Organization and evaluation of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster

Environmental Health Perspectives

Volumn 111, Issue 15, 2003, Pages 1835-1842

  Wang, Haoyi ^a   Donley, Kyle M ^a   Keeney, Diane S ^b   Hoffman, Susan M G ^a  

^a MIAMI UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cyp2a; Cyp2b; Cyp2f; Cyp2g; Cyp2s; Cyp2t cytochrome P450; Gene family; Gene duplication

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2A; CYTOCHROME P450 2B; CYTOCHROME P450 2F; CYTOCHROME P450 2G; CYTOCHROME P450 2S; CYTOCHROME P450 2T; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CHROMOSOME 19; CHROMOSOME 7; CONTROLLED STUDY; DRUG METABOLISM; GENE AMPLIFICATION; GENE CLUSTER; GENE CONTROL; GENE DUPLICATION; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE MAPPING; GENETIC ORGANIZATION; HUMAN; METABOLIC REGULATION; MOLECULAR CLONING; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FAMILY; PSEUDOGENE; RESTRICTION MAPPING; SEQUENCE ANALYSIS; SOUTHERN BLOTTING; ANIMAL; CHROMOSOME; CHROMOSOME MAP; COMPARATIVE STUDY; DNA SEQUENCE; GENE LIBRARY; GENETICS; GENOME; MULTIGENE FAMILY;

ANIMALS; BLOTTING, SOUTHERN; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 19; CHROMOSOMES, MAMMALIAN; CYTOCHROME P-450 ENZYME SYSTEM; GENE DUPLICATION; GENE LIBRARY; GENOME; HUMANS; MICE; MULTIGENE FAMILY; POLYMERASE CHAIN REACTION; RESTRICTION MAPPING; SEQUENCE ANALYSIS, DNA;

EID: 0346243562     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.6546     Document Type: Article

References (19)

1. Aida K, Moore R, Negishi M. 1994. Lack of the steroid 15α-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily. Genomics 19:564-566.
2. Chen N, Whitehead SE, Caillat AW, Gavit K, Isphording DR, Kovacevic D, et al. 2002. Identification and cross-species comparisons of CYP2F subfamily genes in mammals. Mutat Res 499:151-161.
3. Damon M, Fautrel A, Marc N, Guillouzo A, Corcos L. 1996. Isolation of a new mouse cDNA clone: hybrid form of cytochrome p450 2b10 and NAPDH-cytochrome p450 oxidoreductase. Biochem Biophys Res Commun 226:900-905.
4. Kim J, Gordon L, Dehal P, Badri H, Christensen M, Groza M, et al. 2001. Homology-driven assembly of a sequence-ready mouse BAC contig map spanning regions related to the 46-Mb gene-rich euchromatic segments of human chromosome 19. Genomics 74:129-141.
5. Eichler EE. 1998. Masquerading repeats: paralogous pitfalls of the human genome. Genome Res 8:758-762.
6. Fernandez-Salguero P, Hoffman S, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, et al. 1995. A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. Am J Hum Genet 57:651-660.
7. Gonzalez F, Nebert D. 1990. Evolution of the P450 gene superfamily: animal-plant "warfare," molecular drive and human genetic differences in drug oxidation. Trend Genet 6:182-186.
8. Hoffman S, Fernandez-Salguero P, Gonzalez F, Mohrenweiser H. 1995. Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19. J Mol Evol 41:894-900.
9. Hoffman S, Keeney D. 2002. Fine-scale mapping of CYP gene clusters: an example from the human CYP4 family. Methods Enzymol 357:36-44.
10. Hoffman S, Nelson D, Keeney D. 2001. Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19. Pharmacogenetics 11:687-698.
11. Iwasaki M, Lindberg R, Juvonen R, Negishi M. 1993. Site-directed mutagenesis of mouse steroid 7α-hydroxylase (cytochrome P-450 7α): role of residue-209 in determining steroid-cytochrome P-450 interaction. Biochem J 291:569-573.
12. Lewis DF, Watson E, Lake BG. 1998. Evolution of the cytochrome P450 superfamily: sequence alignments and pharmacogenetics. Mutat Res 410:245-270.
13. Marc N, Damon M, Fautrel A, Guillouzo A, Corcos L. 1999. Isolation of a cyp2b10-like cDNA and of a clone derived from a cyp2b10-like pseudogene. Biochem Biophys Res Commun 258:11-16.
14. Nebert DW, Russell DW. 2002. Clinical importance of the cytochromes P450. Lancet 360:1155-1162.
15. Nelson D. 2003. Cytochrome P450 Homepage. Memphis, TN:University of Tennessee. Available: http://drnelson.utmem.edu/CytochromeP450.html [accessed 19 June 2003].
16. Nelson D, Kamataki T, Waxman D, Guengerich F, Esterbrook R, Feyereisen R, et al. 1993. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol 12:1-51.
17. Nelson D, Koymans L, Kamataki T, Stegeman J, Feyereisen R, Waxman D, et al. 1996. Cytochrome P450 superfamily: update on new sequences, gene mapping, accession numbers, and nomenclature. Pharmacogenetics 6:1-42.
18. Noshiro M, Lakso M, Kawajiri K, Negishi M. 1988. Rip locus: regulation of female-specific isozyme (I-P450 16α.) of testosterone 16α-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA. Biochemistry 27:6434-6443.
19. Waterson RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, et al. 2002. Initial sequencing and comparative analysis of the mouse genome. Nature 420:520-562.