69. Cupp M.S., Cupp E.W. Antithrombin protein and DNA sequences from black fly. US Patent Application 10/973, 046 2000.
70. Cupp M.S., Cupp E.W., Ramberg F.B. Salivary gland apyrase in black flies (Simulium vittatum). J. Insect Physiol. 1993, 39:817-821.
71. Cupp M.S., Cupp E.W., Ochoa A.J., Moulton J.K. Salivary apyrase in New World blackflies (Diptera: Simuliidae) and its relationship to onchocerciasis vector status. Med. Vet. Entomol. 1995, 9:325-330.
72. Cupp M.S., Ribeiro J.M.C., Champagne D.E., Cupp E.W. Analyses of cDNA and recombinant protein for a potent vasoactive protein in saliva of a blood-feeding black fly, Simulium vittatum. J. Exp. Biol. 1998, 201:1553-1561.
73. Dan A., Pereira M.H., Pesquero J.L., Diotaiuti L., Beirão P.S. Action of the saliva of Triatoma infestans (Heteroptera: Reduviidae) on sodium channels. J. Med. Entomol. 1999, 36:875-879.
74. Dansa-Petreski M., Ribeiro J.M.C., Atella G.C., Masuda H., Oliveira P.L. Antioxidant role of Rhodnius prolixus heme-binding proteins. J. Biol. Chem. 1995, 270:10893-10896.
75. De Meillon B. The relationship between ectoparasites and host. IV. Host reaction to bites of arthropods. The Leech 1949, 19:43-46.
76. DeGiusti D.L., Sterling C.R., Dobrzechowski D. Transmission of the chelonian haemoproteid Haemoproteus metchnikovi by a Tabanid fly Chrysops callidus. Nature 1973, 242:50-51.
77. Demeure C.E., Brahimi K., Hacini F., Marchand F., Péronet R., Huerre M., St.-Mezard P., Nicolas J.-F., Brey P., Delespesse G., Mécheri S. Anopheles mosquito bites activate cutaneous mast cells leading to a local inflammatory response and lymph node hyperplasia. J. Immunol. 2005, 174:3932-3940.
78. Dickerson G., Lavoipierre M.M.J. Studies on the methods of feeding of blood sucking arthropods. II. The method of feeding adopted by the bedbug (Cimex lectularius) when obtaining a blood meal from the mammalian host. Ann. Trop. Med. Parasitol. 1959, 53:347-357.
79. Dickinson R.G., O'Hagan J.E., Shotz M., Binnington K.C., Hegarty M.P. Prostaglandin in the saliva of the cattle tick Boophilus microplus. Aust. J. Exp. Biol. Med. Sci. 1976, 54:475-486.
80. Dionisotti S., Zocchi C., Varani K., Borea P.A., Ongini E. Effects of adenosine derivatives on human and rabbit platelet aggregation. Correlation of adenosine receptor affinities and antiaggregatory activity. Naun. Schm. Arch. Pharmacol. 1992, 346:673-676.
81. Eichler E.E., Sankoff D. Structural dynamics of eukaryotic chromosome evolution. Science 2003, 301:793-797.
82. 2+-dependent endoplasmic reticulum nucleoside diphosphatase. J. Biol. Chem. 2002, 277:36978-36986.
83. Faudry E., Lozzi S.P., Santana J.M., D'Souza-Ault M., Kieffer S., Felix C.R., Ricart C.A.O., Sousa M.V., Vernet T., Teixeira A.R.L. Triatoma infestans apyrases belong to the 5'-nucleotidase family. J. Biol. Chem. 2004, 279:19607-19613.
84. Feingold B. The allergic responses to insect bites. Annu. Rev. Entomol. 1968, 13:137-158.
85. Flower D.R., North A.C., Sansom C.E. The lipocalin protein family: structural and sequence overview. Biochim. Biophys. Acta 2000, 1482:9-24.
86. Francischetti I.M.B., Valenzuela J.G., Ribeiro J.M.C. Anophelin: kinetics and mechanism of thrombin inhibition. Biochemistry 1999, 38:16678-16685.
87. Francischetti I.M.B., Ribeiro J.M.C., Champagne D.E., Andersen J. Purification, cloning, expression, and mechanism of action of a novel platelet aggregation inhibitor from the salivary gland of the blood-sucking bug, Rhodnius prolixus. J. Biol. Chem. 2000, 275:12639-12650.
88. Francischetti I.M.B., Andersen J.F., Ribeiro J.M.C. Biochemical and functional characterization of recombinant Rhodnius prolixus platelet aggregation inhibitor 1 as a novel lipocalin with high affinity for adenosine diphosphate and other adenine nucleotides. Biochemistry 2002, 41:3810-3818.
89. Francischetti I.M.B., Valenzuela J.G., Andersen J.F., Mather T.N., Ribeiro J.M.C. Ixolaris, a novel recombinant tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick, Ixodes scapularis: identification of factor X and factor Xa as scaffolds for the inhibition of factor VIIa/tissue factor complex. Blood 2002, 99:3602-3612.
90. Francischetti I.M.B., Valenzuela J.G., Pham V.M., Garfield M.K., Ribeiro J.M.C. Toward a catalog for the transcripts and proteins (sialome) from the salivary gland of the malaria vector Anopheles gambiae. J. Exp. Biol. 2002, 205:2429-2451.
91. Francischetti I.M.B., Mather T.N., Ribeiro J.M.C. Cloning of a salivary gland metalloprotease and characterization of gelatinase and fibrin(ogen)lytic activities in the saliva of the Lyme disease tick vector Ixodes scapularis. Biochem. Biophys. Res. Commun. 2003, 305:869-875.
92. Francischetti I.M.B., Mather T.N., Ribeiro J.M.C. Penthalaris, a novel recombinant five-Kunitz tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick vector of Lyme disease, Ixodes scapularis. Thromb. Haemost. 2004, 91:886-898.
93. Francischetti I.M.B., Sá-Nunes A., Mans B.J., Santos I.M., Ribeiro J.M.C. The role of saliva in tick feeding. Front. Biosci. 2009, 14:2051-2088.
94. Friend W.G., Smith J.J.B. Feeding in Rhodnius prolixus: mouthpart activity and salivation, and their correlation with changes of electrical resistance. J. Insect Physiol. 1971, 17:233-243.
95. Fuentes-Prior P., Noeske-Jungblut C., Donner P., Schleuning W.D., Huber R., Bode W. Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug. Proc. Natl. Acad. Sci. USA 1997, 94:11845-11850.
96. Galperin M.Y., Koonin E.V. 'Conserved hypothetical' proteins: prioritization of targets for experimental study. Nucleic Acids Res. 2004, 32:5452-5463.
97. Gillett J.D. Natural selection and feeding speed in a blood sucking insect. Proc. R. Soc. B 1967, 167:316-329.
98. Glusa E., Bretschneider E., Daum J., Noeske-Jungblut C. Inhibition of thrombin-mediated cellular effects by triabin, a highly potent anion-binding exosite thrombin inhibitor. Thromb. Haemost. 1997, 77:1196-1200.
