Nicotine is more efficient than cotinine at passing the blood-brain barrier in rats

Cellular and Molecular Neurobiology

Volumn 18, Issue 3, 1998, Pages 311-318

  Riah, Omar ^a,b   Courrière, Philippe ^a   Dousset, Jean Claude ^a   Todeschi, Nathalie ^a   Labat, Christian ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b FACULTÉ DES SCIENCES   (Morocco)

Author keywords

Blood brain barrier; Cotinine; High pressure liquid chromatography; Nicotine; Radioimmunoassay; Rats; Thin layer chromatography

Indexed keywords

COTININE; NICOTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; BLOOD BRAIN BARRIER; CONTAMINATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; THIN LAYER CHROMATOGRAPHY;

ANIMALIA; MAMMALIA;

EID: 0031980297     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022501131709     Document Type: Article

References (26)

1. 3H]methylcarbamylcholine in rat brain. Eur. J. Pharmacol. 253:261-267.
2. Andersson, K., Jasson, A., Kuylenstierna, F., and Eneroth, P. (1993). Nicotine and its major metabolite cotinine have different effects on aldosterone and prolactin serum levels in the normal male rat. Eur. J. Pharmacol. 228:305-312.
3. Benowitz, N. L., Kuyt, F., Jacob, P., III, Jones, R. T., and Osman, A.-L. (1983). Cotinine disposition and effects. Clin. Pharmacol. Ther. 34:604-611.
4. Bowman, E. R., and McKennis, H., Jr. (1963). Cotinine preparation. Biochem. Prep. 10:36-39.
5. Bowman, E. R., Turnbull, L. B., and McKennis, H., Jr. (1959). Metabolism of nicotine in the human and excretion of pyridine compounds by smokers. J. Pharmacol. Exp. Ther. 127:92-95.
6. 3 in the mouse. J. Pharmacol. Exp. Ther. 143:301-308.
7. Dar, M. S., Li, C., and Bowman, E. R. (1993). Central behavioral interactions between ethanol, (-)-nicotine and (-)-cotinine in mice. Brain Res. Bull. 32:23-28.
8. Dar, M. S., Bowman, E. R., and Li, C. (1994). Intracerebellar nicotinic-cholinergic participation in the cerebellar adenosinergic modulation of ethanol-induced motor incoordination in mice. Brain Res. 644:117-127.
9. Davis, R. A., Stiles, M. F., deBethizy, J. D., and Reynolds, J. H. (1991). Dietary nicotine: A source of urinary cotinine. Fd. Chem. Toxic. 29(12):821-827.
10. Erenmemisoglu, A., and Tekol, Y. (1994). Do nicotine metabolites have an effect on pain perception? Antinociceptive effect of cotinine in mice. Pharmazie 49:374-375.
11. Fuxe, K., Everitt, B. J., and Hökfelt, T. (1979). On the action of nicotine and cotinine on central 5-hydoxytryptamine neurons. Pharmacol. Biochem. Behav. 10(5):671-677.
12. Goldberg, S. R., Risner, M. E., Stolerman, I. P., Reavill, C., and Garcha, H. S. (1989). Nicotine and some related compounds: Effects on schedule-controlled behavior and discriminative properties in rats. Psychopharmacology 97:295-302.
13. 11C]cotinine. Preparation, metabolite studies and in vivo disposition in the human brain using PET. Nucl. Med. Biol. 19(8):871-877.
14. Hariharan, M., VanNoor, T., and Geen, J. (1988). A high performance liquid Chromatographic method for routine simultaneous determination of nicotine and cotinine in plasma. Clin. Chem. 34(4):724-729.
15. Keenan, R. M., Hatsukami, D. K., Pentel, P. R., Thompson, T. N., and Grillo, M. A. (1994). Pharmacodynamic effects of cotinine in abstinent cigarette smokers. Clin. Pharmacol. Ther. 55:581-590.
16. Li, N.-Y., Li, Y., and Gorrod, J. W. (1992). Determination of partition coefficients and ionisation constants of (S)-(-)-nicotine and certain metabolites. Med. Sci. Res. 20:901-902.
17. Plowchalk, D. R., Andersen, M. E., and DeBethizy, J. D. (1992). A physiologically based pharmacokinetic model for nicotine disposition in the Sprague-Dawley rat. Toxicol. Appl. Pharmacol. 116:177-188.
18. Reavill, C., Walther, B., Stolerman, I. P., and Testa, B. (1990). Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline. Neuropharmacology 29(7):619-624.
19. Risner, M. E., Goldberg, S. R., Prada, J. A., and Cone, E. J. (1985). Effects of nicotine, cocaine and some of their metabolites on schedule-controlled responding by beagle dogs and squirrel monkeys. J. Pharmacol. Exp. Ther. 234(1):113-119.
20. Rosenberg, J., Benowitz, N. L., Jacob, P., III, and Wilson, K. M. (1980). Disposition kinetics and effects of intravenous nicotine. Clin. Pharmacol. Ther. 28:517-522.
21. Schmiterlöw, C. G., Hansson, E., Andersson, G., Appelgren, L. E., and Huffman, P. C. (1966). Distribution of nicotine in the central nervous system. The effects of nicotine and smoking on the central nervous system. In Academy Sciences Conferences, Elsevier, New York, p. 2.
22. Stalhandske, T. (1969). The metabolisms of nicotine and cotinine by a mouse liver preparation. Acta. Physiol. Scand. 78:236-248.
23. Stolerman, I. P., Kumar, R., Pratt, J. A., and Reavill, C. (1987). Discriminative stimulus effects of nicotine: Correlation with binding study. In Martin, W. R., Van Loon, G. R., Iwamoto, E. T., and Davis, L. (ed.), Advances in Behavioural Biology: Tobacco Smoking and Nicotine: A Neurobiologic Approch, New York, p. 113.
24. Takada, K., Swedberg, M. D. B., Goldberg, S. R., and Katz, J. L. (1989). Discriminative stimulus effects of intravenous 1-nicotine and nicotine analogs or metabolites in squirrel monkeys. Psychopharmacology 99:208-212.
25. 14C in tissues of the mouse. Drug Metab. Dispos. 4(6):530-539.
26. Yamamoto, K. I., and Domino, E. F. (1965). Nicotine-induced EEG and behavioral arousal. Int. J. Neuropharmacol. 4:359-373.