99. Gogarten J.P., Townsend J.P. Horizontal gene transfer, genome innovation and evolution. Nat. Rev. Microbiol. 2005, 3:679-687.
100. Golodne D.M., Monteiro R.Q., Graça-Souza A.V., Silva-Neto M.A.C., Atella G.C. Lysophosphatidylcholine acts as an anti-hemostatic molecule in the saliva of the blood-sucking bug Rhodnius prolixus. J. Biol. Chem. 2003, 278:27766-27771.
101. Gomes R., Teixeira C., Teixeira M.J., Oliveira F., Menezes M.J., Silva C., de Oliveira C.I., Miranda J.C., Elnaiem D.-E., Kamhawi S., Valenzuela J.G., Brodskyn C.I. Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model. Proc. Natl. Acad. Sci. USA 2008, 105:7845-7850.
102. Gordon R.M., Crewe W. The mechanism by which mosquitoes and tsetse flies obtain their blood meal, the histology of the lesions produced, and the subsequent reactions of the mammalian host, together with some observations on the feeding of Chrysops and Cimex. Ann. Trop. Med. Parasitol. 1948, 42:334-356.
103. Gordon R.M., Lumsden W.H.R. A study of the behaviour of the mouthparts of mosquitoes when taking up blood from living tissue; together with some observations on the ingestion of microfilariae. Ann. Trop. Med. Parasitol. 1939, 33:259-278.
104. Grimaldi D., Engel M. Evolution of the Insects 2005, Cambridge University Press, New York, NY.
105. Gudderra N.P., Ribeiro J.M.C., Andersen J.F. Structural determinants of factor IX(a) binding in nitrophorin 2, a lipocalin inhibitor of the intrinsic coagulation pathway. J. Biol. Chem. 2005, 280:25022-25028.
106. Hanifin C.T., Brodie E.D., Brodie E.D. Phenotypic mismatches reveal escape from arms-race coevolution. PLoS Biol. 2008, 6:471-482.
107. Harris S.J., Parry R.V., Westwick J., Ward S.G. Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. J. Biol. Chem. 2008, 283:2465-2469.
108. Hekmat-Scafe D.S., Dorit R.L., Carlson J.R. Molecular evolution of odorant-binding protein genes OS-E and OS-F in Drosophila. Genetics 2000, 155:117-127.
109. Hellmann K., Hawkins R.I. Prolixin-S and Prolixin-G: two anticoagulants from Rhodnius prolixus Stahl. Nature 1965, 207:265-267.
110. Higgs G.A., Vane J.R., Hart R.J., Porter C., Wilson R.G. Prostaglandins in the saliva of the cattle tick, Boophilus microplus (Canestrini) (Acarina, Ixodidae). Bull. Entomol. Res. 1976, 66:665-670.
111. Hilgartner R., Raoilison M., Buttiker W., Lees D.C., Krenn H.W. Malagasy birds as hosts for eye-frequenting moths. Biol. Lett. 2007, 3:117-120.
112. Hill P., Saunders D.S., Campbell J.A. Letter: the production of "symbiont-free"Glossina morsitans and an associated loss of female fertility. Trans. R. Soc. Trop. Med. Hyg. 1973, 67:727-728.
113. Hill P., Campbell J.A., Petrie I.A. Rhodnius prolixus and its symbiotic actinomycete: a microbiological, physiological and behavioral study. Proc. R. Soc. Lond. B 1976, 194:501-525.
114. Hoffman D.R. Biting insect allergens. Clin. Allergy Immunol. 2008, 21:251-260.
115. Holland P.W. Gene duplication: past, present and future. Semin. Cell. Dev. Biol. 1999, 10:541-547.
116. Horuk R., Colby T.J., Darbonne W.C., Schall T.J., Neote K. The human erythrocyte inflammatory peptide (chemokine) receptor. Biochemical characterization, solubilization, and development of a binding assay for the soluble receptor. Biochemistry 1993, 32:5733-5738.
117. Hovius J.W., Levi M., Fikrig E. Salivating for knowledge: potential pharmacological agents in tick saliva. PLoS Med. 2008, 5:202-208.
118. Hudson A. Some functions of the salivary glands of mosquitoes and other blood-sucking arthropods. Can. J. Zool. 1964, 42:113-120.
119. Hudson A., Bowman L., Orr C.W.M. Effects of absence of saliva on blood feeding by mosquitoes. Science 1960, 131:1730-1731.
120. Hypsa V. Endosymbionts of Triatoma infestans: distribution and transmission. J. Invert. Pathol. 1993, 61:32-38.
121. Inokuma H., Kemp D.H., Willadsen P. Prostaglandin E2 production by the cattle tick (Boophilus microplus) into feeding sites and its effect on the response of bovine mononuclear cells to mitogen. Vet. Parasitol. 1994, 53:293-299.
122. Isawa H., Yuda M., Yoneda K., Chinzei Y. The insect salivary protein, prolixin-S, inhibits factor IXa generation and Xase complex formation in the blood coagulation pathway. J. Biol. Chem. 2000, 275:6636-6641.
123. Isawa H., Yuda M., Orito Y., Chinzei Y. A mosquito salivary protein inhibits activation of the plasma contact system by binding to factor XII and high molecular weight kininogen. J. Biol. Chem. 2002, 277:27651-27658.
124. Isawa H., Orito Y., Iwanaga S., Jingushi N., Morita A., Chinzei Y., Yuda M. Identification and characterization of a new kallikrein-kinin system inhibitor from the salivary glands of the malaria vector mosquito Anopheles stephensi. Insect Biochem. Mol. Biol. 2007, 37:466-477.
125. Jain R., Rivera M.C., Moore J.E., Lake J.A. Horizontal gene transfer in microbial genome evolution. Theor. Popul. Biol. 2002, 61:489-495.
126. James A.A., Blackmer K., Marinotti O., Ghosn C.R., Racioppi J.V. Isolation and characterization of the gene expressing the major salivary gland protein of the female mosquito, Aedes aegypti. Mol. Biochem. Parasitol. 1991, 44:245-254.
127. Kalesnikoff J., Sly L.M., Hughes M.R., Buchse T., Rauh M.J., Cao L.P., Lam V., Mui A., Huber M., Krystal G. The role of SHIP in cytokine-induced signaling. Rev. Physiol. Biochem. Pharmacol. 2003, 149:87-103.
128. Kanost M.R., Jiang H., Yu X.Q. Innate immune responses of a lepidopteran insect, Manduca sexta. Immunol. Rev. 2004, 198:97-105.
129. Kashiwada M., Lu P., Rothman P.B. PIP3 pathway in regulatory T cells and autoimmunity. Immunol. Res. 2007, 39:194-224.
130. Kato H., Anderson J.M., Kamhawi S., Oliveira F., Lawyer P.G., Pham V.M., Sangare C.S., Samake S., Sissoko I., Garfield M., Sigutova L., Volf P., et al. High degree of conservancy among secreted salivary gland proteins from two geographically distant Phlebotomus duboscqi sandflies populations (Mali and Kenya). BMC Genomics 2006, 7:226.
131. Kato H., Jochim R.C., Lawyer P.G., Valenzuela J.G. Identification and characterization of a salivary adenosine deaminase from the sand fly Phlebotomus duboscqi, the vector of Leishmania major in sub-Saharan Africa. J. Exp. Biol. 2007, 210:733-740.
132. Katz O., Waitumbi J.N., Zer R., Warburg A. Adenosine, AMP, and protein phosphatase activity in sandfly saliva. Am. J. Trop. Med. Hyg. 2000, 62:145-150.
133. Keeling P.J., Palmer J.D. Horizontal gene transfer in eukaryotic evolution. Nat. Rev. Genet. 2008, 9:605-618.
134. 1-receptor-mediated release of endothelium-derived nitric oxide. J. Vasc. Res. 1993, 30:132-138.
135. Kerlin R.L., Hughes S. Enzymes in saliva from four parasitic arthropods. Med. Vet. Entomol. 1992, 6:121-126.
136. King T.P., Spangfort M.D. Structure and biology of stinging insect venom allergens. Int. Arch. Allergy Immunol. 2000, 123:99-106.
137. Korochkina S., Barreau C., Pradel G., Jeffery E., Li J., Natarajan R., Shabanowitz J., Hunt D., Frevert U., Vernick K.D. A mosquito-specific protein family includes candidate receptors for malaria sporozoite invasion of salivary glands. Cell. Microbiol. 2006, 8:163-175.
138. Kovalick G.E., Griffin D.L. Characterization of the SCP/TAPS gene family in Drosophila melanogaster. Insect Biochem. Mol. Biol. 2005, 35:825-835.
139. Krzywinski J., Grushko O.G., Besansky N.J. Analysis of the complete mitochondrial DNA from Anopheles funestus: an improved dipteran mitochondrial genome annotation and a temporal dimension of mosquito evolution. Mol. Phylogenet. Evol. 2006, 39:417-423.
140. Kumar V., Abbas A.K., Fausto N., Mitchell R. Pathologic Basis of Disease 2004, Saunders, Philadelphia, PA.
141. Lai R., Takeuchi H., Jonczy J., Rees H.H., Turner P.C. A thrombin inhibitor from the ixodid tick, Amblyomma hebraeum. Gene 2004, 342:243-249.
142. Lane R.P., Crosskey R.W. Medical Insects and Arachnids 1993, Chapman and Hall, New York, NY.
143. Lanzaro G.C., Lopes A.H., Ribeiro J.M.C., Shoemaker C.B., Warburg A., Soares M., Titus R.G. Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex. Insect Mol. Biol. 1999, 8:267-275.
144. Lavoipierre M.M.J. Feeding mechanisms of blood-sucking arthropods. Nature 1964, 208:302-303.
145. Lavoipierre M.M.J., Dickerson G., Gordon R.M. Studies on the methods of feeding of blood sucking arthropods. I. The manner in which triatomine bugs obtain their blood meal, as observed in the tissues of the living rodent, with some remarks on the effects of the bite on human volunteers. Ann. Trop. Med. Parasitol. 1959, 53:235-250.
146. Law J., Ribeiro J.M.C., Wells M. Biochemical insights derived from diversity in insects. Annu. Rev. Biochem. 1992, 61:87-112.
147. Lehane M.J. The Biology of Blood-Sucking in Insects 2005, Cambridge University Press, Cambridge.
148. Lent H., Wygodzinsky P. Revision of the triatominae (Hemiptera, Reduviidae), and their significance as vectors of Chagas' disease. Bull. Am. Mus. Nat. Hist. 1979, 63:127-520.
149. Lerner E.A., Shoemaker C.B. Maxadilan: cloning and functional expression of the gene encoding this potent vasodilator peptide. J. Biol. Chem. 1992, 267:1062-1066.
150. Lerner E.A., Ribeiro J.M.C., Nelson R.J., Lerner M.R. Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis. J. Biol. Chem. 1991, 266:11234-11236.
151. Lester H.M.O., Lloyd L. Notes on the process of digestion in tsetse flies. Bull. Entomol. Res. 1928, 19:39-60.
152. Leung W.H., Tarasenko T., Bolland S. Differential roles for the inositol phosphatase SHIP in the regulation of macrophages and lymphocytes. Immunol. Res. 2008, 43:243-251.
153. Lewis D.J. Functional morphology of the mouthparts in New World phlebotomine sandflies (Diptera: Psychodidae). Trans. R. Entomol. Soc. Lond. 1975, 126:497-532.
154. Li S., Aksoy S. A family of genes with growth factor and adenosine deaminase similarity are preferentially expressed in the salivary glands of Glossina m. morsitans. Gene 2000, 252:83-93.
155. Li S., Kwon J., Aksoy S. Characterization of genes expressed in the salivary glands of the tsetse fly, Glossina morsitans morsitans. Insect Mol. Biol. 2001, 10:69-76.
156. Lohse M.J., Maurer K., Gensheimer H.P., Schwabe U. Dual actions of adenosine on rat peritoneal mast cells. Naun. Schm. Arch. Pharmacol. 1987, 335:555-560.
157. Lombardo F., Di Cristina M., Spanos L., Louis C., Coluzzi M., Arcà B. Promoter sequences of the putative Anopheles gambiae apyrase confer salivary gland expression in Drosophila melanogaster. J. Biol. Chem. 2000, 275:23861-23868.
158. Lombardo F., Ronca R., Rizzo C., Mestres-Simòn M., Lanfrancotti A., Currà C., Fiorentino G., Bourgouin C., Ribeiro J.M., Petrarca V., Ponzi M., Coluzzi M., et al. The Anopheles gambiae salivary protein gSG6: an anopheline-specific protein with a blood-feeding role. Insect Biochem. Mol. Biol. 2009, 39:457-466.
159. Lu X., Deadman J.J., Williams J.A., Kakkar V.V., Rahman S. Synthetic RGD peptides derived from the adhesive domains of snake-venom proteins: evaluation as inhibitors of platelet aggregation. Biochem. J. 1993, 296:21-24.
160. Maa T.C. Genera and species of Hippoboscidae (Diptera): types, synonymy, habits and natural groupings. J. Med. Entomol. 1964, 1:4-41.
161. Maa T.C. An interim world list of batflies. J. Med. Entomol. 1965, 1:377-386.
162. Mans B.J., Ribeiro J.M.C. Function, mechanism and evolution of the moubatin-clade of soft tick lipocalins. Insect Biochem. Mol. Biol. 2008, 38:841-852.
163. Mans B.J., Ribeiro J.M.C. A novel clade of cysteinyl leukotriene scavengers in soft ticks. Insect Biochem. Mol. Biol. 2008, 38:862-870.
164. Mans B.J., Louw A.I., Neitz A.W. Evolution of hematophagy in ticks: common origins for blood coagulation and platelet aggregation inhibitors from soft ticks of the genus Ornithodoros. Mol. Biol. Evol. 2002, 19:1695-1705.
165. Mans B.J., Calvo E., Ribeiro J.M.C., Andersen J.F. The crystal structure of D7r4, a salivary biogenic amine-binding protein from the malaria mosquito Anopheles gambiae. J. Biol. Chem. 2007, 282:36626-36633.
166. Mans B.J., Andersen J.F., Schwan T.G., Ribeiro J.M.C. Characterization of anti-hemostatic factors in the argasid, Argas monolakensis: implications for the evolution of blood-feeding in the soft tick family. Insect Biochem. Mol. Biol. 2008, 38:22-41.
167. Mant M.J., Parker K.R. Two platelet aggregation inhibitors in tsetse (Glossina) saliva with studies of roles of thrombin and citrate in in vitro platelet aggregation. Br. J. Haematol. 1981, 48:601-608.
168. Marchler-Bauer A., Panchenko A.R., Shoemaker B.A., Thiessen P.A., Geer L.Y., Bryant S.H. CDD: a database of conserved domain alignments with links to domain three-dimensional structure. Nucleic Acids Res. 2002, 30:281-283.
169. Marinotti O., de Brito M., Moreira C.K. Apyrase and alpha-glucosidase in the salivary glands of Aedes albopictus. Comp. Biochem. Physiol. B 1996, 113:675-679.
170. Martins R.M., Sforca M.L., Amino R., Juliano M.A., Oyama S., Juliano L., Pertinhez T.A., Spisni A., Schenkman S. Lytic activity and structural differences of amphipathic peptides derived from trialysin. Biochemistry 2006, 45:1765-1774.
171. Mattila J.T., Munderloh U.G., Kurtti T.J. Rickettsia peacockii, an endosymbiont of Dermacentor andersoni, does not elicit or inhibit humoral immune responses from immunocompetent D. andersoni or Ixodes scapularis cell lines. Dev. Comp. Immunol. 2007, 31:1095-1106.
172. Mazet F., Shimeld S.M. Gene duplication and divergence in the early evolution of vertebrates. Curr. Opin. Genet. Dev. 2002, 12:393-396.
173. Megraw T., Kaufman T.C., Kovalick G.E. Sequence and expression of Drosophila Antigen 5-related 2, a new member of the CAP gene family. Gene 1998, 222:297-304.
174. Mejia J.S., Bishop J.V., Titus R.G. Is it possible to develop pan-arthropod vaccines?. Trends Parasitol. 2006, 22:367-370.
175. Mellanby K. Man's reaction to mosquito bites. Nature 1946, 158:554.
176. Mellink J.J., Van Den Boven Kamp W. Functional aspects of mosquito salivation in blood feeding in Aedes aegypti. Mosq. News 1981, 41:115-119.
177. Metcalf R.L. The physiology of the salivary glands of Anopheles quadrimaculatus. J. Nat. Malar. Soc. 1945, 4:271-278.
178. Millan M.J. The induction of pain: an integrative review. Prog. Neurobiol. 1999, 57:1-164.
179. Milleron R.S., Ribeiro J.M.C., Elnaime D., Soong L., Lanzaro G.C. Negative effect of antibodies against maxadilan on the fitness of the sand fly vector of American visceral leishmaniasis. Am. J. Trop. Med. Hyg. 2004, 70:278-285.
180. Milne T.J., Abbenante G., Tyndall J.D., Halliday J., Lewis R.J. Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. J. Biol. Chem. 2003, 278:31105-31110.
181. Morita A., Isawa H., Orito Y., Iwanaga S., Chinzei Y., Yuda M. Identification and characterization of a collagen-induced platelet aggregation inhibitor, triplatin, from salivary glands of the assassin bug, Triatoma infestans. FEBS J. 2006, 273:2955-2962.
182. Moro O., Lerner E.A. Maxadilan, the vasodilator from sand flies, is a specific pituitary adenylate cyclase activating peptide type I receptor agonist. J. Biol. Chem. 1997, 272:966-970.
183. Morrow J.D., Awad J.A., Oates J.A., Roberts L.J.I.I. Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J. Invest. Dermatol. 1992, 98:812-815.
184. Nascimento R.J., Santana J.M., Lozzi S.P., Araujo C.N., Teixeira A.R. Human IgG1 and IgG4: the main antibodies against Triatoma infestans (Hemiptera: Reduviidae) salivary gland proteins. Am. J. Trop. Med. Hyg. 2001, 65:219-226.
185. Nei M., Rooney A.P. Concerted and birth-and-death evolution of multigene families. Annu. Rev. Genet. 2005, 39:121-152.
186. Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., Loftus B., Xi Z., Megy K., Grabherr M., Ren K., Zbodonov E.M. Genome sequence of Aedes aegypti, a major arbovirus vector. Science 2007, 316:1718-1723.
187. Nielsen H., Engelbrecht J., Brunak S., von Heijne G. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng. 1997, 10:1-6.
188. Noeske-Jungblut C., Kratzschmar J., Haendler B., Alagon A., Possani L., Verhallen P., Donner P., Schleuning W.D. An inhibitor of collagen-induced platelet aggregation from the saliva of Triatoma pallidipennis. J. Biol. Chem. 1994, 269:5050-5053.
189. Noeske-Jungblut C., Haendler B., Donner P., Alagon A., Possani L., Schleuning W.D. Triabin, a highly potent exosite inhibitor of thrombin. J. Biol. Chem. 1995, 270:28629-28634.
190. Nogge G. Aposymbiotic tsetse flies, Glossina morsitans morsitans obtained by feeding on rabbits immunized specifically with symbionts. J. Insect Physiol. 1978, 24:299-304.
191. Nunn M.A., Sharma A., Paesen G.C., Adamson S., Lissina O., Willis A.C., Nuttall P.A. Complement inhibitor of C5 activation from the soft tick Ornithodoros moubata. J. Immunol. 2005, 174:2084-2091.
192. Nuttall P.A., Trimnell A.R., Kazimirova M., Labuda M. Exposed and concealed antigens as vaccine targets for controlling ticks and tick-borne diseases. Parasite Immunol. 2006, 28:155-163.
193. O'Rourke F.J. Observations on pool and capillary feeding in Aedes aegypti (L.). Nature 1956, 177:1087-1088.
194. Ohno S. Gene duplication and the uniqueness of vertebrate genomes circa 1970-1999. Semin. Cell. Dev. Biol. 1999, 10:517-522.
195. Oliveira F., Kamhawi S., Seitz A.E., Pham V.M., Guigal P.M., Fischer L., Ward J., Valenzuela J.G. From transcriptome to immunome: identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library. Vaccine 2006, 24:374-390.
196. Orlandi-Pradines E., Almeras L., Denis de Senneville L., Barbe S., Remoue F., Villard C., Cornelie S., Penhoat K., Pascual A., Bourgouin C., et al. Antibody response against saliva antigens of Anopheles gambiae and Aedes aegypti in travellers in tropical Africa. Microbes Infect. 2007, 9:1454-1462.
197. Paesen G.C., Adams P.L., Harlos K., Nuttall P.A., Stuart D.I. Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure. Mol. Cell 1999, 3:661-671.
198. Paesen G.C., Adams P.L., Nuttall P.A., Stuart D.L. Tick histamine-binding proteins: lipocalins with a second binding cavity. Biochim. Biophys. Acta 2000, 1482:92-101.
199. Paesen G.C., Siebold C., Harlos K., Peacey M.F., Nuttall P.A., Stuart D.I. A tick protein with a modified Kunitz fold inhibits human tryptase. J. Mol. Biol. 2007, 368:1172-1186.
200. Pais R., Lohs C., Wu Y., Wang J., Aksoy S. The obligate mutualist Wigglesworthia glossinidia influences reproduction, digestion, and immunity processes of its host, the tsetse fly. Appl. Environ. Microbiol. 2008, 74:5965-5974.
201. Paul W.E. Fundamental Immunology 2008, Lippincott Williams & Wilkins, Philadelphia, PA.
202. Pavlov I.P. The Work of the Digestive Glands 1902, Charles Griffin & Co., London.
203. Peng Z., Simons E.R. Cross-reactivity of skin and serum specific IgE responses and allergen analysis for three mosquito species with worldwide distribution. J. Allergy Clin. Immunol. 1997, 100:192-198.
204. Peng Z., Simons F.E. A prospective study of naturally acquired sensitization and subsequent desensitization to mosquito bites and concurrent antibody responses. J. Allergy Clin. Immunol. 1998, 101:284-286.
205. Peng Z., Simons F.E. Advances in mosquito allergy. Curr. Opin. Allergy Clin. Immunol. 2007, 7:350-354.
206. Peng Z., Li H., Simons F.E. Immunoblot analysis of salivary allergens in 10 mosquito species with worldwide distribution and the human IgE responses to these allergens. J. Allergy Clin. Immunol. 1998, 101:498-505.
207. Poinsignon A., Cornelie S., Mestres-Simon M., Lanfrancotti A., Rossignol M., Boulanger D., Cisse B., Sokhna C., Arcà B., Simondon F., et al. Novel peptide marker corresponding to salivary protein gSG6 potentially identifies exposure to Anopheles bites. PLoS ONE 2008, 3:1-7.
208. Reddy V.B., Kounga K., Mariano F., Lerner E.A. Chrysoptin is a potent glycoprotein IIb/IIIa fibrinogen receptor antagonist present in salivary gland extracts of the deerfly. J. Biol. Chem. 2000, 275:15861-15867.
209. Remoue F., Cisse B., Ba F., Sokhna C., Herve J.P., Boulanger D., Simondon F. Evaluation of the antibody response to Anopheles salivary antigens as a potential marker of risk of malaria. Trans. R. Soc. Trop. Med. Hyg. 2006, 100:363-370.
210. Ribeiro J.M.C. The antiserotonin and antihistamine activities of salivary secretion of Rhodnius prolixus. J. Insect Physiol. 1982, 28:69-75.
211. Ribeiro J.M.C. Role of arthropod saliva in blood feeding. Annu. Rev. Entomol. 1987, 32:463-478.
212. Ribeiro J.M.C. How mosquitoes find blood. Misc. Publ. Entomol. Soc. Am. 1988, 68:18-24.
213. Ribeiro J.M.C. Blood-feeding arthropods: live syringes or invertebrate pharmacologists?. Infect. Agents Dis. 1995, 4:143-152.
214. Ribeiro J.M.C. Blood-feeding in mosquitoes: probing time and salivary gland anti-haemostatic activities in representatives of three genera (Aedes, Anopheles, Culex). Med. Vet. Entomol. 2000, 14:142-148.
215. Ribeiro J.M.C., Francischetti I.M.B. Platelet-activating-factor-hydrolyzing phospholipase C in the salivary glands and saliva of the mosquito Culex quinquefasciatus. J. Exp. Biol. 2001, 204:3887-3894.
216. Ribeiro J.M.C., Francischetti I.M.B. Role of arthropod saliva in blood feeding: sialome and post-sialome perspectives. Annu. Rev. Entomol. 2003, 48:73-88.
217. Ribeiro J.M.C., Garcia E.S. The salivary and crop apyrase activity of Rhodnius prolixus. J. Insect Physiol. 1980, 26:303-307.
218. Ribeiro J.M.C., Garcia E.S. The role of saliva in feeding in Rhodnius prolixus. J. Exp. Biol. 1981, 94:219-230.
219. Ribeiro J.M.C., Mather T.N. Ixodes scapularis: salivary kininase activity is a metallo dipeptidyl carboxypeptidase. Exp. Parasitol. 1998, 89:213-221.
220. Ribeiro J.M.C., Modi G. The salivary adenosine/AMP content of Phlebotomus argentipes Annandale and Brunetti, the main vector of human kala-azar. J. Parasitol. 2001, 87:915-917.
221. Ribeiro J.M.C., Nussenzveig R.H. The salivary catechol oxidase/peroxidase activities of the mosquito, Anopheles albimanus. J. Exp. Biol. 1993, 179:273-287.
222. Ribeiro J.M.C., Spielman A. Ixodes dammini: salivary anaphylatoxin inactivating activity. Exp. Parasitol. 1986, 62:292-297.
223. Ribeiro J.M.C., Valenzuela J.G. Purification and cloning of the salivary peroxidase/catechol oxidase of the mosquito Anopheles albimanus. J. Exp. Biol. 1999, 202:809-816.
224. Ribeiro J.M.C., Valenzuela J.G. The salivary purine nucleosidase of the mosquito, Aedes aegypti. Insect Biochem. Mol. Biol. 2003, 33:13-22.
225. Ribeiro J.M.C., Walker F.A. High affinity histamine-binding and anti-histaminic activity of the salivary NO-carrying heme protein (Nitrophorin) of Rhodnius prolixus. J. Exp. Med. 1994, 180:2251-2257.
226. Ribeiro J.M.C., Rossignol P.A., Spielman A. Role of mosquito saliva in blood vessel location. J. Exp. Biol. 1984, 108:1-7.
227. Ribeiro J.M.C., Sarkis J.J.F., Rossignol P.A., Spielman A. Salivary apyrase of Aedes aegypti: characterization and secretory fate. Comp. Biochem. Physiol. B 1984, 79:81-86.
228. Ribeiro J.M.C., Rossignol P.A., Spielman A. Aedes aegypti: model for blood finding behavior and prediction of parasite manipulation. Exp. Parasitol. 1985, 60:118-132.
229. Ribeiro J.M.C., Rossignol P.A., Spielman A. Salivary gland apyrase determines probing time in anopheline mosquitoes. J. Insect Physiol. 1985, 9:551-560.
230. Ribeiro J.M.C., Rossignol P.A., Spielman A. Blood finding strategy of a capillary feeding sandfly, Lutzomyia longipalpis. Comp. Biochem. Physiol. A 1986, 83:683-686.
231. Ribeiro J.M.C., Modi G.B., Resh R.B. Salivary apyrase activity of some old world phlebotomine sand flies. Insect Biochem. 1989, 19:409-412.
232. Ribeiro J.M.C., Vaughan J.A., Azad A.F. Characterization of the salivary apyrase activity of three rodent flea species. Comp. Biochem. Physiol. B 1990, 95:215-218.
233. Ribeiro J.M.C., Endris T.M., Endris R. Saliva of the soft tick, Ornithodoros moubata, contains anti-platelet and apyrase activities. Comp. Biochem. Physiol. A 1991, 100:109-112.
234. Ribeiro J.M.C., Evans P.M., MacSwain J.L., Sauer J. Amblyomma americanum: characterization of salivary prostaglandins E2 and F2α by RP-HPLC/bioassay and gas chromatography-mass spectrometry. Exp. Parasitol. 1992, 74:112-116.
235. Ribeiro J.M.C., Nussenzveig R.H., Tortorella G. Salivary vasodilators of Aedes triseriatus and Anopheles gambiae (Diptera: Culicidae). J. Med. Entomol. 1994, 31:747-753.
236. Ribeiro J.M.C., Schneider M., Guimarães J.A. Purification and characterization of prolixin S (nitrophorin 2), the salivary anticoagulant of the blood sucking bug, Rhodnius prolixus. Biochem. J. 1995, 308:243-249.
237. Ribeiro J.M.C., Schneider M., Isaias T., Jurberg J., Galvão C., Guimarães J.A. Role of salivary antihemostatic components in blood feeding by triatomine bugs (Heteroptera). J. Med. Entomol. 1998, 35:599-610.
238. Ribeiro J.M.C., Katz O., Pannell L.K., Waitumbi J., Warburg A. Salivary glands of the sand fly Phlebotomus papatasi contain pharmacologically active amounts of adenosine and 5'-AMP. J. Exp. Biol. 1999, 202:1551-1559.
239. Ribeiro J.M.C., Charlab R., Rowton E.D., Cupp E.W. Simulium vittatum (Diptera: Simuliidae) and Lutzomyia longipalpis (Diptera: Psychodidae) salivary gland hyaluronidase activity. J. Med. Entomol. 2000, 37:743-747.
240. Ribeiro J.M.C., Rowton E.D., Charlab R. The salivary 5'-nucleotidase/phosphodiesterase of the hematophagus sand fly, Lutzomyia longipalpis [corrected]. Insect Biochem. Mol. Biol. 2000, 30:279-285.
241. Ribeiro J.M.C., Charlab R., Valenzuela J.G. The salivary adenosine deaminase activity of the mosquitoes Culex quinquefasciatus and Aedes aegypti. J. Exp. Biol. 2001, 204:2001-2010.
242. Ribeiro J.M.C., Andersen J., Silva-Neto M.A., Pham V.M., Garfield M.K., Valenzuela J.G. Exploring the sialome of the blood-sucking bug Rhodnius prolixus. Insect Biochem. Mol. Biol. 2004, 34:61-79.
243. Ribeiro J.M.C., Charlab R., Pham V.M., Garfield M., Valenzuela J.G. An insight into the salivary transcriptome and proteome of the adult female mosquito Culex pipiens quinquefasciatus. Insect Biochem. Mol. Biol. 2004, 34:543-563.
244. Ribeiro J.M.C., Arcà B., Lombardo F., Calvo E., Phan V.M., Chandra P.K., Wikel S.K. An annotated catalogue of salivary gland transcripts in the adult female mosquito, Aedes aegypti. BMC Genomics 2007, 8:6.
245. Ricci I., Cancrini G., Gabrielli S., D'Amelio S., Favi G. Searching for Wolbachia (Rickettsiales: Rickettsiaceae) in mosquitoes (Diptera: Culicidae): large polymerase chain reaction survey and new identifications. J. Med. Entomol. 2002, 39:562-567.
246. Rossignol P.A., Spielman A. Fluid transport across the ducts of the salivary glands of a mosquito. J. Insect Physiol. 1982, 28:579-583.
247. Rothschild M. Recent advances in our knowledge of the order Siphonaptera. Annu. Rev. Entomol. 1975, 20:241-259.
248. Ruiz F.A., Lea C.R., Oldfield E., Docampo R. Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J. Biol. Chem. 2004, 279:44250-44257.
249. Sá-Nunes A., Bafica A., Lucas D.A., Conrads T.P., Veenstra T.D., Andersen J.F., Mather T.N., Ribeiro J.M.C., Francischetti I.M.B. Prostaglandin E2 is a major inhibitor of dendritic cell maturation and function in Ixodes scapularis saliva. J. Immunol. 2007, 179:1497-1505.
250. Sanders M.L., Jaworski D.C., Sanchez J.L., DeFraites R.F., Glass G.E., Scott A.L., Raha S., Ritchie B.C., Needham G.R., Schwartz B.S. Antibody to a cDNA-derived calreticulin protein from Amblyomma americanum as a biomarker of tick exposure in humans. Am. J. Trop. Med. Hyg. 1998, 59:279-285.
251. Sanders M.L., Glass G.E., Nadelman R.B., Wormser G.P., Scott A.L., Raha S., Ritchie B.C., Jaworski D.C., Schwartz B.S. Antibody levels to recombinant tick calreticulin increase in humans after exposure to Ixodes scapularis (Say) and are correlated with tick engorgement indices. Am. J. Epidemiol. 1999, 149:777-784.
252. Sangamnatdej S., Paesen G.C., Slovak M., Nuttall P.A. A high affinity serotonin- and histamine-binding lipocalin from tick saliva. Insect Mol. Biol. 2002, 11:79-86.
253. Sankoff D. Gene and genome duplication. Curr. Opin. Genet. Dev. 2001, 11:681-684.
254. Santos A., Ribeiro J.M.C., Lehane M.J., Gontijo N.F., Veloso A.B., Sant'Anna M.R., Nascimento Araujo R., Grisard E.C., Pereira M.H. The sialotranscriptome of the blood-sucking bug Triatoma brasiliensis (Hemiptera, Triatominae). Insect Biochem. Mol. Biol. 2007, 37:702-712.
255. Schlehuber S., Skerra A. Lipocalins in drug discovery: from natural ligand-binding proteins to "anticalins". Drug Discov. Today 2005, 10:23-33.
256. Schofield C.J. The behavior of Triatominae: a review. Bull. Entomol. Res. 1979, 69:363-379.
257. Schreiber M.C., Karlo J.C., Kovalick G.E. A novel cDNA from Drosophila encoding a protein with similarity to mammalian cysteine-rich secretory proteins, wasp venom antigen 5, and plant group 1 pathogenesis-related proteins. Gene 1997, 191:135-141.
258. Schwartz B.S., Ribeiro J.M.C., Goldstein M.D. Anti-tick antibodies: an epidemiologic tool in Lyme disease research. Am. J. Epidemiol. 1990, 132:58-66.
259. Schwartz B.S., Ford D.P., Childs J.E., Thomas R.J. Anti-tick saliva antibody: a biologic marker of tick exposure that is a risk factor for Lyme disease seropositivity. Am. J. Epidemiol. 1991, 134:86-95.
260. Shaw M.K., Moloo S.K. Comparative study on Rickettsia-like organisms in the midgut epithelial cells of different Glossina species. Parasitology 1991, 102:193-199.
261. Shepard J.J., Andreadis T.G., Vossbrinck C.R. Molecular phylogeny and evolutionary relationships among mosquitoes (Diptera: Culicidae) from the northeastern United States based on small subunit ribosomal DNA (18S rDNA) sequences. J. Med. Entomol. 2006, 43:443-454.
262. Short H.E., Swaminath C.S. The method of feeding of Phlebotomus argentipes with relation to its bearing on the transmission of Kalazar. Indian J. Med. Res. 1928, 15:827-836.
263. Simons F.E., Peng Z. Mosquito allergy: recombinant mosquito salivary antigens for new diagnostic tests. Int. Arch. Allergy Immunol. 2001, 124:403-405.
264. Sinkins S.P. Wolbachia and cytoplasmic incompatibility in mosquitoes. Insect Biochem. Mol. Biol. 2004, 34:723-729.
265. Sly L.M., Ho V., Antignano F., Ruschmann J., Hamilton M., Lam V., Rauh M.J., Krystal G. The role of SHIP in macrophages. Front. Biosci. 2007, 12:2836-2848.
266. Smith J.J.B., Cornish R.A., Wilkes J. Properties of a calcium-dependent apyrase in the saliva of the blood-feeding bug, Rhodnius prolixus. Experientia 1980, 36:898-900.
267. Soares M.B.P., Titus R.G., Shoemaker C.B., David J.R., Bozza M. The vasoactive peptide maxadilan from sand fly saliva inhibits TNF-α and induces IL-6 by mouse macrophages through interaction with the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor. J. Immunol. 1998, 160:1811-1816.
268. Soares R.P.P., Gontijo N.F., Romanha A.J., Diotaiuti L., Pereira M.H. Salivary heme proteins distinguish Rhodnius prolixus from Rhodnius robustus (Hemiptera: Reduviidae: Triatominae). Acta Trop. 1998, 71:285-291.
269. Soares R.P.P., Sant'Anna M.R.V., Gontijo N.F., Romanha A.J., Diotaiuti L., Pereira M.H. Identification of morphologically similar Rhodnius species (Hemiptera: Reduviidae: Triatominae) by electrophoresis of salivary heme proteins. Am. J. Trop. Med. Hyg. 2000, 62:157-161.
270. Soares A.C., Carvalho-Tavares J., Gontijo Nde F., dos Santos V.C., Teixeira M.M., Pereira M.H. Salivation pattern of Rhodnius prolixus (Reduviidae; Triatominae) in mouse skin. J. Insect Physiol. 2006, 52:468-472.
271. Stark K.R., James A.A. A factor Xa-directed anticoagulant from the salivary glands of the yellow fever mosquito Aedes aegypti. Exp. Parasitol. 1995, 81:321-331.
272. Stark K.R., James A.A. Isolation and characterization of the gene encoding a novel factor Xa-directed anticoagulant from the yellow fever mosquito, Aedes aegypti. J. Biol. Chem. 1998, 273:20802-20809.
273. Steen N.A., Barker S.C., Alewood P.F. Proteins in the saliva of the Ixodida (ticks): pharmacological features and biological significance. Toxicon 2006, 47:1-20.
274. 3 integrins. J. Biol. Chem. 1996, 271:10365-10371.
275. Sun J., Yamaguchi M., Yuda M., Miura K., Takeya H., Hirai M., Matsuoka H., Ando K., Watanabe T., Suzuki K., Chinzei Y. Purification, characterization and cDNA cloning of a novel anticoagulant of the intrinsic pathway, (prolixin-S) from salivary glands of the blood sucking bug, Rhodnius prolixus. Thromb. Haemost. 1996, 75:573-577.
276. Sun D., McNicol A., James A.A., Peng Z. Expression of functional recombinant mosquito salivary apyrase: a potential therapeutic platelet aggregation inhibitor. Platelets 2006, 17:178-184.
277. Sweet M.H. On the original feeding habits of the Hemiptera (Insect). Ann. Entomol. Soc. Am. 1979, 72:575-579.
278. Takáč P., Nunn M.A., Mészáros J., Pecháňová O., Vrbjar N., Vlasáková P., Kozánek M., Kazimírová M., Hart G., Nuttall P.A., Labuda M. Vasotab, a vasoactive peptide from horse fly Hybomitra bimaculata (Diptera, Tabanidae) salivary glands. J. Exp. Biol. 2006, 209:343-352.
279. Thiel S. Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol. Immunol. 2007, 44:3875-3888.
280. Thompson J.N. Coevolution: the geographic mosaic of coevolutionary arms races. Curr. Biol. 2005, 15:R992-R994.
281. 3 receptors on mast cells. J. Clin. Invest. 2000, 105:361-367.
282. Titus R.G., Bishop J.V., Mejia J.S. The immunomodulatory factors of arthropod saliva and the potential for these factors to serve as vaccine targets to prevent pathogen transmission. Parasite Immunol. 2006, 28:131-141.
283. Trevejo R.T., Reeves W.C. Antibody response to Culex tarsalis salivary gland antigens among sentinel chickens in California. Am. J. Trop. Med. Hyg. 2005, 72:481-487.
284. Trevejo R.T., Reisen W.K., Yoshimura G., Reeves W.C. Detection of chicken antibodies to mosquito salivary gland antigens by enzyme immunoassay. J. Am. Mosq. Control Assoc. 2005, 21:39-48.
285. Tsimanis A., Kalinkovich A., Bentwich Z. Soluble chemokine CCR5 receptor is present in human plasma. Immunol. Lett. 2005, 96:55-61.
286. Ujihara M., Horiguchi Y., Ikai K., Urade Y. Characterization and distribution of prostaglandin D synthase in rat skin. J. Invest. Dermatol. 1988, 90:448-451.
287. Valenzuela J.G. Exploring tick saliva: from Biochemistry to 'sialomes' and functional genomics. Parasitology 2004, 129:S83-S94.
288. Valenzuela J.G., Ribeiro J.M.C. Purification and cloning of the salivary nitrophorin from the hemipteran Cimex lectularius. J. Exp. Biol. 1998, 201:2659-2664.
289. Valenzuela J.G., Chuffe O.M., Ribeiro J.M.C. Apyrase and anti-platelet activities from the salivary glands of the bed bug Cimex lectularius. Insect Biochem. Mol. Biol. 1996, 21:557-562.
290. Valenzuela J.G., Charlab R., Galperin M.Y., Ribeiro J.M.C. Purification, cloning, and expression of an apyrase from the bed bug Cimex lectularius. A new type of nucleotide-binding enzyme. J. Biol. Chem. 1998, 273:30583-30590.
291. Valenzuela J.G., Francischetti I.M.B., Ribeiro J.M.C. Purification, cloning, and synthesis of a novel salivary anti-thrombin from the mosquito Anopheles albimanus. Biochemistry 1999, 38:11209-11215.
292. Valenzuela J.G., Charlab R., Mather T.N., Ribeiro J.M.C. Purification, cloning, and expression of a novel salivary anticomplement protein from the tick, Ixodes scapularis. J. Biol. Chem. 2000, 275:18717-18723.
293. Valenzuela J.G., Belkaid Y., Garfield M.K., Mendez S., Kamhawi S., Rowton E.D., Sacks D.L., Ribeiro J.M.C. Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein. J. Exp. Med. 2001, 194:331-342.
294. Valenzuela J.G., Belkaid Y., Rowton E., Ribeiro J.M.C. The salivary apyrase of the blood-sucking sand fly Phlebotomus papatasi belongs to the novel Cimex family of apyrases. J. Exp. Biol. 2001, 204:229-237.
295. Valenzuela J.G., Charlab R., Gonzalez E.C., de Miranda-Santos I.K., Marinotti O., Francischetti I.M.B., Ribeiro J.M.C. The D7 family of salivary proteins in blood sucking diptera. Insect Mol. Biol. 2002, 11:149-155.
296. Valenzuela J.G., Pham V.M., Garfield M.K., Francischetti I.M.B., Ribeiro J.M.C. Toward a description of the sialome of the adult female mosquito Aedes aegypti. Insect Biochem. Mol. Biol. 2002, 32:1101-1122.
297. Valenzuela J.G., Francischetti I.M.B., Pham V.M., Garfield M.K., Ribeiro J.M.C. Exploring the salivary gland transcriptome and proteome of the Anopheles stephensi mosquito. Insect Biochem. Mol. Biol. 2003, 33:717-732.
298. Valenzuela J.G., Garfield M., Rowton E.D., Pham V.M. Identification of the most abundant secreted proteins from the salivary glands of the sand fly Lutzomyia longipalpis, vector of Leishmania chagasi. J. Exp. Biol. 2004, 207:3717-3729.
299. Van Den Abbeele J., Caljon G., Dierick J.F., Moens L., De Ridder K., Coosemans M. The Glossina morsitans tsetse fly saliva: general characteristics and identification of novel salivary proteins. Insect Biochem. Mol. Biol. 2007, 37:1075-1085.
300. Volfova V., Hostomska J., Cerny M., Votypka J., Volf P. Hyaluronidase of bloodsucking insects and its enhancing effect on leishmania infection in mice. PLoS Negl. Trop. Dis. 2008, 2:1-8.
301. von Hundelshausen P., Petersen F., Brandt E. Platelet-derived chemokines in vascular biology. Thromb. Haemost. 2007, 97:704-713.
302. Waitayakul A., Somsri S., Sattabongkot J., Looareesuwan S., Cui L., Udomsangpetch R. Natural human humoral response to salivary gland proteins of Anopheles mosquitoes in Thailand. Acta Trop. 2006, 98:66-73.
303. Warren J.B., Loi R.K., Wilson A.J. PGD2 is an intermediate in agonist-stimulated nitric oxide release in rabbit skin microcirculation. Am. J. Physiol. 1994, 266:H1846-H1853.
304. Weichsel A., Andersen J.F., Champagne D.E., Walker F.A., Montfort W.R. Crystal structures of a nitric oxide transport protein from a blood-sucking insect. Nat. Struct. Biol. 1998, 5:304-309.
305. Wigglesworth V.B. Symbiotic bacteria in a blood sucking insect, Rhodnius prolixus Stal. Parasitology 1936, 28:284-289.
306. Wilson A.D., Heesom K.J., Mawby W.J., Mellor P.S., Russell C.L. Identification of abundant proteins and potential allergens in Culicoides nubeculosus salivary glands. Vet. Immunol. Immunopathol. 2008, 122:94-103.
307. Wirtz H.P. Quantitating histamine in the saliva and salivary glands of two Palaearctic blackfly species (Diptera: Simuliidae). Trop. Med. Parasitol. 1988, 39:309-312.
308. Wirtz H.P. Bioamines and proteins in the saliva and salivary glands of Palaearctic blackflies (Diptera: Simuliidae). Trop. Med. Parasitol. 1990, 41:59-64.
309. Xu X., Yang H., Ma D., Wu J., Wang Y., Song Y., Wang X., Lu Y., Yang J., Lai R. Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glands. Mol. Cell. Proteomics 2008, 7:582-590.
310. Yamazaki Y., Morita T. Structure and function of snake venom cysteine-rich secretory proteins. Toxicon 2004, 44:227-231.
311. Yamazaki Y., Hyodo F., Morita T. Wide distribution of cysteine-rich secretory proteins in snake venoms: isolation and cloning of novel snake venom cysteine-rich secretory proteins. Arch. Biochem. Biophys. 2003, 412:133-141.
312. Yorkee W., Macfie J.W.S. The action of the salivary secretion of mosquitoes and Glossina tachinoides on human blood. Ann. Trop. Med. Parasitol. 1924, 18:103-108.
313. Yoshida S., Sudo T., Niimi M., Tao L., Sun B., Kambayashi J., Watanabe H., Luo E., Matsuoka H. Inhibition of collagen-induced platelet aggregation by anopheline antiplatelet protein, a saliva protein from a malaria vector mosquito. Blood 2008, 111:2007-2014.
314. Zaspel J.M., Kononenko V.S., Goldstein P.Z. Another blood feeder? Experimental feeding of a fruit-piercing moth species on human blood in the Primorye Territory of Far Eastern Russia (Lepidoptera: Noctuidae: Calpinae). J. Insect Behav. 2007, 20:437-451.
315. Zhang Y., Ribeiro J.M.C., Guimarães J.A., Walsh P.N. Nitrophorin-2: a novel mixed-type reversible specific inhibitor of the intrinsic factor-X activating complex. Biochemistry 1998, 37:10681-10690.
316. Zhang D., Cupp M.S., Cupp E.W. Thrombostasin: purification, molecular cloning and expression of a novel anti-thrombin protein from horn fly saliva. Insect Biochem. Mol. Biol. 2002, 32:321-330.
317. Zhu K., Dillwith J.W., Bowman A.S., Sauer J.R. Identification of hemolytic activity in saliva of the lone star tick (Acari: Ixodidae). J. Med. Entomol. 1997, 34:160-166.
318. Zhu K., Bowman A.S., Dillwith J.W., Sauer J.R. Phospholipase A2 activity in salivary glands and saliva of the lone star tick (Acari: Ixodidae) during tick feeding. J. Med. Entomol. 1998, 35:500-504.